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Q9BWW8

- APOL6_HUMAN

UniProt

Q9BWW8 - APOL6_HUMAN

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Protein
Apolipoprotein L6
Gene
APOL6, UNQ3095/PRO21341
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
  2. lipoprotein metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L6
Alternative name(s):
Apolipoprotein L-VI
Short name:
ApoL-VI
Gene namesi
Name:APOL6
ORF Names:UNQ3095/PRO21341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:14870. APOL6.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Apolipoprotein L6
PRO_0000137604Add
BLAST

Proteomic databases

PaxDbiQ9BWW8.
PRIDEiQ9BWW8.

PTM databases

PhosphoSiteiQ9BWW8.

Expressioni

Tissue specificityi

Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.

Gene expression databases

ArrayExpressiQ9BWW8.
BgeeiQ9BWW8.
CleanExiHS_APOL6.
GenevestigatoriQ9BWW8.

Organism-specific databases

HPAiCAB028574.
HPA029165.
HPA029167.

Interactioni

Protein-protein interaction databases

BioGridi123323. 1 interaction.
STRINGi9606.ENSP00000386280.

Structurei

3D structure databases

ProteinModelPortaliQ9BWW8.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein L family.

Phylogenomic databases

eggNOGiNOG72064.
HOGENOMiHOG000294132.
HOVERGENiHBG106550.
InParanoidiQ9BWW8.
KOiK14480.
OMAiEEKIFLR.
OrthoDBiEOG71RXK9.
PhylomeDBiQ9BWW8.
TreeFamiTF334681.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWW8-1 [UniParc]FASTAAdd to Basket

« Hide

MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK    50
EDLKGNIDKL RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP 100
ATGGGSLLLS TAGQGLATAA GVTSIVSGTL ERSKNKEAQA RAEDILPTYD 150
QEDREDEEEK ADYVTAAGKI IYNLRNTLKY AKKNVRAFWK LRANPRLANA 200
TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM SAFSLGYDLA 250
TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA 300
RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT 343
Length:343
Mass (Da):38,128
Last modified:June 1, 2001 - v1
Checksum:i9101D15ABAE71CDE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti173 – 1731N → K.1 Publication
Corresponds to variant rs5999923 [ dbSNP | Ensembl ].
VAR_053013

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014879 mRNA. Translation: AAK07724.1.
AY358210 mRNA. Translation: AAQ88577.1.
CR456381 mRNA. Translation: CAG30267.1.
AL834420 mRNA. Translation: CAH56356.1.
Z79996 Genomic DNA. Translation: CAI18758.1.
BC038950 mRNA. Translation: AAH38950.2.
BC047864 mRNA. Translation: AAH47864.1.
CCDSiCCDS13919.1.
RefSeqiNP_085144.1. NM_030641.3.
UniGeneiHs.257352.

Genome annotation databases

EnsembliENST00000409652; ENSP00000386280; ENSG00000221963.
GeneIDi80830.
KEGGihsa:80830.
UCSCiuc003aoe.3. human.

Polymorphism databases

DMDMi17433286.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014879 mRNA. Translation: AAK07724.1 .
AY358210 mRNA. Translation: AAQ88577.1 .
CR456381 mRNA. Translation: CAG30267.1 .
AL834420 mRNA. Translation: CAH56356.1 .
Z79996 Genomic DNA. Translation: CAI18758.1 .
BC038950 mRNA. Translation: AAH38950.2 .
BC047864 mRNA. Translation: AAH47864.1 .
CCDSi CCDS13919.1.
RefSeqi NP_085144.1. NM_030641.3.
UniGenei Hs.257352.

3D structure databases

ProteinModelPortali Q9BWW8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123323. 1 interaction.
STRINGi 9606.ENSP00000386280.

PTM databases

PhosphoSitei Q9BWW8.

Polymorphism databases

DMDMi 17433286.

Proteomic databases

PaxDbi Q9BWW8.
PRIDEi Q9BWW8.

Protocols and materials databases

DNASUi 80830.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409652 ; ENSP00000386280 ; ENSG00000221963 .
GeneIDi 80830.
KEGGi hsa:80830.
UCSCi uc003aoe.3. human.

Organism-specific databases

CTDi 80830.
GeneCardsi GC22P036044.
HGNCi HGNC:14870. APOL6.
HPAi CAB028574.
HPA029165.
HPA029167.
MIMi 607256. gene.
neXtProti NX_Q9BWW8.
PharmGKBi PA24909.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72064.
HOGENOMi HOG000294132.
HOVERGENi HBG106550.
InParanoidi Q9BWW8.
KOi K14480.
OMAi EEKIFLR.
OrthoDBi EOG71RXK9.
PhylomeDBi Q9BWW8.
TreeFami TF334681.

Miscellaneous databases

ChiTaRSi APOL6. human.
GeneWikii APOL6.
GenomeRNAii 80830.
NextBioi 71240.
PROi Q9BWW8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BWW8.
Bgeei Q9BWW8.
CleanExi HS_APOL6.
Genevestigatori Q9BWW8.

Family and domain databases

InterProi IPR008405. ApoL.
[Graphical view ]
PANTHERi PTHR14096. PTHR14096. 1 hit.
Pfami PF05461. ApoL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
    Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
    Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-173.
    Tissue: Lymph node.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.

Entry informationi

Entry nameiAPOL6_HUMAN
AccessioniPrimary (citable) accession number: Q9BWW8
Secondary accession number(s): Q5R3S1
, Q658J1, Q8IXX6, Q9UGG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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