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Q9BWT3

- PAPOG_HUMAN

UniProt

Q9BWT3 - PAPOG_HUMAN

Protein

Poly(A) polymerase gamma

Gene

PAPOLG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.2 Publications

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).2 Publications

    Cofactori

    Binds 2 magnesium ions. Also active with manganese By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei108 – 1081ATPBy similarity
    Metal bindingi112 – 1121Magnesium 1; catalytic
    Metal bindingi112 – 1121Magnesium 2; catalyticBy similarity
    Metal bindingi114 – 1141Magnesium 1; catalytic
    Metal bindingi114 – 1141Magnesium 2; catalyticBy similarity
    Sitei152 – 1521Interaction with RNABy similarity
    Sitei157 – 1571Interaction with RNABy similarity
    Metal bindingi166 – 1661Magnesium 2; catalyticBy similarity
    Binding sitei166 – 1661ATPBy similarity
    Binding sitei227 – 2271ATP1 Publication
    Binding sitei236 – 2361ATP1 Publication
    Sitei327 – 3271Interaction with RNABy similarity
    Sitei398 – 3981Interaction with RNABy similarity
    Sitei532 – 5321Interaction with RNABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi99 – 1013ATP1 Publication
    Nucleotide bindingi112 – 1143ATP1 Publication
    Nucleotide bindingi245 – 2462ATP1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB
    3. polynucleotide adenylyltransferase activity Source: UniProtKB
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA polyadenylation Source: RefGenome
    2. RNA polyadenylation Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase gamma (EC:2.7.7.19)
    Short name:
    PAP-gamma
    Alternative name(s):
    Neo-poly(A) polymerase
    Short name:
    Neo-PAP
    Polynucleotide adenylyltransferase gamma
    SRP RNA 3'-adenylating enzyme
    Gene namesi
    Name:PAPOLG
    Synonyms:PAP2, PAPG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:14982. PAPOLG.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. membrane Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32934.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 736736Poly(A) polymerase gammaPRO_0000051624Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N6-acetyllysine1 Publication
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei648 – 6481Phosphoserine1 Publication
    Modified residuei654 – 6541Phosphothreonine1 Publication
    Modified residuei684 – 6841Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BWT3.
    PaxDbiQ9BWT3.
    PRIDEiQ9BWT3.

    PTM databases

    PhosphoSiteiQ9BWT3.

    Expressioni

    Tissue specificityi

    Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors.1 Publication

    Gene expression databases

    ArrayExpressiQ9BWT3.
    BgeeiQ9BWT3.
    CleanExiHS_PAPOLG.
    GenevestigatoriQ9BWT3.

    Organism-specific databases

    HPAiCAB017795.
    HPA035349.
    HPA035350.

    Interactioni

    Protein-protein interaction databases

    BioGridi122338. 6 interactions.
    STRINGi9606.ENSP00000238714.

    Structurei

    Secondary structure

    1
    736
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi19 – 224
    Helixi32 – 4514
    Helixi46 – 483
    Helixi54 – 7825
    Turni79 – 835
    Helixi86 – 894
    Beta strandi95 – 995
    Helixi100 – 1045
    Beta strandi113 – 1197
    Helixi125 – 13814
    Beta strandi142 – 1487
    Beta strandi150 – 1534
    Beta strandi155 – 1606
    Beta strandi163 – 1719
    Beta strandi173 – 1753
    Helixi186 – 1894
    Helixi194 – 21118
    Helixi216 – 23217
    Turni238 – 2414
    Helixi245 – 25814
    Helixi264 – 27714
    Turni301 – 3033
    Helixi307 – 3093
    Beta strandi318 – 3203
    Helixi330 – 35021
    Turni351 – 3533
    Helixi357 – 3615
    Turni366 – 3683
    Beta strandi371 – 38212
    Helixi383 – 39412
    Helixi397 – 40610
    Beta strandi410 – 42011
    Beta strandi432 – 44211
    Helixi456 – 47217
    Beta strandi481 – 4899
    Helixi492 – 4943

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LT6X-ray2.79A/B1-508[»]
    ProteinModelPortaliQ9BWT3.
    SMRiQ9BWT3. Positions 17-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the poly(A) polymerase family.Curated

    Phylogenomic databases

    eggNOGiCOG5186.
    HOGENOMiHOG000204376.
    HOVERGENiHBG053502.
    InParanoidiQ9BWT3.
    KOiK14376.
    OMAiGECMPIP.
    OrthoDBiEOG7XH6PT.
    PhylomeDBiQ9BWT3.
    TreeFamiTF300842.

    Family and domain databases

    Gene3Di3.30.70.590. 1 hit.
    InterProiIPR002934. Nucleotidyltransferase.
    IPR011068. NuclTrfase_I_C.
    IPR007012. PolA_pol_cen_dom.
    IPR007010. PolA_pol_RNA-bd_dom.
    IPR014492. PolyA_polymerase.
    [Graphical view]
    PfamiPF01909. NTP_transf_2. 1 hit.
    PF04928. PAP_central. 1 hit.
    PF04926. PAP_RNA-bind. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
    SUPFAMiSSF55003. SSF55003. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BWT3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKEMSANTVL DSQRQQKHYG ITSPISLASP KEIDHIYTQK LIDAMKPFGV    50
    FEDEEELNHR LVVLGKLNNL VKEWISDVSE SKNLPPSVVA TVGGKIFTFG 100
    SYRLGVHTKG ADIDALCVAP RHVERSDFFQ SFFEKLKHQD GIRNLRAVED 150
    AFVPVIKFEF DGIEIDLVFA RLAIQTISDN LDLRDDSRLR SLDIRCIRSL 200
    NGCRVTDEIL HLVPNKETFR LTLRAVKLWA KRRGIYSNML GFLGGVSWAM 250
    LVARTCQLYP NAAASTLVHK FFLVFSKWEW PNPVLLKQPE ESNLNLPVWD 300
    PRVNPSDRYH LMPIITPAYP QQNSTYNVST STRTVMVEEF KQGLAVTDEI 350
    LQGKSDWSKL LEPPNFFQKY RHYIVLTASA STEENHLEWV GLVESKIRVL 400
    VGNLERNEFI TLAHVNPQSF PGNKEHHKDN NYVSMWFLGI IFRRVENAES 450
    VNIDLTYDIQ SFTDTVYRQA NNINMLKEGM KIEATHVKKK QLHHYLPAEI 500
    LQKKKKQSLS DVNRSSGGLQ SKRLSLDSSC LDSSRDTDNG TPFNSPASKS 550
    DSPSVGETER NSAEPAAVIV EKPLSVPPAQ GLSIPVIGAK VDSTVKTVSP 600
    PTVCTIPTVV GRNVIPRITT PHNPAQGQPH LNGMSNITKT VTPKRSHSPS 650
    IDGTPKRLKD VEKFIRLEST FKDPRTAEER KRKSVDAIGG ESMPIPTIDT 700
    SRKKRLPSKE LPDSSSPVPA NNIRVIKNSI RLTLNR 736
    Length:736
    Mass (Da):82,803
    Last modified:October 17, 2006 - v2
    Checksum:iB0F6F217AA36E552
    GO
    Isoform 2 (identifier: Q9BWT3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         664-685: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:714
    Mass (Da):80,127
    Checksum:i0467FCF53C3CE806
    GO

    Sequence cautioni

    The sequence BAB14604.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311K → E in AAK31791. (PubMed:11287430)Curated
    Sequence conflicti289 – 2891P → S in AAK31791. (PubMed:11287430)Curated
    Sequence conflicti619 – 6191T → I in AAK31791. (PubMed:11287430)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei664 – 68522Missing in isoform 2. 1 PublicationVSP_054379Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029162 mRNA. Translation: AAK31791.1.
    AF312211 mRNA. Translation: AAK83701.1.
    AJ308101 mRNA. Translation: CAC59751.1.
    AK021867 mRNA. Translation: BAB13919.1.
    AK023544 mRNA. Translation: BAB14604.1. Different initiation.
    AK314663 mRNA. Translation: BAG37221.1.
    AC011245 Genomic DNA. No translation available.
    AC012498 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00034.1.
    BC111701 mRNA. Translation: AAI11702.1.
    BC113747 mRNA. Translation: AAI13748.1.
    AB209304 mRNA. Translation: BAD92541.1.
    CCDSiCCDS1863.1. [Q9BWT3-1]
    RefSeqiNP_075045.2. NM_022894.3. [Q9BWT3-1]
    XP_005264557.1. XM_005264500.1. [Q9BWT3-2]
    UniGeneiHs.387471.

    Genome annotation databases

    EnsembliENST00000238714; ENSP00000238714; ENSG00000115421. [Q9BWT3-1]
    ENST00000412217; ENSP00000405570; ENSG00000115421.
    GeneIDi64895.
    KEGGihsa:64895.
    UCSCiuc002sai.3. human. [Q9BWT3-1]

    Polymorphism databases

    DMDMi116242699.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029162 mRNA. Translation: AAK31791.1 .
    AF312211 mRNA. Translation: AAK83701.1 .
    AJ308101 mRNA. Translation: CAC59751.1 .
    AK021867 mRNA. Translation: BAB13919.1 .
    AK023544 mRNA. Translation: BAB14604.1 . Different initiation.
    AK314663 mRNA. Translation: BAG37221.1 .
    AC011245 Genomic DNA. No translation available.
    AC012498 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00034.1 .
    BC111701 mRNA. Translation: AAI11702.1 .
    BC113747 mRNA. Translation: AAI13748.1 .
    AB209304 mRNA. Translation: BAD92541.1 .
    CCDSi CCDS1863.1. [Q9BWT3-1 ]
    RefSeqi NP_075045.2. NM_022894.3. [Q9BWT3-1 ]
    XP_005264557.1. XM_005264500.1. [Q9BWT3-2 ]
    UniGenei Hs.387471.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LT6 X-ray 2.79 A/B 1-508 [» ]
    ProteinModelPortali Q9BWT3.
    SMRi Q9BWT3. Positions 17-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122338. 6 interactions.
    STRINGi 9606.ENSP00000238714.

    PTM databases

    PhosphoSitei Q9BWT3.

    Polymorphism databases

    DMDMi 116242699.

    Proteomic databases

    MaxQBi Q9BWT3.
    PaxDbi Q9BWT3.
    PRIDEi Q9BWT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000238714 ; ENSP00000238714 ; ENSG00000115421 . [Q9BWT3-1 ]
    ENST00000412217 ; ENSP00000405570 ; ENSG00000115421 .
    GeneIDi 64895.
    KEGGi hsa:64895.
    UCSCi uc002sai.3. human. [Q9BWT3-1 ]

    Organism-specific databases

    CTDi 64895.
    GeneCardsi GC02P060983.
    HGNCi HGNC:14982. PAPOLG.
    HPAi CAB017795.
    HPA035349.
    HPA035350.
    neXtProti NX_Q9BWT3.
    PharmGKBi PA32934.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5186.
    HOGENOMi HOG000204376.
    HOVERGENi HBG053502.
    InParanoidi Q9BWT3.
    KOi K14376.
    OMAi GECMPIP.
    OrthoDBi EOG7XH6PT.
    PhylomeDBi Q9BWT3.
    TreeFami TF300842.

    Miscellaneous databases

    GeneWikii PAPOLG.
    GenomeRNAii 64895.
    NextBioi 67037.
    PROi Q9BWT3.

    Gene expression databases

    ArrayExpressi Q9BWT3.
    Bgeei Q9BWT3.
    CleanExi HS_PAPOLG.
    Genevestigatori Q9BWT3.

    Family and domain databases

    Gene3Di 3.30.70.590. 1 hit.
    InterProi IPR002934. Nucleotidyltransferase.
    IPR011068. NuclTrfase_I_C.
    IPR007012. PolA_pol_cen_dom.
    IPR007010. PolA_pol_RNA-bd_dom.
    IPR014492. PolyA_polymerase.
    [Graphical view ]
    Pfami PF01909. NTP_transf_2. 1 hit.
    PF04928. PAP_central. 1 hit.
    PF04926. PAP_RNA-bind. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018425. PolyA_polymerase. 1 hit.
    SUPFAMi SSF55003. SSF55003. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme."
      Perumal K., Sinha K., Henning D., Reddy R.
      J. Biol. Chem. 276:21791-21796(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    2. "Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors."
      Topalian S.L., Kaneko S., Gonzales M.I., Bond G.L., Ward Y., Manley J.L.
      Mol. Cell. Biol. 21:5614-5623(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Melanoma.
    3. "A novel nuclear human poly(A) polymerase, PAPg."
      Kyriakopoulou C.B., Virtanen A.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Cervix carcinoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo and Placenta.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 333-736 (ISOFORM 2).
      Tissue: Brain.
    9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-648; THR-654 AND SER-684, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases."
      Yang Q., Nausch L., Martin G., Keller W., Doublie S.
      J. Mol. Biol. 426:43-50(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.79 ANGSTROMS) OF 1-508 IN COMPLEX WITH ATP AND CALCIUM IONS.

    Entry informationi

    Entry nameiPAPOG_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWT3
    Secondary accession number(s): B2RBH4
    , Q59G05, Q969N1, Q9H8L2, Q9HAD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3