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Protein

PHD finger protein 7

Gene

PHF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 68C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri96 – 145PHD-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri160 – 208RING-type; degeneratePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 7
Alternative name(s):
Testis development protein NYD-SP6
Gene namesi
Name:PHF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18458. PHF7.

Subcellular locationi

GO - Cellular componenti

  • microtubule organizing center Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000010318.
PharmGKBiPA38541.

Polymorphism and mutation databases

DMDMi62900704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559961 – 381PHD finger protein 7Add BLAST381

Proteomic databases

PaxDbiQ9BWX1.
PRIDEiQ9BWX1.

PTM databases

iPTMnetiQ9BWX1.
PhosphoSitePlusiQ9BWX1.

Expressioni

Tissue specificityi

Highly expressed in Sertoli cells, but not in germ cells in adult testis. Expression in embryonic testis is 30-times lower. Highly expressed in colon, spleen, white blood cells, pancreas, lung, liver, placenta and brain. Detected at lower levels in thymus, small intestine, ovary and kidney.1 Publication

Gene expression databases

BgeeiENSG00000010318.
CleanExiHS_PHF7.
ExpressionAtlasiQ9BWX1. baseline and differential.
GenevisibleiQ9BWX1. HS.

Organism-specific databases

HPAiHPA036283.
HPA058159.
HPA070305.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBE2D4Q9Y2X83EBI-4307517,EBI-745527

Protein-protein interaction databases

BioGridi119594. 23 interactors.
IntActiQ9BWX1. 11 interactors.
STRINGi9606.ENSP00000333024.

Structurei

3D structure databases

ProteinModelPortaliQ9BWX1.
SMRiQ9BWX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 68C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri96 – 145PHD-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri160 – 208RING-type; degeneratePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00390000005246.
HOGENOMiHOG000236336.
HOVERGENiHBG053588.
InParanoidiQ9BWX1.
OMAiCLYEQGR.
OrthoDBiEOG091G0Q24.
PhylomeDBiQ9BWX1.
TreeFamiTF325426.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTVKEKKEC QRLRKSAKTR RVTQRKPSSG PVCWLCLREP GDPEKLGEFL
60 70 80 90 100
QKDNISVHYF CLILSSKLPQ RGQSNRGFHG FLPEDIKKEA ARASRKICFV
110 120 130 140 150
CKKKGAAINC QKDQCLRNFH LPCGQERGCL SQFFGEYKSF CDKHRPTQNI
160 170 180 190 200
QHGHVGEESC ILCCEDLSQQ SVENIQSPCC SQAIYHRKCI QKYAHTSAKH
210 220 230 240 250
FFKCPQCNNR KEFPQEMLRM GIHIPDRDAA WELEPGAFSD LYQRYQHCDA
260 270 280 290 300
PICLYEQGRD SFEDEGRWCL ILCATCGSHG THRDCSSLRS NSKKWECEEC
310 320 330 340 350
SPAAATDYIP ENSGDIPCCS STFHPEEHFC RDNTLEENPG LSWTDWPEPS
360 370 380
LLEKPESSRG RRSYSWRSKG VRITNSCKKS K
Length:381
Mass (Da):43,767
Last modified:June 1, 2001 - v1
Checksum:i5219D262D8135B8D
GO
Isoform 2 (identifier: Q9BWX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-266: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:342
Mass (Da):39,259
Checksum:i760DEF8BFABB5CAD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035957369K → N in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046255228 – 266Missing in isoform 2. CuratedAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014283 mRNA. Translation: AAK27308.1.
AC006208 Genomic DNA. No translation available.
AC092045 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65224.1.
BC022002 mRNA. Translation: AAH22002.1.
CCDSiCCDS2854.1. [Q9BWX1-1]
CCDS2855.1. [Q9BWX1-2]
RefSeqiNP_001265150.1. NM_001278221.2. [Q9BWX1-2]
NP_001308055.1. NM_001321126.1. [Q9BWX1-1]
NP_001308056.1. NM_001321127.1. [Q9BWX1-1]
NP_057567.3. NM_016483.6. [Q9BWX1-1]
UniGeneiHs.372719.

Genome annotation databases

EnsembliENST00000327906; ENSP00000333024; ENSG00000010318. [Q9BWX1-1]
ENST00000347025; ENSP00000246282; ENSG00000010318. [Q9BWX1-2]
ENST00000614886; ENSP00000480003; ENSG00000010318. [Q9BWX1-2]
GeneIDi51533.
KEGGihsa:51533.
UCSCiuc003ddy.5. human. [Q9BWX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014283 mRNA. Translation: AAK27308.1.
AC006208 Genomic DNA. No translation available.
AC092045 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65224.1.
BC022002 mRNA. Translation: AAH22002.1.
CCDSiCCDS2854.1. [Q9BWX1-1]
CCDS2855.1. [Q9BWX1-2]
RefSeqiNP_001265150.1. NM_001278221.2. [Q9BWX1-2]
NP_001308055.1. NM_001321126.1. [Q9BWX1-1]
NP_001308056.1. NM_001321127.1. [Q9BWX1-1]
NP_057567.3. NM_016483.6. [Q9BWX1-1]
UniGeneiHs.372719.

3D structure databases

ProteinModelPortaliQ9BWX1.
SMRiQ9BWX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119594. 23 interactors.
IntActiQ9BWX1. 11 interactors.
STRINGi9606.ENSP00000333024.

PTM databases

iPTMnetiQ9BWX1.
PhosphoSitePlusiQ9BWX1.

Polymorphism and mutation databases

DMDMi62900704.

Proteomic databases

PaxDbiQ9BWX1.
PRIDEiQ9BWX1.

Protocols and materials databases

DNASUi51533.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327906; ENSP00000333024; ENSG00000010318. [Q9BWX1-1]
ENST00000347025; ENSP00000246282; ENSG00000010318. [Q9BWX1-2]
ENST00000614886; ENSP00000480003; ENSG00000010318. [Q9BWX1-2]
GeneIDi51533.
KEGGihsa:51533.
UCSCiuc003ddy.5. human. [Q9BWX1-1]

Organism-specific databases

CTDi51533.
GeneCardsiPHF7.
HGNCiHGNC:18458. PHF7.
HPAiHPA036283.
HPA058159.
HPA070305.
neXtProtiNX_Q9BWX1.
OpenTargetsiENSG00000010318.
PharmGKBiPA38541.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00390000005246.
HOGENOMiHOG000236336.
HOVERGENiHBG053588.
InParanoidiQ9BWX1.
OMAiCLYEQGR.
OrthoDBiEOG091G0Q24.
PhylomeDBiQ9BWX1.
TreeFamiTF325426.

Miscellaneous databases

ChiTaRSiPHF7. human.
GenomeRNAii51533.
PROiQ9BWX1.

Gene expression databases

BgeeiENSG00000010318.
CleanExiHS_PHF7.
ExpressionAtlasiQ9BWX1. baseline and differential.
GenevisibleiQ9BWX1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHF7_HUMAN
AccessioniPrimary (citable) accession number: Q9BWX1
Secondary accession number(s): K4DI82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.