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Protein

GTP-binding protein 2

Gene

GTPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 1868GTPBy similarity
Nucleotide bindingi260 – 2645GTPBy similarity
Nucleotide bindingi316 – 3194GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 2
Gene namesi
Name:GTPBP2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4670. GTPBP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29058.

Polymorphism and mutation databases

BioMutaiGTPBP2.
DMDMi74752415.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602GTP-binding protein 2PRO_0000248500Add
BLAST

Proteomic databases

EPDiQ9BX10.
MaxQBiQ9BX10.
PaxDbiQ9BX10.
PRIDEiQ9BX10.

PTM databases

PhosphoSiteiQ9BX10.

Expressioni

Tissue specificityi

Predominantly expressed in thymus, spleen, and testis. Expressed at lower levels in brain, lung, kidney, and ovary.1 Publication

Inductioni

Up-regulated by IFNG/IFN-gamma in human monocytic cell line THP-1.1 Publication

Gene expression databases

BgeeiQ9BX10.
CleanExiHS_GTPBP2.
ExpressionAtlasiQ9BX10. baseline and differential.
GenevisibleiQ9BX10. HS.

Organism-specific databases

HPAiHPA031418.
HPA031419.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-6115579,EBI-710124
PRMT5O147442EBI-6115579,EBI-351098
PRMT6Q96LA82EBI-6115579,EBI-912440
SUV39H1O434632EBI-6115579,EBI-349968

Protein-protein interaction databases

BioGridi120097. 25 interactions.
IntActiQ9BX10. 14 interactions.
MINTiMINT-3062961.
STRINGi9606.ENSP00000303997.

Structurei

3D structure databases

ProteinModelPortaliQ9BX10.
SMRiQ9BX10. Positions 173-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 398229tr-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOVERGENiHBG004471.
InParanoidiQ9BX10.
OMAiDQHNIEV.
OrthoDBiEOG70KGPM.
PhylomeDBiQ9BX10.
TreeFamiTF350446.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9BX10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSRVSELFG GCCRPGGGPA VGGTLKARGA GSSSGCGGPK GKKKNGRNRG
60 70 80 90 100
GKANNPPYLP PEAEDGNIEY KLKLVNPSQY RFEHLVTQMK WRLQEGRGEA
110 120 130 140 150
VYQIGVEDNG LLVGLAEEEM RASLKTLHRM AEKVGADITV LREREVDYDS
160 170 180 190 200
DMPRKITEVL VRKVPDNQQF LDLRVAVLGN VDSGKSTLLG VLTQGELDNG
210 220 230 240 250
RGRARLNLFR HLHEIQSGRT SSISFEILGF NSKGEVVNYS DSRTAEEICE
260 270 280 290 300
SSSKMITFID LAGHHKYLHT TIFGLTSYCP DCALLLVSAN TGIAGTTREH
310 320 330 340 350
LGLALALKVP FFIVVSKIDL CAKTTVERTV RQLERVLKQP GCHKVPMLVT
360 370 380 390 400
SEDDAVTAAQ QFAQSPNVTP IFTLSSVSGE SLDLLKVFLN ILPPLTNSKE
410 420 430 440 450
QEELMQQLTE FQVDEIYTVP EVGTVVGGTL SSGICREGDQ LVVGPTDDGC
460 470 480 490 500
FLELRVCSIQ RNRSACRVLR AGQAATLALG DFDRALLRKG MVMVSPEMNP
510 520 530 540 550
TICSVFEAEI VLLFHATTFR RGFQVTVHVG NVRQTAVVEK IHAKDKLRTG
560 570 580 590 600
EKAVVRFRFL KHPEYLKVGA KLLFREGVTK GIGHVTDVQA ITAGEAQANM

GF
Note: No experimental confirmation available.Curated
Length:602
Mass (Da):65,768
Last modified:June 1, 2001 - v1
Checksum:iBA9CA08F3797A7B1
GO
Isoform 21 Publication (identifier: Q9BX10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:514
Mass (Da):56,612
Checksum:iF3E76A54BE6AAAB7
GO
Isoform 31 Publication (identifier: Q9BX10-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     101-370: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:244
Mass (Da):26,907
Checksum:i7889B21FDCBB89F1
GO
Isoform 41 Publication (identifier: Q9BX10-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-79: Missing.

Note: Gene prediction based upon EST data.Curated
Show »
Length:594
Mass (Da):64,888
Checksum:i6A46EFD5C3B135A0
GO

Sequence cautioni

The sequence CAD38999.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 432KK → TR in AAF78884 (PubMed:10833435).Curated
Sequence conflicti234 – 2341G → E in BAB12431 (PubMed:11054535).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888Missing in isoform 2 and isoform 3. 2 PublicationsVSP_052154Add
BLAST
Alternative sequencei72 – 798Missing in isoform 4. 1 PublicationVSP_052155
Alternative sequencei101 – 370270Missing in isoform 3. 1 PublicationVSP_052156Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024574 mRNA. Translation: BAB12431.1.
AL353602 Genomic DNA. Translation: CAC36269.1.
AL353602 Genomic DNA. Translation: CAI12785.1.
AK000430 mRNA. Translation: BAA91160.1.
BC020980 mRNA. Translation: AAH20980.2.
BC028347 mRNA. Translation: AAH28347.2.
BC064968 mRNA. Translation: AAH64968.1.
AF168990 mRNA. Translation: AAF78884.1.
AL834331 mRNA. Translation: CAD38999.1. Different initiation.
CCDSiCCDS4903.1. [Q9BX10-1]
CCDS69124.1. [Q9BX10-2]
PIRiPC7084.
RefSeqiNP_001273145.1. NM_001286216.1. [Q9BX10-2]
NP_061969.3. NM_019096.4. [Q9BX10-1]
UniGeneiHs.485449.

Genome annotation databases

EnsembliENST00000307114; ENSP00000304893; ENSG00000172432. [Q9BX10-2]
ENST00000307126; ENSP00000303997; ENSG00000172432. [Q9BX10-1]
GeneIDi54676.
KEGGihsa:54676.
UCSCiuc003ovs.5. human. [Q9BX10-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024574 mRNA. Translation: BAB12431.1.
AL353602 Genomic DNA. Translation: CAC36269.1.
AL353602 Genomic DNA. Translation: CAI12785.1.
AK000430 mRNA. Translation: BAA91160.1.
BC020980 mRNA. Translation: AAH20980.2.
BC028347 mRNA. Translation: AAH28347.2.
BC064968 mRNA. Translation: AAH64968.1.
AF168990 mRNA. Translation: AAF78884.1.
AL834331 mRNA. Translation: CAD38999.1. Different initiation.
CCDSiCCDS4903.1. [Q9BX10-1]
CCDS69124.1. [Q9BX10-2]
PIRiPC7084.
RefSeqiNP_001273145.1. NM_001286216.1. [Q9BX10-2]
NP_061969.3. NM_019096.4. [Q9BX10-1]
UniGeneiHs.485449.

3D structure databases

ProteinModelPortaliQ9BX10.
SMRiQ9BX10. Positions 173-569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120097. 25 interactions.
IntActiQ9BX10. 14 interactions.
MINTiMINT-3062961.
STRINGi9606.ENSP00000303997.

PTM databases

PhosphoSiteiQ9BX10.

Polymorphism and mutation databases

BioMutaiGTPBP2.
DMDMi74752415.

Proteomic databases

EPDiQ9BX10.
MaxQBiQ9BX10.
PaxDbiQ9BX10.
PRIDEiQ9BX10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307114; ENSP00000304893; ENSG00000172432. [Q9BX10-2]
ENST00000307126; ENSP00000303997; ENSG00000172432. [Q9BX10-1]
GeneIDi54676.
KEGGihsa:54676.
UCSCiuc003ovs.5. human. [Q9BX10-1]

Organism-specific databases

CTDi54676.
GeneCardsiGTPBP2.
HGNCiHGNC:4670. GTPBP2.
HPAiHPA031418.
HPA031419.
MIMi607434. gene.
neXtProtiNX_Q9BX10.
PharmGKBiPA29058.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOVERGENiHBG004471.
InParanoidiQ9BX10.
OMAiDQHNIEV.
OrthoDBiEOG70KGPM.
PhylomeDBiQ9BX10.
TreeFamiTF350446.

Miscellaneous databases

ChiTaRSiGTPBP2. human.
GenomeRNAii54676.
NextBioi57232.
PROiQ9BX10.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BX10.
CleanExiHS_GTPBP2.
ExpressionAtlasiQ9BX10. baseline and differential.
GenevisibleiQ9BX10. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family."
    Watanabe M., Yoshida K., Hida M., Kato H., Uchida K., Yamaguchi R., Tateyama S., Sugano S.
    Gene 256:51-58(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: ColonImported, OvaryImported and SkinImported.
  5. "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase."
    Kudo H., Senju S., Mitsuya H., Nishimura Y.
    Biochem. Biophys. Res. Commun. 272:456-465(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-602 (ISOFORM 1), INDUCTION.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-602 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiGTPB2_HUMAN
AccessioniPrimary (citable) accession number: Q9BX10
Secondary accession number(s): Q5T7E8
, Q8ND84, Q8TAH7, Q8WUA5, Q9HCS9, Q9NRU4, Q9NX60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: April 13, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.