ID   FAIM2_HUMAN             Reviewed;         316 AA.
AC   Q9BWQ8; A8K1W6; Q9UJY9; Q9Y2F7;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-JAN-2012, entry version 80.
DE   RecName: Full=Fas apoptotic inhibitory molecule 2;
DE   AltName: Full=Protein lifeguard;
DE   AltName: Full=Transmembrane BAX inhibitor motif-containing protein 2;
GN   Name=FAIM2; Synonyms=KIAA0950, LFG, TMBIM2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TNFRSF6, AND
RP   TISSUE SPECIFICITY.
RC   TISSUE=Lung fibroblast;
RX   MEDLINE=20006292; PubMed=10535980; DOI=10.1073/pnas.96.22.12667;
RA   Somia N.V., Schmitt M.J., Vetter D.E., Van Antwerp D., Heinemann S.F.,
RA   Verma I.M.;
RT   "LFG: an anti-apoptotic gene that provides protection from fas-
RT   mediated cell death.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=99246063; PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M.,
RA   Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 6:63-70(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Protects cells uniquely from Fas-induced apoptosis.
CC   -!- SUBUNIT: Interacts with TNFRSF6.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity). Cell junction, synapse, postsynaptic cell
CC       membrane (By similarity).
CC   -!- TISSUE SPECIFICITY: Widely expressed. Expressed at high levels in
CC       the brain especially in the hippocampus.
CC   -!- SIMILARITY: Belongs to the BI1 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF06327.1; Type=Frameshift; Positions=82, 130;
CC       Sequence=BAA76794.1; Type=Erroneous initiation;
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF190461; AAF06327.1; ALT_FRAME; mRNA.
DR   EMBL; AB023167; BAA76794.1; ALT_INIT; mRNA.
DR   EMBL; AK290031; BAF82720.1; -; mRNA.
DR   EMBL; CH471111; EAW58103.1; -; Genomic_DNA.
DR   EMBL; BC000051; AAH00051.1; -; mRNA.
DR   IPI; IPI00017569; -.
DR   RefSeq; NP_036438.2; NM_012306.3.
DR   UniGene; Hs.567424; -.
DR   ProteinModelPortal; Q9BWQ8; -.
DR   STRING; Q9BWQ8; -.
DR   PhosphoSite; Q9BWQ8; -.
DR   DMDM; 38503167; -.
DR   Ensembl; ENST00000320634; ENSP00000321951; ENSG00000135472.
DR   GeneID; 23017; -.
DR   KEGG; hsa:23017; -.
DR   UCSC; uc001rvj.1; human.
DR   CTD; 23017; -.
DR   GeneCards; GC12M050260; -.
DR   H-InvDB; HIX0010615; -.
DR   HGNC; HGNC:17067; FAIM2.
DR   HPA; HPA018790; -.
DR   MIM; 604306; gene.
DR   neXtProt; NX_Q9BWQ8; -.
DR   PharmGKB; PA134879081; -.
DR   eggNOG; prNOG18817; -.
DR   GeneTree; ENSGT00500000044791; -.
DR   HOGENOM; HBG595196; -.
DR   HOVERGEN; HBG012084; -.
DR   InParanoid; Q9BWQ8; -.
DR   OMA; SCQGVIF; -.
DR   OrthoDB; EOG43R3N3; -.
DR   PhylomeDB; Q9BWQ8; -.
DR   NextBio; 43956; -.
DR   ArrayExpress; Q9BWQ8; -.
DR   Bgee; Q9BWQ8; -.
DR   CleanEx; HS_FAIM2; -.
DR   Genevestigator; Q9BWQ8; -.
DR   GermOnline; ENSG00000135472; Homo sapiens.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006916; P:anti-apoptosis; NAS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR006214; Inhibitor_apoptosis_Bax1.
DR   PANTHER; PTHR23291; UPF0005; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Cell junction; Cell membrane; Complete proteome;
KW   Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane;
KW   Reference proteome; Synapse; Transmembrane; Transmembrane helix.
FT   CHAIN         1    316       Fas apoptotic inhibitory molecule 2.
FT                                /FTId=PRO_0000179087.
FT   TRANSMEM    106    126       Helical; (Potential).
FT   TRANSMEM    138    158       Helical; (Potential).
FT   TRANSMEM    165    185       Helical; (Potential).
FT   TRANSMEM    194    214       Helical; (Potential).
FT   TRANSMEM    225    245       Helical; (Potential).
FT   TRANSMEM    250    270       Helical; (Potential).
FT   TRANSMEM    290    310       Helical; (Potential).
FT   COMPBIAS     71     75       Poly-Ser.
FT   MOD_RES      38     38       Phosphotyrosine (By similarity).
FT   CARBOHYD    191    191       N-linked (GlcNAc...) (Potential).
FT   CONFLICT      3      3       Q -> R (in Ref. 1; AAF06327).
SQ   SEQUENCE   316 AA;  35110 MW;  574128C7ADCC51C0 CRC64;
     MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP
     LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV
     VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA
     YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI
     LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI
     IYIFTFFLQL FGTNRE
//