Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BX59

- TPSNR_HUMAN

UniProt

Q9BX59 - TPSNR_HUMAN

Protein

Tapasin-related protein

Gene

TAPBPL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. protein complex binding Source: UniProt

    GO - Biological processi

    1. negative regulation of antigen processing and presentation of peptide antigen via MHC class I Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tapasin-related protein
    Short name:
    TAPASIN-R
    Alternative name(s):
    TAP-binding protein-like
    TAP-binding protein-related protein
    Short name:
    TAPBP-R
    Tapasin-like
    Gene namesi
    Name:TAPBPL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:30683. TAPBPL.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Microsome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: Mainly found in endoplasmic reticulum but a minority is found on the cell surface.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134955671.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 468450Tapasin-related proteinPRO_0000014993Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi212 ↔ 283PROSITE-ProRule annotation
    Disulfide bondi321 ↔ 382PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9BX59.
    PaxDbiQ9BX59.
    PRIDEiQ9BX59.

    PTM databases

    PhosphoSiteiQ9BX59.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BX59.
    BgeeiQ9BX59.
    CleanExiHS_TAPBPL.
    GenevestigatoriQ9BX59.

    Organism-specific databases

    HPAiHPA039545.

    Interactioni

    Protein-protein interaction databases

    BioGridi120395. 1 interaction.
    STRINGi9606.ENSP00000266556.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BX59.
    SMRiQ9BX59. Positions 193-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 405387LumenalSequence AnalysisAdd
    BLAST
    Topological domaini427 – 46842CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei406 – 42621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini181 – 297117Ig-like V-typeAdd
    BLAST
    Domaini304 – 39491Ig-like C1-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45273.
    HOGENOMiHOG000168499.
    HOVERGENiHBG057669.
    InParanoidiQ9BX59.
    OMAiHADCSGK.
    PhylomeDBiQ9BX59.
    TreeFamiTF334274.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BX59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTQEGWCLL LCLALSGAAE TKPHPAEGQW RAVDVVLDCF LAKDGAHRGA    50
    LASSEDRARA SLVLKQVPVL DDGSLEDFTD FQGGTLAQDD PPIIFEASVD 100
    LVQIPQAEAL LHADCSGKEV TCEISRYFLQ MTETTVKTAA WFMANMQVSG 150
    GGPSISLVMK TPRVTKNEAL WHPTLNLPLS PQGTVRTAVE FQVMTQTQSL 200
    SFLLGSSASL DCGFSMAPGL DLISVEWRLQ HKGRGQLVYS WTAGQGQAVR 250
    KGATLEPAQL GMARDASLTL PGLTIQDEGT YICQITTSLY RAQQIIQLNI 300
    QASPKVRLSL ANEALLPTLI CDIAGYYPLD VVVTWTREEL GGSPAQVSGA 350
    SFSSLRQSVA GTYSISSSLT AEPGSAGATY TCQVTHISLE EPLGASTQVV 400
    PPERRTALGV IFASSLFLLA LMFLGLQRRQ APTGLGLLQA ERWETTSCAD 450
    TQSSHLHEDR TARVSQPS 468
    Length:468
    Mass (Da):50,183
    Last modified:May 18, 2010 - v2
    Checksum:iFA39C335FC22960E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421A → V in BAB41077. (PubMed:14702039)Curated
    Sequence conflicti42 – 421A → V in AAH15017. (PubMed:15489334)Curated
    Sequence conflicti146 – 1461M → V in BAA91465. (PubMed:14702039)Curated
    Sequence conflicti146 – 1461M → V in BAB41077. (PubMed:14702039)Curated
    Sequence conflicti146 – 1461M → V in AAH15017. (PubMed:15489334)Curated
    Sequence conflicti165 – 1651T → A in BAA91465. (PubMed:14702039)Curated
    Sequence conflicti165 – 1651T → A in BAB41077. (PubMed:14702039)Curated
    Sequence conflicti165 – 1651T → A in AAH15017. (PubMed:15489334)Curated
    Sequence conflicti169 – 1691A → V in BAB41077. (PubMed:14702039)Curated
    Sequence conflicti169 – 1691A → V in AAH15017. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511G → R.2 Publications
    Corresponds to variant rs7295376 [ dbSNP | Ensembl ].
    VAR_033627
    Natural varianti334 – 3341T → M.1 Publication
    Corresponds to variant rs1045546 [ dbSNP | Ensembl ].
    VAR_056090

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001005 mRNA. Translation: BAA91465.1.
    AK002056 mRNA. Translation: BAB41077.1.
    AC005840 Genomic DNA. No translation available.
    BC015017 mRNA. Translation: AAH15017.1.
    CCDSiCCDS8546.1.
    RefSeqiNP_060479.3. NM_018009.4.
    UniGeneiHs.504597.

    Genome annotation databases

    EnsembliENST00000266556; ENSP00000266556; ENSG00000139192.
    GeneIDi55080.
    KEGGihsa:55080.
    UCSCiuc001qog.4. human.

    Polymorphism databases

    DMDMi296452847.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001005 mRNA. Translation: BAA91465.1 .
    AK002056 mRNA. Translation: BAB41077.1 .
    AC005840 Genomic DNA. No translation available.
    BC015017 mRNA. Translation: AAH15017.1 .
    CCDSi CCDS8546.1.
    RefSeqi NP_060479.3. NM_018009.4.
    UniGenei Hs.504597.

    3D structure databases

    ProteinModelPortali Q9BX59.
    SMRi Q9BX59. Positions 193-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120395. 1 interaction.
    STRINGi 9606.ENSP00000266556.

    PTM databases

    PhosphoSitei Q9BX59.

    Polymorphism databases

    DMDMi 296452847.

    Proteomic databases

    MaxQBi Q9BX59.
    PaxDbi Q9BX59.
    PRIDEi Q9BX59.

    Protocols and materials databases

    DNASUi 55080.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266556 ; ENSP00000266556 ; ENSG00000139192 .
    GeneIDi 55080.
    KEGGi hsa:55080.
    UCSCi uc001qog.4. human.

    Organism-specific databases

    CTDi 55080.
    GeneCardsi GC12P006561.
    HGNCi HGNC:30683. TAPBPL.
    HPAi HPA039545.
    MIMi 607081. gene.
    neXtProti NX_Q9BX59.
    PharmGKBi PA134955671.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45273.
    HOGENOMi HOG000168499.
    HOVERGENi HBG057669.
    InParanoidi Q9BX59.
    OMAi HADCSGK.
    PhylomeDBi Q9BX59.
    TreeFami TF334274.

    Miscellaneous databases

    ChiTaRSi TAPBPL. human.
    GenomeRNAii 55080.
    NextBioi 58622.
    PROi Q9BX59.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BX59.
    Bgeei Q9BX59.
    CleanExi HS_TAPBPL.
    Genevestigatori Q9BX59.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, VARIANTS ARG-151 AND MET-334.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-151.
      Tissue: Embryo and Placenta.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-33.

    Entry informationi

    Entry nameiTPSNR_HUMAN
    AccessioniPrimary (citable) accession number: Q9BX59
    Secondary accession number(s): Q9NWB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3