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Protein

Gamma-glutamyltransferase light chain 1

Gene

GGTLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371NucleophileBy similarity
Binding sitei55 – 551GlutamateBy similarity
Binding sitei76 – 761GlutamateBy similarity

GO - Molecular functioni

  • gamma-glutamyltransferase activity Source: UniProtKB

GO - Biological processi

  • glutathione metabolic process Source: UniProtKB
  • leukotriene biosynthetic process Source: UniProtKB
Complete GO annotation...

Protein family/group databases

MEROPSiT03.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyltransferase light chain 1
Alternative name(s):
Gamma-glutamyltransferase-like activity 4
Gamma-glutamyltransferase-like protein 6
Gene namesi
Name:GGTLC1
Synonyms:GGTLA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16437. GGTLC1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28671.

Polymorphism and mutation databases

BioMutaiGGTLC1.
DMDMi34395714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Gamma-glutamyltransferase light chain 1PRO_0000205983Add
BLAST

Proteomic databases

PaxDbiQ9BX51.
PRIDEiQ9BX51.

Expressioni

Gene expression databases

BgeeiQ9BX51.
CleanExiHS_GGTLC1.
GenevisibleiQ9BX51. HS.

Organism-specific databases

HPAiHPA045635.
HPA047534.

Interactioni

Protein-protein interaction databases

BioGridi124906. 1 interaction.
STRINGi9606.ENSP00000278765.

Structurei

3D structure databases

ProteinModelPortaliQ9BX51.
SMRiQ9BX51. Positions 1-30, 37-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1082Glutamate bindingBy similarity
Regioni129 – 1302Glutamate bindingBy similarity

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000074069.
HOVERGENiHBG051730.
InParanoidiQ9BX51.
OMAiTQITMAT.
OrthoDBiEOG7V7665.
PhylomeDBiQ9BX51.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00462. G_GLU_TRANSPEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BX51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEFFSAQL RAQISDDTTH PISYYKPEFY MPDDGGTAHL SVVAEDGSAV
60 70 80 90 100
SATSTINLYF GSKVRSPVSG ILLNNEMDDF SSTSITNEFG VPPSPANFIQ
110 120 130 140 150
PGKQPLSSMC PTIMVGQDGQ VRMVVGAAGG TQITMATALA IIYNLWFGYD
160 170 180 190 200
VKWAVEEPRL HNQLLPNVTT VERNIDQEVT AALETRHHHT QITSTFIAVV
210 220
QAIVRMAGGW AAASDSRKGG EPAGY
Length:225
Mass (Da):24,274
Last modified:August 29, 2003 - v2
Checksum:i126947D3DBBE7536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20491 mRNA. Translation: AAA02885.1.
L20492 mRNA. Translation: AAA35864.1.
AL133466 Genomic DNA. Translation: CAC03399.1.
CH471133 Genomic DNA. Translation: EAX10125.1.
CH471133 Genomic DNA. Translation: EAX10129.1.
CH471133 Genomic DNA. Translation: EAX10130.1.
CH471133 Genomic DNA. Translation: EAX10131.1.
BC040904 mRNA. Translation: AAH40904.1.
CCDSiCCDS13163.1.
PIRiB47739.
RefSeqiNP_842563.1. NM_178311.2.
NP_842564.1. NM_178312.2.
XP_005260922.1. XM_005260865.3.
UniGeneiHs.355394.

Genome annotation databases

EnsembliENST00000278765; ENSP00000278765; ENSG00000149435.
ENST00000286890; ENSP00000286890; ENSG00000149435.
ENST00000335694; ENSP00000337587; ENSG00000149435.
GeneIDi92086.
KEGGihsa:92086.
UCSCiuc002wts.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20491 mRNA. Translation: AAA02885.1.
L20492 mRNA. Translation: AAA35864.1.
AL133466 Genomic DNA. Translation: CAC03399.1.
CH471133 Genomic DNA. Translation: EAX10125.1.
CH471133 Genomic DNA. Translation: EAX10129.1.
CH471133 Genomic DNA. Translation: EAX10130.1.
CH471133 Genomic DNA. Translation: EAX10131.1.
BC040904 mRNA. Translation: AAH40904.1.
CCDSiCCDS13163.1.
PIRiB47739.
RefSeqiNP_842563.1. NM_178311.2.
NP_842564.1. NM_178312.2.
XP_005260922.1. XM_005260865.3.
UniGeneiHs.355394.

3D structure databases

ProteinModelPortaliQ9BX51.
SMRiQ9BX51. Positions 1-30, 37-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124906. 1 interaction.
STRINGi9606.ENSP00000278765.

Protein family/group databases

MEROPSiT03.016.

Polymorphism and mutation databases

BioMutaiGGTLC1.
DMDMi34395714.

Proteomic databases

PaxDbiQ9BX51.
PRIDEiQ9BX51.

Protocols and materials databases

DNASUi92086.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278765; ENSP00000278765; ENSG00000149435.
ENST00000286890; ENSP00000286890; ENSG00000149435.
ENST00000335694; ENSP00000337587; ENSG00000149435.
GeneIDi92086.
KEGGihsa:92086.
UCSCiuc002wts.3. human.

Organism-specific databases

CTDi92086.
GeneCardsiGGTLC1.
HGNCiHGNC:16437. GGTLC1.
HPAiHPA045635.
HPA047534.
MIMi612338. gene.
neXtProtiNX_Q9BX51.
PharmGKBiPA28671.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000074069.
HOVERGENiHBG051730.
InParanoidiQ9BX51.
OMAiTQITMAT.
OrthoDBiEOG7V7665.
PhylomeDBiQ9BX51.

Miscellaneous databases

GenomeRNAii92086.
PROiQ9BX51.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BX51.
CleanExiHS_GGTLC1.
GenevisibleiQ9BX51. HS.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00462. G_GLU_TRANSPEPTIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human lung expresses unique gamma-glutamyl transpeptidase transcripts."
    Wetmore L.A., Gerard C., Drazen J.M.
    Proc. Natl. Acad. Sci. U.S.A. 90:7461-7465(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiGGTL1_HUMAN
AccessioniPrimary (citable) accession number: Q9BX51
Secondary accession number(s): D3DW43, Q08246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: June 8, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.