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Protein

Meiotic nuclear division protein 1 homolog

Gene

MND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA recombination, Meiosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121211-MONOMER.
ReactomeiR-HSA-912446. Meiotic recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic nuclear division protein 1 homolog
Gene namesi
Name:MND1Imported
Synonyms:GAJImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24839. MND1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84057.
OpenTargetsiENSG00000121211.
PharmGKBiPA143485544.

Polymorphism and mutation databases

BioMutaiMND1.
DMDMi74733462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003180812 – 205Meiotic nuclear division protein 1 homologAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BWT6.
MaxQBiQ9BWT6.
PaxDbiQ9BWT6.
PeptideAtlasiQ9BWT6.
PRIDEiQ9BWT6.

PTM databases

iPTMnetiQ9BWT6.
PhosphoSitePlusiQ9BWT6.

Expressioni

Gene expression databases

BgeeiENSG00000121211.
CleanExiHS_MND1.
ExpressionAtlasiQ9BWT6. baseline and differential.
GenevisibleiQ9BWT6. HS.

Organism-specific databases

HPAiHPA039941.

Interactioni

Subunit structurei

Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA.By similarity1 Publication

Protein-protein interaction databases

BioGridi123852. 7 interactors.
IntActiQ9BWT6. 2 interactors.
STRINGi9606.ENSP00000240488.

Structurei

3D structure databases

ProteinModelPortaliQ9BWT6.
SMRiQ9BWT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili84 – 173Sequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the MND1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3433. Eukaryota.
COG5124. LUCA.
GeneTreeiENSGT00490000043413.
HOGENOMiHOG000006783.
HOVERGENiHBG055698.
InParanoidiQ9BWT6.
OMAiDDGMVDT.
OrthoDBiEOG091G0Q02.
PhylomeDBiQ9BWT6.
TreeFamiTF314068.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005647. Mnd1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03962. Mnd1. 1 hit.
[Graphical view]
PIRSFiPIRSF026991. Mnd1. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BWT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV
60 70 80 90 100
LQSLVDDGMV DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH
110 120 130 140 150
ASLQKSIEKA KIGRCETEER TRLAKELSSL RDQREQLKAE VEKYKDCDPQ
160 170 180 190 200
VVEEIRQANK VAKEAANRWT DNIFAIKSWA KRKFGFEENK IDRTFGIPED

FDYID
Length:205
Mass (Da):23,753
Last modified:June 1, 2001 - v1
Checksum:i95B0B14068DA0B51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028916 mRNA. Translation: AAK26168.1.
AK312172 mRNA. Translation: BAG35106.1.
CH471056 Genomic DNA. Translation: EAX04964.1.
CH471056 Genomic DNA. Translation: EAX04965.1.
BC032142 mRNA. Translation: AAH32142.1.
CCDSiCCDS3782.1.
RefSeqiNP_115493.1. NM_032117.3.
UniGeneiHs.294088.

Genome annotation databases

EnsembliENST00000240488; ENSP00000240488; ENSG00000121211.
GeneIDi84057.
KEGGihsa:84057.
UCSCiuc003ink.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028916 mRNA. Translation: AAK26168.1.
AK312172 mRNA. Translation: BAG35106.1.
CH471056 Genomic DNA. Translation: EAX04964.1.
CH471056 Genomic DNA. Translation: EAX04965.1.
BC032142 mRNA. Translation: AAH32142.1.
CCDSiCCDS3782.1.
RefSeqiNP_115493.1. NM_032117.3.
UniGeneiHs.294088.

3D structure databases

ProteinModelPortaliQ9BWT6.
SMRiQ9BWT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123852. 7 interactors.
IntActiQ9BWT6. 2 interactors.
STRINGi9606.ENSP00000240488.

PTM databases

iPTMnetiQ9BWT6.
PhosphoSitePlusiQ9BWT6.

Polymorphism and mutation databases

BioMutaiMND1.
DMDMi74733462.

Proteomic databases

EPDiQ9BWT6.
MaxQBiQ9BWT6.
PaxDbiQ9BWT6.
PeptideAtlasiQ9BWT6.
PRIDEiQ9BWT6.

Protocols and materials databases

DNASUi84057.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240488; ENSP00000240488; ENSG00000121211.
GeneIDi84057.
KEGGihsa:84057.
UCSCiuc003ink.3. human.

Organism-specific databases

CTDi84057.
DisGeNETi84057.
GeneCardsiMND1.
HGNCiHGNC:24839. MND1.
HPAiHPA039941.
MIMi611422. gene.
neXtProtiNX_Q9BWT6.
OpenTargetsiENSG00000121211.
PharmGKBiPA143485544.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3433. Eukaryota.
COG5124. LUCA.
GeneTreeiENSGT00490000043413.
HOGENOMiHOG000006783.
HOVERGENiHBG055698.
InParanoidiQ9BWT6.
OMAiDDGMVDT.
OrthoDBiEOG091G0Q02.
PhylomeDBiQ9BWT6.
TreeFamiTF314068.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121211-MONOMER.
ReactomeiR-HSA-912446. Meiotic recombination.

Miscellaneous databases

GenomeRNAii84057.
PROiQ9BWT6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121211.
CleanExiHS_MND1.
ExpressionAtlasiQ9BWT6. baseline and differential.
GenevisibleiQ9BWT6. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005647. Mnd1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03962. Mnd1. 1 hit.
[Graphical view]
PIRSFiPIRSF026991. Mnd1. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMND1_HUMAN
AccessioniPrimary (citable) accession number: Q9BWT6
Secondary accession number(s): B2R5F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.