MND1

Functionⁱ

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.By similarity1 Publication

GO - Molecular functionⁱ

double-stranded DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

double-strand break repair Source: GO_Central
reciprocal meiotic recombination Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	DNA recombination, Meiosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-912446. Meiotic recombination.

Reactomeⁱ

R-HSA-912446. Meiotic recombination.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Meiotic nuclear division protein 1 homolog
Gene namesⁱ	Name:MND1Imported Synonyms:GAJImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000121211.7.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24839. MND1.
MIMⁱ	611422. gene.
neXtProtⁱ	NX_Q9BWT6.

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84057.
Open Targets More...OpenTargetsⁱ	ENSG00000121211.
PharmGKBⁱ	PA143485544.

Polymorphism and mutation databases

BioMutaⁱ	MND1.
DMDMⁱ	74733462.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000318081	2 – 205	Meiotic nuclear division protein 1 homologAdd BLAST		204

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9BWT6.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BWT6.
PaxDbⁱ	Q9BWT6.
PeptideAtlas More...PeptideAtlasⁱ	Q9BWT6.
PRIDEⁱ	Q9BWT6.

PTM databases

iPTMnetⁱ	Q9BWT6.
PhosphoSitePlusⁱ	Q9BWT6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000121211.
CleanExⁱ	HS_MND1.
ExpressionAtlasⁱ	Q9BWT6. baseline and differential.
Genevisibleⁱ	Q9BWT6. HS.

Interactionⁱ

Subunit structureⁱ

Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA.By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	123852. 8 interactors.
CORUMⁱ	Q9BWT6.
IntActⁱ	Q9BWT6. 2 interactors.
STRINGⁱ	9606.ENSP00000240488.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BWT6.
SMRⁱ	Q9BWT6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	84 – 173	Sequence analysisAdd BLAST		90

Sequence similaritiesⁱ

Belongs to the MND1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3433. Eukaryota. COG5124. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00490000043413.
HOGENOMⁱ	HOG000006783.
HOVERGENⁱ	HBG055698.
InParanoidⁱ	Q9BWT6.
OMAⁱ	KIGRHET.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q02.
PhylomeDBⁱ	Q9BWT6.
TreeFamⁱ	TF314068.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005647. Mnd1. IPR036390. WH_DNA-bd_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03962. Mnd1. 1 hit.
PIRSFⁱ	PIRSF026991. Mnd1. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9BWT6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV 
        60         70         80         90        100
LQSLVDDGMV DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH 
       110        120        130        140        150
ASLQKSIEKA KIGRCETEER TRLAKELSSL RDQREQLKAE VEKYKDCDPQ 
       160        170        180        190        200
VVEEIRQANK VAKEAANRWT DNIFAIKSWA KRKFGFEENK IDRTFGIPED 

FDYID

Length:205

Mass (Da):23,753

Last modified:June 1, 2001 - v1

Checksum:ⁱ95B0B14068DA0B51

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028916 mRNA. Translation: AAK26168.1. AK312172 mRNA. Translation: BAG35106.1. CH471056 Genomic DNA. Translation: EAX04964.1. CH471056 Genomic DNA. Translation: EAX04965.1. BC032142 mRNA. Translation: AAH32142.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3782.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_115493.1. NM_032117.3.
UniGeneⁱ	Hs.294088.

Genome annotation databases

Ensemblⁱ	ENST00000240488; ENSP00000240488; ENSG00000121211.
GeneIDⁱ	84057.
KEGGⁱ	hsa:84057.
UCSC genome browser More...UCSCⁱ	uc003ink.3. human.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9BWT6	H2QQA6	Pan troglodytes (Chimpanzee)	205	UniRef100_Q9BWT6	Cluster: Meiotic nuclear division protein 1 homolog	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9BWT6	H2QQA6 A0A1D5QEI4 A0A2K5WIW7 A0A2K6EAR8 A0A2K6RR66 A0A2I3M002 UPI0005ABBA20 UPI0009047B25 UPI000333C447 F1PV98 +59	Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Papio anubis (Olive baboon) Panthera tigris altaica (Siberian tiger) Panthera pardus (Leopard) (Felis pardus) Octodon degus (Degu) (Sciurus degus) Canis lupus familiaris (Dog) (Canis familiaris) And more	205	UniRef90_Q9BWT6	Cluster: Meiotic nuclear division protein 1 homolog	70

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9BWT6	H2QQA6 A0A1D5QEI4 A0A2K5WIW7 A0A2K6EAR8 A0A2K6RR66 A0A2I3M002 UPI0005ABBA20 UPI0009047B25 UPI000328DF68 UPI0005BAC98A +201	Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Papio anubis (Olive baboon) Panthera tigris altaica (Siberian tiger) Panthera pardus (Leopard) (Felis pardus) Dasypus novemcinctus (Nine-banded armadillo) Pteropus vampyrus (Large flying fox) And more	205	UniRef50_Q9BWT6	Cluster: Meiotic nuclear division protein 1 homolog	212

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028916 mRNA. Translation: AAK26168.1. AK312172 mRNA. Translation: BAG35106.1. CH471056 Genomic DNA. Translation: EAX04964.1. CH471056 Genomic DNA. Translation: EAX04965.1. BC032142 mRNA. Translation: AAH32142.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3782.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_115493.1. NM_032117.3.
UniGeneⁱ	Hs.294088.

3D structure databases

ProteinModelPortalⁱ	Q9BWT6.
SMRⁱ	Q9BWT6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123852. 8 interactors.
CORUMⁱ	Q9BWT6.
IntActⁱ	Q9BWT6. 2 interactors.
STRINGⁱ	9606.ENSP00000240488.

PTM databases

iPTMnetⁱ	Q9BWT6.
PhosphoSitePlusⁱ	Q9BWT6.

Polymorphism and mutation databases

BioMutaⁱ	MND1.
DMDMⁱ	74733462.

Proteomic databases

EPDⁱ	Q9BWT6.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BWT6.
PaxDbⁱ	Q9BWT6.
PeptideAtlas More...PeptideAtlasⁱ	Q9BWT6.
PRIDEⁱ	Q9BWT6.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84057.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000240488; ENSP00000240488; ENSG00000121211.
GeneIDⁱ	84057.
KEGGⁱ	hsa:84057.
UCSC genome browser More...UCSCⁱ	uc003ink.3. human.

Organism-specific databases

CTDⁱ	84057.
DisGeNET More...DisGeNETⁱ	84057.
EuPathDBⁱ	HostDB:ENSG00000121211.7.
GeneCardsⁱ	MND1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24839. MND1.
MIMⁱ	611422. gene.
neXtProtⁱ	NX_Q9BWT6.
Open Targets More...OpenTargetsⁱ	ENSG00000121211.
PharmGKBⁱ	PA143485544.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3433. Eukaryota. COG5124. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00490000043413.
HOGENOMⁱ	HOG000006783.
HOVERGENⁱ	HBG055698.
InParanoidⁱ	Q9BWT6.
OMAⁱ	KIGRHET.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q02.
PhylomeDBⁱ	Q9BWT6.
TreeFamⁱ	TF314068.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-912446. Meiotic recombination.

Reactomeⁱ

R-HSA-912446. Meiotic recombination.

Miscellaneous databases

ChiTaRSⁱ	MND1. human.
GenomeRNAiⁱ	84057.
Protein Ontology More...PROⁱ	PR:Q9BWT6.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000121211.
CleanExⁱ	HS_MND1.
ExpressionAtlasⁱ	Q9BWT6. baseline and differential.
Genevisibleⁱ	Q9BWT6. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005647. Mnd1. IPR036390. WH_DNA-bd_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03962. Mnd1. 1 hit.
PIRSFⁱ	PIRSF026991. Mnd1. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MND1_HUMAN
Accessionⁱ	Q9BWT6Primary (citable) accession number: Q9BWT6 Secondary accession number(s): B2R5F9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	June 1, 2001
	Last modified:	February 28, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BWT6 (MND1_HUMAN)

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Meiotic nuclear division protein 1 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ