Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein LSM14 homolog B

Gene

LSM14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in control of mRNA translation.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM14 homolog B
Alternative name(s):
Protein FAM61B
RNA-associated protein 55B
Short name:
hRAP55B
Gene namesi
Name:LSM14B
Synonyms:C20orf40, FAM61B, RAP55B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15887. LSM14B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25754.

Polymorphism and mutation databases

BioMutaiLSM14B.
DMDMi71151896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 385384Protein LSM14 homolog BPRO_0000187093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei106 – 1061PhosphoserineCombined sources
Modified residuei115 – 1151PhosphoserineCombined sources
Modified residuei154 – 1541PhosphoserineCombined sources
Modified residuei165 – 1651PhosphoserineCombined sources
Modified residuei329 – 3291PhosphoserineCombined sources
Modified residuei349 – 3491PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BX40.
MaxQBiQ9BX40.
PaxDbiQ9BX40.
PeptideAtlasiQ9BX40.
PRIDEiQ9BX40.

PTM databases

iPTMnetiQ9BX40.
PhosphoSiteiQ9BX40.

Expressioni

Gene expression databases

BgeeiENSG00000149657.
CleanExiHS_LSM14B.
ExpressionAtlasiQ9BX40. baseline and differential.
GenevisibleiQ9BX40. HS.

Organism-specific databases

HPAiHPA041274.
HPA061189.

Interactioni

Subunit structurei

Component of a ribonucleoprotein (RNP) complex.By similarity

Protein-protein interaction databases

BioGridi127252. 21 interactions.
IntActiQ9BX40. 9 interactions.
STRINGi9606.ENSP00000279068.

Structurei

3D structure databases

ProteinModelPortaliQ9BX40.
SMRiQ9BX40. Positions 8-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini241 – 27737DFDFPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi310 – 32617FFD boxAdd
BLAST
Motifi330 – 35021TFG boxAdd
BLAST

Sequence similaritiesi

Belongs to the LSM14 family.Curated
Contains 1 DFDF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1073. Eukaryota.
ENOG41122RA. LUCA.
GeneTreeiENSGT00390000004174.
HOGENOMiHOG000231251.
HOVERGENiHBG054326.
InParanoidiQ9BX40.
KOiK18749.
OMAiQSRPTNI.
OrthoDBiEOG091G0FJG.
PhylomeDBiQ9BX40.
TreeFamiTF313514.

Family and domain databases

InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR025761. FFD_box.
IPR025609. Lsm14_N.
IPR010920. LSM_dom.
IPR025768. TFG_box.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
SM01271. LSM14. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51513. FFD. 1 hit.
PS51536. TFG. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BX40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSSGTPYL GSKISLISKA QIRYEGILYT IDTDNSTVAL AKVRSFGTED
60 70 80 90 100
RPTDRPAPPR EEIYEYIIFR GSDIKDITVC EPPKAQHTLP QDPAIVQSSL
110 120 130 140 150
GSASASPFQP HVPYSPFRGM APYGPLAASS LLSQQYAASL GLGAGFPSIP
160 170 180 190 200
VGKSPMVEQA VQTGSADNLN AKKLLPGKGT TGTQLNGRQA QPSSKTASDV
210 220 230 240 250
VQPAAVQAQG QVNDENRRPQ RRRSGNRRTR NRSRGQNRPT NVKENTIKFE
260 270 280 290 300
GDFDFESANA QFNREELDKE FKKKLNFKDD KAEKGEEKDL AVVTQSAEAP
310 320 330 340 350
AEEDLLGPNC YYDKSKSFFD NISSELKTSS RRTTWAEERK LNTETFGVSG
360 370 380
RFLRGRSSRG GFRGGRGNGT TRRNPTSHRA GTGRV
Length:385
Mass (Da):42,071
Last modified:June 1, 2001 - v1
Checksum:i9F1216A57330EE32
GO
Isoform 2 (identifier: Q9BX40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-220: GAGFPSIPVG...QVNDENRRPQ → EKLVSPPASA...VADHLPSPCS

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):42,021
Checksum:i1026731ADECB5A43
GO
Isoform 3 (identifier: Q9BX40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     45-142: SFGTEDRPTD...SQQYAASLGL → MAPYGPLAAS...GTLEREEMER
     274-283: KLNFKDDKAE → RPILLLVFWT
     284-385: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):26,019
Checksum:i8EB2347F1DE7AEEF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661Y → N in BX354437 (Ref. 4) Curated
Sequence conflicti87 – 871H → N in BX354437 (Ref. 4) Curated
Sequence conflicti114 – 1141Y → N in BX354437 (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4444Missing in isoform 3. 1 PublicationVSP_014658Add
BLAST
Alternative sequencei45 – 14298SFGTE…ASLGL → MAPYGPLAASSLLSQQYAAS LGLEKLVSPPASAAASSPSS SPSPQPVSELDLSSEPQQLT AKGCLFCFRSLFTYTQSHIV LFRVPTGPGTLEREEMER in isoform 3. 1 PublicationVSP_014659Add
BLAST
Alternative sequencei143 – 22078GAGFP…NRRPQ → EKLVSPPASAAASSPSSSPS PQPVSELDLSSEPQQLTAKG NSSLGELHAVLQTILRARGK AADRMTVAVADHLPSPCS in isoform 2. 1 PublicationVSP_014660Add
BLAST
Alternative sequencei274 – 28310KLNFKDDKAE → RPILLLVFWT in isoform 3. 1 PublicationVSP_014661
Alternative sequencei284 – 385102Missing in isoform 3. 1 PublicationVSP_014662Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058202 mRNA. Translation: BAB71714.1.
AL137077 Genomic DNA. Translation: CAI11047.1.
AL137077 Genomic DNA. Translation: CAI11051.1.
BC057387 mRNA. Translation: AAH57387.1.
BX354437 mRNA. No translation available.
CCDSiCCDS46626.1. [Q9BX40-1]
RefSeqiNP_653304.2. NM_144703.2. [Q9BX40-1]
UniGeneiHs.105379.

Genome annotation databases

EnsembliENST00000279068; ENSP00000279068; ENSG00000149657. [Q9BX40-1]
GeneIDi149986.
KEGGihsa:149986.
UCSCiuc002ybt.3. human. [Q9BX40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058202 mRNA. Translation: BAB71714.1.
AL137077 Genomic DNA. Translation: CAI11047.1.
AL137077 Genomic DNA. Translation: CAI11051.1.
BC057387 mRNA. Translation: AAH57387.1.
BX354437 mRNA. No translation available.
CCDSiCCDS46626.1. [Q9BX40-1]
RefSeqiNP_653304.2. NM_144703.2. [Q9BX40-1]
UniGeneiHs.105379.

3D structure databases

ProteinModelPortaliQ9BX40.
SMRiQ9BX40. Positions 8-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127252. 21 interactions.
IntActiQ9BX40. 9 interactions.
STRINGi9606.ENSP00000279068.

PTM databases

iPTMnetiQ9BX40.
PhosphoSiteiQ9BX40.

Polymorphism and mutation databases

BioMutaiLSM14B.
DMDMi71151896.

Proteomic databases

EPDiQ9BX40.
MaxQBiQ9BX40.
PaxDbiQ9BX40.
PeptideAtlasiQ9BX40.
PRIDEiQ9BX40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279068; ENSP00000279068; ENSG00000149657. [Q9BX40-1]
GeneIDi149986.
KEGGihsa:149986.
UCSCiuc002ybt.3. human. [Q9BX40-1]

Organism-specific databases

CTDi149986.
GeneCardsiLSM14B.
HGNCiHGNC:15887. LSM14B.
HPAiHPA041274.
HPA061189.
neXtProtiNX_Q9BX40.
PharmGKBiPA25754.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1073. Eukaryota.
ENOG41122RA. LUCA.
GeneTreeiENSGT00390000004174.
HOGENOMiHOG000231251.
HOVERGENiHBG054326.
InParanoidiQ9BX40.
KOiK18749.
OMAiQSRPTNI.
OrthoDBiEOG091G0FJG.
PhylomeDBiQ9BX40.
TreeFamiTF313514.

Miscellaneous databases

ChiTaRSiLSM14B. human.
GenomeRNAii149986.
PROiQ9BX40.

Gene expression databases

BgeeiENSG00000149657.
CleanExiHS_LSM14B.
ExpressionAtlasiQ9BX40. baseline and differential.
GenevisibleiQ9BX40. HS.

Family and domain databases

InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR025761. FFD_box.
IPR025609. Lsm14_N.
IPR010920. LSM_dom.
IPR025768. TFG_box.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
SM01271. LSM14. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51513. FFD. 1 hit.
PS51536. TFG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLS14B_HUMAN
AccessioniPrimary (citable) accession number: Q9BX40
Secondary accession number(s): Q6PFW8, Q96LH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.