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Protein

Zinc finger protein 416

Gene

ZNF416

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri242 – 264C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 416
Gene namesi
Name:ZNF416
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000083817.8
HGNCiHGNC:20645 ZNF416
neXtProtiNX_Q9BWM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083817
PharmGKBiPA134905500

Polymorphism and mutation databases

BioMutaiZNF416
DMDMi74762716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339841 – 594Zinc finger protein 416Add BLAST594

Proteomic databases

EPDiQ9BWM5
MaxQBiQ9BWM5
PaxDbiQ9BWM5
PeptideAtlasiQ9BWM5
PRIDEiQ9BWM5

PTM databases

iPTMnetiQ9BWM5
PhosphoSitePlusiQ9BWM5

Expressioni

Gene expression databases

BgeeiENSG00000083817
CleanExiHS_ZNF416
GenevisibleiQ9BWM5 HS

Organism-specific databases

HPAiHPA063318

Interactioni

Protein-protein interaction databases

BioGridi120791, 7 interactors
STRINGi9606.ENSP00000196489

Structurei

3D structure databases

ProteinModelPortaliQ9BWM5
SMRiQ9BWM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 111KRABPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri242 – 264C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9BWM5
KOiK09228
OMAiYTLVEHQ
OrthoDBiEOG091G02KC
PhylomeDBiQ9BWM5
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

Q9BWM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVLRDST SVPVTAEAKL MGFTQGCVTF EDVAIYFSQE EWGLLDEAQR
60 70 80 90 100
LLYRDVMLEN FALITALVCW HGMEDEETPE QSVSVEGVPQ VRTPEASPST
110 120 130 140 150
QKIQSCDMCV PFLTDILHLT DLPGQELYLT GACAVFHQDQ KHHSAEKPLE
160 170 180 190 200
SDMDKASFVQ CCLFHESGMP FTSSEVGKDF LAPLGILQPQ AIANYEKPNK
210 220 230 240 250
ISKCEEAFHV GISHYKWSQC RRESSHKHTF FHPRVCTGKR LYESSKCGKA
260 270 280 290 300
CCCECSLVQL QRVHPGERPY ECSECGKSFS QTSHLNDHRR IHTGERPYVC
310 320 330 340 350
GQCGKSFSQR ATLIKHHRVH TGERPYECGE CGKSFSQSSN LIEHCRIHTG
360 370 380 390 400
ERPYECDECG KAFGSKSTLV RHQRTHTGEK PYECGECGKL FRQSFSLVVH
410 420 430 440 450
QRIHTTARPY ECGQCGKSFS LKCGLIQHQL IHSGARPFEC DECGKSFSQR
460 470 480 490 500
TTLNKHHKVH TAERPYVCGE CGKAFMFKSK LVRHQRTHTG ERPFECSECG
510 520 530 540 550
KFFRQSYTLV EHQKIHTGLR PYDCGQCGKS FIQKSSLIQH QVVHTGERPY
560 570 580 590
ECGKCGKSFT QHSGLILHRK SHTVERPRDS SKCGKPYSPR SNIV
Length:594
Mass (Da):67,188
Last modified:June 1, 2001 - v1
Checksum:i6ABC5ED049066C6D
GO

Sequence cautioni

The sequence BAA91257 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti463E → I (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000130 mRNA Translation: AAH00130.1
AK000564 mRNA Translation: BAA91257.1 Sequence problems.
CCDSiCCDS12954.1
RefSeqiNP_060349.1, NM_017879.1
UniGeneiHs.247711

Genome annotation databases

EnsembliENST00000196489; ENSP00000196489; ENSG00000083817
GeneIDi55659
KEGGihsa:55659
UCSCiuc002qpf.4 human

Similar proteinsi

Entry informationi

Entry nameiZN416_HUMAN
AccessioniPrimary (citable) accession number: Q9BWM5
Secondary accession number(s): Q9NWW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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