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Q9BWW7

- SCRT1_HUMAN

UniProt

Q9BWW7 - SCRT1_HUMAN

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Protein

Transcriptional repressor scratch 1

Gene
SCRT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri191 – 21323C2H2-type 1Add
BLAST
Zinc fingeri222 – 24423C2H2-type 2Add
BLAST
Zinc fingeri248 – 27023C2H2-type 3Add
BLAST
Zinc fingeri276 – 29823C2H2-type 4Add
BLAST
Zinc fingeri304 – 32724C2H2-type 5; atypicalAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor scratch 1
Alternative name(s):
Scratch homolog 1 zinc finger protein
Short name:
SCRT
Short name:
Scratch 1
Short name:
hScrt
Gene namesi
Name:SCRT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:15950. SCRT1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Transcriptional repressor scratch 1PRO_0000047036Add
BLAST

Proteomic databases

PaxDbiQ9BWW7.
PRIDEiQ9BWW7.

PTM databases

PhosphoSiteiQ9BWW7.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Gene expression databases

BgeeiQ9BWW7.
CleanExiHS_SCRT1.
GenevestigatoriQ9BWW7.

Organism-specific databases

HPAiHPA045265.

Interactioni

Subunit structurei

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) By similarity.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000331692.

Structurei

3D structure databases

ProteinModelPortaliQ9BWW7.
SMRiQ9BWW7. Positions 191-327.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domain By similarityAdd
BLAST

Domaini

The N-terminal non zinc-finger region mediates the repressor activity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri191 – 21323C2H2-type 1Add
BLAST
Zinc fingeri222 – 24423C2H2-type 2Add
BLAST
Zinc fingeri248 – 27023C2H2-type 3Add
BLAST
Zinc fingeri276 – 29823C2H2-type 4Add
BLAST
Zinc fingeri304 – 32724C2H2-type 5; atypicalAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ9BWW7.
KOiK09219.
OMAiNCQHARE.
OrthoDBiEOG7P2XSG.
PhylomeDBiQ9BWW7.
TreeFamiTF315515.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWW7-1 [UniParc]FASTAAdd to Basket

« Hide

MPRSFLVKKV KLDAFSSADL ESAYGRARSD LGAPLHDKGY LSDYVGPSSV    50
YDGDAEAALL KGPSPEPMYA AAVRGELGPA AAGSAPPPTP RPELATAAGG 100
YINGDAAVSE GYAADAFFIT DGRSRRKASN AGSAAAPSTA SAAAPDGDAG 150
GGGGAGGRSL GSGPGGRGGT RAGAGTEARA GPGAAGAGGR HACGECGKTY 200
ATSSNLSRHK QTHRSLDSQL ARRCPTCGKV YVSMPAMAMH LLTHDLRHKC 250
GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH CGKAFADRSN LRAHMQTHSA 300
FKHFQCKRCK KSFALKSYLN KHYESACFKG GAGGPAAPAP PQLSPVQA 348
Length:348
Mass (Da):35,570
Last modified:June 1, 2001 - v1
Checksum:iD85CDC31B79AD4F6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331S → A.1 Publication
Corresponds to variant rs7013127 [ dbSNP | Ensembl ].
VAR_045990

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014996 mRNA. Translation: AAK01467.1.
CH471162 Genomic DNA. Translation: EAW82125.1.
BC014675 mRNA. Translation: AAH14675.1.
CCDSiCCDS6421.1.
RefSeqiNP_112599.2. NM_031309.5.
UniGeneiHs.31746.

Genome annotation databases

EnsembliENST00000332135; ENSP00000331692; ENSG00000170616.
ENST00000569446; ENSP00000455711; ENSG00000261678.
GeneIDi83482.
KEGGihsa:83482.
UCSCiuc003zbw.1. human.

Polymorphism databases

DMDMi46397014.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014996 mRNA. Translation: AAK01467.1 .
CH471162 Genomic DNA. Translation: EAW82125.1 .
BC014675 mRNA. Translation: AAH14675.1 .
CCDSi CCDS6421.1.
RefSeqi NP_112599.2. NM_031309.5.
UniGenei Hs.31746.

3D structure databases

ProteinModelPortali Q9BWW7.
SMRi Q9BWW7. Positions 191-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331692.

PTM databases

PhosphoSitei Q9BWW7.

Polymorphism databases

DMDMi 46397014.

Proteomic databases

PaxDbi Q9BWW7.
PRIDEi Q9BWW7.

Protocols and materials databases

DNASUi 83482.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332135 ; ENSP00000331692 ; ENSG00000170616 .
ENST00000569446 ; ENSP00000455711 ; ENSG00000261678 .
GeneIDi 83482.
KEGGi hsa:83482.
UCSCi uc003zbw.1. human.

Organism-specific databases

CTDi 83482.
GeneCardsi GC08M145554.
HGNCi HGNC:15950. SCRT1.
HPAi HPA045265.
MIMi 605858. gene.
neXtProti NX_Q9BWW7.
PharmGKBi PA35015.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000261665.
HOVERGENi HBG007477.
InParanoidi Q9BWW7.
KOi K09219.
OMAi NCQHARE.
OrthoDBi EOG7P2XSG.
PhylomeDBi Q9BWW7.
TreeFami TF315515.

Miscellaneous databases

GenomeRNAii 83482.
NextBioi 72433.
PROi Q9BWW7.
SOURCEi Search...

Gene expression databases

Bgeei Q9BWW7.
CleanExi HS_SCRT1.
Genevestigatori Q9BWW7.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH E-BOX MOTIF.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-133.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-348.
    Tissue: Brain.

Entry informationi

Entry nameiSCRT1_HUMAN
AccessioniPrimary (citable) accession number: Q9BWW7
Secondary accession number(s): A8MX66, Q96C52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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