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Protein

Sideroflexin-3

Gene

SFXN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-3
Gene namesi
Name:SFXN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107819.13
HGNCiHGNC:16087 SFXN3
MIMi615571 gene
neXtProtiNX_Q9BWM7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei146 – 164HelicalSequence analysisAdd BLAST19
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107819
PharmGKBiPA38092

Polymorphism and mutation databases

BioMutaiSFXN3
DMDMi308153497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001770371 – 321Sideroflexin-3Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BWM7
PaxDbiQ9BWM7
PeptideAtlasiQ9BWM7
PRIDEiQ9BWM7
ProteomicsDBi79293

PTM databases

iPTMnetiQ9BWM7
PhosphoSitePlusiQ9BWM7
SwissPalmiQ9BWM7

Expressioni

Gene expression databases

BgeeiENSG00000107819
CleanExiHS_SFXN3
ExpressionAtlasiQ9BWM7 baseline and differential
GenevisibleiQ9BWM7 HS

Organism-specific databases

HPAiHPA008028
HPA048105

Interactioni

Protein-protein interaction databases

BioGridi123605, 63 interactors
IntActiQ9BWM7, 18 interactors
MINTiQ9BWM7
STRINGi9606.ENSP00000224807

Structurei

3D structure databases

ProteinModelPortaliQ9BWM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767 Eukaryota
ENOG410YU8V LUCA
GeneTreeiENSGT00390000002026
HOGENOMiHOG000203440
HOVERGENiHBG056083
InParanoidiQ9BWM7
OrthoDBiEOG091G0BOU
PhylomeDBiQ9BWM7
TreeFamiTF313205

Family and domain databases

InterProiView protein in InterPro
IPR004686 Mtc
PANTHERiPTHR11153 PTHR11153, 1 hit
PfamiView protein in Pfam
PF03820 Mtc, 1 hit
TIGRFAMsiTIGR00798 mtc, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BWM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELPLDINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG AQLEASRNIV
60 70 80 90 100
QNYRAGVVTP GITEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM
110 120 130 140 150
TITGCMLTFY RKTPTVVFWQ WVNQSFNAIV NYSNRSGDTP ITVRQLGTAY
160 170 180 190 200
VSATTGAVAT ALGLKSLTKH LPPLVGRFVP FAAVAAANCI NIPLMRQREL
210 220 230 240 250
QVGIPVADEA GQRLGYSVTA AKQGIFQVVI SRICMAIPAM AIPPLIMDTL
260 270 280 290 300
EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQKS SIHISNLEPE
310 320
LRAQIHEQNP SVEVVYYNKG L
Length:321
Mass (Da):35,503
Last modified:January 18, 2017 - v3
Checksum:i54718C600B3D34BD
GO

Sequence cautioni

The sequence AAH00124 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11151 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI10936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074707 mRNA Translation: BAC11151.1 Different initiation.
AL133215 Genomic DNA Translation: CAI10936.1 Different initiation.
BC000124 mRNA Translation: AAH00124.2 Different initiation.
RefSeqiNP_112233.2, NM_030971.3
UniGeneiHs.283844

Genome annotation databases

EnsembliENST00000393459; ENSP00000377103; ENSG00000107819
GeneIDi81855
KEGGihsa:81855
UCSCiuc057vma.1 human

Similar proteinsi

Entry informationi

Entry nameiSFXN3_HUMAN
AccessioniPrimary (citable) accession number: Q9BWM7
Secondary accession number(s): Q8NCJ0, Q9NTP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 18, 2017
Last modified: June 20, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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