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Protein

Sideroflexin-3

Gene

SFXN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107819-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-3
Gene namesi
Name:SFXN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16087. SFXN3.

Subcellular locationi

  • Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107819.
PharmGKBiPA38092.

Polymorphism and mutation databases

BioMutaiSFXN3.
DMDMi308153497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001770371 – 325Sideroflexin-3Add BLAST325

Proteomic databases

EPDiQ9BWM7.
MaxQBiQ9BWM7.
PaxDbiQ9BWM7.
PeptideAtlasiQ9BWM7.
PRIDEiQ9BWM7.

PTM databases

iPTMnetiQ9BWM7.
PhosphoSitePlusiQ9BWM7.
SwissPalmiQ9BWM7.

Expressioni

Gene expression databases

BgeeiENSG00000107819.
CleanExiHS_SFXN3.
ExpressionAtlasiQ9BWM7. baseline and differential.
GenevisibleiQ9BWM7. HS.

Organism-specific databases

HPAiHPA008028.
HPA048105.

Interactioni

Protein-protein interaction databases

BioGridi123605. 54 interactors.
IntActiQ9BWM7. 18 interactors.
STRINGi9606.ENSP00000224807.

Structurei

3D structure databases

ProteinModelPortaliQ9BWM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ9BWM7.
OMAiIPPLIMD.
OrthoDBiEOG091G0BOU.
PhylomeDBiQ9BWM7.
TreeFamiTF313205.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BWM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKMGELPL DINIQEPRWD QSTFLGRARH FFTVTDPRNL LLSGAQLEAS
60 70 80 90 100
RNIVQNYRAG VVTPGITEDQ LWRAKYVYDS AFHPDTGEKV VLIGRMSAQV
110 120 130 140 150
PMNMTITGCM LTFYRKTPTV VFWQWVNQSF NAIVNYSNRS GDTPITVRQL
160 170 180 190 200
GTAYVSATTG AVATALGLKS LTKHLPPLVG RFVPFAAVAA ANCINIPLMR
210 220 230 240 250
QRELQVGIPV ADEAGQRLGY SVTAAKQGIF QVVISRICMA IPAMAIPPLI
260 270 280 290 300
MDTLEKKDFL KRRPWLGAPL QVGLVGFCLV FATPLCCALF PQKSSIHISN
310 320
LEPELRAQIH EQNPSVEVVY YNKGL
Length:325
Mass (Da):35,979
Last modified:October 5, 2010 - v2
Checksum:i783F288DAF52C137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074707 mRNA. Translation: BAC11151.1.
AL133215 Genomic DNA. Translation: CAI10936.1.
BC000124 mRNA. Translation: AAH00124.2.
CCDSiCCDS7508.2.
RefSeqiNP_112233.2. NM_030971.3.
UniGeneiHs.283844.

Genome annotation databases

EnsembliENST00000224807; ENSP00000224807; ENSG00000107819.
GeneIDi81855.
KEGGihsa:81855.
UCSCiuc057vma.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074707 mRNA. Translation: BAC11151.1.
AL133215 Genomic DNA. Translation: CAI10936.1.
BC000124 mRNA. Translation: AAH00124.2.
CCDSiCCDS7508.2.
RefSeqiNP_112233.2. NM_030971.3.
UniGeneiHs.283844.

3D structure databases

ProteinModelPortaliQ9BWM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123605. 54 interactors.
IntActiQ9BWM7. 18 interactors.
STRINGi9606.ENSP00000224807.

PTM databases

iPTMnetiQ9BWM7.
PhosphoSitePlusiQ9BWM7.
SwissPalmiQ9BWM7.

Polymorphism and mutation databases

BioMutaiSFXN3.
DMDMi308153497.

Proteomic databases

EPDiQ9BWM7.
MaxQBiQ9BWM7.
PaxDbiQ9BWM7.
PeptideAtlasiQ9BWM7.
PRIDEiQ9BWM7.

Protocols and materials databases

DNASUi81855.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000224807; ENSP00000224807; ENSG00000107819.
GeneIDi81855.
KEGGihsa:81855.
UCSCiuc057vma.1. human.

Organism-specific databases

CTDi81855.
GeneCardsiSFXN3.
HGNCiHGNC:16087. SFXN3.
HPAiHPA008028.
HPA048105.
MIMi615571. gene.
neXtProtiNX_Q9BWM7.
OpenTargetsiENSG00000107819.
PharmGKBiPA38092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ9BWM7.
OMAiIPPLIMD.
OrthoDBiEOG091G0BOU.
PhylomeDBiQ9BWM7.
TreeFamiTF313205.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107819-MONOMER.

Miscellaneous databases

ChiTaRSiSFXN3. human.
GenomeRNAii81855.
PROiQ9BWM7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107819.
CleanExiHS_SFXN3.
ExpressionAtlasiQ9BWM7. baseline and differential.
GenevisibleiQ9BWM7. HS.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSFXN3_HUMAN
AccessioniPrimary (citable) accession number: Q9BWM7
Secondary accession number(s): Q8NCJ0, Q9NTP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.