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Q9BWT6

- MND1_HUMAN

UniProt

Q9BWT6 - MND1_HUMAN

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Protein

Meiotic nuclear division protein 1 homolog

Gene

MND1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.By similarity1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. meiotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA recombination, Meiosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_27271. Meiotic recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic nuclear division protein 1 homolog
Gene namesi
Name:MND1Imported
Synonyms:GAJImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:24839. MND1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 205204Meiotic nuclear division protein 1 homologPRO_0000318081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BWT6.
PaxDbiQ9BWT6.
PRIDEiQ9BWT6.

PTM databases

PhosphoSiteiQ9BWT6.

Expressioni

Gene expression databases

BgeeiQ9BWT6.
CleanExiHS_MND1.
ExpressionAtlasiQ9BWT6. baseline and differential.
GenevestigatoriQ9BWT6.

Organism-specific databases

HPAiHPA039941.

Interactioni

Subunit structurei

Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA.By similarity1 Publication

Protein-protein interaction databases

BioGridi123852. 2 interactions.
STRINGi9606.ENSP00000240488.

Structurei

3D structure databases

ProteinModelPortaliQ9BWT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili84 – 17390Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the MND1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5124.
GeneTreeiENSGT00490000043413.
HOGENOMiHOG000006783.
HOVERGENiHBG055698.
InParanoidiQ9BWT6.
OMAiDDGMVDT.
OrthoDBiEOG75MVXQ.
PhylomeDBiQ9BWT6.
TreeFamiTF314068.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005647. Mnd1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03962. Mnd1. 1 hit.
[Graphical view]
PIRSFiPIRSF026991. Mnd1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BWT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV
60 70 80 90 100
LQSLVDDGMV DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH
110 120 130 140 150
ASLQKSIEKA KIGRCETEER TRLAKELSSL RDQREQLKAE VEKYKDCDPQ
160 170 180 190 200
VVEEIRQANK VAKEAANRWT DNIFAIKSWA KRKFGFEENK IDRTFGIPED

FDYID
Length:205
Mass (Da):23,753
Last modified:June 1, 2001 - v1
Checksum:i95B0B14068DA0B51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028916 mRNA. Translation: AAK26168.1.
AK312172 mRNA. Translation: BAG35106.1.
CH471056 Genomic DNA. Translation: EAX04964.1.
CH471056 Genomic DNA. Translation: EAX04965.1.
BC032142 mRNA. Translation: AAH32142.1.
CCDSiCCDS3782.1.
RefSeqiNP_115493.1. NM_032117.3.
UniGeneiHs.294088.

Genome annotation databases

EnsembliENST00000240488; ENSP00000240488; ENSG00000121211.
GeneIDi84057.
KEGGihsa:84057.
UCSCiuc003ink.2. human.

Polymorphism databases

DMDMi74733462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028916 mRNA. Translation: AAK26168.1 .
AK312172 mRNA. Translation: BAG35106.1 .
CH471056 Genomic DNA. Translation: EAX04964.1 .
CH471056 Genomic DNA. Translation: EAX04965.1 .
BC032142 mRNA. Translation: AAH32142.1 .
CCDSi CCDS3782.1.
RefSeqi NP_115493.1. NM_032117.3.
UniGenei Hs.294088.

3D structure databases

ProteinModelPortali Q9BWT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123852. 2 interactions.
STRINGi 9606.ENSP00000240488.

PTM databases

PhosphoSitei Q9BWT6.

Polymorphism databases

DMDMi 74733462.

Proteomic databases

MaxQBi Q9BWT6.
PaxDbi Q9BWT6.
PRIDEi Q9BWT6.

Protocols and materials databases

DNASUi 84057.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240488 ; ENSP00000240488 ; ENSG00000121211 .
GeneIDi 84057.
KEGGi hsa:84057.
UCSCi uc003ink.2. human.

Organism-specific databases

CTDi 84057.
GeneCardsi GC04P154265.
HGNCi HGNC:24839. MND1.
HPAi HPA039941.
MIMi 611422. gene.
neXtProti NX_Q9BWT6.
PharmGKBi PA143485544.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5124.
GeneTreei ENSGT00490000043413.
HOGENOMi HOG000006783.
HOVERGENi HBG055698.
InParanoidi Q9BWT6.
OMAi DDGMVDT.
OrthoDBi EOG75MVXQ.
PhylomeDBi Q9BWT6.
TreeFami TF314068.

Enzyme and pathway databases

Reactomei REACT_27271. Meiotic recombination.

Miscellaneous databases

GenomeRNAii 84057.
NextBioi 73199.
PROi Q9BWT6.
SOURCEi Search...

Gene expression databases

Bgeei Q9BWT6.
CleanExi HS_MND1.
ExpressionAtlasi Q9BWT6. baseline and differential.
Genevestigatori Q9BWT6.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR005647. Mnd1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF03962. Mnd1. 1 hit.
[Graphical view ]
PIRSFi PIRSF026991. Mnd1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GAJ protein isolated from Jurkat cells."
    Solis G., Hofer H.W.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LymphImported.
  5. "Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex."
    Enomoto R., Kinebuchi T., Sato M., Yagi H., Kurumizaka H., Yokoyama S.
    J. Biol. Chem. 281:5575-5581(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PSMC3IP.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMND1_HUMAN
AccessioniPrimary (citable) accession number: Q9BWT6
Secondary accession number(s): B2R5F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3