Reviewed, UniProtKB/Swiss-Prot Q9BWV3 (CDAC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytidine and dCMP deaminase domain-containing protein 1
Alternative name(s):
    Testis development protein NYD-SP15

Gene names

Name:

CDADC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play an important role in testicular development and spermatogenesis. Ref.1
Cofactor	Zinc By similarity.
Tissue specificity	Widely expressed. Expressed at high levels in the testis. Ref.1
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BWV3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BWV3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-99: VKRTGLVVVKNMKIV → KTMFCLFENDCKCWS
     100-514: Missing.

Isoform 3 (identifier: Q9BWV3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     144-154: AGVNRISYWPA → GLLGAAKMPR
     155-514: Missing.

Isoform 4 (identifier: Q9BWV3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-380: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 514	514	Cytidine and dCMP deaminase domain-containing protein 1		PRO_0000300491
Sites
	Active site	400	1	Proton donor By similarity
	Metal binding	398	1	Zinc; catalytic By similarity
	Metal binding	426	1	Zinc; catalytic By similarity
	Metal binding	429	1	Zinc; catalytic By similarity
Natural variations
	Alternative sequence	1 – 380	380	Missing in isoform 4.		VSP_027811
	Alternative sequence	85 – 99	15	VKRTG…NMKIV → KTMFCLFENDCKCWS in isoform 2.		VSP_027812
	Alternative sequence	100 – 514	415	Missing in isoform 2.		VSP_027813
	Alternative sequence	144 – 154	11	AGVNRISYWPA → GLLGAAKMPR in isoform 3.		VSP_027814
	Alternative sequence	155 – 514	360	Missing in isoform 3.		VSP_027815

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 6560103A65C03D69	FASTA	514	58,455
	10 20 30 40 50 60 MKEAGQMQNL ESARAGRSVS TQTGSMTGQI PRLSKVNLFT LLSLWMELFP AEAQRQKSQK 70 80 90 100 110 120 NEEGKHGPLG DNEERTRVST DKRQVKRTGL VVVKNMKIVG LHCSSEDLHA GQIALIKHGS 130 140 150 160 170 180 RLKNCDLYFS RKPCSACLKM IVNAGVNRIS YWPADPEISL LTEASSSEDA KLDAKAVERL 190 200 210 220 230 240 KSNSRAHVCV LLQPLVCYMV QFVEETSYKC DFIQKITKTL PDANTDFYYE CKQERIKEYE 250 260 270 280 290 300 MLFLVSNEEM HKQILMTIGL ENLCENPYFS NLRQNMKDLI LLLATVASSV PNFKHFGFYR 310 320 330 340 350 360 SNPEQINEIH NQSLPQEIAR HCMVQARLLA YRTEDHKTGV GAVIWAEGKS RSCDGTGAMY 370 380 390 400 410 420 FVGCGYNAFP VGSEYADFPH MDDKQKDREI RKFRYIIHAE QNALTFRCQE IKPEERSMIF 430 440 450 460 470 480 VTKCPCDECV PLIKGAGIKQ IYAGDVDVGK KKADISYMRF GELEGVSKFT WQLNPSGAYG 490 500 510 LEQNEPERRE NGVLRPVPQK EEQHQDKKLR LGIH
	Isoform 2. Checksum: 3F718A5CB7CD8ECC	FASTA	99	11,270
	10 20 30 40 50 60 MKEAGQMQNL ESARAGRSVS TQTGSMTGQI PRLSKVNLFT LLSLWMELFP AEAQRQKSQK 70 80 90 NEEGKHGPLG DNEERTRVST DKRQKTMFCL FENDCKCWS
	Isoform 3. Checksum: 939B9C4883FDCC2E	FASTA	153	16,935
	10 20 30 40 50 60 MKEAGQMQNL ESARAGRSVS TQTGSMTGQI PRLSKVNLFT LLSLWMELFP AEAQRQKSQK 70 80 90 100 110 120 NEEGKHGPLG DNEERTRVST DKRQVKRTGL VVVKNMKIVG LHCSSEDLHA GQIALIKHGS 130 140 150 RLKNCDLYFS RKPCSACLKM IVNGLLGAAK MPR
	Isoform 4. Checksum: 7F94A23C143014C1	FASTA	134	15,564
	10 20 30 40 50 60 MDDKQKDREI RKFRYIIHAE QNALTFRCQE IKPEERSMIF VTKCPCDECV PLIKGAGIKQ 70 80 90 100 110 120 IYAGDVDVGK KKADISYMRF GELEGVSKFT WQLNPSGAYG LEQNEPERRE NGVLRPVPQK 130 EEQHQDKKLR LGIH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis." Liu Q., Liu J., Cao Q., Sha J., Zhou Z., Wang H., Li J. Biochem. Genet. 44:409-423(2006) [PubMed: 16955368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Bone marrow, Brain, Pancreas and Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 400-514. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY027525 mRNA. Translation: AAK16745.1. AL138875 Genomic DNA. Translation: CAI10890.2. CH471075 Genomic DNA. Translation: EAX08817.1. BC009562 mRNA. Translation: AAH09562.1. BC032889 mRNA. Translation: AAH32889.1. BC048092 mRNA. Translation: AAH48092.1. BC125202 mRNA. Translation: AAI25203.1. AL137554 mRNA. Translation: CAB70808.1.
IPI	IPI00008444. IPI00513939. IPI00844211. IPI00855793.
PIR	T46393.
RefSeq	NP_112173.1.
UniGene	Hs.388220
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9BWV3.
Genome annotation databases
Ensembl	ENST00000251108; ENSP00000251108; ENSG00000102543; Homo sapiens. [Genome view]
GeneID	81602.
KEGG	hsa:81602.
UCSC	uc001vcu.1. human.
Organism-specific databases
CTD	81602.
GeneCards	GC13P048720.
HGNC	HGNC:20299. CDADC1.
PharmGKB	PA134884656.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG715430.
HOVERGEN	Q9BWV3.
InParanoid	Q9BWV3.
OMA	TGAMYFI.
Gene expression databases
ArrayExpress	Q9BWV3.
Bgee	Q9BWV3.
CleanEx	HS_CDADC1.
Genevestigator	Q9BWV3.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR015517. Cyt_deaminase. IPR016193. Cytidine_deaminase-like. [Graphical view]
PANTHER	PTHR11086. Cyt_deaminase. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	71904.

Entry information

Entry name

CDAC1_HUMAN

Accession

Primary (citable) accession number: Q9BWV3
Secondary accession number(s): Q49A08 , Q4G119, Q5TAW9, Q7Z764, Q9NT36

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 1, 2001
Last modified:	December 15, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.