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Protein

Single-stranded DNA-binding protein 3

Gene

SSBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 3
Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein
Gene namesi
Name:SSBP3
Synonyms:SSDP, SSDP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15674. SSBP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23648.
OpenTargetsiENSG00000157216.
PharmGKBiPA38017.

Polymorphism and mutation databases

DMDMi27734581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238281 – 388Single-stranded DNA-binding protein 3Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei155Asymmetric dimethylarginineCombined sources1
Modified residuei161Asymmetric dimethylarginineCombined sources1
Modified residuei165Asymmetric dimethylarginineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphoserineBy similarity1
Modified residuei360PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9BWW4.
MaxQBiQ9BWW4.
PaxDbiQ9BWW4.
PeptideAtlasiQ9BWW4.
PRIDEiQ9BWW4.

PTM databases

iPTMnetiQ9BWW4.
PhosphoSitePlusiQ9BWW4.

Expressioni

Tissue specificityi

Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle.

Gene expression databases

BgeeiENSG00000157216.
CleanExiHS_SSBP3.
ExpressionAtlasiQ9BWW4. baseline and differential.
GenevisibleiQ9BWW4. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EWSR1Q018443EBI-2902395,EBI-739737
IL36RNQ9UBH05EBI-2902395,EBI-465156
LDB1Q86U703EBI-2902395,EBI-677177
NXT2Q9NPJ83EBI-2902395,EBI-752122
PIN1Q135265EBI-2902395,EBI-714158
TBC1D23Q9NUY83EBI-2902395,EBI-2853126
TBC1D23Q9NUY8-23EBI-2902395,EBI-10314276
YES1P079473EBI-2902395,EBI-515331

Protein-protein interaction databases

BioGridi117175. 34 interactors.
DIPiDIP-48897N.
IntActiQ9BWW4. 11 interactors.
STRINGi9606.ENSP00000360371.

Structurei

3D structure databases

ProteinModelPortaliQ9BWW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 48LisHPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 319Pro-richAdd BLAST222
Compositional biasi158 – 369Gly-richAdd BLAST212

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4594. Eukaryota.
ENOG410XPQX. LUCA.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiQ9BWW4.
OMAiHNPNSMM.
OrthoDBiEOG091G111C.
PhylomeDBiQ9BWW4.
TreeFamiTF318961.

Family and domain databases

InterProiIPR006594. LisH.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFAKGKGSAV PSDGQAREKL ALYVYEYLLH VGAQKSAQTF LSEIRWEKNI
60 70 80 90 100
TLGEPPGFLH SWWCVFWDLY CAAPERRDTC EHSSEAKAFH DYSAAAAPSP
110 120 130 140 150
VLGNIPPNDG MPGGPIPPGF FQGPPGSQPS PHAQPPPHNP SSMMGPHSQP
160 170 180 190 200
FMSPRYAGGP RPPIRMGNQP PGGVPGTQPL LPNSMDPTRQ QGHPNMGGSM
210 220 230 240 250
QRMNPPRGMG PMGPGPQNYG SGMRPPPNSL GPAMPGINMG PGAGRPWPNP
260 270 280 290 300
NSANSIPYSS SSPGTYVGPP GGGGPPGTPI MPSPADSTNS SDNIYTMINP
310 320 330 340 350
VPPGGSRSNF PMGPGSDGPM GGMGGMEPHH MNGSLGSGDI DGLPKNSPNN
360 370 380
ISGISNPPGT PRDDGELGGN FLHSFQNDNY SPSMTMSV
Length:388
Mass (Da):40,421
Last modified:June 1, 2001 - v1
Checksum:iDBBB169D4EE10536
GO
Isoform 2 (identifier: Q9BWW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-149: Missing.

Show »
Length:361
Mass (Da):37,697
Checksum:iCECDA59F18EFC0B2
GO
Isoform 3 (identifier: Q9BWW4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-169: Missing.

Show »
Length:368
Mass (Da):38,210
Checksum:i87D2E99D9C11B620
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006260123 – 149Missing in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_006261150 – 169Missing in isoform 3. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026310
, AY026293, AY026294, AY026295, AY026296, AY026297, AY026298, AY026299, AY026300, AY026301, AY026302, AY026303, AY026304, AY026305, AY026306, AY026307, AY026308, AY026309 Genomic DNA. Translation: AAK21984.1.
AY026310
, AY026293, AY026294, AY026295, AY026296, AY026297, AY026299, AY026300, AY026301, AY026302, AY026303, AY026304, AY026305, AY026306, AY026307, AY026308, AY026309 Genomic DNA. Translation: AAK21985.1.
AF500116 mRNA. Translation: AAM22101.1.
AK289474 mRNA. Translation: BAF82163.1.
CH471059 Genomic DNA. Translation: EAX06692.1.
AL035415, AL161644 Genomic DNA. Translation: CAI22487.1.
AL035415, AL161644 Genomic DNA. Translation: CAI22488.1.
AL161644, AL035415 Genomic DNA. Translation: CAI23562.1.
AL161644, AL035415 Genomic DNA. Translation: CAI23563.1.
BC003605 mRNA. Translation: AAH03605.1.
BC066365 mRNA. Translation: AAH66365.1.
CCDSiCCDS30726.1. [Q9BWW4-2]
CCDS590.1. [Q9BWW4-3]
CCDS591.1. [Q9BWW4-1]
RefSeqiNP_001009955.1. NM_001009955.3. [Q9BWW4-2]
NP_060540.2. NM_018070.4. [Q9BWW4-3]
NP_663768.1. NM_145716.3. [Q9BWW4-1]
UniGeneiHs.476706.
Hs.658676.

Genome annotation databases

EnsembliENST00000357475; ENSP00000350067; ENSG00000157216. [Q9BWW4-3]
ENST00000371319; ENSP00000360370; ENSG00000157216. [Q9BWW4-2]
ENST00000371320; ENSP00000360371; ENSG00000157216. [Q9BWW4-1]
GeneIDi23648.
KEGGihsa:23648.
UCSCiuc001cxe.5. human. [Q9BWW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026310
, AY026293, AY026294, AY026295, AY026296, AY026297, AY026298, AY026299, AY026300, AY026301, AY026302, AY026303, AY026304, AY026305, AY026306, AY026307, AY026308, AY026309 Genomic DNA. Translation: AAK21984.1.
AY026310
, AY026293, AY026294, AY026295, AY026296, AY026297, AY026299, AY026300, AY026301, AY026302, AY026303, AY026304, AY026305, AY026306, AY026307, AY026308, AY026309 Genomic DNA. Translation: AAK21985.1.
AF500116 mRNA. Translation: AAM22101.1.
AK289474 mRNA. Translation: BAF82163.1.
CH471059 Genomic DNA. Translation: EAX06692.1.
AL035415, AL161644 Genomic DNA. Translation: CAI22487.1.
AL035415, AL161644 Genomic DNA. Translation: CAI22488.1.
AL161644, AL035415 Genomic DNA. Translation: CAI23562.1.
AL161644, AL035415 Genomic DNA. Translation: CAI23563.1.
BC003605 mRNA. Translation: AAH03605.1.
BC066365 mRNA. Translation: AAH66365.1.
CCDSiCCDS30726.1. [Q9BWW4-2]
CCDS590.1. [Q9BWW4-3]
CCDS591.1. [Q9BWW4-1]
RefSeqiNP_001009955.1. NM_001009955.3. [Q9BWW4-2]
NP_060540.2. NM_018070.4. [Q9BWW4-3]
NP_663768.1. NM_145716.3. [Q9BWW4-1]
UniGeneiHs.476706.
Hs.658676.

3D structure databases

ProteinModelPortaliQ9BWW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117175. 34 interactors.
DIPiDIP-48897N.
IntActiQ9BWW4. 11 interactors.
STRINGi9606.ENSP00000360371.

PTM databases

iPTMnetiQ9BWW4.
PhosphoSitePlusiQ9BWW4.

Polymorphism and mutation databases

DMDMi27734581.

Proteomic databases

EPDiQ9BWW4.
MaxQBiQ9BWW4.
PaxDbiQ9BWW4.
PeptideAtlasiQ9BWW4.
PRIDEiQ9BWW4.

Protocols and materials databases

DNASUi23648.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357475; ENSP00000350067; ENSG00000157216. [Q9BWW4-3]
ENST00000371319; ENSP00000360370; ENSG00000157216. [Q9BWW4-2]
ENST00000371320; ENSP00000360371; ENSG00000157216. [Q9BWW4-1]
GeneIDi23648.
KEGGihsa:23648.
UCSCiuc001cxe.5. human. [Q9BWW4-1]

Organism-specific databases

CTDi23648.
DisGeNETi23648.
GeneCardsiSSBP3.
HGNCiHGNC:15674. SSBP3.
MIMi607390. gene.
neXtProtiNX_Q9BWW4.
OpenTargetsiENSG00000157216.
PharmGKBiPA38017.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4594. Eukaryota.
ENOG410XPQX. LUCA.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiQ9BWW4.
OMAiHNPNSMM.
OrthoDBiEOG091G111C.
PhylomeDBiQ9BWW4.
TreeFamiTF318961.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157216-MONOMER.

Miscellaneous databases

ChiTaRSiSSBP3. human.
GeneWikiiSSBP3.
GenomeRNAii23648.
PROiQ9BWW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157216.
CleanExiHS_SSBP3.
ExpressionAtlasiQ9BWW4. baseline and differential.
GenevisibleiQ9BWW4. HS.

Family and domain databases

InterProiIPR006594. LisH.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSBP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BWW4
Secondary accession number(s): A8K0A9
, Q5T860, Q5T861, Q9BTM0, Q9BWW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.