Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase 19

Gene

CDK19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 35ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08031-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiQ9BWU1.
SIGNORiQ9BWU1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 19 (EC:2.7.11.22)
Alternative name(s):
CDC2-related protein kinase 6
Cell division cycle 2-like protein kinase 6
Cell division protein kinase 19
Cyclin-dependent kinase 11
Death-preventing kinase
Gene namesi
Name:CDK19
Synonyms:CDC2L6, CDK11, KIAA1028
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19338. CDK19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23097.
OpenTargetsiENSG00000155111.
PharmGKBiPA165617767.

Chemistry databases

ChEMBLiCHEMBL6002.
GuidetoPHARMACOLOGYi1972.

Polymorphism and mutation databases

BioMutaiCDK19.
DMDMi60391917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857131 – 502Cyclin-dependent kinase 19Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei449PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BWU1.
MaxQBiQ9BWU1.
PaxDbiQ9BWU1.
PeptideAtlasiQ9BWU1.
PRIDEiQ9BWU1.

PTM databases

iPTMnetiQ9BWU1.
PhosphoSitePlusiQ9BWU1.

Expressioni

Gene expression databases

BgeeiENSG00000155111.
CleanExiHS_CDC2L6.
ExpressionAtlasiQ9BWU1. baseline and differential.
GenevisibleiQ9BWU1. HS.

Organism-specific databases

HPAiHPA007053.

Interactioni

Protein-protein interaction databases

BioGridi116725. 61 interactors.
DIPiDIP-29013N.
IntActiQ9BWU1. 38 interactors.
STRINGi9606.ENSP00000357907.

Chemistry databases

BindingDBiQ9BWU1.

Structurei

3D structure databases

ProteinModelPortaliQ9BWU1.
SMRiQ9BWU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 335Protein kinasePROSITE-ProRule annotationAdd BLAST315

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi372 – 404Gln-richAdd BLAST33
Compositional biasi461 – 491Ser-richAdd BLAST31

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0666. Eukaryota.
ENOG410XPPA. LUCA.
GeneTreeiENSGT00530000064012.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ9BWU1.
KOiK02208.
OMAiSQSTMGY.
OrthoDBiEOG091G0812.
PhylomeDBiQ9BWU1.
TreeFamiTF101025.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA
60 70 80 90 100
LKQIEGTGIS MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA
110 120 130 140 150
EHDLWHIIKF HRASKANKKP MQLPRSMVKS LLYQILDGIH YLHANWVLHR
160 170 180 190 200
DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR
210 220 230 240 250
APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPFHHD
260 270 280 290 300
QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH
310 320 330 340 350
KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ
360 370 380 390 400
IPYPKREFLN EDDPEEKGDK NQQQQQNQHQ QPTAPPQQAA APPQAPPPQQ
410 420 430 440 450
NSTQTNGTAG GAGAGVGGTG AGLQHSQDSS LNQVPPNKKP RLGPSGANSG
460 470 480 490 500
GPVMPSDYQH SSSRLNYQSS VQGSSQSQST LGYSSSSQQS SQYHPSHQAH

RY
Length:502
Mass (Da):56,802
Last modified:June 1, 2001 - v1
Checksum:iD9EED1BBB582EABA
GO
Isoform 2 (identifier: Q9BWU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):49,870
Checksum:i102214DB403B5C59
GO

Sequence cautioni

The sequence AAH24247 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0158571 – 60Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028424 mRNA. Translation: AAK27731.1.
Z84480, AL512430, AL603914 Genomic DNA. Translation: CAI20520.1.
AL512430, AL603914 Genomic DNA. Translation: CAI40282.1.
AL512430, AL603914, Z84480 Genomic DNA. Translation: CAI40286.1.
AL603914, AL512430 Genomic DNA. Translation: CAI41172.1.
AL603914, AL512430, Z84480 Genomic DNA. Translation: CAI41175.1.
BC024247 mRNA. Translation: AAH24247.1. Different initiation.
BC037289 mRNA. Translation: AAH37289.1.
AB028951 mRNA. Translation: BAA82980.2.
CCDSiCCDS5085.1. [Q9BWU1-1]
CCDS75503.1. [Q9BWU1-2]
RefSeqiNP_001287889.1. NM_001300960.1.
NP_001287892.1. NM_001300963.1. [Q9BWU1-2]
NP_001287893.1. NM_001300964.1. [Q9BWU1-2]
NP_055891.1. NM_015076.4. [Q9BWU1-1]
UniGeneiHs.744895.

Genome annotation databases

EnsembliENST00000323817; ENSP00000317665; ENSG00000155111. [Q9BWU1-2]
ENST00000368911; ENSP00000357907; ENSG00000155111. [Q9BWU1-1]
GeneIDi23097.
KEGGihsa:23097.
UCSCiuc003puh.2. human. [Q9BWU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028424 mRNA. Translation: AAK27731.1.
Z84480, AL512430, AL603914 Genomic DNA. Translation: CAI20520.1.
AL512430, AL603914 Genomic DNA. Translation: CAI40282.1.
AL512430, AL603914, Z84480 Genomic DNA. Translation: CAI40286.1.
AL603914, AL512430 Genomic DNA. Translation: CAI41172.1.
AL603914, AL512430, Z84480 Genomic DNA. Translation: CAI41175.1.
BC024247 mRNA. Translation: AAH24247.1. Different initiation.
BC037289 mRNA. Translation: AAH37289.1.
AB028951 mRNA. Translation: BAA82980.2.
CCDSiCCDS5085.1. [Q9BWU1-1]
CCDS75503.1. [Q9BWU1-2]
RefSeqiNP_001287889.1. NM_001300960.1.
NP_001287892.1. NM_001300963.1. [Q9BWU1-2]
NP_001287893.1. NM_001300964.1. [Q9BWU1-2]
NP_055891.1. NM_015076.4. [Q9BWU1-1]
UniGeneiHs.744895.

3D structure databases

ProteinModelPortaliQ9BWU1.
SMRiQ9BWU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116725. 61 interactors.
DIPiDIP-29013N.
IntActiQ9BWU1. 38 interactors.
STRINGi9606.ENSP00000357907.

Chemistry databases

BindingDBiQ9BWU1.
ChEMBLiCHEMBL6002.
GuidetoPHARMACOLOGYi1972.

PTM databases

iPTMnetiQ9BWU1.
PhosphoSitePlusiQ9BWU1.

Polymorphism and mutation databases

BioMutaiCDK19.
DMDMi60391917.

Proteomic databases

EPDiQ9BWU1.
MaxQBiQ9BWU1.
PaxDbiQ9BWU1.
PeptideAtlasiQ9BWU1.
PRIDEiQ9BWU1.

Protocols and materials databases

DNASUi23097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323817; ENSP00000317665; ENSG00000155111. [Q9BWU1-2]
ENST00000368911; ENSP00000357907; ENSG00000155111. [Q9BWU1-1]
GeneIDi23097.
KEGGihsa:23097.
UCSCiuc003puh.2. human. [Q9BWU1-1]

Organism-specific databases

CTDi23097.
DisGeNETi23097.
GeneCardsiCDK19.
HGNCiHGNC:19338. CDK19.
HPAiHPA007053.
MIMi614720. gene.
neXtProtiNX_Q9BWU1.
OpenTargetsiENSG00000155111.
PharmGKBiPA165617767.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0666. Eukaryota.
ENOG410XPPA. LUCA.
GeneTreeiENSGT00530000064012.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ9BWU1.
KOiK02208.
OMAiSQSTMGY.
OrthoDBiEOG091G0812.
PhylomeDBiQ9BWU1.
TreeFamiTF101025.

Enzyme and pathway databases

BioCyciZFISH:HS08031-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiQ9BWU1.
SIGNORiQ9BWU1.

Miscellaneous databases

ChiTaRSiCDK19. human.
GenomeRNAii23097.
PROiQ9BWU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155111.
CleanExiHS_CDC2L6.
ExpressionAtlasiQ9BWU1. baseline and differential.
GenevisibleiQ9BWU1. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK19_HUMAN
AccessioniPrimary (citable) accession number: Q9BWU1
Secondary accession number(s): Q5JQZ7
, Q5JR00, Q8TC78, Q9UPX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.