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Protein

Protein LSM14 homolog B

Gene

LSM14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in control of mRNA translation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM14 homolog B
Alternative name(s):
Protein FAM61B
RNA-associated protein 55B
Short name:
hRAP55B
Gene namesi
Name:LSM14B
Synonyms:C20orf40, FAM61B, RAP55B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000149657.19
HGNCiHGNC:15887 LSM14B
neXtProtiNX_Q9BX40

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149657
PharmGKBiPA25754

Polymorphism and mutation databases

BioMutaiLSM14B
DMDMi71151896

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001870932 – 385Protein LSM14 homolog BAdd BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei329PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei351Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BX40
MaxQBiQ9BX40
PaxDbiQ9BX40
PeptideAtlasiQ9BX40
PRIDEiQ9BX40

PTM databases

iPTMnetiQ9BX40
PhosphoSitePlusiQ9BX40

Expressioni

Gene expression databases

BgeeiENSG00000149657
CleanExiHS_LSM14B
ExpressionAtlasiQ9BX40 baseline and differential
GenevisibleiQ9BX40 HS

Organism-specific databases

HPAiHPA041274
HPA061189

Interactioni

Subunit structurei

Component of a ribonucleoprotein (RNP) complex.By similarity

Protein-protein interaction databases

BioGridi127252, 26 interactors
IntActiQ9BX40, 11 interactors
STRINGi9606.ENSP00000279068

Structurei

3D structure databases

ProteinModelPortaliQ9BX40
SMRiQ9BX40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 277DFDFPROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi310 – 326FFD boxAdd BLAST17
Motifi330 – 350TFG boxAdd BLAST21

Sequence similaritiesi

Belongs to the LSM14 family.Curated

Phylogenomic databases

eggNOGiKOG1073 Eukaryota
ENOG41122RA LUCA
GeneTreeiENSGT00390000004174
HOGENOMiHOG000231251
HOVERGENiHBG054326
InParanoidiQ9BX40
KOiK18749
OMAiKCFFDNI
OrthoDBiEOG091G0FJG
PhylomeDBiQ9BX40
TreeFamiTF313514

Family and domain databases

CDDicd01736 LSm14_N, 1 hit
InterProiView protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR025761 FFD_box
IPR025609 Lsm14-like_N
IPR010920 LSM_dom_sf
IPR025768 TFG_box
PfamiView protein in Pfam
PF09532 FDF, 1 hit
PF12701 LSM14, 1 hit
SMARTiView protein in SMART
SM01199 FDF, 1 hit
SM01271 LSM14, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
PROSITEiView protein in PROSITE
PS51512 DFDF, 1 hit
PS51513 FFD, 1 hit
PS51536 TFG, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BX40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSSGTPYL GSKISLISKA QIRYEGILYT IDTDNSTVAL AKVRSFGTED
60 70 80 90 100
RPTDRPAPPR EEIYEYIIFR GSDIKDITVC EPPKAQHTLP QDPAIVQSSL
110 120 130 140 150
GSASASPFQP HVPYSPFRGM APYGPLAASS LLSQQYAASL GLGAGFPSIP
160 170 180 190 200
VGKSPMVEQA VQTGSADNLN AKKLLPGKGT TGTQLNGRQA QPSSKTASDV
210 220 230 240 250
VQPAAVQAQG QVNDENRRPQ RRRSGNRRTR NRSRGQNRPT NVKENTIKFE
260 270 280 290 300
GDFDFESANA QFNREELDKE FKKKLNFKDD KAEKGEEKDL AVVTQSAEAP
310 320 330 340 350
AEEDLLGPNC YYDKSKSFFD NISSELKTSS RRTTWAEERK LNTETFGVSG
360 370 380
RFLRGRSSRG GFRGGRGNGT TRRNPTSHRA GTGRV
Length:385
Mass (Da):42,071
Last modified:June 1, 2001 - v1
Checksum:i9F1216A57330EE32
GO
Isoform 2 (identifier: Q9BX40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-220: GAGFPSIPVG...QVNDENRRPQ → EKLVSPPASA...VADHLPSPCS

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):42,021
Checksum:i1026731ADECB5A43
GO
Isoform 3 (identifier: Q9BX40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     45-142: SFGTEDRPTD...SQQYAASLGL → MAPYGPLAAS...GTLEREEMER
     274-283: KLNFKDDKAE → RPILLLVFWT
     284-385: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):26,019
Checksum:i8EB2347F1DE7AEEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66Y → N in BX354437 (Ref. 4) Curated1
Sequence conflicti87H → N in BX354437 (Ref. 4) Curated1
Sequence conflicti114Y → N in BX354437 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0146581 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_01465945 – 142SFGTE…ASLGL → MAPYGPLAASSLLSQQYAAS LGLEKLVSPPASAAASSPSS SPSPQPVSELDLSSEPQQLT AKGCLFCFRSLFTYTQSHIV LFRVPTGPGTLEREEMER in isoform 3. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_014660143 – 220GAGFP…NRRPQ → EKLVSPPASAAASSPSSSPS PQPVSELDLSSEPQQLTAKG NSSLGELHAVLQTILRARGK AADRMTVAVADHLPSPCS in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_014661274 – 283KLNFKDDKAE → RPILLLVFWT in isoform 3. 1 Publication10
Alternative sequenceiVSP_014662284 – 385Missing in isoform 3. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058202 mRNA Translation: BAB71714.1
AL137077 Genomic DNA No translation available.
BC057387 mRNA Translation: AAH57387.1
BX354437 mRNA No translation available.
CCDSiCCDS46626.1 [Q9BX40-1]
RefSeqiNP_653304.2, NM_144703.2 [Q9BX40-1]
UniGeneiHs.105379

Genome annotation databases

EnsembliENST00000279068; ENSP00000279068; ENSG00000149657 [Q9BX40-1]
GeneIDi149986
KEGGihsa:149986
UCSCiuc002ybt.3 human [Q9BX40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLS14B_HUMAN
AccessioniPrimary (citable) accession number: Q9BX40
Secondary accession number(s): Q6PFW8, Q96LH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health