Q9BX66 (SRBS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorbin and SH3 domain-containing protein 1

Alternative name(s):
Ponsin
SH3 domain protein 5
SH3P12
c-Cbl-associated protein
Short name=CAP

Gene names

Name:	SORBS1
Synonyms:	KIAA0894, KIAA1296, SH3D5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1292 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions By similarity. UniProtKB Q62417
Subunit structure	Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus By similarity. Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/FAK1 and flotillin. Interacts (via SH3 domain 2) with PXN. Ref.1 Ref.2 Ref.4 Ref.5
Subcellular location	Cell junction › adherens junction. Cell membrane. Cytoplasm › cytoskeleton. Cell junction › focal adhesion. Nucleus By similarity. Nucleus matrix By similarity. Note: Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus By similarity. Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. Ref.2 Ref.5
Tissue specificity	Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle. Ref.1 Ref.5
Post-translational modification	O-glycosylated By similarity.
Sequence similarities	Contains 3 SH3 domains. Contains 1 SoHo domain.
Sequence caution	The sequence AAB93496.1 differs from that shown. Reason: Frameshift at positions 861, 867 and 885. The sequence BAA92534.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat SH3 domain
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	focal adhesion assembly Inferred from sequence or structural similarity. Source: UniProtKB glucose transport Inferred from sequence or structural similarity. Source: UniProtKB insulin receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB muscle contraction Traceable author statement. Source: Reactome positive regulation of establishment of protein localization to plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of glucose import Inferred from sequence or structural similarity PubMed 11001060. Source: BHF-UCL positive regulation of glycogen biosynthetic process Inferred from sequence or structural similarity PubMed 11001060. Source: BHF-UCL positive regulation of lipid biosynthetic process Inferred from sequence or structural similarity PubMed 11001060. Source: BHF-UCL stress fiber assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytosol Inferred from sequence or structural similarity PubMed 9447983. Source: BHF-UCL focal adhesion Inferred from direct assay. Source: HPA membrane raft Inferred from sequence or structural similarity. Source: UniProtKB nuclear matrix Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay Ref.2. Source: UniProtKB plasma membrane Inferred from direct assay. Source: HPA stress fiber Inferred from sequence or structural similarity. Source: UniProtKB zonula adherens Traceable author statement PubMed 10085297. Source: ProtInc
Molecular_function	SH3/SH2 adaptor activity Inferred from sequence or structural similarity PubMed 9447983. Source: BHF-UCL actin binding Traceable author statement PubMed 10085297. Source: ProtInc insulin receptor binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	2	EBI-433642,EBI-375543
INPPL1	O15357	5	EBI-433642,EBI-1384248

Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q9BX66-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: Q9BX66-2)

The sequence of this isoform differs from the canonical sequence as follows:
     434-453: DNPYTPTYQFPASTPSPKSE → TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA
     955-1117: Missing.

Note: Ref.1 (AAK37564) sequence is in conflict in positions: 435:K->E, 452-455:AHCS->SRCG, 463:N->D.

Isoform 3 Ref.1 (identifier: Q9BX66-3)

The sequence of this isoform differs from the canonical sequence as follows:
     147-215: Missing.
     408-453: Missing.
     602-635: Missing.
     956-975: FSSHSKLITPAPSSLPHSRR → LSHHSLRAGPDLTESEKSYV
     976-1213: Missing.

Isoform 4 Ref.1 (identifier: Q9BX66-4)

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     101-109: Missing.
     148-270: Missing.
     408-453: Missing.
     552-635: Missing.
     738-793: Missing.
     955-1212: Missing.

Note: Contains a phosphoserine at position 346. Contains a phosphoserine at position 603.

Isoform 5 Ref.3 (identifier: Q9BX66-5)

The sequence of this isoform differs from the canonical sequence as follows:
     101-109: Missing.
     431-451: Missing.
     955-1212: Missing.

Note: Contains a phosphoserine at position 923.

Isoform 6 Ref.4 (identifier: Q9BX66-6)

The sequence of this isoform differs from the canonical sequence as follows:
     101-109: Missing.
     148-270: Missing.
     580-635: Missing.
     955-1212: Missing.

Note: Contains a phosphoserine at position 765.

Isoform 7 (identifier: Q9BX66-7)

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     101-109: Missing.
     408-453: Missing.
     552-635: Missing.
     795-799: MRPAR → KYDWA
     800-1292: Missing.

Note: No experimental confirmation available. Contains a phosphoserine at position 469.

Isoform 8 Ref.2 (identifier: Q9BX66-8)

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     148-270: Missing.
     408-453: Missing.
     580-601: Missing.
     955-1212: Missing.

Note: Contains a phosphoserine at position 730.

Isoform 9 (identifier: Q9BX66-9)

The sequence of this isoform differs from the canonical sequence as follows:
     148-270: Missing.
     408-453: Missing.
     552-635: Missing.
     955-1212: Missing.

Note: Contains a phosphoserine at position 387. Contains a phosphoserine at position 700.

Isoform 10 (identifier: Q9BX66-10)

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     408-453: Missing.
     552-635: Missing.
     738-793: Missing.
     955-1212: Missing.

Note: No experimental confirmation available. Contains a phosphoserine at position 478. Contains a phosphoserine at position 735.

Isoform 11 (identifier: Q9BX66-11)

The sequence of this isoform differs from the canonical sequence as follows:
     408-453: Missing.
     1213-1213: Q → QLSHHSLRAGPDLTESEKSYV

Isoform 12 (identifier: Q9BX66-12)

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     148-270: Missing.
     319-328: Missing.
     408-453: Missing.
     580-601: Missing.
     709-709: K → KVDRKGGNAH...PQSELAPSRG
     955-1212: Missing.

Note: No experimental confirmation available. Derived from mouse ortholog data. Contains a phosphoserine at position 1213.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1292

1292

Sorbin and SH3 domain-containing protein 1

PRO_0000072185

Regions

Domain

366 – 469

104

SoHo

Domain

793 – 852

60

SH3 1

Domain

867 – 928

62

SH3 2

Domain

1231 – 1292

62

SH3 3

Amino acid modifications

Modified residue

86

1

Phosphoserine Ref.12

Modified residue

89

1

Phosphoserine Ref.12

Modified residue

134

1

Phosphotyrosine By similarity

Modified residue

349

1

Phosphothreonine By similarity

Modified residue

472

1

Phosphoserine Ref.12

Modified residue

481

1

Phosphoserine Ref.14

Modified residue

497

1

Phosphothreonine By similarity

Modified residue

536

1

Phosphotyrosine; by ABL1 By similarity

Modified residue

556

1

Phosphoserine By similarity

Modified residue

640

1

Phosphoserine By similarity

Modified residue

654

1

Phosphotyrosine; by ABL1 By similarity

Modified residue

665

1

Phosphoserine Ref.12

Modified residue

862

1

Phosphothreonine Ref.12

Modified residue

945

1

Phosphoserine Ref.12

Modified residue

1240

1

Phosphotyrosine; by ABL1 By similarity

Natural variations

Alternative sequence

26 – 57

32

Missing in isoform 4, isoform 7, isoform 8, isoform 10 and isoform 12. Ref.1 Ref.2

VSP_050895

Alternative sequence

101 – 109

9

Missing in isoform 4, isoform 5, isoform 6 and isoform 7. Ref.4

VSP_050896

Alternative sequence

147 – 215

69

Missing in isoform 3. Ref.1

VSP_050898

Alternative sequence

148 – 270

123

Missing in isoform 4, isoform 6, isoform 8, isoform 9 and isoform 12. Ref.1 Ref.2 Ref.4

VSP_050899

Alternative sequence

319 – 328

10

Missing in isoform 12.

VSP_041193

Alternative sequence

408 – 453

46

Missing in isoform 3, isoform 4, isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. Ref.1 Ref.2

VSP_050900

Alternative sequence

431 – 451

21

Missing in isoform 5. Ref.1 Ref.2

VSP_050901

Alternative sequence

434 – 453

20

DNPYT…SPKSE → TKSCSVMSPRLECSGTVIAH CSLKLLDSSNPPTSASQVAG TA in isoform 2. Ref.1

VSP_050902

Alternative sequence

552 – 635

84

Missing in isoform 4, isoform 7, isoform 9 and isoform 10. Ref.1

VSP_050903

Alternative sequence

580 – 635

56

Missing in isoform 6. Ref.4

VSP_050905

Alternative sequence

580 – 601

22

Missing in isoform 8 and isoform 12. Ref.2

VSP_050904

Alternative sequence

602 – 635

34

Missing in isoform 3. Ref.1

VSP_050906

Alternative sequence

709

1

K → KVDRKGGNAHMISSSSVHSR TFNTSNALGPVCKHKKPLSA AKACISEILPSKFKPRLSAP SALLQEQKSILLPSEKAQSC ENLCVSGSLNDSKRGLPLQV GGSIENLLMRSRRDYDSKSS STMSLQEYSTSGRRPCPLSR KAGMQFTMLYRDMHQINRSG LFLGSISSSSSVRDLASHFE KSSLALSRGELGPSQEGSEH IPKHTVSSRITAFEQLIQRS RSMPSLDLSGRLSKSPTPVL SRGSLTSARSAESLLESTKL HPKEMDGMNSSGVYASPTCS NMAHHALSFRGLVPSEPLST CSDDVDRCSNISTDSREGSG GSVHGDFPKHRLNKCKGTCP ASYTRFTTIRKHEQQQTSRQ PEWRLDARGDKSTLLRNIYL MSPLPFRLKKPLHHHPRQPS PGDSSGLLVGQKPDLPSQPH QDQPPSGGKPVVPTRLSSRH TMARLSRSSEPSQERPTALE DYPRAINNGNSVPYSDHSLD RNNNPQSELAPSRG in isoform 12.

VSP_041194

Alternative sequence

738 – 793

56

Missing in isoform 4 and isoform 10. Ref.1

VSP_050907

Alternative sequence

795 – 799

5

MRPAR → KYDWA in isoform 7.

VSP_050908

Alternative sequence

800 – 1292

493

Missing in isoform 7.

VSP_050909

Alternative sequence

955 – 1212

258

Missing in isoform 4, isoform 5, isoform 6, isoform 8, isoform 9, isoform 10 and isoform 12. Ref.1 Ref.2 Ref.3 Ref.4

VSP_050911

Alternative sequence

955 – 1117

163

Missing in isoform 2. Ref.1

VSP_050910

Alternative sequence

956 – 975

20

FSSHS…PHSRR → LSHHSLRAGPDLTESEKSYV in isoform 3. Ref.1

VSP_050912

Alternative sequence

976 – 1213

238

Missing in isoform 3. Ref.1

VSP_050913

Alternative sequence

1213

1

Q → QLSHHSLRAGPDLTESEKSY V in isoform 11.

VSP_039210

Natural variant

61

1

L → P. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.10
Corresponds to variant rs943542 [ dbSNP | Ensembl ].

VAR_047652

Natural variant

74

1

R → W. Ref.3

VAR_019653

Natural variant

175

1

G → V.
Corresponds to variant rs7081076 [ dbSNP | Ensembl ].

VAR_047653

Natural variant

195

1

T → A in a breast cancer sample; somatic mutation. Ref.17

VAR_035661

Natural variant

237

1

T → A Has a protective role in both obesity and diabetes. Ref.3
Corresponds to variant rs2281939 [ dbSNP | Ensembl ].

VAR_019654

Natural variant

485

1

Y → C.
Corresponds to variant rs35808802 [ dbSNP | Ensembl ].

VAR_047654

Experimental info

Sequence conflict

9

1

S → P in CAJ97431. Ref.5

Sequence conflict

18

1

P → S in AAD27647. Ref.1

Sequence conflict

18

1

P → S in AAF22175. Ref.3

Sequence conflict

110

1

D → G in AAD27647. Ref.1

Sequence conflict

110

1

D → G in AAF22175. Ref.3

Sequence conflict

113

1

R → K in AAD27647. Ref.1

Sequence conflict

113

1

R → K in AAF22175. Ref.3

Sequence conflict

131

1

A → V in AAD27647. Ref.1

Sequence conflict

131

1

A → V in AAF22175. Ref.3

Sequence conflict

134

1

Y → S in AAD27647. Ref.1

Sequence conflict

134

1

Y → S in AAF22175. Ref.3

Sequence conflict

226 – 228

3

RAS → SAC in AAF22175. Ref.3

Sequence conflict

264

1

T → P in AAF22175. Ref.3

Sequence conflict

292 – 295

4

PSVS → SSEC in AAD27647. Ref.1

Sequence conflict

292 – 295

4

PSVS → SSEC in AAF22175. Ref.3

Sequence conflict

481

1

S → R in AAF22175. Ref.3

Sequence conflict

489

1

E → V in AAD27647. Ref.1

Sequence conflict

489

1

E → V in AAF22175. Ref.3

Sequence conflict

607

1

D → E in AAF22175. Ref.3

Sequence conflict

610

1

L → F in AAF22175. Ref.3

Sequence conflict

644

1

E → G in AAD27647. Ref.1

Sequence conflict

644

1

E → G in AAF22175. Ref.3

Sequence conflict

679

1

R → S in AAD27647. Ref.1

Sequence conflict

679

1

R → S in AAF22175. Ref.3

Sequence conflict

690

1

D → V in AAD27647. Ref.1

Sequence conflict

690

1

D → V in AAF22175. Ref.3

Sequence conflict

694

1

Q → R in CAJ97431. Ref.5

Sequence conflict

695

1

G → D in AAD27647. Ref.1

Sequence conflict

695

1

G → D in AAF22175. Ref.3

Sequence conflict

710

1

D → N in AAD27647. Ref.1

Sequence conflict

710

1

D → N in AAF22175. Ref.3

Sequence conflict

1156

1

V → G in AAK37563. Ref.1

Sequence conflict

1156

1

V → G in AAK37564. Ref.1

Secondary structure

1

.

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1292

Helix Strand Turn

Details...

Beta strand

795 – 802

8

Beta strand

819 – 824

6

Beta strand

830 – 834

5

Beta strand

839 – 843

5

Turn

844 – 846

3

Beta strand

847 – 849

3

Beta strand

870 – 874

5

Beta strand

893 – 899

7

Beta strand

901 – 908

8

Turn

910 – 912

3

Beta strand

915 – 919

5

Helix

920 – 922

3

Beta strand

923 – 927

5

Beta strand

1230 – 1233

4

Beta strand

1235 – 1240

6

Beta strand

1257 – 1263

7

Beta strand

1267 – 1273

7

Turn

1274 – 1276

3

Beta strand

1279 – 1283

5

Beta strand

1286 – 1289

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: 70DA4169B6D82F06	FASTA	1,292	142,513
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 70 80 90 100 110 120 LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP GLEPEPSSAD EWRLSSSADA 130 140 150 160 170 180 NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT SSSAAQPEVI VVPLYLVNTD RGQEGTARPP 190 200 210 220 230 240 TPLGPLGCVP TIPATASAAS PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS 250 260 270 280 290 300 FSPPPPLVPP APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA 310 320 330 340 350 360 YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS PGKAIEKRAK 370 380 390 400 410 420 DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK QIHKLNRDTP EENPYFPTYK 430 440 450 460 470 480 FPELPEIQQT SEEDNPYTPT YQFPASTPSP KSEDDDSDLY SPRYSFSEDT KSPLSVPRSK 490 500 510 520 530 540 SEMSYIDGEK VVKRSATLPL PARSSSLKSS SERNDWEPPD KKVDTRKYRA EPKSIYEYQP 550 560 570 580 590 600 GKSSVLTNEK MSRDISPEEI DLKNEPWYKF FSELEFGKPP PKKIWDYTPG DCSILPREDR 610 620 630 640 650 660 KTNLDKDLSL CQTELEADLE KMETLNKAPS ANVPQSSAIS PTPEISSETP GYIYSSNFHA 670 680 690 700 710 720 VKRESDGAPG DLTSLENERQ IYKSVLEGGD IPLQGLSGLK RPSSSASTKD SESPRHFIPA 730 740 750 760 770 780 DYLESTEEFI RRRHDDKEKL LADQRRLKRE QEEADIAARR HTGVIPTHHQ FITNERFGDL 790 800 810 820 830 840 LNIDDTAKRK SGSEMRPARA KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG 850 860 870 880 890 900 IFPRTYIELL PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK GERITLLRQV 910 920 930 940 950 960 DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL PFSSSPSRSA TASPQFSSHS 970 980 990 1000 1010 1020 KLITPAPSSL PHSRRALSPE MHAVTSEWIS LTVGVPGRRS LALTPPLPPL PEASIYNTDH 1030 1040 1050 1060 1070 1080 LALSPRASPS LSLSLPHLSW SDRPTPRSVA SPLALPSPHK TYSLAPTSQA SLHMNGDGGV 1090 1100 1110 1120 1130 1140 HTPSSGIHQD SFLQLPLGSS DSVISQLSDA FSSQSKRQPW REESGQYERK AERGAGERGP 1150 1160 1170 1180 1190 1200 GGPKISKKSC LKPSDVVRCL STEQRLSDLN TPEESRPGKP LGSAFPGSEA EQTERHRGGE 1210 1220 1230 1240 1250 1260 QAGRKAARRG GSQQPQAQQR RVTPDRSQTS QDLFSYQALY SYIPQNDDEL ELRDGDIVDV 1270 1280 1290 MEKCDDGWFV GTSRRTKQFG TFPGNYVKPL YL
	Isoform 2 [UniParc]. Checksum: C1BD7AD5D5BE1300	FASTA	1,151	127,276
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 70 80 90 100 110 120 LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP GLEPEPSSAD EWRLSSSADA 130 140 150 160 170 180 NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT SSSAAQPEVI VVPLYLVNTD RGQEGTARPP 190 200 210 220 230 240 TPLGPLGCVP TIPATASAAS PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS 250 260 270 280 290 300 FSPPPPLVPP APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA 310 320 330 340 350 360 YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS PGKAIEKRAK 370 380 390 400 410 420 DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK QIHKLNRDTP EENPYFPTYK 430 440 450 460 470 480 FPELPEIQQT SEETKSCSVM SPRLECSGTV IAHCSLKLLD SSNPPTSASQ VAGTADDDSD 490 500 510 520 530 540 LYSPRYSFSE DTKSPLSVPR SKSEMSYIDG EKVVKRSATL PLPARSSSLK SSSERNDWEP 550 560 570 580 590 600 PDKKVDTRKY RAEPKSIYEY QPGKSSVLTN EKMSRDISPE EIDLKNEPWY KFFSELEFGK 610 620 630 640 650 660 PPPKKIWDYT PGDCSILPRE DRKTNLDKDL SLCQTELEAD LEKMETLNKA PSANVPQSSA 670 680 690 700 710 720 ISPTPEISSE TPGYIYSSNF HAVKRESDGA PGDLTSLENE RQIYKSVLEG GDIPLQGLSG 730 740 750 760 770 780 LKRPSSSAST KDSESPRHFI PADYLESTEE FIRRRHDDKE KLLADQRRLK REQEEADIAA 790 800 810 820 830 840 RRHTGVIPTH HQFITNERFG DLLNIDDTAK RKSGSEMRPA RAKFDFKAQT LKELPLQKGD 850 860 870 880 890 900 IVYIYKQIDQ NWYEGEHHGR VGIFPRTYIE LLPPAEKAQP KKLTPVQVLE YGEAIAKFNF 910 920 930 940 950 960 NGDTQVEMSF RKGERITLLR QVDENWYEGR IPGTSRQGIF PITYVDVIKR PLVKNPVDYM 970 980 990 1000 1010 1020 DLPFSSSPSR SATASPQPWR EESGQYERKA ERGAGERGPG GPKISKKSCL KPSDVVRCLS 1030 1040 1050 1060 1070 1080 TEQRLSDLNT PEESRPGKPL GSAFPGSEAE QTERHRGGEQ AGRKAARRGG SQQPQAQQRR 1090 1100 1110 1120 1130 1140 VTPDRSQTSQ DLFSYQALYS YIPQNDDELE LRDGDIVDVM EKCDDGWFVG TSRRTKQFGT 1150 FPGNYVKPLY L
	Isoform 3 [UniParc]. Checksum: C44DB4C9B0526933	FASTA	905	101,082
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 70 80 90 100 110 120 LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP GLEPEPSSAD EWRLSSSADA 130 140 150 160 170 180 NGNAQPSSLA AKGYRSVHPN LPSDKSQRWP HHSQPARASG SFAPISQTPP SFSPPPPLVP 190 200 210 220 230 240 PAPEDLRRVS EPDLTGAVSS TDSSPLLNEV SSSLIGTDSQ AFPSVSKPSS AYPSTTIVNP 250 260 270 280 290 300 TIVLLQHNRE QQKRLSSLSD PVSERRVGEQ DSAPTQEKPT SPGKAIEKRA KDDSRRVVKS 310 320 330 340 350 360 TQDLSDVSMD EVGIPLRNTE RSKDWYKTMF KQIHKLNRDD DSDLYSPRYS FSEDTKSPLS 370 380 390 400 410 420 VPRSKSEMSY IDGEKVVKRS ATLPLPARSS SLKSSSERND WEPPDKKVDT RKYRAEPKSI 430 440 450 460 470 480 YEYQPGKSSV LTNEKMSRDI SPEEIDLKNE PWYKFFSELE FGKPPPKKIW DYTPGDCSIL 490 500 510 520 530 540 PREDRKSSAI SPTPEISSET PGYIYSSNFH AVKRESDGAP GDLTSLENER QIYKSVLEGG 550 560 570 580 590 600 DIPLQGLSGL KRPSSSASTK DSESPRHFIP ADYLESTEEF IRRRHDDKEK LLADQRRLKR 610 620 630 640 650 660 EQEEADIAAR RHTGVIPTHH QFITNERFGD LLNIDDTAKR KSGSEMRPAR AKFDFKAQTL 670 680 690 700 710 720 KELPLQKGDI VYIYKQIDQN WYEGEHHGRV GIFPRTYIEL LPPAEKAQPK KLTPVQVLEY 730 740 750 760 770 780 GEAIAKFNFN GDTQVEMSFR KGERITLLRQ VDENWYEGRI PGTSRQGIFP ITYVDVIKRP 790 800 810 820 830 840 LVKNPVDYMD LPFSSSPSRS ATASPQLSHH SLRAGPDLTE SEKSYVQPQA QQRRVTPDRS 850 860 870 880 890 900 QTSQDLFSYQ ALYSYIPQND DELELRDGDI VDVMEKCDDG WFVGTSRRTK QFGTFPGNYV KPLYL
	Isoform 4 [UniParc]. Checksum: 9A417161477CB810	FASTA	684	76,596
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET PSSSPASPQE 70 80 90 100 110 120 TRQHESKPDE WRLSSSADAN GNAQPSSLAA KGYRSVHPNL PSDKSQDSSP LLNEVSSSLI 130 140 150 160 170 180 GTDSQAFPSV SKPSSAYPST TIVNPTIVLL QHNREQQKRL SSLSDPVSER RVGEQDSAPT 190 200 210 220 230 240 QEKPTSPGKA IEKRAKDDSR RVVKSTQDLS DVSMDEVGIP LRNTERSKDW YKTMFKQIHK 250 260 270 280 290 300 LNRDDDSDLY SPRYSFSEDT KSPLSVPRSK SEMSYIDGEK VVKRSATLPL PARSSSLKSS 310 320 330 340 350 360 SERNDWEPPD KKVDTRKYRA EPKSIYEYQP GKSSVLTNEK MSSAISPTPE ISSETPGYIY 370 380 390 400 410 420 SSNFHAVKRE SDGAPGDLTS LENERQIYKS VLEGGDIPLQ GLSGLKRPSS SASTKDSESP 430 440 450 460 470 480 RHFIPADYLE STEEFIRRRH DDKEMRPARA KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW 490 500 510 520 530 540 YEGEHHGRVG IFPRTYIELL PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK 550 560 570 580 590 600 GERITLLRQV DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL PFSSSPSRSA 610 620 630 640 650 660 TASPQQPQAQ QRRVTPDRSQ TSQDLFSYQA LYSYIPQNDD ELELRDGDIV DVMEKCDDGW 670 680 FVGTSRRTKQ FGTFPGNYVK PLYL
	Isoform 5 [UniParc]. Checksum: 45A17463F7373E8B	FASTA	1,004	111,791
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 70 80 90 100 110 120 LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP DEWRLSSSAD ANGNAQPSSL 130 140 150 160 170 180 AAKGYRSVHP NLPSDKSQDA TSSSAAQPEV IVVPLYLVNT DRGQEGTARP PTPLGPLGCV 190 200 210 220 230 240 PTIPATASAA SPLTFPTLDD FIPPHLQRWP HHSQPARASG SFAPISQTPP SFSPPPPLVP 250 260 270 280 290 300 PAPEDLRRVS EPDLTGAVSS TDSSPLLNEV SSSLIGTDSQ AFPSVSKPSS AYPSTTIVNP 310 320 330 340 350 360 TIVLLQHNRE QQKRLSSLSD PVSERRVGEQ DSAPTQEKPT SPGKAIEKRA KDDSRRVVKS 370 380 390 400 410 420 TQDLSDVSMD EVGIPLRNTE RSKDWYKTMF KQIHKLNRDT PEENPYFPTY KFPELPEIQQ 430 440 450 460 470 480 TSEDDDSDLY SPRYSFSEDT KSPLSVPRSK SEMSYIDGEK VVKRSATLPL PARSSSLKSS 490 500 510 520 530 540 SERNDWEPPD KKVDTRKYRA EPKSIYEYQP GKSSVLTNEK MSRDISPEEI DLKNEPWYKF 550 560 570 580 590 600 FSELEFGKPP PKKIWDYTPG DCSILPREDR KTNLDKDLSL CQTELEADLE KMETLNKAPS 610 620 630 640 650 660 ANVPQSSAIS PTPEISSETP GYIYSSNFHA VKRESDGAPG DLTSLENERQ IYKSVLEGGD 670 680 690 700 710 720 IPLQGLSGLK RPSSSASTKD SESPRHFIPA DYLESTEEFI RRRHDDKEKL LADQRRLKRE 730 740 750 760 770 780 QEEADIAARR HTGVIPTHHQ FITNERFGDL LNIDDTAKRK SGSEMRPARA KFDFKAQTLK 790 800 810 820 830 840 ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG IFPRTYIELL PPAEKAQPKK LTPVQVLEYG 850 860 870 880 890 900 EAIAKFNFNG DTQVEMSFRK GERITLLRQV DENWYEGRIP GTSRQGIFPI TYVDVIKRPL 910 920 930 940 950 960 VKNPVDYMDL PFSSSPSRSA TASPQQPQAQ QRRVTPDRSQ TSQDLFSYQA LYSYIPQNDD 970 980 990 1000 ELELRDGDIV DVMEKCDDGW FVGTSRRTKQ FGTFPGNYVK PLYL
	Isoform 6 [UniParc]. Checksum: 61FC1B8026A7D9A1	FASTA	846	95,036
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 70 80 90 100 110 120 LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP DEWRLSSSAD ANGNAQPSSL 130 140 150 160 170 180 AAKGYRSVHP NLPSDKSQDS SPLLNEVSSS LIGTDSQAFP SVSKPSSAYP STTIVNPTIV 190 200 210 220 230 240 LLQHNREQQK RLSSLSDPVS ERRVGEQDSA PTQEKPTSPG KAIEKRAKDD SRRVVKSTQD 250 260 270 280 290 300 LSDVSMDEVG IPLRNTERSK DWYKTMFKQI HKLNRDTPEE NPYFPTYKFP ELPEIQQTSE 310 320 330 340 350 360 EDNPYTPTYQ FPASTPSPKS EDDDSDLYSP RYSFSEDTKS PLSVPRSKSE MSYIDGEKVV 370 380 390 400 410 420 KRSATLPLPA RSSSLKSSSE RNDWEPPDKK VDTRKYRAEP KSIYEYQPGK SSVLTNEKMS 430 440 450 460 470 480 RDISPEEIDL KNEPWYKFFS ELEFGKPSSA ISPTPEISSE TPGYIYSSNF HAVKRESDGA 490 500 510 520 530 540 PGDLTSLENE RQIYKSVLEG GDIPLQGLSG LKRPSSSAST KDSESPRHFI PADYLESTEE 550 560 570 580 590 600 FIRRRHDDKE KLLADQRRLK REQEEADIAA RRHTGVIPTH HQFITNERFG DLLNIDDTAK 610 620 630 640 650 660 RKSGSEMRPA RAKFDFKAQT LKELPLQKGD IVYIYKQIDQ NWYEGEHHGR VGIFPRTYIE 670 680 690 700 710 720 LLPPAEKAQP KKLTPVQVLE YGEAIAKFNF NGDTQVEMSF RKGERITLLR QVDENWYEGR 730 740 750 760 770 780 IPGTSRQGIF PITYVDVIKR PLVKNPVDYM DLPFSSSPSR SATASPQQPQ AQQRRVTPDR 790 800 810 820 830 840 SQTSQDLFSY QALYSYIPQN DDELELRDGD IVDVMEKCDD GWFVGTSRRT KQFGTFPGNY VKPLYL
	Isoform 7 [UniParc]. Checksum: 4B5BD67EF6355537	FASTA	628	68,745
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET PSSSPASPQE 70 80 90 100 110 120 TRQHESKPDE WRLSSSADAN GNAQPSSLAA KGYRSVHPNL PSDKSQDATS SSAAQPEVIV 130 140 150 160 170 180 VPLYLVNTDR GQEGTARPPT PLGPLGCVPT IPATASAASP LTFPTLDDFI PPHLQRWPHH 190 200 210 220 230 240 SQPARASGSF APISQTPPSF SPPPPLVPPA PEDLRRVSEP DLTGAVSSTD SSPLLNEVSS 250 260 270 280 290 300 SLIGTDSQAF PSVSKPSSAY PSTTIVNPTI VLLQHNREQQ KRLSSLSDPV SERRVGEQDS 310 320 330 340 350 360 APTQEKPTSP GKAIEKRAKD DSRRVVKSTQ DLSDVSMDEV GIPLRNTERS KDWYKTMFKQ 370 380 390 400 410 420 IHKLNRDDDS DLYSPRYSFS EDTKSPLSVP RSKSEMSYID GEKVVKRSAT LPLPARSSSL 430 440 450 460 470 480 KSSSERNDWE PPDKKVDTRK YRAEPKSIYE YQPGKSSVLT NEKMSSAISP TPEISSETPG 490 500 510 520 530 540 YIYSSNFHAV KRESDGAPGD LTSLENERQI YKSVLEGGDI PLQGLSGLKR PSSSASTKDS 550 560 570 580 590 600 ESPRHFIPAD YLESTEEFIR RRHDDKEKLL ADQRRLKREQ EEADIAARRH TGVIPTHHQF 610 620 ITNERFGDLL NIDDTAKRKS GSEKYDWA
	Isoform 8 [UniParc]. Checksum: 019F4E7E811AFDF5	FASTA	811	91,055
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET PSSSPASPQE 70 80 90 100 110 120 TRQHESKPGL EPEPSSADEW RLSSSADANG NAQPSSLAAK GYRSVHPNLP SDKSQDSSPL 130 140 150 160 170 180 LNEVSSSLIG TDSQAFPSVS KPSSAYPSTT IVNPTIVLLQ HNREQQKRLS SLSDPVSERR 190 200 210 220 230 240 VGEQDSAPTQ EKPTSPGKAI EKRAKDDSRR VVKSTQDLSD VSMDEVGIPL RNTERSKDWY 250 260 270 280 290 300 KTMFKQIHKL NRDDDSDLYS PRYSFSEDTK SPLSVPRSKS EMSYIDGEKV VKRSATLPLP 310 320 330 340 350 360 ARSSSLKSSS ERNDWEPPDK KVDTRKYRAE PKSIYEYQPG KSSVLTNEKM SRDISPEEID 370 380 390 400 410 420 LKNEPWYKFF SELEFGKPTN LDKDLSLCQT ELEADLEKME TLNKAPSANV PQSSAISPTP 430 440 450 460 470 480 EISSETPGYI YSSNFHAVKR ESDGAPGDLT SLENERQIYK SVLEGGDIPL QGLSGLKRPS 490 500 510 520 530 540 SSASTKDSES PRHFIPADYL ESTEEFIRRR HDDKEKLLAD QRRLKREQEE ADIAARRHTG 550 560 570 580 590 600 VIPTHHQFIT NERFGDLLNI DDTAKRKSGS EMRPARAKFD FKAQTLKELP LQKGDIVYIY 610 620 630 640 650 660 KQIDQNWYEG EHHGRVGIFP RTYIELLPPA EKAQPKKLTP VQVLEYGEAI AKFNFNGDTQ 670 680 690 700 710 720 VEMSFRKGER ITLLRQVDEN WYEGRIPGTS RQGIFPITYV DVIKRPLVKN PVDYMDLPFS 730 740 750 760 770 780 SSPSRSATAS PQQPQAQQRR VTPDRSQTSQ DLFSYQALYS YIPQNDDELE LRDGDIVDVM 790 800 810 EKCDDGWFVG TSRRTKQFGT FPGNYVKPLY L
	Isoform 9 [UniParc]. Checksum: EDB752BF6DB3E4E1	FASTA	781	87,199
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 70 80 90 100 110 120 LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP GLEPEPSSAD EWRLSSSADA 130 140 150 160 170 180 NGNAQPSSLA AKGYRSVHPN LPSDKSQDSS PLLNEVSSSL IGTDSQAFPS VSKPSSAYPS 190 200 210 220 230 240 TTIVNPTIVL LQHNREQQKR LSSLSDPVSE RRVGEQDSAP TQEKPTSPGK AIEKRAKDDS 250 260 270 280 290 300 RRVVKSTQDL SDVSMDEVGI PLRNTERSKD WYKTMFKQIH KLNRDDDSDL YSPRYSFSED 310 320 330 340 350 360 TKSPLSVPRS KSEMSYIDGE KVVKRSATLP LPARSSSLKS SSERNDWEPP DKKVDTRKYR 370 380 390 400 410 420 AEPKSIYEYQ PGKSSVLTNE KMSSAISPTP EISSETPGYI YSSNFHAVKR ESDGAPGDLT 430 440 450 460 470 480 SLENERQIYK SVLEGGDIPL QGLSGLKRPS SSASTKDSES PRHFIPADYL ESTEEFIRRR 490 500 510 520 530 540 HDDKEKLLAD QRRLKREQEE ADIAARRHTG VIPTHHQFIT NERFGDLLNI DDTAKRKSGS 550 560 570 580 590 600 EMRPARAKFD FKAQTLKELP LQKGDIVYIY KQIDQNWYEG EHHGRVGIFP RTYIELLPPA 610 620 630 640 650 660 EKAQPKKLTP VQVLEYGEAI AKFNFNGDTQ VEMSFRKGER ITLLRQVDEN WYEGRIPGTS 670 680 690 700 710 720 RQGIFPITYV DVIKRPLVKN PVDYMDLPFS SSPSRSATAS PQQPQAQQRR VTPDRSQTSQ 730 740 750 760 770 780 DLFSYQALYS YIPQNDDELE LRDGDIVDVM EKCDDGWFVG TSRRTKQFGT FPGNYVKPLY L
	Isoform 10 [UniParc]. Checksum: 490FCF5615BF69DB	FASTA	816	90,218
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET PSSSPASPQE 70 80 90 100 110 120 TRQHESKPGL EPEPSSADEW RLSSSADANG NAQPSSLAAK GYRSVHPNLP SDKSQDATSS 130 140 150 160 170 180 SAAQPEVIVV PLYLVNTDRG QEGTARPPTP LGPLGCVPTI PATASAASPL TFPTLDDFIP 190 200 210 220 230 240 PHLQRWPHHS QPARASGSFA PISQTPPSFS PPPPLVPPAP EDLRRVSEPD LTGAVSSTDS 250 260 270 280 290 300 SPLLNEVSSS LIGTDSQAFP SVSKPSSAYP STTIVNPTIV LLQHNREQQK RLSSLSDPVS 310 320 330 340 350 360 ERRVGEQDSA PTQEKPTSPG KAIEKRAKDD SRRVVKSTQD LSDVSMDEVG IPLRNTERSK 370 380 390 400 410 420 DWYKTMFKQI HKLNRDDDSD LYSPRYSFSE DTKSPLSVPR SKSEMSYIDG EKVVKRSATL 430 440 450 460 470 480 PLPARSSSLK SSSERNDWEP PDKKVDTRKY RAEPKSIYEY QPGKSSVLTN EKMSSAISPT 490 500 510 520 530 540 PEISSETPGY IYSSNFHAVK RESDGAPGDL TSLENERQIY KSVLEGGDIP LQGLSGLKRP 550 560 570 580 590 600 SSSASTKDSE SPRHFIPADY LESTEEFIRR RHDDKEMRPA RAKFDFKAQT LKELPLQKGD 610 620 630 640 650 660 IVYIYKQIDQ NWYEGEHHGR VGIFPRTYIE LLPPAEKAQP KKLTPVQVLE YGEAIAKFNF 670 680 690 700 710 720 NGDTQVEMSF RKGERITLLR QVDENWYEGR IPGTSRQGIF PITYVDVIKR PLVKNPVDYM 730 740 750 760 770 780 DLPFSSSPSR SATASPQQPQ AQQRRVTPDR SQTSQDLFSY QALYSYIPQN DDELELRDGD 790 800 810 IVDVMEKCDD GWFVGTSRRT KQFGTFPGNY VKPLYL
	Isoform 11 [UniParc]. Checksum: 857F07CDCB13B97E	FASTA	1,266	139,401
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD 70 80 90 100 110 120 LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP GLEPEPSSAD EWRLSSSADA 130 140 150 160 170 180 NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT SSSAAQPEVI VVPLYLVNTD RGQEGTARPP 190 200 210 220 230 240 TPLGPLGCVP TIPATASAAS PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS 250 260 270 280 290 300 FSPPPPLVPP APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA 310 320 330 340 350 360 YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS PGKAIEKRAK 370 380 390 400 410 420 DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK QIHKLNRDDD SDLYSPRYSF 430 440 450 460 470 480 SEDTKSPLSV PRSKSEMSYI DGEKVVKRSA TLPLPARSSS LKSSSERNDW EPPDKKVDTR 490 500 510 520 530 540 KYRAEPKSIY EYQPGKSSVL TNEKMSRDIS PEEIDLKNEP WYKFFSELEF GKPPPKKIWD 550 560 570 580 590 600 YTPGDCSILP REDRKTNLDK DLSLCQTELE ADLEKMETLN KAPSANVPQS SAISPTPEIS 610 620 630 640 650 660 SETPGYIYSS NFHAVKRESD GAPGDLTSLE NERQIYKSVL EGGDIPLQGL SGLKRPSSSA 670 680 690 700 710 720 STKDSESPRH FIPADYLEST EEFIRRRHDD KEKLLADQRR LKREQEEADI AARRHTGVIP 730 740 750 760 770 780 THHQFITNER FGDLLNIDDT AKRKSGSEMR PARAKFDFKA QTLKELPLQK GDIVYIYKQI 790 800 810 820 830 840 DQNWYEGEHH GRVGIFPRTY IELLPPAEKA QPKKLTPVQV LEYGEAIAKF NFNGDTQVEM 850 860 870 880 890 900 SFRKGERITL LRQVDENWYE GRIPGTSRQG IFPITYVDVI KRPLVKNPVD YMDLPFSSSP 910 920 930 940 950 960 SRSATASPQF SSHSKLITPA PSSLPHSRRA LSPEMHAVTS EWISLTVGVP GRRSLALTPP 970 980 990 1000 1010 1020 LPPLPEASIY NTDHLALSPR ASPSLSLSLP HLSWSDRPTP RSVASPLALP SPHKTYSLAP 1030 1040 1050 1060 1070 1080 TSQASLHMNG DGGVHTPSSG IHQDSFLQLP LGSSDSVISQ LSDAFSSQSK RQPWREESGQ 1090 1100 1110 1120 1130 1140 YERKAERGAG ERGPGGPKIS KKSCLKPSDV VRCLSTEQRL SDLNTPEESR PGKPLGSAFP 1150 1160 1170 1180 1190 1200 GSEAEQTERH RGGEQAGRKA ARRGGSQLSH HSLRAGPDLT ESEKSYVQPQ AQQRRVTPDR 1210 1220 1230 1240 1250 1260 SQTSQDLFSY QALYSYIPQN DDELELRDGD IVDVMEKCDD GWFVGTSRRT KQFGTFPGNY VKPLYL
	Isoform 12 [UniParc]. Checksum: 770EBDC6412A6C03	FASTA	1,294	143,741
	10 20 30 40 50 60 MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET PSSSPASPQE 70 80 90 100 110 120 TRQHESKPGL EPEPSSADEW RLSSSADANG NAQPSSLAAK GYRSVHPNLP SDKSQDSSPL 130 140 150 160 170 180 LNEVSSSLIG TDSQAFPSVS KPSSAYPSTT IVNPTIVLLQ HNRDPVSERR VGEQDSAPTQ 190 200 210 220 230 240 EKPTSPGKAI EKRAKDDSRR VVKSTQDLSD VSMDEVGIPL RNTERSKDWY KTMFKQIHKL 250 260 270 280 290 300 NRDDDSDLYS PRYSFSEDTK SPLSVPRSKS EMSYIDGEKV VKRSATLPLP ARSSSLKSSS 310 320 330 340 350 360 ERNDWEPPDK KVDTRKYRAE PKSIYEYQPG KSSVLTNEKM SRDISPEEID LKNEPWYKFF 370 380 390 400 410 420 SELEFGKPTN LDKDLSLCQT ELEADLEKME TLNKAPSANV PQSSAISPTP EISSETPGYI 430 440 450 460 470 480 YSSNFHAVKR ESDGAPGDLT SLENERQIYK SVLEGGDIPL QGLSGLKRPS SSASTKVDRK 490 500 510 520 530 540 GGNAHMISSS SVHSRTFNTS NALGPVCKHK KPLSAAKACI SEILPSKFKP RLSAPSALLQ 550 560 570 580 590 600 EQKSILLPSE KAQSCENLCV SGSLNDSKRG LPLQVGGSIE NLLMRSRRDY DSKSSSTMSL 610 620 630 640 650 660 QEYSTSGRRP CPLSRKAGMQ FTMLYRDMHQ INRSGLFLGS ISSSSSVRDL ASHFEKSSLA 670 680 690 700 710 720 LSRGELGPSQ EGSEHIPKHT VSSRITAFEQ LIQRSRSMPS LDLSGRLSKS PTPVLSRGSL 730 740 750 760 770 780 TSARSAESLL ESTKLHPKEM DGMNSSGVYA SPTCSNMAHH ALSFRGLVPS EPLSTCSDDV 790 800 810 820 830 840 DRCSNISTDS REGSGGSVHG DFPKHRLNKC KGTCPASYTR FTTIRKHEQQ QTSRQPEWRL 850 860 870 880 890 900 DARGDKSTLL RNIYLMSPLP FRLKKPLHHH PRQPSPGDSS GLLVGQKPDL PSQPHQDQPP 910 920 930 940 950 960 SGGKPVVPTR LSSRHTMARL SRSSEPSQER PTALEDYPRA INNGNSVPYS DHSLDRNNNP 970 980 990 1000 1010 1020 QSELAPSRGD SESPRHFIPA DYLESTEEFI RRRHDDKEKL LADQRRLKRE QEEADIAARR 1030 1040 1050 1060 1070 1080 HTGVIPTHHQ FITNERFGDL LNIDDTAKRK SGSEMRPARA KFDFKAQTLK ELPLQKGDIV 1090 1100 1110 1120 1130 1140 YIYKQIDQNW YEGEHHGRVG IFPRTYIELL PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG 1150 1160 1170 1180 1190 1200 DTQVEMSFRK GERITLLRQV DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL 1210 1220 1230 1240 1250 1260 PFSSSPSRSA TASPQQPQAQ QRRVTPDRSQ TSQDLFSYQA LYSYIPQNDD ELELRDGDIV 1270 1280 1290 DVMEKCDDGW FVGTSRRTKQ FGTFPGNYVK PLYL

References

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[1]	"Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B." Lin W.-H., Huang C.-J., Liu M.-W., Chang H.-M., Chen Y.-J., Tai T.-Y., Chuang L.-M. Genomics 74:12-20(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, INTERACTION WITH ABL1 AND INSULIN RECEPTOR, VARIANT PRO-61. Tissue: Liver and Skeletal muscle.
[2]	"Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions." Lebre A.-S., Jamot L., Takahashi J., Spassky N., Leprince C., Ravise N., Zander C., Fujigasaki H., Kussel-Andermann P., Duyckaerts C., Camonis J.H., Brice A. Hum. Mol. Genet. 10:1201-1213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), SUBCELLULAR LOCATION, INTERACTION WITH SCA7, VARIANT PRO-61. Tissue: Retina.
[3]	"Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes." Lin W.-H., Chiu K.C., Chang H.-M., Lee K.C., Tai T.-Y., Chuang L.-M. Hum. Mol. Genet. 10:1753-1760(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), VARIANTS PRO-61; TRP-74 AND ALA-237. Tissue: Skeletal muscle.
[4]	"The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2." Vandenbroere I., Paternotte N., Dumont J.E., Erneux C., Pirson I. Biochem. Biophys. Res. Commun. 300:494-500(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), INTERACTION WITH INPPL1, VARIANT PRO-61. Tissue: Brain.
[5]	"Paxillin and ponsin interact in nascent costameres of muscle cells." Gehmlich K., Pinotsis N., Hayess K., van der Ven P.F., Milting H., El Banayosy A., Korfer R., Wilmanns M., Ehler E., Furst D.O. J. Mol. Biol. 369:665-682(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11), INTERACTION WITH PXN, X-RAY CRYSTALLOGRAPHY (0.83 ANGSTROMS) OF 870-930 IN COMPLEX WITH PXN PEPTIDE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT PRO-61. Tissue: Skeletal muscle.
[6]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9), VARIANT PRO-61. Tissue: Brain.
[7]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10), VARIANT PRO-61. Tissue: Uterus.
[8]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 9), VARIANT PRO-61. Tissue: Testis.
[11]	"A Fas-ligand associated factor 2, FLAF2, potentiates Fas-ligand stability." Hachiya T., Kobayasi A., Touji S., Tamai K. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 752-888. Tissue: Placenta.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-89; SER-472; SER-665; THR-862 AND SER-945, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478 AND SER-735 (ISOFORM 10), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346 AND SER-603 (ISOFORM 4), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-923 (ISOFORM 5), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-765 (ISOFORM 6), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469 (ISOFORM 7), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730 (ISOFORM 8), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387 AND SER-700 (ISOFORM 9), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, MASS SPECTROMETRY.
[15]	"Second SH3 domain of ponsin solved from powder diffraction." Margiolaki I., Wright J.P., Wilmanns M., Fitch A.N., Pinotsis N. J. Am. Chem. Soc. 129:11865-11871(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 870-930.
[16]	"Solution structure of SH3 domains of human Sorbin and SH3 domain-containing protein 1." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2009) to the PDB data bank Cited for: STRUCTURE BY NMR OF 796-926.
[17]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-195.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF136380 mRNA. Translation: AAD27647.1.
AF356525 mRNA. Translation: AAK37563.1.
AF356526 mRNA. Translation: AAK37564.1.
AF356527 mRNA. Translation: AAK37565.1.
AF330623 mRNA. Translation: AAK57479.1.
AF330624 mRNA. Translation: AAK57480.1.
AF136381 mRNA. Translation: AAF22175.1.
AJ489942 mRNA. Translation: CAD34588.1.
AM260536 mRNA. Translation: CAJ97431.1.
AB037717 mRNA. Translation: BAA92534.1. Different initiation.
AL117472 mRNA. Translation: CAB55947.1.
AL158165 Genomic DNA. Translation: CAI14378.1.
AL158165 Genomic DNA. Translation: CAI14379.1.
AL158165 Genomic DNA. Translation: CAI14380.1.
AL158165 Genomic DNA. Translation: CAI14381.1.
AL158165 Genomic DNA. Translation: CAI14382.1.
AL158165 Genomic DNA. Translation: CAI14383.1.
AL158165 Genomic DNA. Translation: CAI14384.1.
AL158165 Genomic DNA. Translation: CAI14385.1.
CH471066 Genomic DNA. Translation: EAW49999.1.
CH471066 Genomic DNA. Translation: EAW50007.1.
BC042612 mRNA. Translation: AAH42612.1.
BC152463 mRNA. Translation: AAI52464.1.
U70668 mRNA. Translation: AAB93496.1. Frameshift.

IPI

IPI00002491.
IPI00010554.
IPI00010555.
IPI00064591.
IPI00186452.
IPI00306791.
IPI00334908.
IPI00383430.
IPI00454950.
IPI00454951.
IPI00807389.
IPI01018230.

PIR

T17257.

RefSeq

NP_001030126.1. NM_001034954.1.
NP_001030127.1. NM_001034955.1.
NP_001030128.1. NM_001034956.1.
NP_001030129.1. NM_001034957.1.
NP_006425.2. NM_006434.2.
NP_056200.1. NM_015385.2.
NP_079267.1. NM_024991.1.

UniGene

Hs.38621.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DL3	NMR	-	A	791-850	[»]
2ECZ	NMR	-	A	870-926	[»]
2LJ0	NMR	-	A	1228-1292	[»]
2LJ1	NMR	-	A	1228-1291	[»]
2O2W	X-ray	2.27	A	870-930	[»]
2O31	X-ray	1.50	A	870-930	[»]
2O9S	X-ray	0.83	A	870-930	[»]
2O9V	X-ray	1.63	A	870-930	[»]

ProteinModelPortal

Q9BX66.

SMR

Q9BX66. Positions 791-930, 1228-1292.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BX66. 12 interactions.

MINT

MINT-2792261.

PTM databases

PhosphoSite

Q9BX66.

Polymorphism databases

DMDM

215273913.

Proteomic databases

PaxDb

Q9BX66.

PRIDE

Q9BX66.

Protocols and materials databases

DNASU

10580.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000277982; ENSP00000277982; ENSG00000095637.
ENST00000306402; ENSP00000302556; ENSG00000095637.
ENST00000347291; ENSP00000277985; ENSG00000095637.
ENST00000353505; ENSP00000343998; ENSG00000095637.
ENST00000354106; ENSP00000277984; ENSG00000095637.
ENST00000361941; ENSP00000355136; ENSG00000095637.
ENST00000371227; ENSP00000360271; ENSG00000095637.
ENST00000371239; ENSP00000360283; ENSG00000095637.
ENST00000371241; ENSP00000360285; ENSG00000095637.
ENST00000371245; ENSP00000360291; ENSG00000095637.
ENST00000371246; ENSP00000360292; ENSG00000095637.
ENST00000371247; ENSP00000360293; ENSG00000095637.
ENST00000371249; ENSP00000360295; ENSG00000095637.
ENST00000393949; ENSP00000377521; ENSG00000095637.

GeneID

10580.

KEGG

hsa:10580.

UCSC

uc001kkl.3. human.
uc001kkm.3. human.
uc001kkn.3. human.
uc001kko.3. human.
uc001kkp.3. human.
uc001kkq.3. human.
uc001kkr.3. human.
uc001kks.3. human.
uc001kkv.3. human.
uc001kkw.3. human.

Organism-specific databases

CTD

10580.

GeneCards

GC10M097061.

HGNC

HGNC:14565. SORBS1.

HPA

HPA027559.
HPA036994.

MIM

605264. gene.

neXtProt

NX_Q9BX66.

PharmGKB

PA37899.

HUGE

Search...
Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG256936.

HOVERGEN

HBG053053.

InParanoid

Q9BX66.

KO

K06086.

OMA

ECDVGAS.

OrthoDB

EOG40K7Z2.

PhylomeDB

Q9BX66.

Enzyme and pathway databases

Pathway_Interaction_DB

insulin_pathway. Insulin Pathway.

Reactome

REACT_17044. Muscle contraction.

Gene expression databases

ArrayExpress

Q9BX66.

Bgee

Q9BX66.

Genevestigator

Q9BX66.

GermOnline

ENSG00000095637. Homo sapiens.

Family and domain databases

InterPro

IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR003127. Sorb.
[Graphical view]

Pfam

PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF02208. Sorb. 1 hit.
[Graphical view]

SMART

SM00326. SH3. 3 hits.
SM00459. Sorb. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 3 hits.

PROSITE

PS50002. SH3. 3 hits.
PS50831. SOHO. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SORBS1. human.

EvolutionaryTrace

Q9BX66.

GenomeRNAi

10580.

NextBio

40165.

SOURCE

Search...

Entry information

Entry name

SRBS1_HUMAN

Accession

Primary (citable) accession number: Q9BX66
Secondary accession number(s): A0AED4 , A6NEK3, A6NID8, A6NJS4, A7MD40, D3DR42, O43857, Q5T923, Q5T924, Q5T927, Q5T928, Q5T929, Q5T930, Q5T931, Q5T932, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 124 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.