Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 416

Gene

ZNF416

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri242 – 26423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 416
Gene namesi
Name:ZNF416
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20645. ZNF416.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905500.

Polymorphism and mutation databases

BioMutaiZNF416.
DMDMi74762716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Zinc finger protein 416PRO_0000233984Add
BLAST

Proteomic databases

MaxQBiQ9BWM5.
PaxDbiQ9BWM5.
PeptideAtlasiQ9BWM5.
PRIDEiQ9BWM5.

PTM databases

iPTMnetiQ9BWM5.
PhosphoSiteiQ9BWM5.

Expressioni

Gene expression databases

BgeeiENSG00000083817.
CleanExiHS_ZNF416.
GenevisibleiQ9BWM5. HS.

Organism-specific databases

HPAiHPA063318.

Interactioni

Protein-protein interaction databases

BioGridi120791. 7 interactions.
STRINGi9606.ENSP00000196489.

Structurei

3D structure databases

ProteinModelPortaliQ9BWM5.
SMRiQ9BWM5. Positions 170-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 11184KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri242 – 26423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BWM5.
KOiK09228.
OMAiYTLVEHQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9BWM5.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVLRDST SVPVTAEAKL MGFTQGCVTF EDVAIYFSQE EWGLLDEAQR
60 70 80 90 100
LLYRDVMLEN FALITALVCW HGMEDEETPE QSVSVEGVPQ VRTPEASPST
110 120 130 140 150
QKIQSCDMCV PFLTDILHLT DLPGQELYLT GACAVFHQDQ KHHSAEKPLE
160 170 180 190 200
SDMDKASFVQ CCLFHESGMP FTSSEVGKDF LAPLGILQPQ AIANYEKPNK
210 220 230 240 250
ISKCEEAFHV GISHYKWSQC RRESSHKHTF FHPRVCTGKR LYESSKCGKA
260 270 280 290 300
CCCECSLVQL QRVHPGERPY ECSECGKSFS QTSHLNDHRR IHTGERPYVC
310 320 330 340 350
GQCGKSFSQR ATLIKHHRVH TGERPYECGE CGKSFSQSSN LIEHCRIHTG
360 370 380 390 400
ERPYECDECG KAFGSKSTLV RHQRTHTGEK PYECGECGKL FRQSFSLVVH
410 420 430 440 450
QRIHTTARPY ECGQCGKSFS LKCGLIQHQL IHSGARPFEC DECGKSFSQR
460 470 480 490 500
TTLNKHHKVH TAERPYVCGE CGKAFMFKSK LVRHQRTHTG ERPFECSECG
510 520 530 540 550
KFFRQSYTLV EHQKIHTGLR PYDCGQCGKS FIQKSSLIQH QVVHTGERPY
560 570 580 590
ECGKCGKSFT QHSGLILHRK SHTVERPRDS SKCGKPYSPR SNIV
Length:594
Mass (Da):67,188
Last modified:June 1, 2001 - v1
Checksum:i6ABC5ED049066C6D
GO

Sequence cautioni

The sequence BAA91257 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti463 – 4631E → I (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000130 mRNA. Translation: AAH00130.1.
AK000564 mRNA. Translation: BAA91257.1. Sequence problems.
CCDSiCCDS12954.1.
RefSeqiNP_060349.1. NM_017879.1.
UniGeneiHs.247711.

Genome annotation databases

EnsembliENST00000196489; ENSP00000196489; ENSG00000083817.
GeneIDi55659.
KEGGihsa:55659.
UCSCiuc002qpf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000130 mRNA. Translation: AAH00130.1.
AK000564 mRNA. Translation: BAA91257.1. Sequence problems.
CCDSiCCDS12954.1.
RefSeqiNP_060349.1. NM_017879.1.
UniGeneiHs.247711.

3D structure databases

ProteinModelPortaliQ9BWM5.
SMRiQ9BWM5. Positions 170-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120791. 7 interactions.
STRINGi9606.ENSP00000196489.

PTM databases

iPTMnetiQ9BWM5.
PhosphoSiteiQ9BWM5.

Polymorphism and mutation databases

BioMutaiZNF416.
DMDMi74762716.

Proteomic databases

MaxQBiQ9BWM5.
PaxDbiQ9BWM5.
PeptideAtlasiQ9BWM5.
PRIDEiQ9BWM5.

Protocols and materials databases

DNASUi55659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000196489; ENSP00000196489; ENSG00000083817.
GeneIDi55659.
KEGGihsa:55659.
UCSCiuc002qpf.4. human.

Organism-specific databases

CTDi55659.
GeneCardsiZNF416.
HGNCiHGNC:20645. ZNF416.
HPAiHPA063318.
neXtProtiNX_Q9BWM5.
PharmGKBiPA134905500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BWM5.
KOiK09228.
OMAiYTLVEHQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9BWM5.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii55659.
PROiQ9BWM5.

Gene expression databases

BgeeiENSG00000083817.
CleanExiHS_ZNF416.
GenevisibleiQ9BWM5. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN416_HUMAN
AccessioniPrimary (citable) accession number: Q9BWM5
Secondary accession number(s): Q9NWW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.