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Protein

Glutathione hydrolase light chain 1

Gene

GGTLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37NucleophileBy similarity1
Binding sitei55GlutamateBy similarity1
Binding sitei76GlutamateBy similarity1

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiT03.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione hydrolase light chain 1
Alternative name(s):
Gamma-glutamyltransferase light chain 1
Gamma-glutamyltransferase-like activity 4
Gamma-glutamyltransferase-like protein 6
Gene namesi
Name:GGTLC1
Synonyms:GGTLA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000149435.12.
HGNCiHGNC:16437. GGTLC1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi92086.
OpenTargetsiENSG00000149435.
PharmGKBiPA28671.

Polymorphism and mutation databases

BioMutaiGGTLC1.
DMDMi34395714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059831 – 225Glutathione hydrolase light chain 1Add BLAST225

Proteomic databases

MaxQBiQ9BX51.
PaxDbiQ9BX51.
PeptideAtlasiQ9BX51.
PRIDEiQ9BX51.

Expressioni

Gene expression databases

BgeeiENSG00000149435.
CleanExiHS_GGTLC1.
GenevisibleiQ9BX51. HS.

Organism-specific databases

HPAiHPA045635.
HPA047534.

Interactioni

Protein-protein interaction databases

BioGridi124906. 1 interactor.
STRINGi9606.ENSP00000278765.

Structurei

3D structure databases

ProteinModelPortaliQ9BX51.
SMRiQ9BX51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 108Glutamate bindingBy similarity2
Regioni129 – 130Glutamate bindingBy similarity2

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000074069.
HOVERGENiHBG051730.
InParanoidiQ9BX51.
OMAiRERNHNT.
OrthoDBiEOG091G03Y3.
PhylomeDBiQ9BX51.

Family and domain databases

InterProiView protein in InterPro
IPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiView protein in Pfam
PF01019. G_glu_transpept. 1 hit.
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00462. G_GLU_TRANSPEPTIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BX51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEFFSAQL RAQISDDTTH PISYYKPEFY MPDDGGTAHL SVVAEDGSAV
60 70 80 90 100
SATSTINLYF GSKVRSPVSG ILLNNEMDDF SSTSITNEFG VPPSPANFIQ
110 120 130 140 150
PGKQPLSSMC PTIMVGQDGQ VRMVVGAAGG TQITMATALA IIYNLWFGYD
160 170 180 190 200
VKWAVEEPRL HNQLLPNVTT VERNIDQEVT AALETRHHHT QITSTFIAVV
210 220
QAIVRMAGGW AAASDSRKGG EPAGY
Length:225
Mass (Da):24,274
Last modified:August 29, 2003 - v2
Checksum:i126947D3DBBE7536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20491 mRNA. Translation: AAA02885.1.
L20492 mRNA. Translation: AAA35864.1.
AL133466 Genomic DNA. Translation: CAC03399.1.
CH471133 Genomic DNA. Translation: EAX10125.1.
CH471133 Genomic DNA. Translation: EAX10129.1.
CH471133 Genomic DNA. Translation: EAX10130.1.
CH471133 Genomic DNA. Translation: EAX10131.1.
BC040904 mRNA. Translation: AAH40904.1.
CCDSiCCDS13163.1.
PIRiB47739.
RefSeqiNP_842563.1. NM_178311.2.
NP_842564.1. NM_178312.2.
XP_005260922.1. XM_005260865.4.
XP_016883615.1. XM_017028126.1.
UniGeneiHs.355394.

Genome annotation databases

EnsembliENST00000278765; ENSP00000278765; ENSG00000149435.
ENST00000286890; ENSP00000286890; ENSG00000149435.
ENST00000335694; ENSP00000337587; ENSG00000149435.
GeneIDi92086.
KEGGihsa:92086.
UCSCiuc002wts.3. human.

Similar proteinsi

Entry informationi

Entry nameiGGTL1_HUMAN
AccessioniPrimary (citable) accession number: Q9BX51
Secondary accession number(s): D3DW43, Q08246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: September 27, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families