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Protein

Cytidine and dCMP deaminase domain-containing protein 1

Gene

CDADC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important role in testicular development and spermatogenesis.1 Publication

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi398Zinc; catalyticBy similarity1
Active sitei400Proton donorBy similarity1
Metal bindingi426Zinc; catalyticBy similarity1
Metal bindingi429Zinc; catalyticBy similarity1

GO - Molecular functioni

  • cytidine deaminase activity Source: UniProtKB
  • importin-alpha family protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cytidine deamination Source: UniProtKB
  • DNA cytosine deamination Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine and dCMP deaminase domain-containing protein 1
Alternative name(s):
Testis development protein NYD-SP15
Gene namesi
Name:CDADC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102543.14
HGNCiHGNC:20299 CDADC1
neXtProtiNX_Q9BWV3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102543
PharmGKBiPA134884656

Polymorphism and mutation databases

BioMutaiCDADC1
DMDMi74724888

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003004911 – 514Cytidine and dCMP deaminase domain-containing protein 1Add BLAST514

Proteomic databases

EPDiQ9BWV3
PaxDbiQ9BWV3
PeptideAtlasiQ9BWV3
PRIDEiQ9BWV3

PTM databases

iPTMnetiQ9BWV3
PhosphoSitePlusiQ9BWV3

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in the testis.1 Publication

Gene expression databases

BgeeiENSG00000102543
CleanExiHS_CDADC1
ExpressionAtlasiQ9BWV3 baseline and differential
GenevisibleiQ9BWV3 HS

Organism-specific databases

HPAiHPA047615
HPA058314

Interactioni

GO - Molecular functioni

  • importin-alpha family protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi123540, 8 interactors
STRINGi9606.ENSP00000251108

Structurei

3D structure databases

ProteinModelPortaliQ9BWV3
SMRiQ9BWV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 168CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST99
Domaini317 – 482CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST166

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3127 Eukaryota
COG2131 LUCA
GeneTreeiENSGT00390000001951
HOGENOMiHOG000082665
HOVERGENiHBG057359
InParanoidiQ9BWV3
OMAiECKQERI
OrthoDBiEOG091G0D1U
PhylomeDBiQ9BWV3
TreeFamiTF333295

Family and domain databases

CDDicd01286 deoxycytidylate_deaminase, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
IPR015517 dCMP_deaminase-rel
IPR035105 Deoxycytidylate_deaminase_dom
PANTHERiPTHR11086 PTHR11086, 1 hit
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 2 hits
SUPFAMiSSF53927 SSF53927, 2 hits
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEAGQMQNL ESARAGRSVS TQTGSMTGQI PRLSKVNLFT LLSLWMELFP
60 70 80 90 100
AEAQRQKSQK NEEGKHGPLG DNEERTRVST DKRQVKRTGL VVVKNMKIVG
110 120 130 140 150
LHCSSEDLHA GQIALIKHGS RLKNCDLYFS RKPCSACLKM IVNAGVNRIS
160 170 180 190 200
YWPADPEISL LTEASSSEDA KLDAKAVERL KSNSRAHVCV LLQPLVCYMV
210 220 230 240 250
QFVEETSYKC DFIQKITKTL PDANTDFYYE CKQERIKEYE MLFLVSNEEM
260 270 280 290 300
HKQILMTIGL ENLCENPYFS NLRQNMKDLI LLLATVASSV PNFKHFGFYR
310 320 330 340 350
SNPEQINEIH NQSLPQEIAR HCMVQARLLA YRTEDHKTGV GAVIWAEGKS
360 370 380 390 400
RSCDGTGAMY FVGCGYNAFP VGSEYADFPH MDDKQKDREI RKFRYIIHAE
410 420 430 440 450
QNALTFRCQE IKPEERSMIF VTKCPCDECV PLIKGAGIKQ IYAGDVDVGK
460 470 480 490 500
KKADISYMRF GELEGVSKFT WQLNPSGAYG LEQNEPERRE NGVLRPVPQK
510
EEQHQDKKLR LGIH
Length:514
Mass (Da):58,455
Last modified:June 1, 2001 - v1
Checksum:i6560103A65C03D69
GO
Isoform 2 (identifier: Q9BWV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-99: VKRTGLVVVKNMKIV → KTMFCLFENDCKCWS
     100-514: Missing.

Show »
Length:99
Mass (Da):11,270
Checksum:i3F718A5CB7CD8ECC
GO
Isoform 3 (identifier: Q9BWV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-154: AGVNRISYWPA → GLLGAAKMPR
     155-514: Missing.

Show »
Length:153
Mass (Da):16,935
Checksum:i939B9C4883FDCC2E
GO
Isoform 4 (identifier: Q9BWV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-380: Missing.

Show »
Length:134
Mass (Da):15,564
Checksum:i7F94A23C143014C1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0278111 – 380Missing in isoform 4. 1 PublicationAdd BLAST380
Alternative sequenceiVSP_02781285 – 99VKRTG…NMKIV → KTMFCLFENDCKCWS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_027813100 – 514Missing in isoform 2. 1 PublicationAdd BLAST415
Alternative sequenceiVSP_027814144 – 154AGVNRISYWPA → GLLGAAKMPR in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_027815155 – 514Missing in isoform 3. 1 PublicationAdd BLAST360

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027525 mRNA Translation: AAK16745.1
AL138875 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08817.1
BC009562 mRNA Translation: AAH09562.1
BC032889 mRNA Translation: AAH32889.1
BC048092 mRNA Translation: AAH48092.1
BC125202 mRNA Translation: AAI25203.1
AL137554 mRNA Translation: CAB70808.1
CCDSiCCDS9415.1 [Q9BWV3-1]
PIRiT46393
RefSeqiNP_001180407.1, NM_001193478.1
NP_112173.1, NM_030911.3 [Q9BWV3-1]
UniGeneiHs.388220

Genome annotation databases

EnsembliENST00000251108; ENSP00000251108; ENSG00000102543 [Q9BWV3-1]
GeneIDi81602
KEGGihsa:81602
UCSCiuc001vcu.4 human [Q9BWV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDAC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BWV3
Secondary accession number(s): Q49A08
, Q4G119, Q5TAW9, Q7Z764, Q9NT36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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