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Protein

Cell division cycle-associated protein 7

Gene

CDCA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ9BWT1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 7
Alternative name(s):
Protein JPO1
Gene namesi
Name:CDCA7
Synonyms:JPO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14628. CDCA7.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency-centromeric instability-facial anomalies syndrome 3 (ICF3)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients.
See also OMIM:616910
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076578274R → C in ICF3. 1 Publication1
Natural variantiVAR_076579274R → H in ICF3. 1 PublicationCorresponds to variant rs370384522dbSNPEnsembl.1
Natural variantiVAR_076580294G → V in ICF3; unknown pathological significance. 1 Publication1
Natural variantiVAR_076581304R → H in ICF3; unknown pathological significance. 1 PublicationCorresponds to variant rs772929976dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi158R → A: Does not affect phosphorylation or interaction with YHWAE and YHWAZ. 1 Publication1
Mutagenesisi159P → A: Does not affect phosphorylation or interaction with YHWAE and YHWAZ. 1 Publication1
Mutagenesisi160R → A: Abolishes phosphorylation and interaction with YHWAE and YHWAZ. 1 Publication1
Mutagenesisi160R → E: Predominantly cytoplasmic. 1 Publication1
Mutagenesisi161R → A: Increased phosphorylation, binding to YHWAE and YHWAZ, and cytoplasmic expression. 1 Publication1
Mutagenesisi161R → E: Predominantly cytoplasmic. 1 Publication1
Mutagenesisi162R → A: Does not affect phosphorylation or interaction with YHWAE and YHWAZ. 1 Publication1
Mutagenesisi162R → E: Predominantly cytoplasmic. 1 Publication1
Mutagenesisi163T → A: Abolishes phosphorylation, interaction with YHWAE and YHWAZ, and cytoplasmic localization. 1 Publication1
Mutagenesisi164F → A: Abolishes phosphorylation and interaction with YHWAE and YHWAZ. 1 Publication1
Mutagenesisi165P → A: Abolishes phosphorylation, interaction with YHWAE and YHWAZ, and cytoplasmic localization. 1 Publication1
Mutagenesisi171R → E: Predominantly cytoplasmic. Completely cytoplasmic with no nuclear expression; when associated with E-176. 1 Publication1
Mutagenesisi176R → E: Predominantly cytoplasmic. Completely cytoplasmic with no nuclear expression; when associated with E-171. 1 Publication1
Mutagenesisi182R → E: No effect on subcellular location. 1 Publication1
Mutagenesisi184R → E: No effect on subcellular location. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi83879.
MIMi616910. phenotype.
OpenTargetsiENSG00000144354.
PharmGKBiPA26280.

Polymorphism and mutation databases

BioMutaiCDCA7.
DMDMi74733461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002493101 – 371Cell division cycle-associated protein 7Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphoserineCombined sources1
Modified residuei163PhosphothreonineCombined sources1 Publication1
Modified residuei190PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-163 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. In vitro, phosphorylated at Thr-163 by AKT.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWT1.
MaxQBiQ9BWT1.
PaxDbiQ9BWT1.
PeptideAtlasiQ9BWT1.
PRIDEiQ9BWT1.

PTM databases

iPTMnetiQ9BWT1.
PhosphoSitePlusiQ9BWT1.

Expressioni

Tissue specificityi

Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis.2 Publications

Inductioni

Activated by MYC and possibly E2F1.

Gene expression databases

BgeeiENSG00000144354.
CleanExiHS_CDCA7.
ExpressionAtlasiQ9BWT1. baseline and differential.
GenevisibleiQ9BWT1. HS.

Organism-specific databases

HPAiHPA005565.

Interactioni

Subunit structurei

Interacts with MYC (via C-terminus), YWHAE and YWHAZ.1 Publication

Protein-protein interaction databases

BioGridi123792. 7 interactors.
IntActiQ9BWT1. 1 interactor.
MINTiMINT-8201761.
STRINGi9606.ENSP00000306968.

Structurei

3D structure databases

ProteinModelPortaliQ9BWT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 170Interaction with MYC1 PublicationAdd BLAST25
Regioni247 – 371Mediates transcriptional activityAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi160 – 176Nuclear localization signal1 PublicationAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 186Arg-richAdd BLAST30

Phylogenomic databases

eggNOGiENOG410IFJD. Eukaryota.
ENOG410ZWEA. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ9BWT1.
OMAiNPDCWGV.
OrthoDBiEOG091G0A11.
PhylomeDBiQ9BWT1.
TreeFamiTF101076.

Family and domain databases

InterProiIPR033576. CDCA7.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF2. PTHR31169:SF2. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWT1-1) [UniParc]FASTAAdd to basket
Also known as: isoform 2 variant

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDARRVPQKD LRVKKNLKKF RYVKLISMET SSSSDDSCDS FASDNFANTR
60 70 80 90 100
LQSVREGCRT RSQCRHSGPL RVAMKFPARS TRGATNKKAE SRQPSENSVT
110 120 130 140 150
DSNSDSEDES GMNFLEKRAL NIKQNKAMLA KLMSELESFP GSFRGRHPLP
160 170 180 190 200
GSDSQSRRPR RRTFPGVASR RNPERRARPL TRSRSRILGS LDALPMEEEE
210 220 230 240 250
EEDKYMLVRK RKTVDGYMNE DDLPRSRRSR SSVTLPHIIR PVEEITEEEL
260 270 280 290 300
ENVCSNSREK IYNRSLGSTC HQCRQKTIDT KTNCRNPDCW GVRGQFCGPC
310 320 330 340 350
LRNRYGEEVR DALLDPNWHC PPCRGICNCS FCRQRDGRCA TGVLVYLAKY
360 370
HGFGNVHAYL KSLKQEFEMQ A
Length:371
Mass (Da):42,573
Last modified:June 1, 2001 - v1
Checksum:i30A244E3057D9C43
GO
Isoform 2 (identifier: Q9BWT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-49: T → TKPKFRSDIS...FSESEIQDGM

Show »
Length:450
Mass (Da):51,445
Checksum:iE0AE72184AEDAE39
GO
Isoform 3 (identifier: Q9BWT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-316: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):36,892
Checksum:i2F5A9FA6F14EA200
GO
Isoform 4 (identifier: Q9BWT1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-207: QSRRPRRRTF...EEEEEDKYML → VSTSSCLYTV...PPDRSLDDPP
     208-371: Missing.

Note: No experimental confirmation available.
Show »
Length:207
Mass (Da):23,340
Checksum:i77AF9BB96EFDDF0F
GO
Isoform 5 (identifier: Q9BWT1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-49: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):37,786
Checksum:i50BB8953A4D83BAB
GO
Isoform 6 (identifier: Q9BWT1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-49: T → TKPRPDVTNELAGIFHADSDDESFCGFSESEIQDGM

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):46,400
Checksum:i236883B33F379260
GO

Sequence cautioni

The sequence CAH56357 differs from that shown. Reason: Frameshift at position 260.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152S → G in AAH15124 (PubMed:15489334).Curated1
Sequence conflicti320C → W in BAD97244 (Ref. 3) Curated1
Isoform 2 (identifier: Q9BWT1-2)
Sequence conflicti63N → S in BAB55245 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076578274R → C in ICF3. 1 Publication1
Natural variantiVAR_076579274R → H in ICF3. 1 PublicationCorresponds to variant rs370384522dbSNPEnsembl.1
Natural variantiVAR_076580294G → V in ICF3; unknown pathological significance. 1 Publication1
Natural variantiVAR_076581304R → H in ICF3; unknown pathological significance. 1 PublicationCorresponds to variant rs772929976dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0544078 – 49Missing in isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_02039449T → TKPKFRSDISEELANVFYED SDNESFCGFSESEVQDVLDH CGFLQKPRPDVTNELAGIFH ADSDDESFCGFSESEIQDGM in isoform 2. 1 Publication1
Alternative sequenceiVSP_05440849T → TKPRPDVTNELAGIFHADSD DESFCGFSESEIQDGM in isoform 6. 1 Publication1
Alternative sequenceiVSP_020395155 – 207QSRRP…DKYML → VSTSSCLYTVVFWAHLRSIC VVFKNLISLFVWPSRQTKGT QRKPPDRSLDDPP in isoform 4. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_020396208 – 371Missing in isoform 4. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_020397267 – 316Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029179 mRNA. Translation: AAK31591.1.
AK027628 mRNA. Translation: BAB55245.1.
AK027642 mRNA. Translation: BAB55258.1.
AK075134 mRNA. Translation: BAC11425.1.
AK297097 mRNA. Translation: BAG59610.1.
AK300949 mRNA. Translation: BAG62578.1.
AK223524 mRNA. Translation: BAD97244.1.
AL833728 mRNA. Translation: CAH56253.1.
AL834186 mRNA. Translation: CAH56357.1. Frameshift.
AC092573 Genomic DNA. Translation: AAX82003.1.
BC015124 mRNA. Translation: AAH15124.1.
BC027966 mRNA. Translation: AAH27966.1.
BG354580 mRNA. No translation available.
CCDSiCCDS2252.1. [Q9BWT1-2]
CCDS2253.1. [Q9BWT1-1]
RefSeqiNP_114148.3. NM_031942.4. [Q9BWT1-2]
NP_665809.1. NM_145810.2. [Q9BWT1-1]
UniGeneiHs.470654.

Genome annotation databases

EnsembliENST00000306721; ENSP00000306968; ENSG00000144354. [Q9BWT1-2]
ENST00000347703; ENSP00000272789; ENSG00000144354. [Q9BWT1-1]
ENST00000410019; ENSP00000386833; ENSG00000144354. [Q9BWT1-5]
ENST00000410101; ENSP00000386656; ENSG00000144354. [Q9BWT1-6]
GeneIDi83879.
KEGGihsa:83879.
UCSCiuc002uic.2. human. [Q9BWT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029179 mRNA. Translation: AAK31591.1.
AK027628 mRNA. Translation: BAB55245.1.
AK027642 mRNA. Translation: BAB55258.1.
AK075134 mRNA. Translation: BAC11425.1.
AK297097 mRNA. Translation: BAG59610.1.
AK300949 mRNA. Translation: BAG62578.1.
AK223524 mRNA. Translation: BAD97244.1.
AL833728 mRNA. Translation: CAH56253.1.
AL834186 mRNA. Translation: CAH56357.1. Frameshift.
AC092573 Genomic DNA. Translation: AAX82003.1.
BC015124 mRNA. Translation: AAH15124.1.
BC027966 mRNA. Translation: AAH27966.1.
BG354580 mRNA. No translation available.
CCDSiCCDS2252.1. [Q9BWT1-2]
CCDS2253.1. [Q9BWT1-1]
RefSeqiNP_114148.3. NM_031942.4. [Q9BWT1-2]
NP_665809.1. NM_145810.2. [Q9BWT1-1]
UniGeneiHs.470654.

3D structure databases

ProteinModelPortaliQ9BWT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123792. 7 interactors.
IntActiQ9BWT1. 1 interactor.
MINTiMINT-8201761.
STRINGi9606.ENSP00000306968.

PTM databases

iPTMnetiQ9BWT1.
PhosphoSitePlusiQ9BWT1.

Polymorphism and mutation databases

BioMutaiCDCA7.
DMDMi74733461.

Proteomic databases

EPDiQ9BWT1.
MaxQBiQ9BWT1.
PaxDbiQ9BWT1.
PeptideAtlasiQ9BWT1.
PRIDEiQ9BWT1.

Protocols and materials databases

DNASUi83879.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306721; ENSP00000306968; ENSG00000144354. [Q9BWT1-2]
ENST00000347703; ENSP00000272789; ENSG00000144354. [Q9BWT1-1]
ENST00000410019; ENSP00000386833; ENSG00000144354. [Q9BWT1-5]
ENST00000410101; ENSP00000386656; ENSG00000144354. [Q9BWT1-6]
GeneIDi83879.
KEGGihsa:83879.
UCSCiuc002uic.2. human. [Q9BWT1-1]

Organism-specific databases

CTDi83879.
DisGeNETi83879.
GeneCardsiCDCA7.
HGNCiHGNC:14628. CDCA7.
HPAiHPA005565.
MIMi609937. gene.
616910. phenotype.
neXtProtiNX_Q9BWT1.
OpenTargetsiENSG00000144354.
PharmGKBiPA26280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJD. Eukaryota.
ENOG410ZWEA. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ9BWT1.
OMAiNPDCWGV.
OrthoDBiEOG091G0A11.
PhylomeDBiQ9BWT1.
TreeFamiTF101076.

Enzyme and pathway databases

SIGNORiQ9BWT1.

Miscellaneous databases

ChiTaRSiCDCA7. human.
GeneWikiiCDCA7.
GenomeRNAii83879.
PROiQ9BWT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144354.
CleanExiHS_CDCA7.
ExpressionAtlasiQ9BWT1. baseline and differential.
GenevisibleiQ9BWT1. HS.

Family and domain databases

InterProiIPR033576. CDCA7.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF2. PTHR31169:SF2. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDCA7_HUMAN
AccessioniPrimary (citable) accession number: Q9BWT1
Secondary accession number(s): B4DLP8
, B4DV66, Q53EW5, Q580W9, Q658K4, Q658N4, Q8NBY9, Q96BV8, Q96SP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.