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Protein

Apolipoprotein L5

Gene

APOL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  • high-density lipoprotein particle binding Source: UniProtKB
  • lipid binding Source: InterPro

GO - Biological processi

  • lipid metabolic process Source: UniProtKB
  • lipid transport Source: UniProtKB-KW
  • lipoprotein metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L5
Alternative name(s):
Apolipoprotein L-V
Short name:
ApoL-V
Gene namesi
Name:APOL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14869. APOL5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24908.

Polymorphism and mutation databases

BioMutaiAPOL5.
DMDMi17433287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Apolipoprotein L5PRO_0000137603Add
BLAST

Proteomic databases

PaxDbiQ9BWW9.
PRIDEiQ9BWW9.
TopDownProteomicsiQ9BWW9.

PTM databases

iPTMnetiQ9BWW9.
PhosphoSiteiQ9BWW9.

Expressioni

Tissue specificityi

Low level of expression; detected in uterus, testis, skeletal muscle and stomach.

Gene expression databases

BgeeiQ9BWW9.
CleanExiHS_APOL5.
GenevisibleiQ9BWW9. HS.

Organism-specific databases

HPAiHPA040968.

Interactioni

Protein-protein interaction databases

IntActiQ9BWW9. 7 interactions.
MINTiMINT-7241622.
STRINGi9606.ENSP00000249044.

Structurei

3D structure databases

ProteinModelPortaliQ9BWW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

eggNOGiENOG410IWES. Eukaryota.
ENOG410Y0AF. LUCA.
GeneTreeiENSGT00510000046700.
HOGENOMiHOG000202815.
InParanoidiQ9BWW9.
KOiK14480.
OMAiHIPFWRA.
OrthoDBiEOG7TBC3K.
PhylomeDBiQ9BWW9.
TreeFamiTF334681.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCGKQGNLQ VPGSKVLPGL GEGCKEMWLR KVIYGGEVWG KSPEPEFPSL
60 70 80 90 100
VNLCQSWKIN NLMSTVHSDE AGMLSYFLFE ELMRCDKDSM PDGNLSEEEK
110 120 130 140 150
LFLSYFPLHK FELEQNIKEL NTLADQVDTT HELLTKTSLV ASSSGAVSGV
160 170 180 190 200
MNILGLALAP VTAGGSLMLS ATGTGLGAAA AITNIVTNVL ENRSNSAARD
210 220 230 240 250
KASRLGPLTT SHEAFGGINW SEIEAAGFCV NKCVKAIQGI KDLHAYQMAK
260 270 280 290 300
SNSGFMAMVK NFVAKRHIPF WTARGVQRAF EGTTLAMTNG AWVMGAAGAG
310 320 330 340 350
FLLMKDMSSF LQSWKHLEDG ARTETAEELR ALAKKLEQEL DRLTQHHRHL
360 370 380 390 400
PQKASQTCSS SRGRAVRGSR VVKPEGSRSP LPWPVVEHQP RLGPGVALRT
410 420 430
PKRTVSAPRM LGHQPAPPAP ARKGRQAPGR HRQ
Length:433
Mass (Da):47,044
Last modified:June 1, 2001 - v1
Checksum:iF64416DE8FEB7E9E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811E → K.
Corresponds to variant rs5999985 [ dbSNP | Ensembl ].
VAR_053012
Natural varianti272 – 2721T → M.
Corresponds to variant rs2076671 [ dbSNP | Ensembl ].
VAR_020355
Natural varianti323 – 3231T → M.
Corresponds to variant rs2076672 [ dbSNP | Ensembl ].
VAR_020356
Natural varianti406 – 4061S → C.
Corresponds to variant rs2076673 [ dbSNP | Ensembl ].
VAR_020357

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014878 mRNA. Translation: AAK07723.1.
AL049748 Genomic DNA. No translation available.
CCDSiCCDS13920.1.
RefSeqiNP_085145.1. NM_030642.1.
UniGeneiHs.326561.

Genome annotation databases

EnsembliENST00000249044; ENSP00000249044; ENSG00000128313.
GeneIDi80831.
KEGGihsa:80831.
UCSCiuc003aof.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014878 mRNA. Translation: AAK07723.1.
AL049748 Genomic DNA. No translation available.
CCDSiCCDS13920.1.
RefSeqiNP_085145.1. NM_030642.1.
UniGeneiHs.326561.

3D structure databases

ProteinModelPortaliQ9BWW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BWW9. 7 interactions.
MINTiMINT-7241622.
STRINGi9606.ENSP00000249044.

PTM databases

iPTMnetiQ9BWW9.
PhosphoSiteiQ9BWW9.

Polymorphism and mutation databases

BioMutaiAPOL5.
DMDMi17433287.

Proteomic databases

PaxDbiQ9BWW9.
PRIDEiQ9BWW9.
TopDownProteomicsiQ9BWW9.

Protocols and materials databases

DNASUi80831.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249044; ENSP00000249044; ENSG00000128313.
GeneIDi80831.
KEGGihsa:80831.
UCSCiuc003aof.4. human.

Organism-specific databases

CTDi80831.
GeneCardsiAPOL5.
HGNCiHGNC:14869. APOL5.
HPAiHPA040968.
MIMi607255. gene.
neXtProtiNX_Q9BWW9.
PharmGKBiPA24908.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWES. Eukaryota.
ENOG410Y0AF. LUCA.
GeneTreeiENSGT00510000046700.
HOGENOMiHOG000202815.
InParanoidiQ9BWW9.
KOiK14480.
OMAiHIPFWRA.
OrthoDBiEOG7TBC3K.
PhylomeDBiQ9BWW9.
TreeFamiTF334681.

Miscellaneous databases

GenomeRNAii80831.
PROiQ9BWW9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BWW9.
CleanExiHS_APOL5.
GenevisibleiQ9BWW9. HS.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
    Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
    Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAPOL5_HUMAN
AccessioniPrimary (citable) accession number: Q9BWW9
Secondary accession number(s): Q5TFL9, Q9UGW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.