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Q9BWQ8

- LFG2_HUMAN

UniProt

Q9BWQ8 - LFG2_HUMAN

Protein

Protein lifeguard 2

Gene

FAIM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.2 Publications

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cerebellar granular layer development Source: UniProtKB
    3. cerebellar Purkinje cell differentiation Source: UniProtKB
    4. cerebellar Purkinje cell layer development Source: UniProtKB
    5. cerebellum development Source: UniProtKB
    6. negative regulation of apoptotic process Source: UniProtKB
    7. regulation of neuron apoptotic process Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 2
    Alternative name(s):
    Fas apoptotic inhibitory molecule 2
    Neural membrane protein 35
    Transmembrane BAX inhibitor motif-containing protein 2
    Gene namesi
    Name:FAIM2
    Synonyms:KIAA0950, LFG, LFG2, NMP35, TMBIM2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17067. FAIM2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Membrane raft 1 Publication. Cell junctionsynapsepostsynaptic cell membrane By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: UniProtKB
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879081.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Protein lifeguard 2PRO_0000179087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9BWQ8.
    PRIDEiQ9BWQ8.

    PTM databases

    PhosphoSiteiQ9BWQ8.

    Expressioni

    Tissue specificityi

    Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.2 Publications

    Inductioni

    Regulated by the AKT1/LEF1 pathway in breast cancer cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ9BWQ8.
    BgeeiQ9BWQ8.
    CleanExiHS_FAIM2.
    GenevestigatoriQ9BWQ8.

    Organism-specific databases

    HPAiHPA018790.
    HPA048800.

    Interactioni

    Subunit structurei

    Interacts with FAS/TNFRSF6 and BAX.2 Publications

    Protein-protein interaction databases

    BioGridi116659. 1 interaction.
    STRINGi9606.ENSP00000321951.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BWQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei250 – 27021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi71 – 755Poly-Ser

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    InParanoidiQ9BWQ8.
    OMAiSCQGVIF.
    OrthoDBiEOG7VB2G8.
    PhylomeDBiQ9BWQ8.
    TreeFamiTF319996.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BWQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG    50
    AFPPAPTAVP LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR 100
    VFVRKVYTIL LIQLLVTLAV VALFTFCDPV KDYVQANPGW YWASYAVFFA 150
    TYLTLACCSG PRRHFPWNLI LLTVFTLSMA YLTGMLSSYY NTTSVLLCLG 200
    ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI LAILLPFQYV 250
    PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI 300
    IYIFTFFLQL FGTNRE 316
    Length:316
    Mass (Da):35,110
    Last modified:June 1, 2001 - v1
    Checksum:i574128C7ADCC51C0
    GO

    Sequence cautioni

    The sequence AAF06327.1 differs from that shown. Reason: Frameshift at positions 82 and 130.
    The sequence BAA76794.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31Q → R in AAF06327. (PubMed:10535980)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190461 mRNA. Translation: AAF06327.1. Frameshift.
    AB023167 mRNA. Translation: BAA76794.1. Different initiation.
    AK290031 mRNA. Translation: BAF82720.1.
    CH471111 Genomic DNA. Translation: EAW58103.1.
    BC000051 mRNA. Translation: AAH00051.1.
    CCDSiCCDS8791.1.
    RefSeqiNP_036438.2. NM_012306.3.
    UniGeneiHs.567424.

    Genome annotation databases

    EnsembliENST00000320634; ENSP00000321951; ENSG00000135472.
    GeneIDi23017.
    KEGGihsa:23017.
    UCSCiuc001rvi.2. human.

    Polymorphism databases

    DMDMi38503167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190461 mRNA. Translation: AAF06327.1 . Frameshift.
    AB023167 mRNA. Translation: BAA76794.1 . Different initiation.
    AK290031 mRNA. Translation: BAF82720.1 .
    CH471111 Genomic DNA. Translation: EAW58103.1 .
    BC000051 mRNA. Translation: AAH00051.1 .
    CCDSi CCDS8791.1.
    RefSeqi NP_036438.2. NM_012306.3.
    UniGenei Hs.567424.

    3D structure databases

    ProteinModelPortali Q9BWQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116659. 1 interaction.
    STRINGi 9606.ENSP00000321951.

    PTM databases

    PhosphoSitei Q9BWQ8.

    Polymorphism databases

    DMDMi 38503167.

    Proteomic databases

    PaxDbi Q9BWQ8.
    PRIDEi Q9BWQ8.

    Protocols and materials databases

    DNASUi 23017.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320634 ; ENSP00000321951 ; ENSG00000135472 .
    GeneIDi 23017.
    KEGGi hsa:23017.
    UCSCi uc001rvi.2. human.

    Organism-specific databases

    CTDi 23017.
    GeneCardsi GC12M050260.
    HGNCi HGNC:17067. FAIM2.
    HPAi HPA018790.
    HPA048800.
    MIMi 604306. gene.
    neXtProti NX_Q9BWQ8.
    PharmGKBi PA134879081.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0670.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    InParanoidi Q9BWQ8.
    OMAi SCQGVIF.
    OrthoDBi EOG7VB2G8.
    PhylomeDBi Q9BWQ8.
    TreeFami TF319996.

    Miscellaneous databases

    ChiTaRSi FAIM2. human.
    GenomeRNAii 23017.
    NextBioi 43956.
    PROi Q9BWQ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BWQ8.
    Bgeei Q9BWQ8.
    CleanExi HS_FAIM2.
    Genevestigatori Q9BWQ8.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death."
      Somia N.V., Schmitt M.J., Vetter D.E., Van Antwerp D., Heinemann S.F., Verma I.M.
      Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH FAS/TNFRSF6, TISSUE SPECIFICITY.
      Tissue: Lung fibroblast.
    2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family."
      Reimers K., Choi C.Y., Mau-Thek E., Vogt P.M.
      Int. J. Mol. Med. 18:729-734(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, INTERACTION WITH BAX.
    7. "Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment."
      Fernandez M., Segura M.F., Sole C., Colino A., Comella J.X., Cena V.
      J. Neurochem. 103:190-203(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "LFG: a candidate apoptosis regulatory gene family."
      Hu L., Smith T.F., Goldberger G.
      Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    9. "Transactivation of lifeguard (LFG) by Akt-/LEF-1 pathway in MCF-7 and MDA-MB 231 human breast cancer cells."
      Bucan V., Adili M.Y., Choi C.Y., Eddy M.T., Vogt P.M., Reimers K.
      Apoptosis 15:814-821(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    10. "The anti-apoptotic protein lifeguard is expressed in breast cancer cells and tissues."
      Bucan V., Reimers K., Choi C.Y., Eddy M.T., Vogt P.M.
      Cell. Mol. Biol. Lett. 15:296-310(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLFG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWQ8
    Secondary accession number(s): A8K1W6, Q9UJY9, Q9Y2F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3