Q9BWW9 (APOL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein L5

Alternative name(s):
Apolipoprotein L-V
Short name=ApoL-V

Gene names

Name:

APOL5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Low level of expression; detected in uterus, testis, skeletal muscle and stomach.
Sequence similarities	Belongs to the apolipoprotein L family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid metabolic process Non-traceable author statement Ref.1. Source: UniProtKB lipid transport Inferred from electronic annotation. Source: UniProtKB-KW lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	high-density lipoprotein particle binding Non-traceable author statement Ref.1. Source: UniProtKB lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	1	EBI-1753592,EBI-375543
CRK	P46108	1	EBI-1753592,EBI-886
FYN	P06241	1	EBI-1753592,EBI-515315
GRB2	P62993	1	EBI-1753592,EBI-401755
NCK1	P16333	1	EBI-1753592,EBI-389883
PIK3R1	P27986	1	EBI-1753592,EBI-79464
SRC	P12931	1	EBI-1753592,EBI-621482

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Apolipoprotein L5		PRO_0000137603
Natural variations
	Natural variant	81	1	E → K. Corresponds to variant rs5999985 [ dbSNP | Ensembl ].		VAR_053012
	Natural variant	272	1	T → M. Corresponds to variant rs2076671 [ dbSNP | Ensembl ].		VAR_020355
	Natural variant	323	1	T → M. Corresponds to variant rs2076672 [ dbSNP | Ensembl ].		VAR_020356
	Natural variant	406	1	S → C. Corresponds to variant rs2076673 [ dbSNP | Ensembl ].		VAR_020357

Sequences

	Sequence		Length	Mass (Da)
	Q9BWW9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F64416DE8FEB7E9E	FASTA	433	47,044
	10 20 30 40 50 60 MPCGKQGNLQ VPGSKVLPGL GEGCKEMWLR KVIYGGEVWG KSPEPEFPSL VNLCQSWKIN 70 80 90 100 110 120 NLMSTVHSDE AGMLSYFLFE ELMRCDKDSM PDGNLSEEEK LFLSYFPLHK FELEQNIKEL 130 140 150 160 170 180 NTLADQVDTT HELLTKTSLV ASSSGAVSGV MNILGLALAP VTAGGSLMLS ATGTGLGAAA 190 200 210 220 230 240 AITNIVTNVL ENRSNSAARD KASRLGPLTT SHEAFGGINW SEIEAAGFCV NKCVKAIQGI 250 260 270 280 290 300 KDLHAYQMAK SNSGFMAMVK NFVAKRHIPF WTARGVQRAF EGTTLAMTNG AWVMGAAGAG 310 320 330 340 350 360 FLLMKDMSSF LQSWKHLEDG ARTETAEELR ALAKKLEQEL DRLTQHHRHL PQKASQTCSS 370 380 390 400 410 420 SRGRAVRGSR VVKPEGSRSP LPWPVVEHQP RLGPGVALRT PKRTVSAPRM LGHQPAPPAP 430 ARKGRQAPGR HRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human apolipoprotein L gene cluster: identification, classification, and sites of distribution." Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J. Genomics 74:71-78(2001) [PubMed: 11374903] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY014878 mRNA. Translation: AAK07723.1. AL049748 Genomic DNA. No translation available.
IPI	IPI00032680.
RefSeq	NP_085145.1. NM_030642.1.
UniGene	Hs.326561.
3D structure databases
ProteinModelPortal	Q9BWW9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BWW9. 7 interactions.
MINT	MINT-7241622.
STRING	Q9BWW9.
Polymorphism databases
DMDM	17433287.
Proteomic databases
PRIDE	Q9BWW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249044; ENSP00000249044; ENSG00000128313.
GeneID	80831.
KEGG	hsa:80831.
UCSC	uc003aof.1. human.
Organism-specific databases
CTD	80831.
GeneCards	GC22P036113.
H-InvDB	HIX0203203.
HGNC	HGNC:14869. APOL5.
HPA	HPA040968.
MIM	607255. gene.
neXtProt	NX_Q9BWW9.
PharmGKB	PA24908.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09003.
GeneTree	ENSGT00510000046700.
InParanoid	Q9BWW9.
OMA	NSGFMAM.
OrthoDB	EOG49ZXPX.
PhylomeDB	Q9BWW9.
Gene expression databases
ArrayExpress	Q9BWW9.
Bgee	Q9BWW9.
CleanEx	HS_APOL5.
Genevestigator	Q9BWW9.
GermOnline	ENSG00000128313. Homo sapiens.
Family and domain databases
InterPro	IPR008405. ApoL. [Graphical view]
KO	K14480.
PANTHER	PTHR14096. ApoL. 1 hit.
Pfam	PF05461. ApoL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	71244.
SOURCE	Search...

Entry information

Entry name

APOL5_HUMAN

Accession

Primary (citable) accession number: Q9BWW9
Secondary accession number(s): Q5TFL9, Q9UGW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.