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Q9BWW8 (APOL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein L6
Alternative name(s):
Apolipoprotein L-VI
Short name=ApoL-VI
Gene names
Name:APOL6
ORF Names:UNQ3095/PRO21341
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Subcellular location

Cytoplasm Probable.

Tissue specificity

Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.

Sequence similarities

Belongs to the apolipoprotein L family.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid transport

Inferred from electronic annotation. Source: UniProtKB-KW

lipoprotein metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Apolipoprotein L6
PRO_0000137604

Natural variations

Natural variant1731N → K. Ref.4
Corresponds to variant rs5999923 [ dbSNP | Ensembl ].
VAR_053013

Sequences

Sequence LengthMass (Da)Tools
Q9BWW8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 9101D15ABAE71CDE

FASTA34338,128
        10         20         30         40         50         60 
MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK EDLKGNIDKL 

        70         80         90        100        110        120 
RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP ATGGGSLLLS TAGQGLATAA 

       130        140        150        160        170        180 
GVTSIVSGTL ERSKNKEAQA RAEDILPTYD QEDREDEEEK ADYVTAAGKI IYNLRNTLKY 

       190        200        210        220        230        240 
AKKNVRAFWK LRANPRLANA TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM 

       250        260        270        280        290        300 
SAFSLGYDLA TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA 

       310        320        330        340 
RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT 

« Hide

References

« Hide 'large scale' references
[1]"The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-173.
Tissue: Lymph node.
[5]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY014879 mRNA. Translation: AAK07724.1.
AY358210 mRNA. Translation: AAQ88577.1.
CR456381 mRNA. Translation: CAG30267.1.
AL834420 mRNA. Translation: CAH56356.1.
Z79996 Genomic DNA. Translation: CAI18758.1.
BC038950 mRNA. Translation: AAH38950.2.
BC047864 mRNA. Translation: AAH47864.1.
CCDSCCDS13919.1.
RefSeqNP_085144.1. NM_030641.3.
UniGeneHs.257352.

3D structure databases

ProteinModelPortalQ9BWW8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123323. 1 interaction.
STRING9606.ENSP00000386280.

PTM databases

PhosphoSiteQ9BWW8.

Polymorphism databases

DMDM17433286.

Proteomic databases

PaxDbQ9BWW8.
PRIDEQ9BWW8.

Protocols and materials databases

DNASU80830.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000409652; ENSP00000386280; ENSG00000221963.
GeneID80830.
KEGGhsa:80830.
UCSCuc003aoe.3. human.

Organism-specific databases

CTD80830.
GeneCardsGC22P036044.
HGNCHGNC:14870. APOL6.
HPACAB028574.
HPA029165.
HPA029167.
MIM607256. gene.
neXtProtNX_Q9BWW8.
PharmGKBPA24909.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72064.
HOGENOMHOG000294132.
HOVERGENHBG106550.
InParanoidQ9BWW8.
KOK14480.
OMAEEKIFLR.
OrthoDBEOG71RXK9.
PhylomeDBQ9BWW8.
TreeFamTF334681.

Gene expression databases

ArrayExpressQ9BWW8.
BgeeQ9BWW8.
CleanExHS_APOL6.
GenevestigatorQ9BWW8.

Family and domain databases

InterProIPR008405. ApoL.
[Graphical view]
PANTHERPTHR14096. PTHR14096. 1 hit.
PfamPF05461. ApoL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPOL6. human.
GeneWikiAPOL6.
GenomeRNAi80830.
NextBio71240.
PROQ9BWW8.
SOURCESearch...

Entry information

Entry nameAPOL6_HUMAN
AccessionPrimary (citable) accession number: Q9BWW8
Secondary accession number(s): Q5R3S1 expand/collapse secondary AC list , Q658J1, Q8IXX6, Q9UGG1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM