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Protein

Apolipoprotein L6

Gene

APOL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
  2. lipoprotein metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L6
Alternative name(s):
Apolipoprotein L-VI
Short name:
ApoL-VI
Gene namesi
Name:APOL6
ORF Names:UNQ3095/PRO21341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14870. APOL6.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Apolipoprotein L6PRO_0000137604Add
BLAST

Proteomic databases

PaxDbiQ9BWW8.
PRIDEiQ9BWW8.

PTM databases

PhosphoSiteiQ9BWW8.

Expressioni

Tissue specificityi

Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.

Gene expression databases

BgeeiQ9BWW8.
CleanExiHS_APOL6.
ExpressionAtlasiQ9BWW8. baseline and differential.
GenevestigatoriQ9BWW8.

Organism-specific databases

HPAiCAB028574.
HPA029165.
HPA029167.

Interactioni

Protein-protein interaction databases

BioGridi123323. 6 interactions.
STRINGi9606.ENSP00000386280.

Structurei

3D structure databases

ProteinModelPortaliQ9BWW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

eggNOGiNOG72064.
GeneTreeiENSGT00510000046700.
HOGENOMiHOG000294132.
HOVERGENiHBG106550.
InParanoidiQ9BWW8.
KOiK14480.
OMAiEEKIFLR.
OrthoDBiEOG71RXK9.
PhylomeDBiQ9BWW8.
TreeFamiTF334681.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK
60 70 80 90 100
EDLKGNIDKL RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP
110 120 130 140 150
ATGGGSLLLS TAGQGLATAA GVTSIVSGTL ERSKNKEAQA RAEDILPTYD
160 170 180 190 200
QEDREDEEEK ADYVTAAGKI IYNLRNTLKY AKKNVRAFWK LRANPRLANA
210 220 230 240 250
TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM SAFSLGYDLA
260 270 280 290 300
TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA
310 320 330 340
RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT
Length:343
Mass (Da):38,128
Last modified:May 31, 2001 - v1
Checksum:i9101D15ABAE71CDE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti173 – 1731N → K.1 Publication
Corresponds to variant rs5999923 [ dbSNP | Ensembl ].
VAR_053013

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014879 mRNA. Translation: AAK07724.1.
AY358210 mRNA. Translation: AAQ88577.1.
CR456381 mRNA. Translation: CAG30267.1.
AL834420 mRNA. Translation: CAH56356.1.
Z79996 Genomic DNA. Translation: CAI18758.1.
BC038950 mRNA. Translation: AAH38950.2.
BC047864 mRNA. Translation: AAH47864.1.
CCDSiCCDS13919.1.
RefSeqiNP_085144.1. NM_030641.3.
UniGeneiHs.257352.

Genome annotation databases

EnsembliENST00000409652; ENSP00000386280; ENSG00000221963.
GeneIDi80830.
KEGGihsa:80830.
UCSCiuc003aoe.3. human.

Polymorphism databases

DMDMi17433286.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014879 mRNA. Translation: AAK07724.1.
AY358210 mRNA. Translation: AAQ88577.1.
CR456381 mRNA. Translation: CAG30267.1.
AL834420 mRNA. Translation: CAH56356.1.
Z79996 Genomic DNA. Translation: CAI18758.1.
BC038950 mRNA. Translation: AAH38950.2.
BC047864 mRNA. Translation: AAH47864.1.
CCDSiCCDS13919.1.
RefSeqiNP_085144.1. NM_030641.3.
UniGeneiHs.257352.

3D structure databases

ProteinModelPortaliQ9BWW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123323. 6 interactions.
STRINGi9606.ENSP00000386280.

PTM databases

PhosphoSiteiQ9BWW8.

Polymorphism databases

DMDMi17433286.

Proteomic databases

PaxDbiQ9BWW8.
PRIDEiQ9BWW8.

Protocols and materials databases

DNASUi80830.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409652; ENSP00000386280; ENSG00000221963.
GeneIDi80830.
KEGGihsa:80830.
UCSCiuc003aoe.3. human.

Organism-specific databases

CTDi80830.
GeneCardsiGC22P036044.
HGNCiHGNC:14870. APOL6.
HPAiCAB028574.
HPA029165.
HPA029167.
MIMi607256. gene.
neXtProtiNX_Q9BWW8.
PharmGKBiPA24909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72064.
GeneTreeiENSGT00510000046700.
HOGENOMiHOG000294132.
HOVERGENiHBG106550.
InParanoidiQ9BWW8.
KOiK14480.
OMAiEEKIFLR.
OrthoDBiEOG71RXK9.
PhylomeDBiQ9BWW8.
TreeFamiTF334681.

Miscellaneous databases

ChiTaRSiAPOL6. human.
GeneWikiiAPOL6.
GenomeRNAii80830.
NextBioi71240.
PROiQ9BWW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BWW8.
CleanExiHS_APOL6.
ExpressionAtlasiQ9BWW8. baseline and differential.
GenevestigatoriQ9BWW8.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
    Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
    Genomics 74:71-78(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-173.
    Tissue: Lymph node.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.

Entry informationi

Entry nameiAPOL6_HUMAN
AccessioniPrimary (citable) accession number: Q9BWW8
Secondary accession number(s): Q5R3S1
, Q658J1, Q8IXX6, Q9UGG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 28, 2001
Last sequence update: May 31, 2001
Last modified: March 3, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.