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Protein

Sideroflexin-3

Gene

SFXN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-3
Gene namesi
Name:SFXN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16087. SFXN3.

Subcellular locationi

  • Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei146 – 164HelicalSequence analysisAdd BLAST19
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107819.
PharmGKBiPA38092.

Polymorphism and mutation databases

BioMutaiSFXN3.
DMDMi308153497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001770371 – 321Sideroflexin-3Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BWM7.
PaxDbiQ9BWM7.
PeptideAtlasiQ9BWM7.
PRIDEiQ9BWM7.

PTM databases

iPTMnetiQ9BWM7.
PhosphoSitePlusiQ9BWM7.
SwissPalmiQ9BWM7.

Expressioni

Gene expression databases

BgeeiENSG00000107819.
CleanExiHS_SFXN3.
ExpressionAtlasiQ9BWM7. baseline and differential.
GenevisibleiQ9BWM7. HS.

Organism-specific databases

HPAiHPA008028.
HPA048105.

Interactioni

Protein-protein interaction databases

BioGridi123605. 60 interactors.
IntActiQ9BWM7. 18 interactors.
STRINGi9606.ENSP00000224807.

Structurei

3D structure databases

ProteinModelPortaliQ9BWM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ9BWM7.
OrthoDBiEOG091G0BOU.
PhylomeDBiQ9BWM7.
TreeFamiTF313205.

Family and domain databases

InterProiView protein in InterPro
IPR004686. Mtc.
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiView protein in Pfam
PF03820. Mtc. 1 hit.
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BWM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELPLDINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG AQLEASRNIV
60 70 80 90 100
QNYRAGVVTP GITEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM
110 120 130 140 150
TITGCMLTFY RKTPTVVFWQ WVNQSFNAIV NYSNRSGDTP ITVRQLGTAY
160 170 180 190 200
VSATTGAVAT ALGLKSLTKH LPPLVGRFVP FAAVAAANCI NIPLMRQREL
210 220 230 240 250
QVGIPVADEA GQRLGYSVTA AKQGIFQVVI SRICMAIPAM AIPPLIMDTL
260 270 280 290 300
EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQKS SIHISNLEPE
310 320
LRAQIHEQNP SVEVVYYNKG L
Length:321
Mass (Da):35,503
Last modified:January 18, 2017 - v3
Checksum:i54718C600B3D34BD
GO

Sequence cautioni

The sequence AAH00124 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11151 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI10936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074707 mRNA. Translation: BAC11151.1. Different initiation.
AL133215 Genomic DNA. Translation: CAI10936.1. Different initiation.
BC000124 mRNA. Translation: AAH00124.2. Different initiation.
RefSeqiNP_112233.2. NM_030971.3.
UniGeneiHs.283844.

Genome annotation databases

EnsembliENST00000393459; ENSP00000377103; ENSG00000107819.
GeneIDi81855.
KEGGihsa:81855.
UCSCiuc057vma.1. human.

Similar proteinsi

Entry informationi

Entry nameiSFXN3_HUMAN
AccessioniPrimary (citable) accession number: Q9BWM7
Secondary accession number(s): Q8NCJ0, Q9NTP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 18, 2017
Last modified: August 30, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families