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Q9BWT6

- MND1_HUMAN

UniProt

Q9BWT6 - MND1_HUMAN

Protein

Meiotic nuclear division protein 1 homolog

Gene

MND1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis By similarity. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. meiotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    DNA recombination, Meiosis

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_27271. Meiotic recombination.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Meiotic nuclear division protein 1 homolog
    Gene namesi
    Name:MND1Imported
    Synonyms:GAJImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24839. MND1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485544.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 205204Meiotic nuclear division protein 1 homologPRO_0000318081Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9BWT6.
    PaxDbiQ9BWT6.
    PRIDEiQ9BWT6.

    PTM databases

    PhosphoSiteiQ9BWT6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BWT6.
    BgeeiQ9BWT6.
    CleanExiHS_MND1.
    GenevestigatoriQ9BWT6.

    Organism-specific databases

    HPAiHPA039941.

    Interactioni

    Subunit structurei

    Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi123852. 2 interactions.
    STRINGi9606.ENSP00000240488.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BWT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili84 – 17390Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MND1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5124.
    HOGENOMiHOG000006783.
    HOVERGENiHBG055698.
    InParanoidiQ9BWT6.
    OMAiDDGMVDT.
    OrthoDBiEOG75MVXQ.
    PhylomeDBiQ9BWT6.
    TreeFamiTF314068.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR005647. Mnd1.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF03962. Mnd1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF026991. Mnd1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BWT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV    50
    LQSLVDDGMV DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH 100
    ASLQKSIEKA KIGRCETEER TRLAKELSSL RDQREQLKAE VEKYKDCDPQ 150
    VVEEIRQANK VAKEAANRWT DNIFAIKSWA KRKFGFEENK IDRTFGIPED 200
    FDYID 205
    Length:205
    Mass (Da):23,753
    Last modified:June 1, 2001 - v1
    Checksum:i95B0B14068DA0B51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028916 mRNA. Translation: AAK26168.1.
    AK312172 mRNA. Translation: BAG35106.1.
    CH471056 Genomic DNA. Translation: EAX04964.1.
    CH471056 Genomic DNA. Translation: EAX04965.1.
    BC032142 mRNA. Translation: AAH32142.1.
    CCDSiCCDS3782.1.
    RefSeqiNP_115493.1. NM_032117.3.
    UniGeneiHs.294088.

    Genome annotation databases

    EnsembliENST00000240488; ENSP00000240488; ENSG00000121211.
    GeneIDi84057.
    KEGGihsa:84057.
    UCSCiuc003ink.2. human.

    Polymorphism databases

    DMDMi74733462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028916 mRNA. Translation: AAK26168.1 .
    AK312172 mRNA. Translation: BAG35106.1 .
    CH471056 Genomic DNA. Translation: EAX04964.1 .
    CH471056 Genomic DNA. Translation: EAX04965.1 .
    BC032142 mRNA. Translation: AAH32142.1 .
    CCDSi CCDS3782.1.
    RefSeqi NP_115493.1. NM_032117.3.
    UniGenei Hs.294088.

    3D structure databases

    ProteinModelPortali Q9BWT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123852. 2 interactions.
    STRINGi 9606.ENSP00000240488.

    PTM databases

    PhosphoSitei Q9BWT6.

    Polymorphism databases

    DMDMi 74733462.

    Proteomic databases

    MaxQBi Q9BWT6.
    PaxDbi Q9BWT6.
    PRIDEi Q9BWT6.

    Protocols and materials databases

    DNASUi 84057.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240488 ; ENSP00000240488 ; ENSG00000121211 .
    GeneIDi 84057.
    KEGGi hsa:84057.
    UCSCi uc003ink.2. human.

    Organism-specific databases

    CTDi 84057.
    GeneCardsi GC04P154265.
    HGNCi HGNC:24839. MND1.
    HPAi HPA039941.
    MIMi 611422. gene.
    neXtProti NX_Q9BWT6.
    PharmGKBi PA143485544.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5124.
    HOGENOMi HOG000006783.
    HOVERGENi HBG055698.
    InParanoidi Q9BWT6.
    OMAi DDGMVDT.
    OrthoDBi EOG75MVXQ.
    PhylomeDBi Q9BWT6.
    TreeFami TF314068.

    Enzyme and pathway databases

    Reactomei REACT_27271. Meiotic recombination.

    Miscellaneous databases

    GenomeRNAii 84057.
    NextBioi 73199.
    PROi Q9BWT6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BWT6.
    Bgeei Q9BWT6.
    CleanExi HS_MND1.
    Genevestigatori Q9BWT6.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR005647. Mnd1.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF03962. Mnd1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF026991. Mnd1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "GAJ protein isolated from Jurkat cells."
      Solis G., Hofer H.W.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LymphImported.
    5. "Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex."
      Enomoto R., Kinebuchi T., Sato M., Yagi H., Kurumizaka H., Yokoyama S.
      J. Biol. Chem. 281:5575-5581(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PSMC3IP.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMND1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWT6
    Secondary accession number(s): B2R5F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3