Q9BWL3 (CA043_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C1orf43

Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 4
Short name=HCV NS5A-transactivated protein 4
Protein NICE-3
S863-3

Gene names

Name:	C1orf43
Synonyms:	NICE3, NS5ATP4
ORF Names:	HSPC012

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence caution	The sequence CAH71276.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	coenzyme binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BWL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BWL3-2)

Also known as: Nice-3;

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.

Isoform 3 (identifier: Q9BWL3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     190-253: Missing.

Isoform 4 (identifier: Q9BWL3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.
     96-114: SCYNYLYRMKALDAIRTSE → K

Isoform 5 (identifier: Q9BWL3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     96-114: SCYNYLYRMKALDAIRTSE → K
     170-170: V → G
     171-253: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Uncharacterized protein C1orf43		PRO_0000089256
Regions
	Transmembrane	11 – 31	21	Helical; Potential
Natural variations
	Alternative sequence	23 – 56	34	Missing in isoform 2 and isoform 4.		VSP_014417
	Alternative sequence	96 – 114	19	SCYNY…IRTSE → K in isoform 4 and isoform 5.		VSP_014418
	Alternative sequence	170	1	V → G in isoform 5.		VSP_014419
	Alternative sequence	171 – 253	83	Missing in isoform 5.		VSP_014420
	Alternative sequence	190 – 253	64	Missing in isoform 3.		VSP_014421
Experimental info
	Sequence conflict	39	1	A → V in CAB65096. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 0C8117E25C660C76	FASTA	253	28,779
	10 20 30 40 50 60 MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE 70 80 90 100 110 120 EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY LYRMKALDAI RTSEIPFHSE 130 140 150 160 170 180 GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR KALIDTLLDG YETARYGTGV FGQNEYLRYQ 190 200 210 220 230 240 EALSELATAV KARIGSSQRH HQSAAKDLTQ SPEVSPTTIQ VTYLPSSQKS KRAKHFLELK 250 SFKDNYNTLE STL
	Isoform 2 (Nice-3) [UniParc]. Checksum: 03CCCB629898B7FE	FASTA	219	24,819
	10 20 30 40 50 60 MASGSNWLSG VNVVLVMAYG SLDLKEEIDI RLSRVQDIKY EPQLLADDDA RLLQLETQGN 70 80 90 100 110 120 QSCYNYLYRM KALDAIRTSE IPFHSEGRHP RSLMGKNFRS YLLDLRNTST PFKGVRKALI 130 140 150 160 170 180 DTLLDGYETA RYGTGVFGQN EYLRYQEALS ELATAVKARI GSSQRHHQSA AKDLTQSPEV 190 200 210 SPTTIQVTYL PSSQKSKRAK HFLELKSFKD NYNTLESTL
	Isoform 3 [UniParc]. Checksum: 2115AE1540F8A227	FASTA	189	21,582
	10 20 30 40 50 60 MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE 70 80 90 100 110 120 EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY LYRMKALDAI RTSEIPFHSE 130 140 150 160 170 180 GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR KALIDTLLDG YETARYGTGV FGQNEYLRYQ EALSELATA
	Isoform 4 [UniParc]. Checksum: F93EB95DB17C4967	FASTA	201	22,668
	10 20 30 40 50 60 MASGSNWLSG VNVVLVMAYG SLDLKEEIDI RLSRVQDIKY EPQLLADDDA RLLQLETQGN 70 80 90 100 110 120 QKIPFHSEGR HPRSLMGKNF RSYLLDLRNT STPFKGVRKA LIDTLLDGYE TARYGTGVFG 130 140 150 160 170 180 QNEYLRYQEA LSELATAVKA RIGSSQRHHQ SAAKDLTQSP EVSPTTIQVT YLPSSQKSKR 190 200 AKHFLELKSF KDNYNTLEST L
	Isoform 5 [UniParc]. Checksum: 78732B87F4E15912	FASTA	152	17,203
	10 20 30 40 50 60 MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE 70 80 90 100 110 120 EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQKIPFH SEGRHPRSLM GKNFRSYLLD 130 140 150 LRNTSTPFKG VRKALIDTLL DGYETARYGT GG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library." Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A., Mischke D. Genome Res. 11:341-355(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 37-253 (ISOFORM 1). Tissue: Keratinocyte.
[2]	Liu B., Zhao B., Wang X.Y., Xu Y.Y., Liu Y.Q., Song L., Ye J., Sheng H., Gao Y., Zhang C.L., Wei Y.J., Zhang J., Song L., Jiang Y.X., Zhao Z.W., Ding J.F., Liu L.S., Gao R.L. , Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Aorta.
[3]	"Cloning and identification of human gene 4 transactivated by hepatitis C virus NS5A protein." Liu Y., Cheng J., Wang G., Wang J., Zhang L., Chen J., Li L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Umbilical cord blood.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5). Tissue: Brain, Cervix, Kidney, Lung and Skin.
[10]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-253 (ISOFORM 1). Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ243663 mRNA. Translation: CAB65094.1. AJ243664 mRNA. Translation: CAB65095.1. AJ243665 mRNA. Translation: CAB65096.1. AF109185 mRNA. Translation: AAQ13494.1. AF529365 mRNA. Translation: AAQ09599.1. AF077036 mRNA. Translation: AAD27769.1. AK290583 mRNA. Translation: BAF83272.1. CR457131 mRNA. Translation: CAG33412.1. AL590431 Genomic DNA. Translation: CAH71272.1. AL590431 Genomic DNA. Translation: CAH71273.1. AL590431 Genomic DNA. Translation: CAH71274.1. AL590431 Genomic DNA. Translation: CAH71275.1. AL590431 Genomic DNA. Translation: CAH71276.1. Sequence problems. AL590431 Genomic DNA. Translation: CAH71277.1. CH471121 Genomic DNA. Translation: EAW53221.1. CH471121 Genomic DNA. Translation: EAW53223.1. CH471121 Genomic DNA. Translation: EAW53224.1. CH471121 Genomic DNA. Translation: EAW53226.1. BC000152 mRNA. Translation: AAH00152.1. BC001377 mRNA. Translation: AAH01377.1. BC006514 mRNA. Translation: AAH06514.1. BC008306 mRNA. Translation: AAH08306.1. BC014391 mRNA. Translation: AAH14391.1. BC088353 mRNA. Translation: AAH88353.1. AL117463 mRNA. Translation: CAB55939.2.
IPI	IPI00032413. IPI00034322. IPI00397901. IPI00607603. IPI00607618.
PIR	T17249.
RefSeq	NP_001092086.1. NM_001098616.1. NP_056264.1. NM_015449.2. NP_620077.1. NM_138740.2.
UniGene	Hs.287471.
3D structure databases
ProteinModelPortal	Q9BWL3.
ModBase	Search...
PTM databases
PhosphoSite	Q9BWL3.
Polymorphism databases
DMDM	68565268.
Proteomic databases
PaxDb	Q9BWL3.
PRIDE	Q9BWL3.
Protocols and materials databases
DNASU	25912.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000350592; ENSP00000271925; ENSG00000143612. ENST00000362076; ENSP00000354496; ENSG00000143612. ENST00000368516; ENSP00000357502; ENSG00000143612. ENST00000368518; ENSP00000357504; ENSG00000143612. ENST00000368519; ENSP00000357505; ENSG00000143612. ENST00000368521; ENSP00000357507; ENSG00000143612.
GeneID	25912.
KEGG	hsa:25912.
UCSC	uc001feh.2. human. uc001fei.2. human. uc009wos.1. human.
Organism-specific databases
CTD	25912.
GeneCards	GC01M154179.
H-InvDB	HIX0019798. HIX0028832.
HGNC	HGNC:29876. C1orf43.
HPA	HPA010725.
neXtProt	NX_Q9BWL3.
PharmGKB	PA134961848.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85443.
HOVERGEN	HBG055226.
InParanoid	Q9BWL3.
OMA	FAMRSRR.
OrthoDB	EOG4V9TRD.
PhylomeDB	Q9BWL3.
Gene expression databases
ArrayExpress	Q9BWL3.
Bgee	Q9BWL3.
CleanEx	HS_C1orf43.
Genevestigator	Q9BWL3.
GermOnline	ENSG00000143612. Homo sapiens.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit.
InterPro	IPR013328. DH_multihelical. IPR010876. NICE-3_prd. [Graphical view]
PANTHER	PTHR21425. PTHR21425. 1 hit.
Pfam	PF07406. NICE-3. 1 hit. [Graphical view]
ProDom	PD320812. NICE-3. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
GenomeRNAi	25912.
NextBio	47400.

Entry information

Entry name

CA043_HUMAN

Accession

Primary (citable) accession number: Q9BWL3
Secondary accession number(s): A8K3G8 , D3DV72, D3DV74, Q5M801, Q5VU73, Q5VU83, Q96HP7, Q9UFU2, Q9UGL7, Q9UGL8, Q9Y2R6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.