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Protein

Cytidine and dCMP deaminase domain-containing protein 1

Gene

CDADC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in testicular development and spermatogenesis.1 Publication

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi398 – 3981Zinc; catalyticBy similarity
Active sitei400 – 4001Proton donorBy similarity
Metal bindingi426 – 4261Zinc; catalyticBy similarity
Metal bindingi429 – 4291Zinc; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine and dCMP deaminase domain-containing protein 1
Alternative name(s):
Testis development protein NYD-SP15
Gene namesi
Name:CDADC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20299. CDADC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884656.

Polymorphism and mutation databases

BioMutaiCDADC1.
DMDMi74724888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytidine and dCMP deaminase domain-containing protein 1PRO_0000300491Add
BLAST

Proteomic databases

EPDiQ9BWV3.
PaxDbiQ9BWV3.
PRIDEiQ9BWV3.

PTM databases

iPTMnetiQ9BWV3.
PhosphoSiteiQ9BWV3.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in the testis.1 Publication

Gene expression databases

BgeeiQ9BWV3.
CleanExiHS_CDADC1.
ExpressionAtlasiQ9BWV3. baseline and differential.
GenevisibleiQ9BWV3. HS.

Organism-specific databases

HPAiHPA058314.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000251108.

Structurei

3D structure databases

ProteinModelPortaliQ9BWV3.
SMRiQ9BWV3. Positions 317-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 16899CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd
BLAST
Domaini317 – 482166CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CMP/dCMP-type deaminase domains.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000001951.
HOGENOMiHOG000082665.
HOVERGENiHBG057359.
InParanoidiQ9BWV3.
OMAiYFIGCGY.
OrthoDBiEOG7JDQXN.
PhylomeDBiQ9BWV3.
TreeFamiTF333295.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 3 hits.
PfamiPF00383. dCMP_cyt_deam_1. 2 hits.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 2 hits.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEAGQMQNL ESARAGRSVS TQTGSMTGQI PRLSKVNLFT LLSLWMELFP
60 70 80 90 100
AEAQRQKSQK NEEGKHGPLG DNEERTRVST DKRQVKRTGL VVVKNMKIVG
110 120 130 140 150
LHCSSEDLHA GQIALIKHGS RLKNCDLYFS RKPCSACLKM IVNAGVNRIS
160 170 180 190 200
YWPADPEISL LTEASSSEDA KLDAKAVERL KSNSRAHVCV LLQPLVCYMV
210 220 230 240 250
QFVEETSYKC DFIQKITKTL PDANTDFYYE CKQERIKEYE MLFLVSNEEM
260 270 280 290 300
HKQILMTIGL ENLCENPYFS NLRQNMKDLI LLLATVASSV PNFKHFGFYR
310 320 330 340 350
SNPEQINEIH NQSLPQEIAR HCMVQARLLA YRTEDHKTGV GAVIWAEGKS
360 370 380 390 400
RSCDGTGAMY FVGCGYNAFP VGSEYADFPH MDDKQKDREI RKFRYIIHAE
410 420 430 440 450
QNALTFRCQE IKPEERSMIF VTKCPCDECV PLIKGAGIKQ IYAGDVDVGK
460 470 480 490 500
KKADISYMRF GELEGVSKFT WQLNPSGAYG LEQNEPERRE NGVLRPVPQK
510
EEQHQDKKLR LGIH
Length:514
Mass (Da):58,455
Last modified:June 1, 2001 - v1
Checksum:i6560103A65C03D69
GO
Isoform 2 (identifier: Q9BWV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-99: VKRTGLVVVKNMKIV → KTMFCLFENDCKCWS
     100-514: Missing.

Show »
Length:99
Mass (Da):11,270
Checksum:i3F718A5CB7CD8ECC
GO
Isoform 3 (identifier: Q9BWV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-154: AGVNRISYWPA → GLLGAAKMPR
     155-514: Missing.

Show »
Length:153
Mass (Da):16,935
Checksum:i939B9C4883FDCC2E
GO
Isoform 4 (identifier: Q9BWV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-380: Missing.

Show »
Length:134
Mass (Da):15,564
Checksum:i7F94A23C143014C1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 380380Missing in isoform 4. 1 PublicationVSP_027811Add
BLAST
Alternative sequencei85 – 9915VKRTG…NMKIV → KTMFCLFENDCKCWS in isoform 2. 1 PublicationVSP_027812Add
BLAST
Alternative sequencei100 – 514415Missing in isoform 2. 1 PublicationVSP_027813Add
BLAST
Alternative sequencei144 – 15411AGVNRISYWPA → GLLGAAKMPR in isoform 3. 1 PublicationVSP_027814Add
BLAST
Alternative sequencei155 – 514360Missing in isoform 3. 1 PublicationVSP_027815Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027525 mRNA. Translation: AAK16745.1.
AL138875 Genomic DNA. Translation: CAI10890.2.
CH471075 Genomic DNA. Translation: EAX08817.1.
BC009562 mRNA. Translation: AAH09562.1.
BC032889 mRNA. Translation: AAH32889.1.
BC048092 mRNA. Translation: AAH48092.1.
BC125202 mRNA. Translation: AAI25203.1.
AL137554 mRNA. Translation: CAB70808.1.
CCDSiCCDS9415.1. [Q9BWV3-1]
PIRiT46393.
RefSeqiNP_001180407.1. NM_001193478.1.
NP_112173.1. NM_030911.3. [Q9BWV3-1]
UniGeneiHs.388220.

Genome annotation databases

EnsembliENST00000251108; ENSP00000251108; ENSG00000102543. [Q9BWV3-1]
GeneIDi81602.
KEGGihsa:81602.
UCSCiuc001vcu.4. human. [Q9BWV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027525 mRNA. Translation: AAK16745.1.
AL138875 Genomic DNA. Translation: CAI10890.2.
CH471075 Genomic DNA. Translation: EAX08817.1.
BC009562 mRNA. Translation: AAH09562.1.
BC032889 mRNA. Translation: AAH32889.1.
BC048092 mRNA. Translation: AAH48092.1.
BC125202 mRNA. Translation: AAI25203.1.
AL137554 mRNA. Translation: CAB70808.1.
CCDSiCCDS9415.1. [Q9BWV3-1]
PIRiT46393.
RefSeqiNP_001180407.1. NM_001193478.1.
NP_112173.1. NM_030911.3. [Q9BWV3-1]
UniGeneiHs.388220.

3D structure databases

ProteinModelPortaliQ9BWV3.
SMRiQ9BWV3. Positions 317-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000251108.

PTM databases

iPTMnetiQ9BWV3.
PhosphoSiteiQ9BWV3.

Polymorphism and mutation databases

BioMutaiCDADC1.
DMDMi74724888.

Proteomic databases

EPDiQ9BWV3.
PaxDbiQ9BWV3.
PRIDEiQ9BWV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251108; ENSP00000251108; ENSG00000102543. [Q9BWV3-1]
GeneIDi81602.
KEGGihsa:81602.
UCSCiuc001vcu.4. human. [Q9BWV3-1]

Organism-specific databases

CTDi81602.
GeneCardsiCDADC1.
H-InvDBHIX0011313.
HGNCiHGNC:20299. CDADC1.
HPAiHPA058314.
neXtProtiNX_Q9BWV3.
PharmGKBiPA134884656.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000001951.
HOGENOMiHOG000082665.
HOVERGENiHBG057359.
InParanoidiQ9BWV3.
OMAiYFIGCGY.
OrthoDBiEOG7JDQXN.
PhylomeDBiQ9BWV3.
TreeFamiTF333295.

Miscellaneous databases

GenomeRNAii81602.
PROiQ9BWV3.

Gene expression databases

BgeeiQ9BWV3.
CleanExiHS_CDADC1.
ExpressionAtlasiQ9BWV3. baseline and differential.
GenevisibleiQ9BWV3. HS.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 3 hits.
PfamiPF00383. dCMP_cyt_deam_1. 2 hits.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 2 hits.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis."
    Liu Q., Liu J., Cao Q., Sha J., Zhou Z., Wang H., Li J.
    Biochem. Genet. 44:409-423(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Bone marrow, Brain, Pancreas and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 400-514.
    Tissue: Testis.

Entry informationi

Entry nameiCDAC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BWV3
Secondary accession number(s): Q49A08
, Q4G119, Q5TAW9, Q7Z764, Q9NT36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.