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Protein

Proline-rich protein 14

Gene

PRR14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 14
Gene namesi
Name:PRR14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28458. PRR14.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Proline-rich protein 14PRO_0000307269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei277 – 2771Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BWN1.
PaxDbiQ9BWN1.
PRIDEiQ9BWN1.

PTM databases

PhosphoSiteiQ9BWN1.

Expressioni

Gene expression databases

BgeeiQ9BWN1.
CleanExiHS_PRR14.
ExpressionAtlasiQ9BWN1. baseline and differential.
GenevestigatoriQ9BWN1.

Organism-specific databases

HPAiHPA052022.
HPA060265.

Interactioni

Protein-protein interaction databases

BioGridi122465. 11 interactions.
IntActiQ9BWN1. 3 interactions.
MINTiMINT-1482192.
STRINGi9606.ENSP00000300835.

Structurei

3D structure databases

ProteinModelPortaliQ9BWN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 378294Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG29228.
GeneTreeiENSGT00520000055626.
HOGENOMiHOG000115715.
HOVERGENiHBG095164.
InParanoidiQ9BWN1.
OMAiPPFQPSA.
OrthoDBiEOG7ZPNMP.
PhylomeDBiQ9BWN1.
TreeFamiTF328446.

Family and domain databases

InterProiIPR026320. PRR14.
IPR028149. Tantalus-like.
[Graphical view]
PANTHERiPTHR14522. PTHR14522. 1 hit.
PfamiPF15386. Tantalus. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPGDSSPP GQPRLCRQPL TRALWGARSP KRPRLQLPGA PSPLEKASRR
60 70 80 90 100
VLAVVLEDVM AVHMVPVVPS KQTSIPQHHS YHQDPVHRQP PASPPRQAGW
110 120 130 140 150
SSQARPPDPL CLCREPLSRI HRTSSTLRRR SRTTPGPEEG PSQKVDRAPQ
160 170 180 190 200
PTLVVMLEDI ASPRPPAEGF IDETPNFIIP AQRAEPMRIV RQPTPPPGDL
210 220 230 240 250
EPPFQPSALP ADPLESPPTA PDPALELPST PPPSSLLRPR LSPWGLAPLF
260 270 280 290 300
RSVRSKLESF ADIFLTPNKT PQPPPPSPPM KLELKIAISE AEQSGAAEGT
310 320 330 340 350
ASVSPRPPIR QWRTQDHNTP ALLPKPSLGR SYSCPDLGPP GPGTCTWPPA
360 370 380 390 400
PPQPSRPRPR RHTVGGGEMA RAPPPPRPCL RKEVFPLGGV GASPSLTTSC
410 420 430 440 450
SSTASTSFSE PAEPRLGSTK GKEPRASKDQ VLSEPETKTM GKVSRFRIRR
460 470 480 490 500
TPARPQLNLT PMGLPRPIRL NKKEFSLEEI YTNKNYQSPT TRRTFETIFE
510 520 530 540 550
EPRERNGTLI FTSSRKLRRA VEFRDSSLPR SRRPSRGVRA AGGRTVPPNV
560 570 580
APSPDVGPLL QQRLEELDAL LLEEETVDRE QPHWT
Length:585
Mass (Da):64,328
Last modified:June 1, 2001 - v1
Checksum:iEE706853CE2D2742
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti359 – 3591P → L.1 Publication
Corresponds to variant rs3747481 [ dbSNP | Ensembl ].
VAR_035389

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074783 mRNA. Translation: BAC11207.1.
CH471192 Genomic DNA. Translation: EAW52222.1.
BC000119 mRNA. Translation: AAH00119.1.
BC021934 mRNA. Translation: AAH21934.1.
BC050677 mRNA. Translation: AAH50677.1.
CCDSiCCDS10687.1.
RefSeqiNP_076936.1. NM_024031.2.
XP_005255623.1. XM_005255566.1.
UniGeneiHs.293629.

Genome annotation databases

EnsembliENST00000300835; ENSP00000300835; ENSG00000156858.
ENST00000542965; ENSP00000441641; ENSG00000156858.
GeneIDi78994.
KEGGihsa:78994.
UCSCiuc002dyy.3. human.

Polymorphism databases

DMDMi74733447.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074783 mRNA. Translation: BAC11207.1.
CH471192 Genomic DNA. Translation: EAW52222.1.
BC000119 mRNA. Translation: AAH00119.1.
BC021934 mRNA. Translation: AAH21934.1.
BC050677 mRNA. Translation: AAH50677.1.
CCDSiCCDS10687.1.
RefSeqiNP_076936.1. NM_024031.2.
XP_005255623.1. XM_005255566.1.
UniGeneiHs.293629.

3D structure databases

ProteinModelPortaliQ9BWN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122465. 11 interactions.
IntActiQ9BWN1. 3 interactions.
MINTiMINT-1482192.
STRINGi9606.ENSP00000300835.

PTM databases

PhosphoSiteiQ9BWN1.

Polymorphism databases

DMDMi74733447.

Proteomic databases

MaxQBiQ9BWN1.
PaxDbiQ9BWN1.
PRIDEiQ9BWN1.

Protocols and materials databases

DNASUi78994.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300835; ENSP00000300835; ENSG00000156858.
ENST00000542965; ENSP00000441641; ENSG00000156858.
GeneIDi78994.
KEGGihsa:78994.
UCSCiuc002dyy.3. human.

Organism-specific databases

CTDi78994.
GeneCardsiGC16P030662.
H-InvDBHIX0012967.
HIX0079777.
HGNCiHGNC:28458. PRR14.
HPAiHPA052022.
HPA060265.
neXtProtiNX_Q9BWN1.
PharmGKBiPA144596393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG29228.
GeneTreeiENSGT00520000055626.
HOGENOMiHOG000115715.
HOVERGENiHBG095164.
InParanoidiQ9BWN1.
OMAiPPFQPSA.
OrthoDBiEOG7ZPNMP.
PhylomeDBiQ9BWN1.
TreeFamiTF328446.

Miscellaneous databases

ChiTaRSiPRR14. human.
GenomeRNAii78994.
NextBioi67587.
PROiQ9BWN1.

Gene expression databases

BgeeiQ9BWN1.
CleanExiHS_PRR14.
ExpressionAtlasiQ9BWN1. baseline and differential.
GenevestigatoriQ9BWN1.

Family and domain databases

InterProiIPR026320. PRR14.
IPR028149. Tantalus-like.
[Graphical view]
PANTHERiPTHR14522. PTHR14522. 1 hit.
PfamiPF15386. Tantalus. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-359.
    Tissue: Eye and Pancreas.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPRR14_HUMAN
AccessioniPrimary (citable) accession number: Q9BWN1
Secondary accession number(s): Q8WTX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.