Reviewed,
UniProtKB/Swiss-Prot Q9BX67 (JAM3_HUMAN)
Last modified
October 13, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Junctional adhesion molecule C Short name=JAM-C Alternative name(s): Junctional adhesion molecule 3 Short name=JAM-3 JAM-2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 310 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May participate in cell-cell adhesion distinct from tight junctions. |
| Subunit structure | Interacts with JAM2. Ref.1 |
| Subcellular location | Cell membrane; Single-pass type I membrane protein Potential. |
| Tissue specificity | Widely expressed. Highest expression in placenta, brain and kidney. Ref.1 Ref.4 |
| Sequence similarities | Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Immunoglobulin domain Signal Transmembrane |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 31 | 31 | Ref.9 | ||||||||
| Chain | 32 – 310 | 279 | Junctional adhesion molecule C | PRO_0000015071 | |||||||
Regions | |||||||||||
| Topological domain | 32 – 241 | 210 | Extracellular Potential | ||||||||
| Transmembrane | 242 – 262 | 21 | Potential | ||||||||
| Topological domain | 263 – 310 | 48 | Cytoplasmic Potential | ||||||||
| Domain | 35 – 127 | 93 | Ig-like V-type | ||||||||
| Domain | 139 – 236 | 98 | Ig-like C2-type | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 104 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 192 | 1 | N-linked (GlcNAc...) Ref.12 | ||||||||
| Glycosylation | 198 | 1 | N-linked (GlcNAc...) Ref.12 | ||||||||
| Disulfide bond | 53 ↔ 115 | Potential | |||||||||
| Disulfide bond | 160 ↔ 219 | Potential | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 136 | 1 | Q → R in AAH10690. Ref.8 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor." Arrate M.P., Rodriguez J.M., Tran T.M., Brock T.A., Cunningham S.A. J. Biol. Chem. 276:45826-45832(2001) [PubMed: 11590146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH JAM2, TISSUE SPECIFICITY. Tissue: Brain. |
| [2] | "Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members." Aurrand-Lions M.A., Johnson-Leger C., Wong C., Du Pasquier L., Imhof B.A. Blood 98:3699-3707(2001) [PubMed: 11739175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1." Santoso S., Sachs U.J.H., Kroll H., Linder M., Ruf A., Preissner K.T., Chavakis T. J. Exp. Med. 196:679-691(2002) [PubMed: 12208882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis." Phillips H.M., Renforth G.L., Spalluto C., Hearn T., Curtis A.R.J., Craven L., Havarani B., Clement-Jones M., English C., Stumper O., Salmon T., Hutchinson S., Jackson M.S., Wilson D.I. Genomics 79:475-478(2002) [PubMed: 11944976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [5] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Uterus. |
| [9] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-46. |
| [10] | "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response." Muller W.A. Trends Immunol. 24:327-334(2003) [PubMed: 12810109] [Abstract] Cited for: REVIEW, NOMENCLATURE. |
| [11] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [12] | "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192 AND ASN-198, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF356518 mRNA. Translation: AAK27221.1. AJ344431 mRNA. Translation: CAC69845.1. AF448478 mRNA. Translation: AAM20925.1. AJ416101 mRNA. Translation: CAC94776.1. Different initiation. AK074769 mRNA. Translation: BAC11195.1. AK075309 mRNA. Translation: BAC11538.1. AY358335 mRNA. Translation: AAQ88701.1. AP000911 Genomic DNA. No translation available. AP001775 Genomic DNA. No translation available. BC010690 mRNA. Translation: AAH10690.1. BC012147 mRNA. Translation: AAH12147.1. | |
| IPI | IPI00152850. |
| RefSeq | NP_116190.2. |
| UniGene | Hs.150718 Hs.700882 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1F97 based on UniProtKB O88792. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9BX67. |
Proteomic databases | |
| PRIDE | Q9BX67. |
Genome annotation databases | |
| Ensembl | ENST00000299106; ENSP00000299106; ENSG00000166086; Homo sapiens. [Genome view] ENST00000441717; ENSP00000395742; ENSG00000166086; Homo sapiens. [Genome view] |
| GeneID | 83700. |
| KEGG | hsa:83700. |
| UCSC | uc001qhb.1. human. |
Organism-specific databases | |
| CTD | 83700. |
| GeneCards | GC11P133444. |
| H-InvDB | HIX0010295. |
| HGNC | HGNC:15532. JAM3. |
| MIM | 606871. gene. |
| PharmGKB | PA29993. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9BX67. |
| HOVERGEN | Q9BX67. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | amb2_neutrophils_pathway. amb2 Integrin signaling. |
| Reactome | REACT_13552. Integrin cell surface interactions. REACT_604. Hemostasis. REACT_6900. Signaling in Immune system. |
Gene expression databases | |
| ArrayExpress | Q9BX67. |
| Bgee | Q9BX67. |
| CleanEx | HS_JAM3. |
| Genevestigator | Q9BX67. |
| GermOnline | ENSG00000166086. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 2 hits. |
| Pfam | PF00047. ig. 1 hit. PF07686. V-set. 1 hit. [Graphical view] |
| SMART | SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. [Graphical view] |
| PROSITE | PS50835. IG_LIKE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 72688. |
| SOURCE | Search... |
Entry information
| Entry name | JAM3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BX67 Secondary accession number(s): Q8WWL8, Q96FL1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


