Q9BX59 (TPSNR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tapasin-related protein
Short name=TAPASIN-R

Alternative name(s):
TAP-binding protein-like
TAP-binding protein-related protein
Short name=TAPBP-R
Tapasin-like

Gene names

Name:

TAPBPL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cell membrane; Single-pass type I membrane protein Probable. Endoplasmic reticulum membrane; Single-pass type I membrane protein Probable. Microsome membrane; Single-pass type I membrane protein Probable. Note: Mainly found in endoplasmic reticulum but a minority is found on the cell surface. Ref.1
Sequence similarities	Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Ref.5
	Chain	19 – 468	450	Tapasin-related protein		PRO_0000014993
Regions
	Topological domain	19 – 405	387	Lumenal Potential
	Transmembrane	406 – 426	21	Helical; Potential
	Topological domain	427 – 468	42	Cytoplasmic Potential
	Domain	181 – 297	117	Ig-like V-type
	Domain	304 – 394	91	Ig-like C1-type
Amino acid modifications
	Disulfide bond	212 ↔ 283		By similarity
	Disulfide bond	321 ↔ 382		By similarity
Natural variations
	Natural variant	151	1	G → R. Ref.1 Ref.2 Corresponds to variant rs7295376 [ dbSNP | Ensembl ].		VAR_033627
	Natural variant	334	1	T → M. Ref.1 Corresponds to variant rs1045546 [ dbSNP | Ensembl ].		VAR_056090
Experimental info
	Sequence conflict	42	1	A → V in BAB41077. Ref.2
	Sequence conflict	42	1	A → V in AAH15017. Ref.4
	Sequence conflict	146	1	M → V in BAA91465. Ref.2
	Sequence conflict	146	1	M → V in BAB41077. Ref.2
	Sequence conflict	146	1	M → V in AAH15017. Ref.4
	Sequence conflict	165	1	T → A in BAA91465. Ref.2
	Sequence conflict	165	1	T → A in BAB41077. Ref.2
	Sequence conflict	165	1	T → A in AAH15017. Ref.4
	Sequence conflict	169	1	A → V in BAB41077. Ref.2
	Sequence conflict	169	1	A → V in AAH15017. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9BX59 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: FA39C335FC22960E	FASTA	468	50,183
	10 20 30 40 50 60 MGTQEGWCLL LCLALSGAAE TKPHPAEGQW RAVDVVLDCF LAKDGAHRGA LASSEDRARA 70 80 90 100 110 120 SLVLKQVPVL DDGSLEDFTD FQGGTLAQDD PPIIFEASVD LVQIPQAEAL LHADCSGKEV 130 140 150 160 170 180 TCEISRYFLQ MTETTVKTAA WFMANMQVSG GGPSISLVMK TPRVTKNEAL WHPTLNLPLS 190 200 210 220 230 240 PQGTVRTAVE FQVMTQTQSL SFLLGSSASL DCGFSMAPGL DLISVEWRLQ HKGRGQLVYS 250 260 270 280 290 300 WTAGQGQAVR KGATLEPAQL GMARDASLTL PGLTIQDEGT YICQITTSLY RAQQIIQLNI 310 320 330 340 350 360 QASPKVRLSL ANEALLPTLI CDIAGYYPLD VVVTWTREEL GGSPAQVSGA SFSSLRQSVA 370 380 390 400 410 420 GTYSISSSLT AEPGSAGATY TCQVTHISLE EPLGASTQVV PPERRTALGV IFASSLFLLA 430 440 450 460 LMFLGLQRRQ APTGLGLLQA ERWETTSCAD TQSSHLHEDR TARVSQPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human TAPBP (TAPASIN)-related gene, TAPBP-R." Teng M.S., Stephens R., Du Pasquier L., Freeman T., Lindquist J.A., Trowsdale J. Eur. J. Immunol. 32:1059-1068(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, VARIANTS ARG-151 AND MET-334.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-151. Tissue: Embryo and Placenta.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-33.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001005 mRNA. Translation: BAA91465.1. AK002056 mRNA. Translation: BAB41077.1. AC005840 Genomic DNA. No translation available. BC015017 mRNA. Translation: AAH15017.1.
IPI	IPI00306774.
RefSeq	NP_060479.3. NM_018009.4.
UniGene	Hs.504597.
3D structure databases
ProteinModelPortal	Q9BX59.
SMR	Q9BX59. Positions 34-399.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000266556.
PTM databases
PhosphoSite	Q9BX59.
Polymorphism databases
DMDM	296452847.
Proteomic databases
PaxDb	Q9BX59.
PRIDE	Q9BX59.
Protocols and materials databases
DNASU	55080.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266556; ENSP00000266556; ENSG00000139192.
GeneID	55080.
KEGG	hsa:55080.
UCSC	uc001qog.4. human.
Organism-specific databases
CTD	55080.
GeneCards	GC12P006561.
HGNC	HGNC:30683. TAPBPL.
HPA	HPA039545.
MIM	607081. gene.
neXtProt	NX_Q9BX59.
PharmGKB	PA134955671.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45273.
HOGENOM	HOG000168499.
HOVERGEN	HBG057669.
InParanoid	Q9BX59.
OMA	HADCSGK.
OrthoDB	EOG49W2FC.
PhylomeDB	Q9BX59.
Gene expression databases
ArrayExpress	Q9BX59.
Bgee	Q9BX59.
CleanEx	HS_TAPBPL.
Genevestigator	Q9BX59.
GermOnline	ENSG00000139192. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR008056. Tapasin. [Graphical view]
PANTHER	PTHR23411. PTHR23411. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00407. IGc1. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TAPBPL. human.
GenomeRNAi	55080.
NextBio	58622.
SOURCE	Search...

Entry information

Entry name

TPSNR_HUMAN

Accession

Primary (citable) accession number: Q9BX59
Secondary accession number(s): Q9NWB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.