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Q9BWW7 (SCRT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional repressor scratch 1
Alternative name(s):
Scratch homolog 1 zinc finger protein
Short name=SCRT
Short name=Scratch 1
Short name=hScrt
Gene names
Name:SCRT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation. Ref.1

Subunit structure

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) By similarity. Ref.1

Subcellular location

Nucleus Ref.1.

Tissue specificity

Brain specific. Ref.1

Domain

The N-terminal non zinc-finger region mediates the repressor activity.

Sequence similarities

Belongs to the snail C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Traceable author statement Ref.1. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Transcriptional repressor scratch 1
PRO_0000047036

Regions

Zinc finger191 – 21323C2H2-type 1
Zinc finger222 – 24423C2H2-type 2
Zinc finger248 – 27023C2H2-type 3
Zinc finger276 – 29823C2H2-type 4
Zinc finger304 – 32724C2H2-type 5; atypical
Region1 – 2020SNAG domain By similarity

Natural variations

Natural variant1331S → A. Ref.2
Corresponds to variant rs7013127 [ dbSNP | Ensembl ].
VAR_045990

Sequences

Sequence LengthMass (Da)Tools
Q9BWW7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D85CDC31B79AD4F6

FASTA34835,570
        10         20         30         40         50         60 
MPRSFLVKKV KLDAFSSADL ESAYGRARSD LGAPLHDKGY LSDYVGPSSV YDGDAEAALL 

        70         80         90        100        110        120 
KGPSPEPMYA AAVRGELGPA AAGSAPPPTP RPELATAAGG YINGDAAVSE GYAADAFFIT 

       130        140        150        160        170        180 
DGRSRRKASN AGSAAAPSTA SAAAPDGDAG GGGGAGGRSL GSGPGGRGGT RAGAGTEARA 

       190        200        210        220        230        240 
GPGAAGAGGR HACGECGKTY ATSSNLSRHK QTHRSLDSQL ARRCPTCGKV YVSMPAMAMH 

       250        260        270        280        290        300 
LLTHDLRHKC GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH CGKAFADRSN LRAHMQTHSA 

       310        320        330        340 
FKHFQCKRCK KSFALKSYLN KHYESACFKG GAGGPAAPAP PQLSPVQA 

« Hide

References

« Hide 'large scale' references
[1]"Mammalian scratch: a neural-specific snail family transcriptional repressor."
Nakakura E.K., Watkins D.N., Schuebel K.E., Sriuranpong V., Borges M.W., Nelkin B.D., Ball D.W.
Proc. Natl. Acad. Sci. U.S.A. 98:4010-4015(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH E-BOX MOTIF.
Tissue: Brain.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-133.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-348.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY014996 mRNA. Translation: AAK01467.1.
CH471162 Genomic DNA. Translation: EAW82125.1.
BC014675 mRNA. Translation: AAH14675.1.
RefSeqNP_112599.2. NM_031309.5.
UniGeneHs.31746.

3D structure databases

ProteinModelPortalQ9BWW7.
SMRQ9BWW7. Positions 163-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000331692.

PTM databases

PhosphoSiteQ9BWW7.

Polymorphism databases

DMDM46397014.

Proteomic databases

PaxDbQ9BWW7.
PRIDEQ9BWW7.

Protocols and materials databases

DNASU83482.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332135; ENSP00000331692; ENSG00000170616.
ENST00000569446; ENSP00000455711; ENSG00000261678.
GeneID83482.
KEGGhsa:83482.
UCSCuc003zbw.1. human.

Organism-specific databases

CTD83482.
GeneCardsGC08M145554.
HGNCHGNC:15950. SCRT1.
HPAHPA045265.
MIM605858. gene.
neXtProtNX_Q9BWW7.
PharmGKBPA35015.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000261665.
HOVERGENHBG007477.
InParanoidQ9BWW7.
KOK09219.
OMANCQHARE.
OrthoDBEOG7P2XSG.
PhylomeDBQ9BWW7.
TreeFamTF315515.

Gene expression databases

BgeeQ9BWW7.
CleanExHS_SCRT1.
GenevestigatorQ9BWW7.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi83482.
NextBio72433.
PROQ9BWW7.
SOURCESearch...

Entry information

Entry nameSCRT1_HUMAN
AccessionPrimary (citable) accession number: Q9BWW7
Secondary accession number(s): A8MX66, Q96C52
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM