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Q9BWU0

- NADAP_HUMAN

UniProt

Q9BWU0 - NADAP_HUMAN

Protein

Kanadaptin

Gene

SLC4A1AP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Protein family/group databases

    TCDBi3.A.18.1.2. the nuclear mrna exporter (mrna-e) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kanadaptin
    Alternative name(s):
    Human lung cancer oncogene 3 protein
    Short name:
    HLC-3
    Kidney anion exchanger adapter protein
    Solute carrier family 4 anion exchanger member 1 adapter protein
    Gene namesi
    ORF Names:HLC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:13813. SLC4A1AP.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Mainly nuclear. Small amounts are found in the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37811.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 796796KanadaptinPRO_0000076268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei82 – 821Phosphoserine1 Publication
    Modified residuei312 – 3121Phosphoserine4 Publications
    Modified residuei466 – 4661Phosphoserine4 Publications
    Modified residuei530 – 5301Phosphoserine1 Publication
    Modified residuei712 – 7121Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BWU0.
    PaxDbiQ9BWU0.
    PRIDEiQ9BWU0.

    PTM databases

    PhosphoSiteiQ9BWU0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9BWU0.
    BgeeiQ9BWU0.
    CleanExiHS_SLC4A1AP.
    GenevestigatoriQ9BWU0.

    Organism-specific databases

    HPAiHPA036680.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ILKQ134188EBI-1999704,EBI-747644

    Protein-protein interaction databases

    BioGridi116605. 12 interactions.
    IntActiQ9BWU0. 5 interactions.
    STRINGi9606.ENSP00000323837.

    Structurei

    Secondary structure

    1
    796
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi168 – 1736
    Beta strandi176 – 1827
    Beta strandi187 – 1948
    Beta strandi197 – 2004
    Beta strandi211 – 2166
    Beta strandi231 – 2355
    Beta strandi242 – 2443
    Beta strandi262 – 2654
    Beta strandi269 – 2757

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4H87X-ray1.55A/B149-276[»]
    ProteinModelPortaliQ9BWU0.
    SMRiQ9BWU0. Positions 149-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini189 – 24961FHAPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili497 – 53034Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi644 – 71572Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FHA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG251732.
    HOGENOMiHOG000008002.
    HOVERGENiHBG052984.
    InParanoidiQ9BWU0.
    OMAiELEFEYE.
    OrthoDBiEOG7V1FQC.
    PhylomeDBiQ9BWU0.
    TreeFamiTF314854.

    Family and domain databases

    Gene3Di2.60.200.20. 1 hit.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR000253. FHA_dom.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PfamiPF00035. dsrm. 1 hit.
    PF00498. FHA. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00240. FHA. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    PROSITEiPS50006. FHA_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BWU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAPLRNAPG REGATSPSPP TDATGSLGEW DVDRNVKTEG WVSKERISKL    50
    HRLRMADILS QSETLASQDL SGDFKKPALP VSPAARSKAP ASSSSNPEEV 100
    QKEGPTALQD SNSGEPDIPP PQPDCGDFRS LQEEQSRPPT AVSSPGGPAR 150
    APPYQEPPWG GPATAPYSLE TLKGGTILGT RSLKGTSYCL FGRLSGCDVC 200
    LEHPSVSRYH AVLQHRASGP DGECDSNGPG FYLYDLGSTH GTFLNKTRIP 250
    PRTYCRVHVG HVVRFGGSTR LFILQGPEED REAESELTVT QLKELRKQQQ 300
    ILLEKKMLGE DSDEEEEMDT SERKINAGSQ DDEMGCTWGM GEDAVEDDAE 350
    ENPIVLEFQQ EREAFYIKDP KKALQGFFDR EGEELEYEFD EQGHSTWLCR 400
    VRLPVDDSTG KQLVAEAIHS GKKKEAMIQC SLEACRILDT LGLLRQEAVS 450
    RKRKAKNWED EDFYDSDDDT FLDRTGLIEK KRLNRMKKAG KIDEKPETFE 500
    SLVAKLNDAE RELSEISERL KASSQVLSES PSQDSLDAFM SEMKSGSTLD 550
    GVSRKKLHLR TFELRKEQQR LKGLIKIVKP AEIPELKKTE TQTTGAENKA 600
    KKLTLPLFGA MKGGSKFKLK TGTVGKLPPK RPELPPTLMR MKDEPEVEEE 650
    EEEEEEEEKE KEEHEKKKLE DGSLSRPQPE IEPEAAVQEM RPPTDLTHFK 700
    ETQTHENMSQ LSEEEQNKDY QDCSKTTSLC AGPSASKNEY EKSRGELKKK 750
    KTPGPGKLPP TLSSKYPEDD PDYCVWVPPE GQSGDGRTHL NDKYGY 796
    Length:796
    Mass (Da):88,814
    Last modified:June 1, 2001 - v1
    Checksum:iEE0F560648DA39EF
    GO

    Sequence cautioni

    The sequence AAN12269.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti111 – 1155SNSGE → PIAKP in AAN12269. 1 PublicationCurated
    Sequence conflicti309 – 3091G → R in AAK29177. (PubMed:14702039)Curated
    Sequence conflicti359 – 3591Q → R in AAH98358. (PubMed:15489334)Curated
    Sequence conflicti373 – 3731A → V in AAK29177. (PubMed:14702039)Curated
    Sequence conflicti444 – 4441L → I in AAN12269. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti139 – 1391P → T.3 Publications
    Corresponds to variant rs9678851 [ dbSNP | Ensembl ].
    VAR_024748
    Natural varianti181 – 1811R → C.
    Corresponds to variant rs9679004 [ dbSNP | Ensembl ].
    VAR_051219

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028435 mRNA. Translation: AAK29177.1.
    AK001486 mRNA. Translation: BAA91718.1.
    AC074091 Genomic DNA. Translation: AAX93203.1.
    CH471053 Genomic DNA. Translation: EAX00555.1.
    BC098302 mRNA. Translation: AAH98302.1.
    BC098358 mRNA. Translation: AAH98358.1.
    BC099711 mRNA. Translation: AAH99711.1.
    BC099739 mRNA. Translation: AAH99739.1.
    AY117688 mRNA. Translation: AAN12269.1. Different initiation.
    CCDSiCCDS33166.1.
    RefSeqiNP_060628.2. NM_018158.2.
    UniGeneiHs.306000.

    Genome annotation databases

    EnsembliENST00000326019; ENSP00000323837; ENSG00000163798.
    GeneIDi22950.
    KEGGihsa:22950.
    UCSCiuc002rlk.4. human.

    Polymorphism databases

    DMDMi74724887.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Band 3 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028435 mRNA. Translation: AAK29177.1 .
    AK001486 mRNA. Translation: BAA91718.1 .
    AC074091 Genomic DNA. Translation: AAX93203.1 .
    CH471053 Genomic DNA. Translation: EAX00555.1 .
    BC098302 mRNA. Translation: AAH98302.1 .
    BC098358 mRNA. Translation: AAH98358.1 .
    BC099711 mRNA. Translation: AAH99711.1 .
    BC099739 mRNA. Translation: AAH99739.1 .
    AY117688 mRNA. Translation: AAN12269.1 . Different initiation.
    CCDSi CCDS33166.1.
    RefSeqi NP_060628.2. NM_018158.2.
    UniGenei Hs.306000.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4H87 X-ray 1.55 A/B 149-276 [» ]
    ProteinModelPortali Q9BWU0.
    SMRi Q9BWU0. Positions 149-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116605. 12 interactions.
    IntActi Q9BWU0. 5 interactions.
    STRINGi 9606.ENSP00000323837.

    Protein family/group databases

    TCDBi 3.A.18.1.2. the nuclear mrna exporter (mrna-e) family.

    PTM databases

    PhosphoSitei Q9BWU0.

    Polymorphism databases

    DMDMi 74724887.

    Proteomic databases

    MaxQBi Q9BWU0.
    PaxDbi Q9BWU0.
    PRIDEi Q9BWU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326019 ; ENSP00000323837 ; ENSG00000163798 .
    GeneIDi 22950.
    KEGGi hsa:22950.
    UCSCi uc002rlk.4. human.

    Organism-specific databases

    CTDi 22950.
    GeneCardsi GC02P027886.
    H-InvDB HIX0001931.
    HGNCi HGNC:13813. SLC4A1AP.
    HPAi HPA036680.
    MIMi 602655. gene.
    neXtProti NX_Q9BWU0.
    PharmGKBi PA37811.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251732.
    HOGENOMi HOG000008002.
    HOVERGENi HBG052984.
    InParanoidi Q9BWU0.
    OMAi ELEFEYE.
    OrthoDBi EOG7V1FQC.
    PhylomeDBi Q9BWU0.
    TreeFami TF314854.

    Miscellaneous databases

    ChiTaRSi SLC4A1AP. human.
    GenomeRNAii 22950.
    NextBioi 43719.
    PROi Q9BWU0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BWU0.
    Bgeei Q9BWU0.
    CleanExi HS_SLC4A1AP.
    Genevestigatori Q9BWU0.

    Family and domain databases

    Gene3Di 2.60.200.20. 1 hit.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR000253. FHA_dom.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    Pfami PF00035. dsrm. 1 hit.
    PF00498. FHA. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00240. FHA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    PROSITEi PS50006. FHA_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells."
      Kittanakom S., Keskanokwong T., Akkarapatumwong V., Yenchitsomanus P.-T., Reithmeier R.A.F.
      Mol. Membr. Biol. 21:395-402(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-139.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-139.
    6. "Identification of a new oncogene in human lung cancer."
      Kim J.W.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-796.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312; SER-466 AND SER-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312 AND SER-466, VARIANT [LARGE SCALE ANALYSIS] THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; SER-312; SER-466 AND SER-712, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312 AND SER-466, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Crystal structure of a FHA domain of kanadaptin (SLC4A1AP) from Homo sapiens at 1.55 A resolution."
      Joint center for structural genomics (JCSG)
      Submitted (OCT-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 149-276.

    Entry informationi

    Entry nameiNADAP_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWU0
    Secondary accession number(s): A6NJ39
    , Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3