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Protein

Proline-rich protein 14

Gene

PRR14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 14
Gene namesi
Name:PRR14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28458. PRR14.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156858.
PharmGKBiPA144596393.

Polymorphism and mutation databases

BioMutaiPRR14.
DMDMi74733447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072691 – 585Proline-rich protein 14Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei277PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BWN1.
MaxQBiQ9BWN1.
PaxDbiQ9BWN1.
PeptideAtlasiQ9BWN1.
PRIDEiQ9BWN1.

PTM databases

iPTMnetiQ9BWN1.
PhosphoSitePlusiQ9BWN1.

Expressioni

Gene expression databases

BgeeiENSG00000156858.
CleanExiHS_PRR14.
ExpressionAtlasiQ9BWN1. baseline and differential.
GenevisibleiQ9BWN1. HS.

Organism-specific databases

HPAiHPA052022.
HPA060265.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CBX5P459733EBI-748167,EBI-78219

Protein-protein interaction databases

BioGridi122465. 22 interactors.
IntActiQ9BWN1. 8 interactors.
MINTiMINT-1482192.
STRINGi9606.ENSP00000300835.

Structurei

3D structure databases

ProteinModelPortaliQ9BWN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 378Pro-richAdd BLAST294

Phylogenomic databases

eggNOGiENOG410IJQ9. Eukaryota.
ENOG4111V15. LUCA.
GeneTreeiENSGT00520000055626.
HOGENOMiHOG000115715.
HOVERGENiHBG095164.
InParanoidiQ9BWN1.
OMAiEMARAPP.
OrthoDBiEOG091G004T.
PhylomeDBiQ9BWN1.
TreeFamiTF328446.

Family and domain databases

InterProiIPR026320. PRR14.
IPR028149. Tantalus-like.
[Graphical view]
PANTHERiPTHR14522. PTHR14522. 1 hit.
PfamiPF15386. Tantalus. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPGDSSPP GQPRLCRQPL TRALWGARSP KRPRLQLPGA PSPLEKASRR
60 70 80 90 100
VLAVVLEDVM AVHMVPVVPS KQTSIPQHHS YHQDPVHRQP PASPPRQAGW
110 120 130 140 150
SSQARPPDPL CLCREPLSRI HRTSSTLRRR SRTTPGPEEG PSQKVDRAPQ
160 170 180 190 200
PTLVVMLEDI ASPRPPAEGF IDETPNFIIP AQRAEPMRIV RQPTPPPGDL
210 220 230 240 250
EPPFQPSALP ADPLESPPTA PDPALELPST PPPSSLLRPR LSPWGLAPLF
260 270 280 290 300
RSVRSKLESF ADIFLTPNKT PQPPPPSPPM KLELKIAISE AEQSGAAEGT
310 320 330 340 350
ASVSPRPPIR QWRTQDHNTP ALLPKPSLGR SYSCPDLGPP GPGTCTWPPA
360 370 380 390 400
PPQPSRPRPR RHTVGGGEMA RAPPPPRPCL RKEVFPLGGV GASPSLTTSC
410 420 430 440 450
SSTASTSFSE PAEPRLGSTK GKEPRASKDQ VLSEPETKTM GKVSRFRIRR
460 470 480 490 500
TPARPQLNLT PMGLPRPIRL NKKEFSLEEI YTNKNYQSPT TRRTFETIFE
510 520 530 540 550
EPRERNGTLI FTSSRKLRRA VEFRDSSLPR SRRPSRGVRA AGGRTVPPNV
560 570 580
APSPDVGPLL QQRLEELDAL LLEEETVDRE QPHWT
Length:585
Mass (Da):64,328
Last modified:June 1, 2001 - v1
Checksum:iEE706853CE2D2742
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035389359P → L.1 PublicationCorresponds to variant rs3747481dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074783 mRNA. Translation: BAC11207.1.
CH471192 Genomic DNA. Translation: EAW52222.1.
BC000119 mRNA. Translation: AAH00119.1.
BC021934 mRNA. Translation: AAH21934.1.
BC050677 mRNA. Translation: AAH50677.1.
CCDSiCCDS10687.1.
RefSeqiNP_001307393.1. NM_001320464.1.
NP_076936.1. NM_024031.3.
UniGeneiHs.293629.

Genome annotation databases

EnsembliENST00000300835; ENSP00000300835; ENSG00000156858.
ENST00000542965; ENSP00000441641; ENSG00000156858.
GeneIDi78994.
KEGGihsa:78994.
UCSCiuc002dyy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074783 mRNA. Translation: BAC11207.1.
CH471192 Genomic DNA. Translation: EAW52222.1.
BC000119 mRNA. Translation: AAH00119.1.
BC021934 mRNA. Translation: AAH21934.1.
BC050677 mRNA. Translation: AAH50677.1.
CCDSiCCDS10687.1.
RefSeqiNP_001307393.1. NM_001320464.1.
NP_076936.1. NM_024031.3.
UniGeneiHs.293629.

3D structure databases

ProteinModelPortaliQ9BWN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122465. 22 interactors.
IntActiQ9BWN1. 8 interactors.
MINTiMINT-1482192.
STRINGi9606.ENSP00000300835.

PTM databases

iPTMnetiQ9BWN1.
PhosphoSitePlusiQ9BWN1.

Polymorphism and mutation databases

BioMutaiPRR14.
DMDMi74733447.

Proteomic databases

EPDiQ9BWN1.
MaxQBiQ9BWN1.
PaxDbiQ9BWN1.
PeptideAtlasiQ9BWN1.
PRIDEiQ9BWN1.

Protocols and materials databases

DNASUi78994.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300835; ENSP00000300835; ENSG00000156858.
ENST00000542965; ENSP00000441641; ENSG00000156858.
GeneIDi78994.
KEGGihsa:78994.
UCSCiuc002dyy.4. human.

Organism-specific databases

CTDi78994.
GeneCardsiPRR14.
H-InvDBHIX0012967.
HIX0079777.
HGNCiHGNC:28458. PRR14.
HPAiHPA052022.
HPA060265.
neXtProtiNX_Q9BWN1.
OpenTargetsiENSG00000156858.
PharmGKBiPA144596393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJQ9. Eukaryota.
ENOG4111V15. LUCA.
GeneTreeiENSGT00520000055626.
HOGENOMiHOG000115715.
HOVERGENiHBG095164.
InParanoidiQ9BWN1.
OMAiEMARAPP.
OrthoDBiEOG091G004T.
PhylomeDBiQ9BWN1.
TreeFamiTF328446.

Miscellaneous databases

ChiTaRSiPRR14. human.
GenomeRNAii78994.
PROiQ9BWN1.

Gene expression databases

BgeeiENSG00000156858.
CleanExiHS_PRR14.
ExpressionAtlasiQ9BWN1. baseline and differential.
GenevisibleiQ9BWN1. HS.

Family and domain databases

InterProiIPR026320. PRR14.
IPR028149. Tantalus-like.
[Graphical view]
PANTHERiPTHR14522. PTHR14522. 1 hit.
PfamiPF15386. Tantalus. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRR14_HUMAN
AccessioniPrimary (citable) accession number: Q9BWN1
Secondary accession number(s): Q8WTX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.