Q9BWT6 (MND1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Meiotic nuclear division protein 1 homolog

Gene names

Name:	MND1
Synonyms:	GAJ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis By similarity. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Ref.5 UniProtKB Q8K396
Subunit structure	Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA. Ref.5 UniProtKB Q8K396
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the MND1 family.

Ontologies

Keywords
Biological process	DNA recombination Meiosis
Cellular component	Nucleus
Domain	Coiled coil
Ligand	DNA-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW meiotic nuclear division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.7
	Chain	2 – 205	204	Meiotic nuclear division protein 1 homolog		PRO_0000318081
Regions
	Coiled coil	84 – 173	90	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9BWT6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 95B0B14068DA0B51	FASTA	205	23,753
	10 20 30 40 50 60 MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV LQSLVDDGMV 70 80 90 100 110 120 DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH ASLQKSIEKA KIGRCETEER 130 140 150 160 170 180 TRLAKELSSL RDQREQLKAE VEKYKDCDPQ VVEEIRQANK VAKEAANRWT DNIFAIKSWA 190 200 KRKFGFEENK IDRTFGIPED FDYID

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GAJ protein isolated from Jurkat cells." Solis G., Hofer H.W. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[5]	"Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex." Enomoto R., Kinebuchi T., Sato M., Yagi H., Kurumizaka H., Yokoyama S. J. Biol. Chem. 281:5575-5581(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PSMC3IP.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY028916 mRNA. Translation: AAK26168.1. AK312172 mRNA. Translation: BAG35106.1. CH471056 Genomic DNA. Translation: EAX04964.1. CH471056 Genomic DNA. Translation: EAX04965.1. BC032142 mRNA. Translation: AAH32142.1.
RefSeq	NP_115493.1. NM_032117.3.
UniGene	Hs.294088.
3D structure databases
ProteinModelPortal	Q9BWT6.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	123852. 2 interactions.
STRING	9606.ENSP00000240488.
PTM databases
PhosphoSite	Q9BWT6.
Polymorphism databases
DMDM	74733462.
Proteomic databases
PaxDb	Q9BWT6.
PRIDE	Q9BWT6.
Protocols and materials databases
DNASU	84057.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240488; ENSP00000240488; ENSG00000121211.
GeneID	84057.
KEGG	hsa:84057.
UCSC	uc003ink.2. human.
Organism-specific databases
CTD	84057.
GeneCards	GC04P154265.
HGNC	HGNC:24839. MND1.
HPA	HPA039941.
MIM	611422. gene.
neXtProt	NX_Q9BWT6.
PharmGKB	PA143485544.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5124.
HOGENOM	HOG000006783.
HOVERGEN	HBG055698.
InParanoid	Q9BWT6.
OMA	DDGMVDT.
OrthoDB	EOG75MVXQ.
PhylomeDB	Q9BWT6.
TreeFam	TF314068.
Gene expression databases
ArrayExpress	Q9BWT6.
Bgee	Q9BWT6.
CleanEx	HS_MND1.
Genevestigator	Q9BWT6.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR005647. Mnd1. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF03962. Mnd1. 1 hit. [Graphical view]
PIRSF	PIRSF026991. Mnd1. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	84057.
NextBio	73199.
PRO	Q9BWT6.
SOURCE	Search...

Entry information

Entry name

MND1_HUMAN

Accession

Primary (citable) accession number: Q9BWT6
Secondary accession number(s): B2R5F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 1, 2001
Last modified:	March 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.