SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9BX59

- TPSNR_HUMAN

UniProt

Q9BX59 - TPSNR_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tapasin-related protein

Gene
TAPBPL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein complex binding Source: UniProt

GO - Biological processi

  1. negative regulation of antigen processing and presentation of peptide antigen via MHC class I Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tapasin-related protein
Short name:
TAPASIN-R
Alternative name(s):
TAP-binding protein-like
TAP-binding protein-related protein
Short name:
TAPBP-R
Tapasin-like
Gene namesi
Name:TAPBPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30683. TAPBPL.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein Inferred. Endoplasmic reticulum membrane; Single-pass type I membrane protein Inferred. Microsome membrane; Single-pass type I membrane protein Inferred
Note: Mainly found in endoplasmic reticulum but a minority is found on the cell surface.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 405387Lumenal Reviewed predictionAdd
BLAST
Transmembranei406 – 42621Helical; Reviewed predictionAdd
BLAST
Topological domaini427 – 46842Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134955671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 468450Tapasin-related proteinPRO_0000014993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi212 ↔ 283 By similarity
Disulfide bondi321 ↔ 382 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9BX59.
PaxDbiQ9BX59.
PRIDEiQ9BX59.

PTM databases

PhosphoSiteiQ9BX59.

Expressioni

Gene expression databases

ArrayExpressiQ9BX59.
BgeeiQ9BX59.
CleanExiHS_TAPBPL.
GenevestigatoriQ9BX59.

Organism-specific databases

HPAiHPA039545.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266556.

Structurei

3D structure databases

ProteinModelPortaliQ9BX59.
SMRiQ9BX59. Positions 193-386.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 297117Ig-like V-typeAdd
BLAST
Domaini304 – 39491Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45273.
HOGENOMiHOG000168499.
HOVERGENiHBG057669.
InParanoidiQ9BX59.
OMAiHADCSGK.
PhylomeDBiQ9BX59.
TreeFamiTF334274.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BX59-1 [UniParc]FASTAAdd to Basket

« Hide

MGTQEGWCLL LCLALSGAAE TKPHPAEGQW RAVDVVLDCF LAKDGAHRGA    50
LASSEDRARA SLVLKQVPVL DDGSLEDFTD FQGGTLAQDD PPIIFEASVD 100
LVQIPQAEAL LHADCSGKEV TCEISRYFLQ MTETTVKTAA WFMANMQVSG 150
GGPSISLVMK TPRVTKNEAL WHPTLNLPLS PQGTVRTAVE FQVMTQTQSL 200
SFLLGSSASL DCGFSMAPGL DLISVEWRLQ HKGRGQLVYS WTAGQGQAVR 250
KGATLEPAQL GMARDASLTL PGLTIQDEGT YICQITTSLY RAQQIIQLNI 300
QASPKVRLSL ANEALLPTLI CDIAGYYPLD VVVTWTREEL GGSPAQVSGA 350
SFSSLRQSVA GTYSISSSLT AEPGSAGATY TCQVTHISLE EPLGASTQVV 400
PPERRTALGV IFASSLFLLA LMFLGLQRRQ APTGLGLLQA ERWETTSCAD 450
TQSSHLHEDR TARVSQPS 468
Length:468
Mass (Da):50,183
Last modified:May 18, 2010 - v2
Checksum:iFA39C335FC22960E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511G → R.2 Publications
Corresponds to variant rs7295376 [ dbSNP | Ensembl ].
VAR_033627
Natural varianti334 – 3341T → M.1 Publication
Corresponds to variant rs1045546 [ dbSNP | Ensembl ].
VAR_056090

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → V in BAB41077. 1 Publication
Sequence conflicti42 – 421A → V in AAH15017. 1 Publication
Sequence conflicti146 – 1461M → V in BAA91465. 1 Publication
Sequence conflicti146 – 1461M → V in BAB41077. 1 Publication
Sequence conflicti146 – 1461M → V in AAH15017. 1 Publication
Sequence conflicti165 – 1651T → A in BAA91465. 1 Publication
Sequence conflicti165 – 1651T → A in BAB41077. 1 Publication
Sequence conflicti165 – 1651T → A in AAH15017. 1 Publication
Sequence conflicti169 – 1691A → V in BAB41077. 1 Publication
Sequence conflicti169 – 1691A → V in AAH15017. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001005 mRNA. Translation: BAA91465.1.
AK002056 mRNA. Translation: BAB41077.1.
AC005840 Genomic DNA. No translation available.
BC015017 mRNA. Translation: AAH15017.1.
CCDSiCCDS8546.1.
RefSeqiNP_060479.3. NM_018009.4.
UniGeneiHs.504597.

Genome annotation databases

EnsembliENST00000266556; ENSP00000266556; ENSG00000139192.
GeneIDi55080.
KEGGihsa:55080.
UCSCiuc001qog.4. human.

Polymorphism databases

DMDMi296452847.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001005 mRNA. Translation: BAA91465.1 .
AK002056 mRNA. Translation: BAB41077.1 .
AC005840 Genomic DNA. No translation available.
BC015017 mRNA. Translation: AAH15017.1 .
CCDSi CCDS8546.1.
RefSeqi NP_060479.3. NM_018009.4.
UniGenei Hs.504597.

3D structure databases

ProteinModelPortali Q9BX59.
SMRi Q9BX59. Positions 193-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000266556.

PTM databases

PhosphoSitei Q9BX59.

Polymorphism databases

DMDMi 296452847.

Proteomic databases

MaxQBi Q9BX59.
PaxDbi Q9BX59.
PRIDEi Q9BX59.

Protocols and materials databases

DNASUi 55080.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266556 ; ENSP00000266556 ; ENSG00000139192 .
GeneIDi 55080.
KEGGi hsa:55080.
UCSCi uc001qog.4. human.

Organism-specific databases

CTDi 55080.
GeneCardsi GC12P006561.
HGNCi HGNC:30683. TAPBPL.
HPAi HPA039545.
MIMi 607081. gene.
neXtProti NX_Q9BX59.
PharmGKBi PA134955671.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45273.
HOGENOMi HOG000168499.
HOVERGENi HBG057669.
InParanoidi Q9BX59.
OMAi HADCSGK.
PhylomeDBi Q9BX59.
TreeFami TF334274.

Miscellaneous databases

ChiTaRSi TAPBPL. human.
GenomeRNAii 55080.
NextBioi 58622.
PROi Q9BX59.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BX59.
Bgeei Q9BX59.
CleanExi HS_TAPBPL.
Genevestigatori Q9BX59.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00407. IGc1. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, VARIANTS ARG-151 AND MET-334.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-151.
    Tissue: Embryo and Placenta.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-33.

Entry informationi

Entry nameiTPSNR_HUMAN
AccessioniPrimary (citable) accession number: Q9BX59
Secondary accession number(s): Q9NWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi