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Protein

Kanadaptin

Gene

SLC4A1AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163798-MONOMER.

Protein family/group databases

TCDBi3.A.18.1.2. the nuclear mrna exporter (mrna-e) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Kanadaptin
Alternative name(s):
Human lung cancer oncogene 3 protein
Short name:
HLC-3
Kidney anion exchanger adapter protein
Solute carrier family 4 anion exchanger member 1 adapter protein
Gene namesi
ORF Names:HLC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:13813. SLC4A1AP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22950.
OpenTargetsiENSG00000163798.
PharmGKBiPA37811.

Polymorphism and mutation databases

BioMutaiSLC4A1AP.
DMDMi74724887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762681 – 796KanadaptinAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei712PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWU0.
MaxQBiQ9BWU0.
PaxDbiQ9BWU0.
PeptideAtlasiQ9BWU0.
PRIDEiQ9BWU0.

PTM databases

iPTMnetiQ9BWU0.
PhosphoSitePlusiQ9BWU0.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000163798.
CleanExiHS_SLC4A1AP.
ExpressionAtlasiQ9BWU0. baseline and differential.
GenevisibleiQ9BWU0. HS.

Organism-specific databases

HPAiHPA036679.
HPA036680.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ILKQ134188EBI-1999704,EBI-747644
TCF4P158843EBI-1999704,EBI-533224

Protein-protein interaction databases

BioGridi116605. 29 interactors.
IntActiQ9BWU0. 10 interactors.
STRINGi9606.ENSP00000323837.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi168 – 173Combined sources6
Beta strandi176 – 182Combined sources7
Beta strandi187 – 194Combined sources8
Beta strandi197 – 200Combined sources4
Beta strandi211 – 216Combined sources6
Beta strandi231 – 235Combined sources5
Beta strandi242 – 244Combined sources3
Beta strandi262 – 265Combined sources4
Beta strandi269 – 275Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H87X-ray1.55A/B149-276[»]
ProteinModelPortaliQ9BWU0.
SMRiQ9BWU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini189 – 249FHAPROSITE-ProRule annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili497 – 530Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi644 – 715Glu-richAdd BLAST72

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1881. Eukaryota.
ENOG410XR6C. LUCA.
GeneTreeiENSGT00730000110659.
HOGENOMiHOG000008002.
HOVERGENiHBG052984.
InParanoidiQ9BWU0.
OMAiEGVSWGM.
OrthoDBiEOG091G05D7.
PhylomeDBiQ9BWU0.
TreeFamiTF314854.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAPLRNAPG REGATSPSPP TDATGSLGEW DVDRNVKTEG WVSKERISKL
60 70 80 90 100
HRLRMADILS QSETLASQDL SGDFKKPALP VSPAARSKAP ASSSSNPEEV
110 120 130 140 150
QKEGPTALQD SNSGEPDIPP PQPDCGDFRS LQEEQSRPPT AVSSPGGPAR
160 170 180 190 200
APPYQEPPWG GPATAPYSLE TLKGGTILGT RSLKGTSYCL FGRLSGCDVC
210 220 230 240 250
LEHPSVSRYH AVLQHRASGP DGECDSNGPG FYLYDLGSTH GTFLNKTRIP
260 270 280 290 300
PRTYCRVHVG HVVRFGGSTR LFILQGPEED REAESELTVT QLKELRKQQQ
310 320 330 340 350
ILLEKKMLGE DSDEEEEMDT SERKINAGSQ DDEMGCTWGM GEDAVEDDAE
360 370 380 390 400
ENPIVLEFQQ EREAFYIKDP KKALQGFFDR EGEELEYEFD EQGHSTWLCR
410 420 430 440 450
VRLPVDDSTG KQLVAEAIHS GKKKEAMIQC SLEACRILDT LGLLRQEAVS
460 470 480 490 500
RKRKAKNWED EDFYDSDDDT FLDRTGLIEK KRLNRMKKAG KIDEKPETFE
510 520 530 540 550
SLVAKLNDAE RELSEISERL KASSQVLSES PSQDSLDAFM SEMKSGSTLD
560 570 580 590 600
GVSRKKLHLR TFELRKEQQR LKGLIKIVKP AEIPELKKTE TQTTGAENKA
610 620 630 640 650
KKLTLPLFGA MKGGSKFKLK TGTVGKLPPK RPELPPTLMR MKDEPEVEEE
660 670 680 690 700
EEEEEEEEKE KEEHEKKKLE DGSLSRPQPE IEPEAAVQEM RPPTDLTHFK
710 720 730 740 750
ETQTHENMSQ LSEEEQNKDY QDCSKTTSLC AGPSASKNEY EKSRGELKKK
760 770 780 790
KTPGPGKLPP TLSSKYPEDD PDYCVWVPPE GQSGDGRTHL NDKYGY
Length:796
Mass (Da):88,814
Last modified:June 1, 2001 - v1
Checksum:iEE0F560648DA39EF
GO

Sequence cautioni

The sequence AAN12269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111 – 115SNSGE → PIAKP in AAN12269 (Ref. 6) Curated5
Sequence conflicti309G → R in AAK29177 (PubMed:14702039).Curated1
Sequence conflicti359Q → R in AAH98358 (PubMed:15489334).Curated1
Sequence conflicti373A → V in AAK29177 (PubMed:14702039).Curated1
Sequence conflicti444L → I in AAN12269 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024748139P → T.Combined sources2 PublicationsCorresponds to variant rs9678851dbSNPEnsembl.1
Natural variantiVAR_051219181R → C.Corresponds to variant rs9679004dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028435 mRNA. Translation: AAK29177.1.
AK001486 mRNA. Translation: BAA91718.1.
AC074091 Genomic DNA. Translation: AAX93203.1.
CH471053 Genomic DNA. Translation: EAX00555.1.
BC098302 mRNA. Translation: AAH98302.1.
BC098358 mRNA. Translation: AAH98358.1.
BC099711 mRNA. Translation: AAH99711.1.
BC099739 mRNA. Translation: AAH99739.1.
AY117688 mRNA. Translation: AAN12269.1. Different initiation.
CCDSiCCDS33166.1.
RefSeqiNP_060628.2. NM_018158.2.
UniGeneiHs.306000.

Genome annotation databases

EnsembliENST00000326019; ENSP00000323837; ENSG00000163798.
ENST00000613058; ENSP00000479964; ENSG00000163798.
GeneIDi22950.
KEGGihsa:22950.
UCSCiuc002rlk.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Band 3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028435 mRNA. Translation: AAK29177.1.
AK001486 mRNA. Translation: BAA91718.1.
AC074091 Genomic DNA. Translation: AAX93203.1.
CH471053 Genomic DNA. Translation: EAX00555.1.
BC098302 mRNA. Translation: AAH98302.1.
BC098358 mRNA. Translation: AAH98358.1.
BC099711 mRNA. Translation: AAH99711.1.
BC099739 mRNA. Translation: AAH99739.1.
AY117688 mRNA. Translation: AAN12269.1. Different initiation.
CCDSiCCDS33166.1.
RefSeqiNP_060628.2. NM_018158.2.
UniGeneiHs.306000.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H87X-ray1.55A/B149-276[»]
ProteinModelPortaliQ9BWU0.
SMRiQ9BWU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116605. 29 interactors.
IntActiQ9BWU0. 10 interactors.
STRINGi9606.ENSP00000323837.

Protein family/group databases

TCDBi3.A.18.1.2. the nuclear mrna exporter (mrna-e) family.

PTM databases

iPTMnetiQ9BWU0.
PhosphoSitePlusiQ9BWU0.

Polymorphism and mutation databases

BioMutaiSLC4A1AP.
DMDMi74724887.

Proteomic databases

EPDiQ9BWU0.
MaxQBiQ9BWU0.
PaxDbiQ9BWU0.
PeptideAtlasiQ9BWU0.
PRIDEiQ9BWU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326019; ENSP00000323837; ENSG00000163798.
ENST00000613058; ENSP00000479964; ENSG00000163798.
GeneIDi22950.
KEGGihsa:22950.
UCSCiuc002rlk.5. human.

Organism-specific databases

CTDi22950.
DisGeNETi22950.
GeneCardsiSLC4A1AP.
H-InvDBHIX0001931.
HGNCiHGNC:13813. SLC4A1AP.
HPAiHPA036679.
HPA036680.
MIMi602655. gene.
neXtProtiNX_Q9BWU0.
OpenTargetsiENSG00000163798.
PharmGKBiPA37811.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1881. Eukaryota.
ENOG410XR6C. LUCA.
GeneTreeiENSGT00730000110659.
HOGENOMiHOG000008002.
HOVERGENiHBG052984.
InParanoidiQ9BWU0.
OMAiEGVSWGM.
OrthoDBiEOG091G05D7.
PhylomeDBiQ9BWU0.
TreeFamiTF314854.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163798-MONOMER.

Miscellaneous databases

ChiTaRSiSLC4A1AP. human.
GenomeRNAii22950.
PROiQ9BWU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163798.
CleanExiHS_SLC4A1AP.
ExpressionAtlasiQ9BWU0. baseline and differential.
GenevisibleiQ9BWU0. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNADAP_HUMAN
AccessioniPrimary (citable) accession number: Q9BWU0
Secondary accession number(s): A6NJ39
, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.