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Protein

Single-stranded DNA-binding protein 3

Gene

SSBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 3
Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein
Gene namesi
Name:SSBP3
Synonyms:SSDP, SSDP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000157216.15
HGNCiHGNC:15674 SSBP3
MIMi607390 gene
neXtProtiNX_Q9BWW4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23648
OpenTargetsiENSG00000157216
PharmGKBiPA38017

Polymorphism and mutation databases

DMDMi27734581

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238281 – 388Single-stranded DNA-binding protein 3Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei155Asymmetric dimethylarginineCombined sources1
Modified residuei161Asymmetric dimethylarginineCombined sources1
Modified residuei165Asymmetric dimethylarginineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphoserineBy similarity1
Modified residuei360PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9BWW4
MaxQBiQ9BWW4
PaxDbiQ9BWW4
PeptideAtlasiQ9BWW4
PRIDEiQ9BWW4

PTM databases

iPTMnetiQ9BWW4
PhosphoSitePlusiQ9BWW4

Expressioni

Tissue specificityi

Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle.

Gene expression databases

BgeeiENSG00000157216
CleanExiHS_SSBP3
ExpressionAtlasiQ9BWW4 baseline and differential
GenevisibleiQ9BWW4 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117175, 36 interactors
DIPiDIP-48897N
IntActiQ9BWW4, 13 interactors
STRINGi9606.ENSP00000360371

Structurei

3D structure databases

ProteinModelPortaliQ9BWW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 48LisHPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 319Pro-richAdd BLAST222
Compositional biasi158 – 369Gly-richAdd BLAST212

Phylogenomic databases

eggNOGiKOG4594 Eukaryota
ENOG410XPQX LUCA
GeneTreeiENSGT00390000009187
HOGENOMiHOG000037785
HOVERGENiHBG068487
InParanoidiQ9BWW4
OMAiHNPNSMM
OrthoDBiEOG091G111C
PhylomeDBiQ9BWW4
TreeFamiTF318961

Family and domain databases

InterProiView protein in InterPro
IPR006594 LisH
IPR008116 SSDP_DNA-bd
PRINTSiPR01743 SSDNABINDING
SMARTiView protein in SMART
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFAKGKGSAV PSDGQAREKL ALYVYEYLLH VGAQKSAQTF LSEIRWEKNI
60 70 80 90 100
TLGEPPGFLH SWWCVFWDLY CAAPERRDTC EHSSEAKAFH DYSAAAAPSP
110 120 130 140 150
VLGNIPPNDG MPGGPIPPGF FQGPPGSQPS PHAQPPPHNP SSMMGPHSQP
160 170 180 190 200
FMSPRYAGGP RPPIRMGNQP PGGVPGTQPL LPNSMDPTRQ QGHPNMGGSM
210 220 230 240 250
QRMNPPRGMG PMGPGPQNYG SGMRPPPNSL GPAMPGINMG PGAGRPWPNP
260 270 280 290 300
NSANSIPYSS SSPGTYVGPP GGGGPPGTPI MPSPADSTNS SDNIYTMINP
310 320 330 340 350
VPPGGSRSNF PMGPGSDGPM GGMGGMEPHH MNGSLGSGDI DGLPKNSPNN
360 370 380
ISGISNPPGT PRDDGELGGN FLHSFQNDNY SPSMTMSV
Length:388
Mass (Da):40,421
Last modified:June 1, 2001 - v1
Checksum:iDBBB169D4EE10536
GO
Isoform 2 (identifier: Q9BWW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-149: Missing.

Show »
Length:361
Mass (Da):37,697
Checksum:iCECDA59F18EFC0B2
GO
Isoform 3 (identifier: Q9BWW4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-169: Missing.

Show »
Length:368
Mass (Da):38,210
Checksum:i87D2E99D9C11B620
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006260123 – 149Missing in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_006261150 – 169Missing in isoform 3. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026310
, AY026293, AY026294, AY026295, AY026296, AY026297, AY026298, AY026299, AY026300, AY026301, AY026302, AY026303, AY026304, AY026305, AY026306, AY026307, AY026308, AY026309 Genomic DNA Translation: AAK21984.1
AY026310
, AY026293, AY026294, AY026295, AY026296, AY026297, AY026299, AY026300, AY026301, AY026302, AY026303, AY026304, AY026305, AY026306, AY026307, AY026308, AY026309 Genomic DNA Translation: AAK21985.1
AF500116 mRNA Translation: AAM22101.1
AK289474 mRNA Translation: BAF82163.1
CH471059 Genomic DNA Translation: EAX06692.1
AL035415 Genomic DNA No translation available.
AL161644 Genomic DNA No translation available.
BC003605 mRNA Translation: AAH03605.1
BC066365 mRNA Translation: AAH66365.1
CCDSiCCDS30726.1 [Q9BWW4-2]
CCDS590.1 [Q9BWW4-3]
CCDS591.1 [Q9BWW4-1]
RefSeqiNP_001009955.1, NM_001009955.3 [Q9BWW4-2]
NP_060540.2, NM_018070.4 [Q9BWW4-3]
NP_663768.1, NM_145716.3 [Q9BWW4-1]
UniGeneiHs.476706
Hs.658676

Genome annotation databases

EnsembliENST00000357475; ENSP00000350067; ENSG00000157216 [Q9BWW4-3]
ENST00000371319; ENSP00000360370; ENSG00000157216 [Q9BWW4-2]
ENST00000371320; ENSP00000360371; ENSG00000157216 [Q9BWW4-1]
GeneIDi23648
KEGGihsa:23648
UCSCiuc001cxe.5 human [Q9BWW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSSBP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BWW4
Secondary accession number(s): A8K0A9
, Q5T860, Q5T861, Q9BTM0, Q9BWW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health