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Protein

Caspase recruitment domain-containing protein 10

Gene

CARD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activates NF-kappa-B via BCL10 and IKK.

GO - Molecular functioni

  • receptor signaling complex scaffold activity Source: UniProtKB

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  • protein complex assembly Source: UniProtKB
  • regulation of apoptotic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 10
Alternative name(s):
CARD-containing MAGUK protein 3
Short name:
Carma 3
Gene namesi
Name:CARD10
Synonyms:CARMA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:16422. CARD10.

Subcellular locationi

GO - Cellular componenti

  • CBM complex Source: UniProtKB
  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi29775.
OpenTargetsiENSG00000100065.
PharmGKBiPA134927444.

Polymorphism and mutation databases

BioMutaiCARD10.
DMDMi116241281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440841 – 1032Caspase recruitment domain-containing protein 10Add BLAST1032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWT7.
MaxQBiQ9BWT7.
PaxDbiQ9BWT7.
PeptideAtlasiQ9BWT7.
PRIDEiQ9BWT7.

PTM databases

iPTMnetiQ9BWT7.
PhosphoSitePlusiQ9BWT7.

Expressioni

Tissue specificityi

Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Gene expression databases

BgeeiENSG00000100065.
CleanExiHS_CARD10.
ExpressionAtlasiQ9BWT7. baseline and differential.
GenevisibleiQ9BWT7. HS.

Organism-specific databases

HPAiHPA029359.
HPA055612.

Interactioni

Subunit structurei

CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CARD9Q9H257-24EBI-3866279,EBI-11530605
PIBF1A0A087WUI64EBI-3866279,EBI-11749468

GO - Molecular functioni

  • receptor signaling complex scaffold activity Source: UniProtKB

Protein-protein interaction databases

BioGridi118908. 17 interactors.
IntActiQ9BWT7. 68 interactors.
MINTiMINT-192132.
STRINGi9606.ENSP00000251973.

Structurei

3D structure databases

ProteinModelPortaliQ9BWT7.
SMRiQ9BWT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 115CARDPROSITE-ProRule annotationAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 456Sequence analysisAdd BLAST319

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi567 – 574Poly-Ser8

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000111299.
HOVERGENiHBG050791.
InParanoidiQ9BWT7.
OMAiESVGKKH.
OrthoDBiEOG091G0T58.
PhylomeDBiQ9BWT7.
TreeFamiTF351139.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGRAEAGEA EEEAGAGSGS EAEEDALWER IEGVRHRLAR ALNPAKLTPY
60 70 80 90 100
LRQCRVIDEQ DEEEVLSTYR FPCRVNRTGR LMDILRCRGK RGYEAFLEAL
110 120 130 140 150
EFYYPEHFTL LTGQEPAQRC SMILDEEGPE GLTQFLMTEV RRLREARKSQ
160 170 180 190 200
LQREQQLQAR GRVLEEERAG LEQRLRDQQQ AQERCQRLRE DWEAGSLELL
210 220 230 240 250
RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK VSRLEEECAL
260 270 280 290 300
LRRARGPPPG AEEKEKEKEK EKEPDNVDLV SELRAENQRL TASLRELQEG
310 320 330 340 350
LQQEASRPGA PGSERILLDI LEHDWREAQD SRQELCQKLH AVQGELQWAE
360 370 380 390 400
ELRDQYLQEM EDLRLKHRTL QKDCDLYKHR MATVLAQLEE IEKERDQAIQ
410 420 430 440 450
SRDRIQLQYS QSLIEKDQYR KQVRGLEAER DELLTTLTSL EGTKALLEVQ
460 470 480 490 500
LQRAQGGTCL KACASSHSLC SNLSSTWSLS EFPSPLGGPE ATGEAAVMGG
510 520 530 540 550
PEPHNSEEAT DSEKEINRLS ILPFPPSAGS ILRRQREEDP APPKRSFSSM
560 570 580 590 600
SDITGSVTLK PWSPGLSSSS SSDSVWPLGK PEGLLARGCG LDFLNRSLAI
610 620 630 640 650
RVSGRSPPGG PEPQDKGPDG LSFYGDRWSG AVVRRVLSGP GSARMEPREQ
660 670 680 690 700
RVEAAGLEGA CLEAEAQQRT LLWNQGSTLP SLMDSKACQS FHEALEAWAK
710 720 730 740 750
GPGAEPFYIR ANLTLPERAD PHALCVKAQE ILRLVDSAYK RRQEWFCTRV
760 770 780 790 800
DPLTLRDLDR GTVPNYQRAQ QLLEVQEKCL PSSRHRGPRS NLKKRALDQL
810 820 830 840 850
RLVRPKPVGA PAGDSPDQLL LEPCAEPERS LRPYSLVRPL LVSALRPVVL
860 870 880 890 900
LPECLAPRLI RNLLDLPSSR LDFQVCPAES LSGEELCPSS APGAPKAQPA
910 920 930 940 950
TPGLGSRIRA IQESVGKKHC LLELGARGVR ELVQNEIYPI VIHVEVTEKN
960 970 980 990 1000
VREVRGLLGR PGWRDSELLR QCRGSEQVLW GLPCSWVQVP AHEWGHAEEL
1010 1020 1030
AKVVRGRILQ EQARLVWVEC GSSRGCPSSS EA
Length:1,032
Mass (Da):115,931
Last modified:October 17, 2006 - v2
Checksum:i298AAC132778376A
GO
Isoform 2 (identifier: Q9BWT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MPGRAEAGEAEEEAGAG → MGVGVGLGNGLRLLPWM
     18-303: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):82,541
Checksum:iFDDA94D32E670CD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti932L → R in AAK26165 (PubMed:11259443).Curated1
Sequence conflicti932L → R in AAK54454 (PubMed:11356195).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028116289R → Q.2 PublicationsCorresponds to variant rs9610775dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555231 – 17MPGRA…EAGAG → MGVGVGLGNGLRLLPWM in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05552418 – 303Missing in isoform 2. 1 PublicationAdd BLAST286

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028896 mRNA. Translation: AAK26165.1.
AY032928 mRNA. Translation: AAK54454.1.
AK074906 mRNA. Translation: BAC11282.1.
AL022315 Genomic DNA. No translation available.
FP325335 Genomic DNA. No translation available.
BC113659 mRNA. Translation: AAI13660.1.
CCDSiCCDS13948.1. [Q9BWT7-1]
RefSeqiNP_055365.2. NM_014550.3. [Q9BWT7-1]
UniGeneiHs.57973.

Genome annotation databases

EnsembliENST00000251973; ENSP00000251973; ENSG00000100065. [Q9BWT7-1]
ENST00000403299; ENSP00000384570; ENSG00000100065. [Q9BWT7-1]
ENST00000406271; ENSP00000385799; ENSG00000100065. [Q9BWT7-2]
GeneIDi29775.
KEGGihsa:29775.
UCSCiuc003asw.2. human. [Q9BWT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028896 mRNA. Translation: AAK26165.1.
AY032928 mRNA. Translation: AAK54454.1.
AK074906 mRNA. Translation: BAC11282.1.
AL022315 Genomic DNA. No translation available.
FP325335 Genomic DNA. No translation available.
BC113659 mRNA. Translation: AAI13660.1.
CCDSiCCDS13948.1. [Q9BWT7-1]
RefSeqiNP_055365.2. NM_014550.3. [Q9BWT7-1]
UniGeneiHs.57973.

3D structure databases

ProteinModelPortaliQ9BWT7.
SMRiQ9BWT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118908. 17 interactors.
IntActiQ9BWT7. 68 interactors.
MINTiMINT-192132.
STRINGi9606.ENSP00000251973.

PTM databases

iPTMnetiQ9BWT7.
PhosphoSitePlusiQ9BWT7.

Polymorphism and mutation databases

BioMutaiCARD10.
DMDMi116241281.

Proteomic databases

EPDiQ9BWT7.
MaxQBiQ9BWT7.
PaxDbiQ9BWT7.
PeptideAtlasiQ9BWT7.
PRIDEiQ9BWT7.

Protocols and materials databases

DNASUi29775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251973; ENSP00000251973; ENSG00000100065. [Q9BWT7-1]
ENST00000403299; ENSP00000384570; ENSG00000100065. [Q9BWT7-1]
ENST00000406271; ENSP00000385799; ENSG00000100065. [Q9BWT7-2]
GeneIDi29775.
KEGGihsa:29775.
UCSCiuc003asw.2. human. [Q9BWT7-1]

Organism-specific databases

CTDi29775.
DisGeNETi29775.
GeneCardsiCARD10.
HGNCiHGNC:16422. CARD10.
HPAiHPA029359.
HPA055612.
MIMi607209. gene.
neXtProtiNX_Q9BWT7.
OpenTargetsiENSG00000100065.
PharmGKBiPA134927444.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000111299.
HOVERGENiHBG050791.
InParanoidiQ9BWT7.
OMAiESVGKKH.
OrthoDBiEOG091G0T58.
PhylomeDBiQ9BWT7.
TreeFamiTF351139.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100065-MONOMER.

Miscellaneous databases

ChiTaRSiCARD10. human.
GeneWikiiCARD10.
GenomeRNAii29775.
PROiQ9BWT7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100065.
CleanExiHS_CARD10.
ExpressionAtlasiQ9BWT7. baseline and differential.
GenevisibleiQ9BWT7. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAR10_HUMAN
AccessioniPrimary (citable) accession number: Q9BWT7
Secondary accession number(s): Q14CQ8
, Q5TFG6, Q8NC81, Q9UGR5, Q9UGR6, Q9Y3H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.