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Q9BWT6 (MND1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Meiotic nuclear division protein 1 homolog
Gene names
Name:MND1
Synonyms:GAJ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis By similarity. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Ref.5 UniProtKB Q8K396

Subunit structure

Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA. Ref.5 UniProtKB Q8K396

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the MND1 family.

Ontologies

Keywords
   Biological processDNA recombination
Meiosis
   Cellular componentNucleus
   DomainCoiled coil
   LigandDNA-binding
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA recombination

Inferred from electronic annotation. Source: UniProtKB-KW

meiotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 205204Meiotic nuclear division protein 1 homolog
PRO_0000318081

Regions

Coiled coil84 – 17390 Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q9BWT6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 95B0B14068DA0B51

FASTA20523,753
        10         20         30         40         50         60 
MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV LQSLVDDGMV 

        70         80         90        100        110        120 
DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH ASLQKSIEKA KIGRCETEER 

       130        140        150        160        170        180 
TRLAKELSSL RDQREQLKAE VEKYKDCDPQ VVEEIRQANK VAKEAANRWT DNIFAIKSWA 

       190        200 
KRKFGFEENK IDRTFGIPED FDYID 

« Hide

References

« Hide 'large scale' references
[1]"GAJ protein isolated from Jurkat cells."
Solis G., Hofer H.W.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[5]"Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex."
Enomoto R., Kinebuchi T., Sato M., Yagi H., Kurumizaka H., Yokoyama S.
J. Biol. Chem. 281:5575-5581(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PSMC3IP.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY028916 mRNA. Translation: AAK26168.1.
AK312172 mRNA. Translation: BAG35106.1.
CH471056 Genomic DNA. Translation: EAX04964.1.
CH471056 Genomic DNA. Translation: EAX04965.1.
BC032142 mRNA. Translation: AAH32142.1.
CCDSCCDS3782.1.
RefSeqNP_115493.1. NM_032117.3.
UniGeneHs.294088.

3D structure databases

ProteinModelPortalQ9BWT6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123852. 2 interactions.
STRING9606.ENSP00000240488.

PTM databases

PhosphoSiteQ9BWT6.

Polymorphism databases

DMDM74733462.

Proteomic databases

MaxQBQ9BWT6.
PaxDbQ9BWT6.
PRIDEQ9BWT6.

Protocols and materials databases

DNASU84057.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000240488; ENSP00000240488; ENSG00000121211.
GeneID84057.
KEGGhsa:84057.
UCSCuc003ink.2. human.

Organism-specific databases

CTD84057.
GeneCardsGC04P154265.
HGNCHGNC:24839. MND1.
HPAHPA039941.
MIM611422. gene.
neXtProtNX_Q9BWT6.
PharmGKBPA143485544.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5124.
HOGENOMHOG000006783.
HOVERGENHBG055698.
InParanoidQ9BWT6.
OMADDGMVDT.
OrthoDBEOG75MVXQ.
PhylomeDBQ9BWT6.
TreeFamTF314068.

Gene expression databases

ArrayExpressQ9BWT6.
BgeeQ9BWT6.
CleanExHS_MND1.
GenevestigatorQ9BWT6.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR005647. Mnd1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF03962. Mnd1. 1 hit.
[Graphical view]
PIRSFPIRSF026991. Mnd1. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi84057.
NextBio73199.
PROQ9BWT6.
SOURCESearch...

Entry information

Entry nameMND1_HUMAN
AccessionPrimary (citable) accession number: Q9BWT6
Secondary accession number(s): B2R5F9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM