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Protein

GTP-binding protein 2

Gene

GTPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi179 – 186GTPBy similarity8
Nucleotide bindingi260 – 264GTPBy similarity5
Nucleotide bindingi316 – 319GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 2
Gene namesi
Name:GTPBP2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000172432.18
HGNCiHGNC:4670 GTPBP2
MIMi607434 gene
neXtProtiNX_Q9BX10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54676
OpenTargetsiENSG00000172432
PharmGKBiPA29058

Polymorphism and mutation databases

BioMutaiGTPBP2
DMDMi74752415

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002485001 – 602GTP-binding protein 2Add BLAST602

Proteomic databases

EPDiQ9BX10
MaxQBiQ9BX10
PaxDbiQ9BX10
PeptideAtlasiQ9BX10
PRIDEiQ9BX10
ProteomicsDBi79339
79340 [Q9BX10-2]
79341 [Q9BX10-3]
79342 [Q9BX10-4]

PTM databases

iPTMnetiQ9BX10
PhosphoSitePlusiQ9BX10

Expressioni

Tissue specificityi

Predominantly expressed in thymus, spleen, and testis. Expressed at lower levels in brain, lung, kidney, and ovary.1 Publication

Inductioni

Up-regulated by IFNG/IFN-gamma in human monocytic cell line THP-1.1 Publication

Gene expression databases

BgeeiENSG00000172432
CleanExiHS_GTPBP2
ExpressionAtlasiQ9BX10 baseline and differential
GenevisibleiQ9BX10 HS

Organism-specific databases

HPAiHPA031418
HPA031419

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120097, 25 interactors
IntActiQ9BX10, 20 interactors
MINTiQ9BX10
STRINGi9606.ENSP00000303997

Structurei

3D structure databases

ProteinModelPortaliQ9BX10
SMRiQ9BX10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 398tr-type GPROSITE-ProRule annotationAdd BLAST229

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463 Eukaryota
COG5258 LUCA
GeneTreeiENSGT00730000110829
HOVERGENiHBG004471
InParanoidiQ9BX10
OMAiENMPMKI
OrthoDBiEOG091G06LY
PhylomeDBiQ9BX10
TreeFamiTF350446

Family and domain databases

CDDicd04165 GTPBP1_like, 1 hit
InterProiView protein in InterPro
IPR035531 GTPBP1-like
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9BX10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSRVSELFG GCCRPGGGPA VGGTLKARGA GSSSGCGGPK GKKKNGRNRG
60 70 80 90 100
GKANNPPYLP PEAEDGNIEY KLKLVNPSQY RFEHLVTQMK WRLQEGRGEA
110 120 130 140 150
VYQIGVEDNG LLVGLAEEEM RASLKTLHRM AEKVGADITV LREREVDYDS
160 170 180 190 200
DMPRKITEVL VRKVPDNQQF LDLRVAVLGN VDSGKSTLLG VLTQGELDNG
210 220 230 240 250
RGRARLNLFR HLHEIQSGRT SSISFEILGF NSKGEVVNYS DSRTAEEICE
260 270 280 290 300
SSSKMITFID LAGHHKYLHT TIFGLTSYCP DCALLLVSAN TGIAGTTREH
310 320 330 340 350
LGLALALKVP FFIVVSKIDL CAKTTVERTV RQLERVLKQP GCHKVPMLVT
360 370 380 390 400
SEDDAVTAAQ QFAQSPNVTP IFTLSSVSGE SLDLLKVFLN ILPPLTNSKE
410 420 430 440 450
QEELMQQLTE FQVDEIYTVP EVGTVVGGTL SSGICREGDQ LVVGPTDDGC
460 470 480 490 500
FLELRVCSIQ RNRSACRVLR AGQAATLALG DFDRALLRKG MVMVSPEMNP
510 520 530 540 550
TICSVFEAEI VLLFHATTFR RGFQVTVHVG NVRQTAVVEK IHAKDKLRTG
560 570 580 590 600
EKAVVRFRFL KHPEYLKVGA KLLFREGVTK GIGHVTDVQA ITAGEAQANM

GF
Note: No experimental confirmation available.Curated
Length:602
Mass (Da):65,768
Last modified:June 1, 2001 - v1
Checksum:iBA9CA08F3797A7B1
GO
Isoform 21 Publication (identifier: Q9BX10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:514
Mass (Da):56,612
Checksum:iF3E76A54BE6AAAB7
GO
Isoform 31 Publication (identifier: Q9BX10-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     101-370: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:244
Mass (Da):26,907
Checksum:i7889B21FDCBB89F1
GO
Isoform 41 Publication (identifier: Q9BX10-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-79: Missing.

Note: Gene prediction based upon EST data.Curated
Show »
Length:594
Mass (Da):64,888
Checksum:i6A46EFD5C3B135A0
GO

Sequence cautioni

The sequence CAD38999 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42 – 43KK → TR in AAF78884 (PubMed:10833435).Curated2
Sequence conflicti234G → E in BAB12431 (PubMed:11054535).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0521541 – 88Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_05215572 – 79Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_052156101 – 370Missing in isoform 3. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024574 mRNA Translation: BAB12431.1
AL353602 Genomic DNA Translation: CAC36269.1
AL353602 Genomic DNA Translation: CAI12785.1
AK000430 mRNA Translation: BAA91160.1
BC020980 mRNA Translation: AAH20980.2
BC028347 mRNA Translation: AAH28347.2
BC064968 mRNA Translation: AAH64968.1
AF168990 mRNA Translation: AAF78884.1
AL834331 mRNA Translation: CAD38999.1 Different initiation.
CCDSiCCDS4903.1 [Q9BX10-1]
CCDS69124.1 [Q9BX10-2]
PIRiPC7084
RefSeqiNP_001273145.1, NM_001286216.1 [Q9BX10-2]
NP_061969.3, NM_019096.4 [Q9BX10-1]
UniGeneiHs.485449

Genome annotation databases

EnsembliENST00000307114; ENSP00000304893; ENSG00000172432 [Q9BX10-2]
ENST00000307126; ENSP00000303997; ENSG00000172432 [Q9BX10-1]
GeneIDi54676
KEGGihsa:54676
UCSCiuc003ovs.5 human [Q9BX10-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGTPB2_HUMAN
AccessioniPrimary (citable) accession number: Q9BX10
Secondary accession number(s): Q5T7E8
, Q8ND84, Q8TAH7, Q8WUA5, Q9HCS9, Q9NRU4, Q9NX60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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