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Q9BWT3

- PAPOG_HUMAN

UniProt

Q9BWT3 - PAPOG_HUMAN

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Protein

Poly(A) polymerase gamma

Gene

PAPOLG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.2 Publications

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).2 Publications

Cofactori

Binds 2 magnesium ions. Also active with manganese (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081ATPBy similarity
Metal bindingi112 – 1121Magnesium 1; catalytic
Metal bindingi112 – 1121Magnesium 2; catalyticBy similarity
Metal bindingi114 – 1141Magnesium 1; catalytic
Metal bindingi114 – 1141Magnesium 2; catalyticBy similarity
Sitei152 – 1521Interaction with RNABy similarity
Sitei157 – 1571Interaction with RNABy similarity
Metal bindingi166 – 1661Magnesium 2; catalyticBy similarity
Binding sitei166 – 1661ATPBy similarity
Binding sitei227 – 2271ATP1 Publication
Binding sitei236 – 2361ATP1 Publication
Sitei327 – 3271Interaction with RNABy similarity
Sitei398 – 3981Interaction with RNABy similarity
Sitei532 – 5321Interaction with RNABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi99 – 1013ATP1 Publication
Nucleotide bindingi112 – 1143ATP1 Publication
Nucleotide bindingi245 – 2462ATP1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB
  3. polynucleotide adenylyltransferase activity Source: UniProtKB
  4. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA polyadenylation Source: RefGenome
  2. RNA polyadenylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase gamma (EC:2.7.7.19)
Short name:
PAP-gamma
Alternative name(s):
Neo-poly(A) polymerase
Short name:
Neo-PAP
Polynucleotide adenylyltransferase gamma
SRP RNA 3'-adenylating enzyme
Gene namesi
Name:PAPOLG
Synonyms:PAP2, PAPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14982. PAPOLG.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. membrane Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Poly(A) polymerase gammaPRO_0000051624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N6-acetyllysine1 Publication
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei648 – 6481Phosphoserine1 Publication
Modified residuei654 – 6541Phosphothreonine1 Publication
Modified residuei684 – 6841Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BWT3.
PaxDbiQ9BWT3.
PRIDEiQ9BWT3.

PTM databases

PhosphoSiteiQ9BWT3.

Expressioni

Tissue specificityi

Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors.1 Publication

Gene expression databases

BgeeiQ9BWT3.
CleanExiHS_PAPOLG.
ExpressionAtlasiQ9BWT3. baseline and differential.
GenevestigatoriQ9BWT3.

Organism-specific databases

HPAiCAB017795.
HPA035349.
HPA035350.

Interactioni

Protein-protein interaction databases

BioGridi122338. 6 interactions.
STRINGi9606.ENSP00000238714.

Structurei

Secondary structure

1
736
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 224
Helixi32 – 4514
Helixi46 – 483
Helixi54 – 7825
Turni79 – 835
Helixi86 – 894
Beta strandi95 – 995
Helixi100 – 1045
Beta strandi113 – 1197
Helixi125 – 13814
Beta strandi142 – 1487
Beta strandi150 – 1534
Beta strandi155 – 1606
Beta strandi163 – 1719
Beta strandi173 – 1753
Helixi186 – 1894
Helixi194 – 21118
Helixi216 – 23217
Turni238 – 2414
Helixi245 – 25814
Helixi264 – 27714
Turni301 – 3033
Helixi307 – 3093
Beta strandi318 – 3203
Helixi330 – 35021
Turni351 – 3533
Helixi357 – 3615
Turni366 – 3683
Beta strandi371 – 38212
Helixi383 – 39412
Helixi397 – 40610
Beta strandi410 – 42011
Beta strandi432 – 44211
Helixi456 – 47217
Beta strandi481 – 4899
Helixi492 – 4943

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LT6X-ray2.79A/B1-508[»]
ProteinModelPortaliQ9BWT3.
SMRiQ9BWT3. Positions 17-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the poly(A) polymerase family.Curated

Phylogenomic databases

eggNOGiCOG5186.
GeneTreeiENSGT00390000017928.
HOGENOMiHOG000204376.
HOVERGENiHBG053502.
InParanoidiQ9BWT3.
KOiK14376.
OMAiGECMPIP.
OrthoDBiEOG7XH6PT.
PhylomeDBiQ9BWT3.
TreeFamiTF300842.

Family and domain databases

Gene3Di3.30.70.590. 1 hit.
InterProiIPR002934. Nucleotidyltransferase.
IPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMiSSF55003. SSF55003. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BWT3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEMSANTVL DSQRQQKHYG ITSPISLASP KEIDHIYTQK LIDAMKPFGV
60 70 80 90 100
FEDEEELNHR LVVLGKLNNL VKEWISDVSE SKNLPPSVVA TVGGKIFTFG
110 120 130 140 150
SYRLGVHTKG ADIDALCVAP RHVERSDFFQ SFFEKLKHQD GIRNLRAVED
160 170 180 190 200
AFVPVIKFEF DGIEIDLVFA RLAIQTISDN LDLRDDSRLR SLDIRCIRSL
210 220 230 240 250
NGCRVTDEIL HLVPNKETFR LTLRAVKLWA KRRGIYSNML GFLGGVSWAM
260 270 280 290 300
LVARTCQLYP NAAASTLVHK FFLVFSKWEW PNPVLLKQPE ESNLNLPVWD
310 320 330 340 350
PRVNPSDRYH LMPIITPAYP QQNSTYNVST STRTVMVEEF KQGLAVTDEI
360 370 380 390 400
LQGKSDWSKL LEPPNFFQKY RHYIVLTASA STEENHLEWV GLVESKIRVL
410 420 430 440 450
VGNLERNEFI TLAHVNPQSF PGNKEHHKDN NYVSMWFLGI IFRRVENAES
460 470 480 490 500
VNIDLTYDIQ SFTDTVYRQA NNINMLKEGM KIEATHVKKK QLHHYLPAEI
510 520 530 540 550
LQKKKKQSLS DVNRSSGGLQ SKRLSLDSSC LDSSRDTDNG TPFNSPASKS
560 570 580 590 600
DSPSVGETER NSAEPAAVIV EKPLSVPPAQ GLSIPVIGAK VDSTVKTVSP
610 620 630 640 650
PTVCTIPTVV GRNVIPRITT PHNPAQGQPH LNGMSNITKT VTPKRSHSPS
660 670 680 690 700
IDGTPKRLKD VEKFIRLEST FKDPRTAEER KRKSVDAIGG ESMPIPTIDT
710 720 730
SRKKRLPSKE LPDSSSPVPA NNIRVIKNSI RLTLNR
Length:736
Mass (Da):82,803
Last modified:October 17, 2006 - v2
Checksum:iB0F6F217AA36E552
GO
Isoform 2 (identifier: Q9BWT3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     664-685: Missing.

Note: No experimental confirmation available.

Show »
Length:714
Mass (Da):80,127
Checksum:i0467FCF53C3CE806
GO

Sequence cautioni

The sequence BAB14604.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311K → E in AAK31791. (PubMed:11287430)Curated
Sequence conflicti289 – 2891P → S in AAK31791. (PubMed:11287430)Curated
Sequence conflicti619 – 6191T → I in AAK31791. (PubMed:11287430)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei664 – 68522Missing in isoform 2. 1 PublicationVSP_054379Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY029162 mRNA. Translation: AAK31791.1.
AF312211 mRNA. Translation: AAK83701.1.
AJ308101 mRNA. Translation: CAC59751.1.
AK021867 mRNA. Translation: BAB13919.1.
AK023544 mRNA. Translation: BAB14604.1. Different initiation.
AK314663 mRNA. Translation: BAG37221.1.
AC011245 Genomic DNA. No translation available.
AC012498 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00034.1.
BC111701 mRNA. Translation: AAI11702.1.
BC113747 mRNA. Translation: AAI13748.1.
AB209304 mRNA. Translation: BAD92541.1.
CCDSiCCDS1863.1. [Q9BWT3-1]
RefSeqiNP_075045.2. NM_022894.3. [Q9BWT3-1]
XP_005264557.1. XM_005264500.1. [Q9BWT3-2]
UniGeneiHs.387471.

Genome annotation databases

EnsembliENST00000238714; ENSP00000238714; ENSG00000115421. [Q9BWT3-1]
ENST00000412217; ENSP00000405570; ENSG00000115421.
GeneIDi64895.
KEGGihsa:64895.
UCSCiuc002sai.3. human. [Q9BWT3-1]

Polymorphism databases

DMDMi116242699.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY029162 mRNA. Translation: AAK31791.1 .
AF312211 mRNA. Translation: AAK83701.1 .
AJ308101 mRNA. Translation: CAC59751.1 .
AK021867 mRNA. Translation: BAB13919.1 .
AK023544 mRNA. Translation: BAB14604.1 . Different initiation.
AK314663 mRNA. Translation: BAG37221.1 .
AC011245 Genomic DNA. No translation available.
AC012498 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00034.1 .
BC111701 mRNA. Translation: AAI11702.1 .
BC113747 mRNA. Translation: AAI13748.1 .
AB209304 mRNA. Translation: BAD92541.1 .
CCDSi CCDS1863.1. [Q9BWT3-1 ]
RefSeqi NP_075045.2. NM_022894.3. [Q9BWT3-1 ]
XP_005264557.1. XM_005264500.1. [Q9BWT3-2 ]
UniGenei Hs.387471.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4LT6 X-ray 2.79 A/B 1-508 [» ]
ProteinModelPortali Q9BWT3.
SMRi Q9BWT3. Positions 17-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122338. 6 interactions.
STRINGi 9606.ENSP00000238714.

PTM databases

PhosphoSitei Q9BWT3.

Polymorphism databases

DMDMi 116242699.

Proteomic databases

MaxQBi Q9BWT3.
PaxDbi Q9BWT3.
PRIDEi Q9BWT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000238714 ; ENSP00000238714 ; ENSG00000115421 . [Q9BWT3-1 ]
ENST00000412217 ; ENSP00000405570 ; ENSG00000115421 .
GeneIDi 64895.
KEGGi hsa:64895.
UCSCi uc002sai.3. human. [Q9BWT3-1 ]

Organism-specific databases

CTDi 64895.
GeneCardsi GC02P060983.
HGNCi HGNC:14982. PAPOLG.
HPAi CAB017795.
HPA035349.
HPA035350.
neXtProti NX_Q9BWT3.
PharmGKBi PA32934.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5186.
GeneTreei ENSGT00390000017928.
HOGENOMi HOG000204376.
HOVERGENi HBG053502.
InParanoidi Q9BWT3.
KOi K14376.
OMAi GECMPIP.
OrthoDBi EOG7XH6PT.
PhylomeDBi Q9BWT3.
TreeFami TF300842.

Miscellaneous databases

GeneWikii PAPOLG.
GenomeRNAii 64895.
NextBioi 67037.
PROi Q9BWT3.

Gene expression databases

Bgeei Q9BWT3.
CleanExi HS_PAPOLG.
ExpressionAtlasi Q9BWT3. baseline and differential.
Genevestigatori Q9BWT3.

Family and domain databases

Gene3Di 3.30.70.590. 1 hit.
InterProi IPR002934. Nucleotidyltransferase.
IPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view ]
Pfami PF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view ]
PIRSFi PIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMi SSF55003. SSF55003. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme."
    Perumal K., Sinha K., Henning D., Reddy R.
    J. Biol. Chem. 276:21791-21796(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  2. "Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors."
    Topalian S.L., Kaneko S., Gonzales M.I., Bond G.L., Ward Y., Manley J.L.
    Mol. Cell. Biol. 21:5614-5623(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Melanoma.
  3. "A novel nuclear human poly(A) polymerase, PAPg."
    Kyriakopoulou C.B., Virtanen A.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Cervix carcinoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo and Placenta.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-736 (ISOFORM 2).
    Tissue: Brain.
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-648; THR-654 AND SER-684, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases."
    Yang Q., Nausch L., Martin G., Keller W., Doublie S.
    J. Mol. Biol. 426:43-50(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.79 ANGSTROMS) OF 1-508 IN COMPLEX WITH ATP AND CALCIUM IONS.

Entry informationi

Entry nameiPAPOG_HUMAN
AccessioniPrimary (citable) accession number: Q9BWT3
Secondary accession number(s): B2RBH4
, Q59G05, Q969N1, Q9H8L2, Q9HAD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3