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Q9BWT7 (CAR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caspase recruitment domain-containing protein 10
Alternative name(s):
CARD-containing MAGUK protein 3
Short name=Carma 3
Gene names
Name:CARD10
Synonyms:CARMA3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length1032 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Activates NF-kappa-B via BCL10 and IKK.

Subunit structure

CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Sequence similarities

Contains 1 CARD domain.

Caution

Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processactivation of NF-kappaB-inducing kinase activity

Inferred from direct assay Ref.1. Source: UniProtKB

protein complex assembly

Non-traceable author statement Ref.1. Source: UniProtKB

regulation of apoptotic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentCBM complex

Non-traceable author statement. Source: UniProtKB

   Molecular functionreceptor signaling complex scaffold activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10321032Caspase recruitment domain-containing protein 10
PRO_0000144084

Regions

Domain23 – 11593CARD
Coiled coil138 – 456319 Potential
Compositional bias567 – 5748Poly-Ser

Natural variations

Natural variant2891R → Q. Ref.1 Ref.2
Corresponds to variant rs9610775 [ dbSNP | Ensembl ].
VAR_028116

Experimental info

Sequence conflict9321L → R in AAK26165. Ref.1
Sequence conflict9321L → R in AAK54454. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BWT7 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 298AAC132778376A

FASTA1,032115,931
        10         20         30         40         50         60 
MPGRAEAGEA EEEAGAGSGS EAEEDALWER IEGVRHRLAR ALNPAKLTPY LRQCRVIDEQ 

        70         80         90        100        110        120 
DEEEVLSTYR FPCRVNRTGR LMDILRCRGK RGYEAFLEAL EFYYPEHFTL LTGQEPAQRC 

       130        140        150        160        170        180 
SMILDEEGPE GLTQFLMTEV RRLREARKSQ LQREQQLQAR GRVLEEERAG LEQRLRDQQQ 

       190        200        210        220        230        240 
AQERCQRLRE DWEAGSLELL RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK 

       250        260        270        280        290        300 
VSRLEEECAL LRRARGPPPG AEEKEKEKEK EKEPDNVDLV SELRAENQRL TASLRELQEG 

       310        320        330        340        350        360 
LQQEASRPGA PGSERILLDI LEHDWREAQD SRQELCQKLH AVQGELQWAE ELRDQYLQEM 

       370        380        390        400        410        420 
EDLRLKHRTL QKDCDLYKHR MATVLAQLEE IEKERDQAIQ SRDRIQLQYS QSLIEKDQYR 

       430        440        450        460        470        480 
KQVRGLEAER DELLTTLTSL EGTKALLEVQ LQRAQGGTCL KACASSHSLC SNLSSTWSLS 

       490        500        510        520        530        540 
EFPSPLGGPE ATGEAAVMGG PEPHNSEEAT DSEKEINRLS ILPFPPSAGS ILRRQREEDP 

       550        560        570        580        590        600 
APPKRSFSSM SDITGSVTLK PWSPGLSSSS SSDSVWPLGK PEGLLARGCG LDFLNRSLAI 

       610        620        630        640        650        660 
RVSGRSPPGG PEPQDKGPDG LSFYGDRWSG AVVRRVLSGP GSARMEPREQ RVEAAGLEGA 

       670        680        690        700        710        720 
CLEAEAQQRT LLWNQGSTLP SLMDSKACQS FHEALEAWAK GPGAEPFYIR ANLTLPERAD 

       730        740        750        760        770        780 
PHALCVKAQE ILRLVDSAYK RRQEWFCTRV DPLTLRDLDR GTVPNYQRAQ QLLEVQEKCL 

       790        800        810        820        830        840 
PSSRHRGPRS NLKKRALDQL RLVRPKPVGA PAGDSPDQLL LEPCAEPERS LRPYSLVRPL 

       850        860        870        880        890        900 
LVSALRPVVL LPECLAPRLI RNLLDLPSSR LDFQVCPAES LSGEELCPSS APGAPKAQPA 

       910        920        930        940        950        960 
TPGLGSRIRA IQESVGKKHC LLELGARGVR ELVQNEIYPI VIHVEVTEKN VREVRGLLGR 

       970        980        990       1000       1010       1020 
PGWRDSELLR QCRGSEQVLW GLPCSWVQVP AHEWGHAEEL AKVVRGRILQ EQARLVWVEC 

      1030 
GSSRGCPSSS EA

« Hide

References

« Hide 'large scale' references
[1]"CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with Bcl10 and activates NF-kappa B."
Wang L., Guo Y., Huang W.-J., Ke X., Poyet J.-L., Manji G.A., Merriam S., Glucksmann M.A., DiStefano P.S., Alnemri E.S., Bertin J.
J. Biol. Chem. 276:21405-21409(2001) [PubMed: 11259443] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-289.
[2]"Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation."
Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
FEBS Lett. 496:121-127(2001) [PubMed: 11356195] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-289.
[3]Erratum
Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
FEBS Lett. 505:198-198(2001)
[4]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed: 10591208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY028896 mRNA. Translation: AAK26165.1.
AY032928 mRNA. Translation: AAK54454.1.
AL022315, AL049851 Genomic DNA. Translation: CAI19345.1.
AL049851, AL022315 Genomic DNA. Translation: CAI23165.1.
BC113659 mRNA. Translation: AAI13660.1.
IPIIPI00002313.
RefSeqNP_055365.2. NM_014550.3.
UniGeneHs.57973.

3D structure databases

ProteinModelPortalQ9BWT7.
SMRQ9BWT7. Positions 27-115, 423-451, 619-681, 708-767.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9BWT7.

PTM databases

PhosphoSiteQ9BWT7.

Polymorphism databases

DMDM116241281.

Proteomic databases

PRIDEQ9BWT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000251973; ENSP00000251973; ENSG00000100065.
ENST00000403299; ENSP00000384570; ENSG00000100065.
GeneID29775.
KEGGhsa:29775.
NMPDRfig|9606.3.peg.21665.
UCSCuc003asx.1. human.

Organism-specific databases

CTD29775.
GeneCardsGC22M037886.
H-InvDBHIX0041190.
HGNCHGNC:16422. CARD10.
HPAHPA029359.
MIM607209. gene.
neXtProtNX_Q9BWT7.
PharmGKBPA134927444.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG17664.
GeneTreeENSGT00530000063108.
HOGENOMHBG446197.
HOVERGENHBG050791.
InParanoidQ9BWT7.
OMAWPLGKPE.
OrthoDBEOG4HMJ8P.
PhylomeDBQ9BWT7.

Gene expression databases

ArrayExpressQ9BWT7.
BgeeQ9BWT7.
CleanExHS_CARD10.
GenevestigatorQ9BWT7.
GermOnlineENSG00000100065. Homo sapiens.

Family and domain databases

InterProIPR001315. CARD.
IPR011029. DEATH-like.
[Graphical view]
Gene3DG3DSA:1.10.533.10. DEATH_like. 1 hit.
PfamPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMSSF47986. DEATH_like. 1 hit.
PROSITEPS50209. CARD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio52294.
SOURCESearch...

Entry information

Entry nameCAR10_HUMAN
AccessionPrimary (citable) accession number: Q9BWT7
Secondary accession number(s): Q14CQ8 expand/collapse secondary AC list , Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents