Q9BWQ8 (FAIM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fas apoptotic inhibitory molecule 2

Alternative name(s):
Protein lifeguard
Transmembrane BAX inhibitor motif-containing protein 2

Gene names

Name:	FAIM2
Synonyms:	KIAA0950, LFG, TMBIM2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protects cells uniquely from Fas-induced apoptosis. Ref.1
Subunit structure	Interacts with TNFRSF6. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Cell junction › synapse › postsynaptic cell membrane By similarity.
Tissue specificity	Widely expressed. Expressed at high levels in the brain especially in the hippocampus. Ref.1
Sequence similarities	Belongs to the BI1 family.
Sequence caution	The sequence AAF06327.1 differs from that shown. Reason: Frameshift at positions 82 and 130. The sequence BAA76794.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anti-apoptosis Non-traceable author statement Ref.1. Source: UniProtKB apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Fas apoptotic inhibitory molecule 2		PRO_0000179087
Regions
	Transmembrane	106 – 126	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	194 – 214	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	250 – 270	21	Helical; Potential
	Transmembrane	290 – 310	21	Helical; Potential
	Compositional bias	71 – 75	5	Poly-Ser
Amino acid modifications
	Modified residue	38	1	Phosphotyrosine By similarity
	Glycosylation	191	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	3	1	Q → R in AAF06327. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BWQ8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 574128C7ADCC51C0	FASTA	316	35,110
	10 20 30 40 50 60 MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP 70 80 90 100 110 120 LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV 130 140 150 160 170 180 VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA 190 200 210 220 230 240 YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI 250 260 270 280 290 300 LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI 310 IYIFTFFLQL FGTNRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death." Somia N.V., Schmitt M.J., Vetter D.E., Van Antwerp D., Heinemann S.F., Verma I.M. Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999) [PubMed: 10535980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TNFRSF6, TISSUE SPECIFICITY. Tissue: Lung fibroblast.
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF190461 mRNA. Translation: AAF06327.1. Frameshift. AB023167 mRNA. Translation: BAA76794.1. Different initiation. AK290031 mRNA. Translation: BAF82720.1. CH471111 Genomic DNA. Translation: EAW58103.1. BC000051 mRNA. Translation: AAH00051.1.
IPI	IPI00017569.
RefSeq	NP_036438.2. NM_012306.3.
UniGene	Hs.567424.
3D structure databases
ProteinModelPortal	Q9BWQ8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BWQ8.
PTM databases
PhosphoSite	Q9BWQ8.
Polymorphism databases
DMDM	38503167.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320634; ENSP00000321951; ENSG00000135472.
GeneID	23017.
KEGG	hsa:23017.
UCSC	uc001rvj.1. human.
Organism-specific databases
CTD	23017.
GeneCards	GC12M050260.
H-InvDB	HIX0010615.
HGNC	HGNC:17067. FAIM2.
HPA	HPA018790.
MIM	604306. gene.
neXtProt	NX_Q9BWQ8.
PharmGKB	PA134879081.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18817.
GeneTree	ENSGT00500000044791.
HOGENOM	HBG595196.
HOVERGEN	HBG012084.
InParanoid	Q9BWQ8.
OMA	SCQGVIF.
OrthoDB	EOG43R3N3.
PhylomeDB	Q9BWQ8.
Gene expression databases
ArrayExpress	Q9BWQ8.
Bgee	Q9BWQ8.
CleanEx	HS_FAIM2.
Genevestigator	Q9BWQ8.
GermOnline	ENSG00000135472. Homo sapiens.
Family and domain databases
InterPro	IPR006214. Inhibitor_apoptosis_Bax1. [Graphical view]
PANTHER	PTHR23291. UPF0005. 1 hit.
Pfam	PF01027. Bax1-I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43956.
SOURCE	Search...

Entry information

Entry name

FAIM2_HUMAN

Accession

Primary (citable) accession number: Q9BWQ8
Secondary accession number(s): A8K1W6, Q9UJY9, Q9Y2F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.