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Q9BWW8

- APOL6_HUMAN

UniProt

Q9BWW8 - APOL6_HUMAN

Protein

Apolipoprotein L6

Gene

APOL6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

    GO - Molecular functioni

    1. lipid binding Source: InterPro

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW
    2. lipoprotein metabolic process Source: InterPro

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein L6
    Alternative name(s):
    Apolipoprotein L-VI
    Short name:
    ApoL-VI
    Gene namesi
    Name:APOL6
    ORF Names:UNQ3095/PRO21341
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:14870. APOL6.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24909.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Apolipoprotein L6PRO_0000137604Add
    BLAST

    Proteomic databases

    PaxDbiQ9BWW8.
    PRIDEiQ9BWW8.

    PTM databases

    PhosphoSiteiQ9BWW8.

    Expressioni

    Tissue specificityi

    Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.

    Gene expression databases

    ArrayExpressiQ9BWW8.
    BgeeiQ9BWW8.
    CleanExiHS_APOL6.
    GenevestigatoriQ9BWW8.

    Organism-specific databases

    HPAiCAB028574.
    HPA029165.
    HPA029167.

    Interactioni

    Protein-protein interaction databases

    BioGridi123323. 1 interaction.
    STRINGi9606.ENSP00000386280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BWW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the apolipoprotein L family.Curated

    Phylogenomic databases

    eggNOGiNOG72064.
    HOGENOMiHOG000294132.
    HOVERGENiHBG106550.
    InParanoidiQ9BWW8.
    KOiK14480.
    OMAiEEKIFLR.
    OrthoDBiEOG71RXK9.
    PhylomeDBiQ9BWW8.
    TreeFamiTF334681.

    Family and domain databases

    InterProiIPR008405. ApoL.
    [Graphical view]
    PANTHERiPTHR14096. PTHR14096. 1 hit.
    PfamiPF05461. ApoL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BWW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK    50
    EDLKGNIDKL RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP 100
    ATGGGSLLLS TAGQGLATAA GVTSIVSGTL ERSKNKEAQA RAEDILPTYD 150
    QEDREDEEEK ADYVTAAGKI IYNLRNTLKY AKKNVRAFWK LRANPRLANA 200
    TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM SAFSLGYDLA 250
    TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA 300
    RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT 343
    Length:343
    Mass (Da):38,128
    Last modified:June 1, 2001 - v1
    Checksum:i9101D15ABAE71CDE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti173 – 1731N → K.1 Publication
    Corresponds to variant rs5999923 [ dbSNP | Ensembl ].
    VAR_053013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014879 mRNA. Translation: AAK07724.1.
    AY358210 mRNA. Translation: AAQ88577.1.
    CR456381 mRNA. Translation: CAG30267.1.
    AL834420 mRNA. Translation: CAH56356.1.
    Z79996 Genomic DNA. Translation: CAI18758.1.
    BC038950 mRNA. Translation: AAH38950.2.
    BC047864 mRNA. Translation: AAH47864.1.
    CCDSiCCDS13919.1.
    RefSeqiNP_085144.1. NM_030641.3.
    UniGeneiHs.257352.

    Genome annotation databases

    EnsembliENST00000409652; ENSP00000386280; ENSG00000221963.
    GeneIDi80830.
    KEGGihsa:80830.
    UCSCiuc003aoe.3. human.

    Polymorphism databases

    DMDMi17433286.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014879 mRNA. Translation: AAK07724.1 .
    AY358210 mRNA. Translation: AAQ88577.1 .
    CR456381 mRNA. Translation: CAG30267.1 .
    AL834420 mRNA. Translation: CAH56356.1 .
    Z79996 Genomic DNA. Translation: CAI18758.1 .
    BC038950 mRNA. Translation: AAH38950.2 .
    BC047864 mRNA. Translation: AAH47864.1 .
    CCDSi CCDS13919.1.
    RefSeqi NP_085144.1. NM_030641.3.
    UniGenei Hs.257352.

    3D structure databases

    ProteinModelPortali Q9BWW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123323. 1 interaction.
    STRINGi 9606.ENSP00000386280.

    PTM databases

    PhosphoSitei Q9BWW8.

    Polymorphism databases

    DMDMi 17433286.

    Proteomic databases

    PaxDbi Q9BWW8.
    PRIDEi Q9BWW8.

    Protocols and materials databases

    DNASUi 80830.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409652 ; ENSP00000386280 ; ENSG00000221963 .
    GeneIDi 80830.
    KEGGi hsa:80830.
    UCSCi uc003aoe.3. human.

    Organism-specific databases

    CTDi 80830.
    GeneCardsi GC22P036044.
    HGNCi HGNC:14870. APOL6.
    HPAi CAB028574.
    HPA029165.
    HPA029167.
    MIMi 607256. gene.
    neXtProti NX_Q9BWW8.
    PharmGKBi PA24909.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72064.
    HOGENOMi HOG000294132.
    HOVERGENi HBG106550.
    InParanoidi Q9BWW8.
    KOi K14480.
    OMAi EEKIFLR.
    OrthoDBi EOG71RXK9.
    PhylomeDBi Q9BWW8.
    TreeFami TF334681.

    Miscellaneous databases

    ChiTaRSi APOL6. human.
    GeneWikii APOL6.
    GenomeRNAii 80830.
    NextBioi 71240.
    PROi Q9BWW8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BWW8.
    Bgeei Q9BWW8.
    CleanExi HS_APOL6.
    Genevestigatori Q9BWW8.

    Family and domain databases

    InterProi IPR008405. ApoL.
    [Graphical view ]
    PANTHERi PTHR14096. PTHR14096. 1 hit.
    Pfami PF05461. ApoL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
      Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
      Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-173.
      Tissue: Lymph node.
    5. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.

    Entry informationi

    Entry nameiAPOL6_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWW8
    Secondary accession number(s): Q5R3S1
    , Q658J1, Q8IXX6, Q9UGG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3