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Protein

Probable tubulin polyglutamylase TTLL2

Gene

TTLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253ATPBy similarity1
Binding sitei255ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi240 – 243ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tubulin polyglutamylase TTLL2 (EC:6.-.-.-)
Alternative name(s):
Testis-specific protein NYD-TSPG
Tubulin--tyrosine ligase-like protein 2
Gene namesi
Name:TTLL2
Synonyms:C6orf104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000120440.13
HGNCiHGNC:21211 TTLL2
neXtProtiNX_Q9BWV7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120440
PharmGKBiPA134888799

Polymorphism and mutation databases

BioMutaiTTLL2
DMDMi313104264

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124401 – 592Probable tubulin polyglutamylase TTLL2Add BLAST592

Proteomic databases

PaxDbiQ9BWV7
PeptideAtlasiQ9BWV7
PRIDEiQ9BWV7

PTM databases

iPTMnetiQ9BWV7
PhosphoSitePlusiQ9BWV7

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiENSG00000120440
CleanExiHS_TTLL2
ExpressionAtlasiQ9BWV7 baseline and differential
GenevisibleiQ9BWV7 HS

Organism-specific databases

HPAiHPA027985

Interactioni

Protein-protein interaction databases

BioGridi1237982 interactors.
STRINGi9606.ENSP00000239587

Structurei

3D structure databases

ProteinModelPortaliQ9BWV7
SMRiQ9BWV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 427TTLPROSITE-ProRule annotationAdd BLAST344

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00760000118951
HOGENOMiHOG000119224
HOVERGENiHBG079287
InParanoidiQ9BWV7
KOiK16600
OMAiICKPAEL
OrthoDBiEOG091G04I4
PhylomeDBiQ9BWV7
TreeFamiTF313087

Family and domain databases

Gene3Di3.30.1490.201 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BWV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGRDLCSST QSQALGSLRT TTPAFTLNIP SEANHTEQPP AGLGARLQEA
60 70 80 90 100
GVSIPPRRGR PTPTLEKKKK PHLMAEDEPS GALLKPLVFR VDETTPAVVQ
110 120 130 140 150
SVLLERGWNK FDKQEQNAED WNLYWRTSSF RMTEHNSVKP WQQLNHHPGT
160 170 180 190 200
TKLTRKDCLA KHLKHMRRMY GTSLYQFIPL TFVMPNDYTK FVAEYFQERQ
210 220 230 240 250
MLGTKHSYWI CKPAELSRGR GILIFSDFKD FIFDDMYIVQ KYISNPLLIG
260 270 280 290 300
RYKCDLRIYV CVTGFKPLTI YVYQEGLVRF ATEKFDLSNL QNNYAHLTNS
310 320 330 340 350
SINKSGASYE KIKEVIGHGC KWTLSRFFSY LRSWDVDDLL LWKKIHRMVI
360 370 380 390 400
LTILAIAPSV PFAANCFELF GFDILIDDNL KPWLLEVNYS PALTLDCSTD
410 420 430 440 450
VLVKRKLVHD IIDLIYLNGL RNEGREASNA THGNSNIDAA KSDRGGLDAP
460 470 480 490 500
DCLPYDSLSF TSRMYNEDDS VVEKAVSVRP EAAPASQLEG EMSGQDFHLS
510 520 530 540 550
TREMPQSKPK LRSRHTPHKT LMPYASLFQS HSCKTKTSPC VLSDRGKAPD
560 570 580 590
PQAGNFVLVF PFNEATLGAS RNGLNVKRII QELQKLMNKQ HS
Length:592
Mass (Da):67,336
Last modified:November 30, 2010 - v3
Checksum:i43F7741950AFE70D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377D → N in AAK20169 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0281193G → R. Corresponds to variant dbSNP:rs12526094Ensembl.1
Natural variantiVAR_05731263P → S. Corresponds to variant dbSNP:rs34350976Ensembl.1
Natural variantiVAR_028120127T → A1 PublicationCorresponds to variant dbSNP:rs11540664Ensembl.1
Natural variantiVAR_028121202L → P. Corresponds to variant dbSNP:rs6936639Ensembl.1
Natural variantiVAR_057313356I → V. Corresponds to variant dbSNP:rs34286114Ensembl.1
Natural variantiVAR_028122425R → G4 PublicationsCorresponds to variant dbSNP:rs909545Ensembl.1
Natural variantiVAR_061866441K → T. Corresponds to variant dbSNP:rs41266331Ensembl.1
Natural variantiVAR_028123445G → S. Corresponds to variant dbSNP:rs9457304Ensembl.1
Natural variantiVAR_028124529Q → H. Corresponds to variant dbSNP:rs12528714Ensembl.1
Natural variantiVAR_057314559V → I. Corresponds to variant dbSNP:rs34931196Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026506 mRNA Translation: AAK20169.1
AK093039 mRNA Translation: BAG52639.1
AK314450 mRNA Translation: BAG37058.1
AL021331 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47498.1
BC030650 mRNA Translation: AAH30650.1
BC047411 mRNA Translation: AAH47411.1
CCDSiCCDS5301.1
RefSeqiNP_114155.4, NM_031949.4
UniGeneiHs.520554

Genome annotation databases

EnsembliENST00000239587; ENSP00000239587; ENSG00000120440
ENST00000515138; ENSP00000424130; ENSG00000120440
GeneIDi83887
KEGGihsa:83887
UCSCiuc003qvs.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTLL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BWV7
Secondary accession number(s): B2RB11
, B3KS77, Q7Z6R8, Q86X22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 30, 2010
Last modified: February 28, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome