Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BWU1

- CDK19_HUMAN

UniProt

Q9BWU1 - CDK19_HUMAN

Protein

Cyclin-dependent kinase 19

Gene

CDK19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521ATPPROSITE-ProRule annotation
    Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 359ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiQ9BWU1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 19 (EC:2.7.11.22)
    Alternative name(s):
    CDC2-related protein kinase 6
    Cell division cycle 2-like protein kinase 6
    Cell division protein kinase 19
    Cyclin-dependent kinase 11
    Death-preventing kinase
    Gene namesi
    Name:CDK19
    Synonyms:CDC2L6, CDK11, KIAA1028
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:19338. CDK19.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165617767.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Cyclin-dependent kinase 19PRO_0000085713Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei449 – 4491Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BWU1.
    PaxDbiQ9BWU1.
    PRIDEiQ9BWU1.

    PTM databases

    PhosphoSiteiQ9BWU1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BWU1.
    BgeeiQ9BWU1.
    CleanExiHS_CDC2L6.
    GenevestigatoriQ9BWU1.

    Organism-specific databases

    HPAiHPA007053.

    Interactioni

    Protein-protein interaction databases

    BioGridi116725. 53 interactions.
    DIPiDIP-29013N.
    IntActiQ9BWU1. 38 interactions.
    STRINGi9606.ENSP00000357907.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BWU1.
    SMRiQ9BWU1. Positions 1-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 335315Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi372 – 40433Gln-richAdd
    BLAST
    Compositional biasi461 – 49131Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ9BWU1.
    KOiK02208.
    OMAiSQSTMGY.
    OrthoDBiEOG76739K.
    PhylomeDBiQ9BWU1.
    TreeFamiTF101025.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BWU1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA    50
    LKQIEGTGIS MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA 100
    EHDLWHIIKF HRASKANKKP MQLPRSMVKS LLYQILDGIH YLHANWVLHR 150
    DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR 200
    APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPFHHD 250
    QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH 300
    KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ 350
    IPYPKREFLN EDDPEEKGDK NQQQQQNQHQ QPTAPPQQAA APPQAPPPQQ 400
    NSTQTNGTAG GAGAGVGGTG AGLQHSQDSS LNQVPPNKKP RLGPSGANSG 450
    GPVMPSDYQH SSSRLNYQSS VQGSSQSQST LGYSSSSQQS SQYHPSHQAH 500
    RY 502
    Length:502
    Mass (Da):56,802
    Last modified:June 1, 2001 - v1
    Checksum:iD9EED1BBB582EABA
    GO
    Isoform 2 (identifier: Q9BWU1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:442
    Mass (Da):49,870
    Checksum:i102214DB403B5C59
    GO

    Sequence cautioni

    The sequence AAH24247.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060Missing in isoform 2. 1 PublicationVSP_015857Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028424 mRNA. Translation: AAK27731.1.
    Z84480, AL512430, AL603914 Genomic DNA. Translation: CAI20520.1.
    AL512430, AL603914 Genomic DNA. Translation: CAI40282.1.
    AL512430, AL603914, Z84480 Genomic DNA. Translation: CAI40286.1.
    AL603914, AL512430 Genomic DNA. Translation: CAI41172.1.
    AL603914, AL512430, Z84480 Genomic DNA. Translation: CAI41175.1.
    BC024247 mRNA. Translation: AAH24247.1. Different initiation.
    BC037289 mRNA. Translation: AAH37289.1.
    AB028951 mRNA. Translation: BAA82980.2.
    CCDSiCCDS5085.1. [Q9BWU1-1]
    RefSeqiNP_055891.1. NM_015076.3. [Q9BWU1-1]
    XP_006715465.1. XM_006715402.1. [Q9BWU1-2]
    UniGeneiHs.744895.

    Genome annotation databases

    EnsembliENST00000323817; ENSP00000317665; ENSG00000155111. [Q9BWU1-2]
    ENST00000368911; ENSP00000357907; ENSG00000155111. [Q9BWU1-1]
    GeneIDi23097.
    KEGGihsa:23097.
    UCSCiuc003puh.1. human. [Q9BWU1-1]

    Polymorphism databases

    DMDMi60391917.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028424 mRNA. Translation: AAK27731.1 .
    Z84480 , AL512430 , AL603914 Genomic DNA. Translation: CAI20520.1 .
    AL512430 , AL603914 Genomic DNA. Translation: CAI40282.1 .
    AL512430 , AL603914 , Z84480 Genomic DNA. Translation: CAI40286.1 .
    AL603914 , AL512430 Genomic DNA. Translation: CAI41172.1 .
    AL603914 , AL512430 , Z84480 Genomic DNA. Translation: CAI41175.1 .
    BC024247 mRNA. Translation: AAH24247.1 . Different initiation.
    BC037289 mRNA. Translation: AAH37289.1 .
    AB028951 mRNA. Translation: BAA82980.2 .
    CCDSi CCDS5085.1. [Q9BWU1-1 ]
    RefSeqi NP_055891.1. NM_015076.3. [Q9BWU1-1 ]
    XP_006715465.1. XM_006715402.1. [Q9BWU1-2 ]
    UniGenei Hs.744895.

    3D structure databases

    ProteinModelPortali Q9BWU1.
    SMRi Q9BWU1. Positions 1-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116725. 53 interactions.
    DIPi DIP-29013N.
    IntActi Q9BWU1. 38 interactions.
    STRINGi 9606.ENSP00000357907.

    Chemistry

    BindingDBi Q9BWU1.
    ChEMBLi CHEMBL6002.
    GuidetoPHARMACOLOGYi 1972.

    PTM databases

    PhosphoSitei Q9BWU1.

    Polymorphism databases

    DMDMi 60391917.

    Proteomic databases

    MaxQBi Q9BWU1.
    PaxDbi Q9BWU1.
    PRIDEi Q9BWU1.

    Protocols and materials databases

    DNASUi 23097.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323817 ; ENSP00000317665 ; ENSG00000155111 . [Q9BWU1-2 ]
    ENST00000368911 ; ENSP00000357907 ; ENSG00000155111 . [Q9BWU1-1 ]
    GeneIDi 23097.
    KEGGi hsa:23097.
    UCSCi uc003puh.1. human. [Q9BWU1-1 ]

    Organism-specific databases

    CTDi 23097.
    GeneCardsi GC06M110932.
    HGNCi HGNC:19338. CDK19.
    HPAi HPA007053.
    MIMi 614720. gene.
    neXtProti NX_Q9BWU1.
    PharmGKBi PA165617767.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q9BWU1.
    KOi K02208.
    OMAi SQSTMGY.
    OrthoDBi EOG76739K.
    PhylomeDBi Q9BWU1.
    TreeFami TF101025.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki Q9BWU1.

    Miscellaneous databases

    GenomeRNAii 23097.
    NextBioi 44269.
    PROi Q9BWU1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BWU1.
    Bgeei Q9BWU1.
    CleanExi HS_CDC2L6.
    Genevestigatori Q9BWU1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Delayed onset of apoptosis in factor-dependent T cells expressing a novel cyclin-C associated kinase."
      Lan Y., Zhang H., Lin F., Smith C., Xu H.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-502 (ISOFORM 1).
      Tissue: Brain.
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCDK19_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWU1
    Secondary accession number(s): Q5JQZ7
    , Q5JR00, Q8TC78, Q9UPX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3