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Protein

Protein YIPF2

Gene

YIPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF2
Alternative name(s):
YIP1 family member 2
Gene namesi
Name:YIPF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130733.10
HGNCiHGNC:28476 YIPF2
MIMi617522 gene
neXtProtiNX_Q9BWQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 124Cytoplasmic1 PublicationAdd BLAST123
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 163LumenalCuratedAdd BLAST18
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 196CytoplasmicCuratedAdd BLAST12
Transmembranei197 – 219HelicalSequence analysisAdd BLAST23
Topological domaini220 – 231LumenalCuratedAdd BLAST12
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 256CytoplasmicCurated4
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 316Lumenal1 PublicationAdd BLAST39

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130733
PharmGKBiPA142670556

Polymorphism and mutation databases

BioMutaiYIPF2
DMDMi74733454

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002414542 – 316Protein YIPF2Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BWQ6
MaxQBiQ9BWQ6
PaxDbiQ9BWQ6
PeptideAtlasiQ9BWQ6
PRIDEiQ9BWQ6
ProteomicsDBi79304

PTM databases

iPTMnetiQ9BWQ6
PhosphoSitePlusiQ9BWQ6

Expressioni

Gene expression databases

BgeeiENSG00000130733
CleanExiHS_YIPF2
ExpressionAtlasiQ9BWQ6 baseline and differential
GenevisibleiQ9BWQ6 HS

Organism-specific databases

HPAiHPA019902

Interactioni

Subunit structurei

Interacts with YIPF6; this interaction may stabilize YIPF2. May also form a ternary complex with YIPF1 and YIPF6.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122463, 8 interactors
IntActiQ9BWQ6, 8 interactors
MINTiQ9BWQ6
STRINGi9606.ENSP00000253031

Structurei

3D structure databases

ProteinModelPortaliQ9BWQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3114 Eukaryota
ENOG4110TJR LUCA
GeneTreeiENSGT00390000010157
HOGENOMiHOG000231137
HOVERGENiHBG056746
InParanoidiQ9BWQ6
OMAiELAFHEF
OrthoDBiEOG091G0JY5
PhylomeDBiQ9BWQ6

Family and domain databases

InterProiView protein in InterPro
IPR006977 Yip1
PfamiView protein in Pfam
PF04893 Yip1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BWQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASADELTFH EFEEATNLLA DTPDAATTSR SDQLTPQGHV AVAVGSGGSY
60 70 80 90 100
GAEDEVEEES DKAALLQEQQ QQQQPGFWTF SYYQSFFDVD TSQVLDRIKG
110 120 130 140 150
SLLPRPGHNF VRHHLRNRPD LYGPFWICAT LAFVLAVTGN LTLVLAQRRD
160 170 180 190 200
PSIHYSPQFH KVTVAGISIY CYAWLVPLAL WGFLRWRKGV QERMGPYTFL
210 220 230 240 250
ETVCIYGYSL FVFIPMVVLW LIPVPWLQWL FGALALGLSA AGLVFTLWPV
260 270 280 290 300
VREDTRLVAT VLLSVVVLLH ALLAMGCKLY FFQSLPPENV APPPQITSLP
310
SNIALSPTLP QSLAPS
Length:316
Mass (Da):35,151
Last modified:June 1, 2001 - v1
Checksum:i274E5F2D07EA1A75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000056 mRNA Translation: AAH00056.1
BC013014 mRNA Translation: AAH13014.1
CCDSiCCDS12251.1
RefSeqiNP_001308368.1, NM_001321439.1
NP_076934.1, NM_024029.4
XP_011526572.1, XM_011528270.2
UniGeneiHs.164026
Hs.720136

Genome annotation databases

EnsembliENST00000253031; ENSP00000253031; ENSG00000130733
ENST00000586748; ENSP00000466055; ENSG00000130733
GeneIDi78992
KEGGihsa:78992
UCSCiuc002mqb.4 human

Similar proteinsi

Entry informationi

Entry nameiYIPF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BWQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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