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Reviewed, UniProtKB/Swiss-Prot Q9BWQ8 (FAIM2_HUMAN)

Last modified January 19, 2010. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fas apoptotic inhibitory molecule 2
Alternative name(s):
    Protein lifeguard
    Transmembrane BAX inhibitor motif-containing protein 2
Gene names
Name: FAIM2
Synonyms: KIAA0950, LFG, TMBIM2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Protects cells uniquely from Fas-induced apoptosis. Ref.1

Subunit structure

Interacts with TNFRSF6. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity.

Tissue specificity

Widely expressed. Expressed at high levels in the brain especially in the hippocampus. Ref.1

Sequence similarities

Belongs to the BI1 family.

Sequence caution

The sequence AAF06327.1 differs from that shown. Reason: Frameshift at positions 82 and 130.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   DomainTransmembrane
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processanti-apoptosis Ref.1

Non-traceable author statement. Source: UniProtKB

apoptosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Non-traceable author statement. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Fas apoptotic inhibitory molecule 2
PRO_0000179087

Regions

Transmembrane106 – 12621 Potential
Transmembrane138 – 15821 Potential
Transmembrane165 – 18521 Potential
Transmembrane194 – 21421 Potential
Transmembrane225 – 24521 Potential
Transmembrane250 – 27021 Potential
Transmembrane290 – 31021 Potential
Compositional bias71 – 755Poly-Ser

Amino acid modifications

Modified residue381Phosphotyrosine By similarity
Glycosylation1911N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict31Q → R in AAF06327. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BWQ8-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 574128C7ADCC51C0

FASTA31635,110
        10         20         30         40         50         60 
MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP 

        70         80         90        100        110        120 
LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV 

       130        140        150        160        170        180 
VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA 

       190        200        210        220        230        240 
YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI 

       250        260        270        280        290        300 
LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI 

       310 
IYIFTFFLQL FGTNRE 

« Hide

References

« Hide 'large scale' references
[1]"LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death."
Somia N.V., Schmitt M.J., Vetter D.E., Van Antwerp D., Heinemann S.F., Verma I.M.
Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999) [PubMed: 10535980] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TNFRSF6, TISSUE SPECIFICITY.
Tissue: Lung fibroblast.
[2]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF190461 mRNA. Translation: AAF06327.1. Frameshift.
AB023167 mRNA. Translation: BAA76794.1. Different initiation.
AK290031 mRNA. Translation: BAF82720.1.
CH471111 Genomic DNA. Translation: EAW58103.1.
BC000051 mRNA. Translation: AAH00051.1.
IPIIPI00017569.
RefSeqNP_036438.2.
UniGeneHs.567424

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9BWQ8.

PTM databases

PhosphoSiteQ9BWQ8.

Genome annotation databases

EnsemblENST00000320634; ENSP00000321951; ENSG00000135472; Homo sapiens. [Genome view]
GeneID23017.
KEGGhsa:23017.
UCSCuc001rvj.1. human.

Organism-specific databases

CTD23017.
GeneCardsGC12M048546.
H-InvDBHIX0010615.
HGNCHGNC:17067. FAIM2.
HPAHPA018790.
MIM604306. gene.
PharmGKBPA134879081.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18817.
HOGENOMHBG595196.
HOVERGENQ9BWQ8.
InParanoidQ9BWQ8.
OMASCQGVIF.
OrthoDBEOG9WWV41.
PhylomeDBQ9BWQ8.

Gene expression databases

ArrayExpressQ9BWQ8.
BgeeQ9BWQ8.
CleanExHS_FAIM2.
GenevestigatorQ9BWQ8.
GermOnlineENSG00000135472. Homo sapiens.

Family and domain databases

InterProIPR006214. UPF0005.
[Graphical view]
PANTHERPTHR23291. UPF0005. 1 hit.
PfamPF01027. UPF0005. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio43956.
SOURCESearch...

Entry information

Entry nameFAIM2_HUMAN
AccessionPrimary (citable) accession number: Q9BWQ8
Secondary accession number(s): A8K1W6, Q9UJY9, Q9Y2F7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2001
Last modified: January 19, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents