UniProtKB - Q9BWT6 (MND1_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Meiotic nuclear division protein 1 homolog
Gene
MND1
Organism
Homo sapiens (Human)
Status
Functioni
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.By similarity1 Publication
GO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
GO - Biological processi
- double-strand break repair Source: GO_Central
- reciprocal meiotic recombination Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA recombination, Meiosis |
Enzyme and pathway databases
Reactomei | R-HSA-912446. Meiotic recombination. |
Names & Taxonomyi
Protein namesi | Recommended name: Meiotic nuclear division protein 1 homolog |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000121211.7. |
HGNCi | HGNC:24839. MND1. |
MIMi | 611422. gene. |
neXtProti | NX_Q9BWT6. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84057. |
OpenTargetsi | ENSG00000121211. |
PharmGKBi | PA143485544. |
Polymorphism and mutation databases
BioMutai | MND1. |
DMDMi | 74733462. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000318081 | 2 – 205 | Meiotic nuclear division protein 1 homologAdd BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9BWT6. |
MaxQBi | Q9BWT6. |
PaxDbi | Q9BWT6. |
PeptideAtlasi | Q9BWT6. |
PRIDEi | Q9BWT6. |
PTM databases
iPTMneti | Q9BWT6. |
PhosphoSitePlusi | Q9BWT6. |
Expressioni
Gene expression databases
Bgeei | ENSG00000121211. |
CleanExi | HS_MND1. |
ExpressionAtlasi | Q9BWT6. baseline and differential. |
Genevisiblei | Q9BWT6. HS. |
Interactioni
Subunit structurei
Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA.By similarity1 Publication
Protein-protein interaction databases
BioGridi | 123852. 8 interactors. |
CORUMi | Q9BWT6. |
IntActi | Q9BWT6. 2 interactors. |
STRINGi | 9606.ENSP00000240488. |
Structurei
3D structure databases
ProteinModelPortali | Q9BWT6. |
SMRi | Q9BWT6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 84 – 173 | Sequence analysisAdd BLAST | 90 |
Sequence similaritiesi
Belongs to the MND1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3433. Eukaryota. COG5124. LUCA. |
GeneTreei | ENSGT00490000043413. |
HOGENOMi | HOG000006783. |
HOVERGENi | HBG055698. |
InParanoidi | Q9BWT6. |
OMAi | KIGRHET. |
OrthoDBi | EOG091G0Q02. |
PhylomeDBi | Q9BWT6. |
TreeFami | TF314068. |
Family and domain databases
InterProi | View protein in InterPro IPR005647. Mnd1. IPR036390. WH_DNA-bd_sf. |
Pfami | View protein in Pfam PF03962. Mnd1. 1 hit. |
PIRSFi | PIRSF026991. Mnd1. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9BWT6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV
60 70 80 90 100
LQSLVDDGMV DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH
110 120 130 140 150
ASLQKSIEKA KIGRCETEER TRLAKELSSL RDQREQLKAE VEKYKDCDPQ
160 170 180 190 200
VVEEIRQANK VAKEAANRWT DNIFAIKSWA KRKFGFEENK IDRTFGIPED
FDYID
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028916 mRNA. Translation: AAK26168.1. AK312172 mRNA. Translation: BAG35106.1. CH471056 Genomic DNA. Translation: EAX04964.1. CH471056 Genomic DNA. Translation: EAX04965.1. BC032142 mRNA. Translation: AAH32142.1. |
CCDSi | CCDS3782.1. |
RefSeqi | NP_115493.1. NM_032117.3. |
UniGenei | Hs.294088. |
Genome annotation databases
Ensembli | ENST00000240488; ENSP00000240488; ENSG00000121211. |
GeneIDi | 84057. |
KEGGi | hsa:84057. |
UCSCi | uc003ink.3. human. |
Similar proteinsi
Entry informationi
Entry namei | MND1_HUMAN | |
Accessioni | Q9BWT6Primary (citable) accession number: Q9BWT6 Secondary accession number(s): B2R5F9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |