ID   JAM3_HUMAN              Reviewed;         310 AA.
AC   Q9BX67; Q8WWL8; Q96FL1;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   13-OCT-2009, entry version 73.
DE   RecName: Full=Junctional adhesion molecule C;
DE            Short=JAM-C;
DE   AltName: Full=Junctional adhesion molecule 3;
DE            Short=JAM-3;
DE   AltName: Full=JAM-2;
DE   Flags: Precursor;
GN   Name=JAM3; ORFNames=UNQ859/PRO1868;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH JAM2, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=11590146; DOI=10.1074/jbc.M105972200;
RA   Arrate M.P., Rodriguez J.M., Tran T.M., Brock T.A., Cunningham S.A.;
RT   "Cloning of human junctional adhesion molecule 3 (JAM3) and its
RT   identification as the JAM2 counter-receptor.";
RL   J. Biol. Chem. 276:45826-45832(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11739175; DOI=10.1182/blood.V98.13.3699;
RA   Aurrand-Lions M.A., Johnson-Leger C., Wong C., Du Pasquier L.,
RA   Imhof B.A.;
RT   "Heterogeneity of endothelial junctions is reflected by differential
RT   expression and specific subcellular localization of the three JAM
RT   family members.";
RL   Blood 98:3699-3707(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12208882; DOI=10.1084/jem.20020267;
RA   Santoso S., Sachs U.J.H., Kroll H., Linder M., Ruf A., Preissner K.T.,
RA   Chavakis T.;
RT   "The junctional adhesion molecule 3 (JAM-3) on human platelets is a
RT   counterreceptor for the leukocyte integrin Mac-1.";
RL   J. Exp. Med. 196:679-691(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=21945252; PubMed=11944976; DOI=10.1006/geno.2002.6742;
RA   Phillips H.M., Renforth G.L., Spalluto C., Hearn T., Curtis A.R.J.,
RA   Craven L., Havarani B., Clement-Jones M., English C., Stumper O.,
RA   Salmon T., Hutchinson S., Jackson M.S., Wilson D.I.;
RT   "Narrowing the critical region within 11q24-qter for hypoplastic left
RT   heart and identification of a candidate gene, JAM3, expressed during
RT   cardiogenesis.";
RL   Genomics 79:475-478(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   PROTEIN SEQUENCE OF 32-46.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [10]
RP   REVIEW, AND NOMENCLATURE.
RX   MEDLINE=22695901; PubMed=12810109; DOI=10.1016/S1471-4906(03)00117-0;
RA   Muller W.A.;
RT   "Leukocyte-endothelial-cell interactions in leukocyte transmigration
RT   and the inflammatory response.";
RL   Trends Immunol. 24:327-334(2003).
RN   [11]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
RN   [12]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192 AND ASN-198, AND MASS
RP   SPECTROMETRY.
RX   PubMed=19349973; DOI=10.1038/nbt.1532;
RA   Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA   Schiess R., Aebersold R., Watts J.D.;
RT   "Mass-spectrometric identification and relative quantification of N-
RT   linked cell surface glycoproteins.";
RL   Nat. Biotechnol. 27:378-386(2009).
CC   -!- FUNCTION: May participate in cell-cell adhesion distinct from
CC       tight junctions.
CC   -!- SUBUNIT: Interacts with JAM2.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- TISSUE SPECIFICITY: Widely expressed. Highest expression in
CC       placenta, brain and kidney.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC   -!- SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like)
CC       domain.
CC   -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like)
CC       domain.
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DR   EMBL; AF356518; AAK27221.1; -; mRNA.
DR   EMBL; AJ344431; CAC69845.1; -; mRNA.
DR   EMBL; AF448478; AAM20925.1; -; mRNA.
DR   EMBL; AJ416101; CAC94776.1; ALT_INIT; mRNA.
DR   EMBL; AK074769; BAC11195.1; -; mRNA.
DR   EMBL; AK075309; BAC11538.1; -; mRNA.
DR   EMBL; AY358335; AAQ88701.1; -; mRNA.
DR   EMBL; AP000911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC010690; AAH10690.1; -; mRNA.
DR   EMBL; BC012147; AAH12147.1; -; mRNA.
DR   IPI; IPI00152850; -.
DR   RefSeq; NP_116190.2; -.
DR   UniGene; Hs.150718; -.
DR   UniGene; Hs.700882; -.
DR   HSSP; O88792; 1F97.
DR   STRING; Q9BX67; -.
DR   PRIDE; Q9BX67; -.
DR   Ensembl; ENST00000299106; ENSP00000299106; ENSG00000166086; Homo sapiens.
DR   Ensembl; ENST00000441717; ENSP00000395742; ENSG00000166086; Homo sapiens.
DR   GeneID; 83700; -.
DR   KEGG; hsa:83700; -.
DR   UCSC; uc001qhb.1; human.
DR   CTD; 83700; -.
DR   GeneCards; GC11P133444; -.
DR   H-InvDB; HIX0010295; -.
DR   HGNC; HGNC:15532; JAM3.
DR   MIM; 606871; gene.
DR   PharmGKB; PA29993; -.
DR   HOGENOM; Q9BX67; -.
DR   HOVERGEN; Q9BX67; -.
DR   Pathway_Interaction_DB; amb2_neutrophils_pathway; amb2 Integrin signaling.
DR   Reactome; REACT_13552; Integrin cell surface interactions.
DR   Reactome; REACT_604; Hemostasis.
DR   Reactome; REACT_6900; Signaling in Immune system.
DR   NextBio; 72688; -.
DR   ArrayExpress; Q9BX67; -.
DR   Bgee; Q9BX67; -.
DR   CleanEx; HS_JAM3; -.
DR   Genevestigator; Q9BX67; -.
DR   GermOnline; ENSG00000166086; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR013151; Ig.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Signal;
KW   Transmembrane.
FT   SIGNAL        1     31
FT   CHAIN        32    310       Junctional adhesion molecule C.
FT                                /FTId=PRO_0000015071.
FT   TOPO_DOM     32    241       Extracellular (Potential).
FT   TRANSMEM    242    262       Potential.
FT   TOPO_DOM    263    310       Cytoplasmic (Potential).
FT   DOMAIN       35    127       Ig-like V-type.
FT   DOMAIN      139    236       Ig-like C2-type.
FT   CARBOHYD    104    104       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    192    192       N-linked (GlcNAc...).
FT   CARBOHYD    198    198       N-linked (GlcNAc...).
FT   DISULFID     53    115       Potential.
FT   DISULFID    160    219       Potential.
FT   CONFLICT    136    136       Q -> R (in Ref. 8; AAH10690).
SQ   SEQUENCE   310 AA;  35020 MW;  CE39ADF33EA1DAB9 CRC64;
     MALRRPPRLR LCARLPDFFL LLLFRGCLIG AVNLKSSNRT PVVQEFESVE LSCIITDSQT
     SDPRIEWKKI QDEQTTYVFF DNKIQGDLAG RAEILGKTSL KIWNVTRRDS ALYRCEVVAR
     NDRKEIDEIV IELTVQVKPV TPVCRVPKAV PVGKMATLHC QESEGHPRPH YSWYRNDVPL
     PTDSRANPRF RNSSFHLNSE TGTLVFTAVH KDDSGQYYCI ASNDAGSARC EEQEMEVYDL
     NIGGIIGGVL VVLAVLALIT LGICCAYRRG YFINNKQDGE SYKNPGKPDG VNYIRTDEEG
     DFRHKSSFVI
//