Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BWW7

- SCRT1_HUMAN

UniProt

Q9BWW7 - SCRT1_HUMAN

Protein

Transcriptional repressor scratch 1

Gene

SCRT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri191 – 21323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 24423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32724C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional repressor scratch 1
    Alternative name(s):
    Scratch homolog 1 zinc finger protein
    Short name:
    SCRT
    Short name:
    Scratch 1
    Short name:
    hScrt
    Gene namesi
    Name:SCRT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:15950. SCRT1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Transcriptional repressor scratch 1PRO_0000047036Add
    BLAST

    Proteomic databases

    PaxDbiQ9BWW7.
    PRIDEiQ9BWW7.

    PTM databases

    PhosphoSiteiQ9BWW7.

    Expressioni

    Tissue specificityi

    Brain specific.1 Publication

    Gene expression databases

    BgeeiQ9BWW7.
    CleanExiHS_SCRT1.
    GenevestigatoriQ9BWW7.

    Organism-specific databases

    HPAiHPA045265.

    Interactioni

    Subunit structurei

    Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331692.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BWW7.
    SMRiQ9BWW7. Positions 191-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020SNAG domainBy similarityAdd
    BLAST

    Domaini

    The N-terminal non zinc-finger region mediates the repressor activity.

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri191 – 21323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 24423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32724C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000261665.
    HOVERGENiHBG007477.
    InParanoidiQ9BWW7.
    KOiK09219.
    OMAiNCQHARE.
    OrthoDBiEOG7P2XSG.
    PhylomeDBiQ9BWW7.
    TreeFamiTF315515.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BWW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRSFLVKKV KLDAFSSADL ESAYGRARSD LGAPLHDKGY LSDYVGPSSV    50
    YDGDAEAALL KGPSPEPMYA AAVRGELGPA AAGSAPPPTP RPELATAAGG 100
    YINGDAAVSE GYAADAFFIT DGRSRRKASN AGSAAAPSTA SAAAPDGDAG 150
    GGGGAGGRSL GSGPGGRGGT RAGAGTEARA GPGAAGAGGR HACGECGKTY 200
    ATSSNLSRHK QTHRSLDSQL ARRCPTCGKV YVSMPAMAMH LLTHDLRHKC 250
    GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH CGKAFADRSN LRAHMQTHSA 300
    FKHFQCKRCK KSFALKSYLN KHYESACFKG GAGGPAAPAP PQLSPVQA 348
    Length:348
    Mass (Da):35,570
    Last modified:June 1, 2001 - v1
    Checksum:iD85CDC31B79AD4F6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331S → A.1 Publication
    Corresponds to variant rs7013127 [ dbSNP | Ensembl ].
    VAR_045990

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014996 mRNA. Translation: AAK01467.1.
    CH471162 Genomic DNA. Translation: EAW82125.1.
    BC014675 mRNA. Translation: AAH14675.1.
    CCDSiCCDS6421.1.
    RefSeqiNP_112599.2. NM_031309.5.
    UniGeneiHs.31746.

    Genome annotation databases

    EnsembliENST00000569446; ENSP00000455711; ENSG00000261678.
    GeneIDi83482.
    KEGGihsa:83482.
    UCSCiuc003zbw.1. human.

    Polymorphism databases

    DMDMi46397014.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014996 mRNA. Translation: AAK01467.1 .
    CH471162 Genomic DNA. Translation: EAW82125.1 .
    BC014675 mRNA. Translation: AAH14675.1 .
    CCDSi CCDS6421.1.
    RefSeqi NP_112599.2. NM_031309.5.
    UniGenei Hs.31746.

    3D structure databases

    ProteinModelPortali Q9BWW7.
    SMRi Q9BWW7. Positions 191-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331692.

    PTM databases

    PhosphoSitei Q9BWW7.

    Polymorphism databases

    DMDMi 46397014.

    Proteomic databases

    PaxDbi Q9BWW7.
    PRIDEi Q9BWW7.

    Protocols and materials databases

    DNASUi 83482.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000569446 ; ENSP00000455711 ; ENSG00000261678 .
    GeneIDi 83482.
    KEGGi hsa:83482.
    UCSCi uc003zbw.1. human.

    Organism-specific databases

    CTDi 83482.
    GeneCardsi GC08M145554.
    HGNCi HGNC:15950. SCRT1.
    HPAi HPA045265.
    MIMi 605858. gene.
    neXtProti NX_Q9BWW7.
    PharmGKBi PA35015.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000261665.
    HOVERGENi HBG007477.
    InParanoidi Q9BWW7.
    KOi K09219.
    OMAi NCQHARE.
    OrthoDBi EOG7P2XSG.
    PhylomeDBi Q9BWW7.
    TreeFami TF315515.

    Miscellaneous databases

    GenomeRNAii 83482.
    NextBioi 72433.
    PROi Q9BWW7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BWW7.
    CleanExi HS_SCRT1.
    Genevestigatori Q9BWW7.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH E-BOX MOTIF.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-133.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-348.
      Tissue: Brain.

    Entry informationi

    Entry nameiSCRT1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWW7
    Secondary accession number(s): A8MX66, Q96C52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3