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Q9BWL3 (CA043_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C1orf43
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 4
Short name=HCV NS5A-transactivated protein 4
Protein NICE-3
S863-3
Gene names
Name:C1orf43
Synonyms:NICE3, NS5ATP4
ORF Names:HSPC012
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence caution

The sequence CAH71276.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BWL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BWL3-2)

Also known as: Nice-3;

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.
Isoform 3 (identifier: Q9BWL3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     190-253: Missing.
Isoform 4 (identifier: Q9BWL3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.
     96-114: SCYNYLYRMKALDAIRTSE → K
Isoform 5 (identifier: Q9BWL3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     96-114: SCYNYLYRMKALDAIRTSE → K
     170-170: V → G
     171-253: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Uncharacterized protein C1orf43
PRO_0000089256

Regions

Transmembrane11 – 3121Helical; Potential

Natural variations

Alternative sequence23 – 5634Missing in isoform 2 and isoform 4.
VSP_014417
Alternative sequence96 – 11419SCYNY…IRTSE → K in isoform 4 and isoform 5.
VSP_014418
Alternative sequence1701V → G in isoform 5.
VSP_014419
Alternative sequence171 – 25383Missing in isoform 5.
VSP_014420
Alternative sequence190 – 25364Missing in isoform 3.
VSP_014421

Experimental info

Sequence conflict391A → V in CAB65096. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0C8117E25C660C76

FASTA25328,779
        10         20         30         40         50         60 
MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE 

        70         80         90        100        110        120 
EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY LYRMKALDAI RTSEIPFHSE 

       130        140        150        160        170        180 
GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR KALIDTLLDG YETARYGTGV FGQNEYLRYQ 

       190        200        210        220        230        240 
EALSELATAV KARIGSSQRH HQSAAKDLTQ SPEVSPTTIQ VTYLPSSQKS KRAKHFLELK 

       250 
SFKDNYNTLE STL 

« Hide

Isoform 2 (Nice-3) [UniParc].

Checksum: 03CCCB629898B7FE
Show »

FASTA21924,819
Isoform 3 [UniParc].

Checksum: 2115AE1540F8A227
Show »

FASTA18921,582
Isoform 4 [UniParc].

Checksum: F93EB95DB17C4967
Show »

FASTA20122,668
Isoform 5 [UniParc].

Checksum: 78732B87F4E15912
Show »

FASTA15217,203

References

« Hide 'large scale' references
[1]"Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library."
Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A., Mischke D.
Genome Res. 11:341-355(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 37-253 (ISOFORM 1).
Tissue: Keratinocyte.
[2]Liu B., Zhao B., Wang X.Y., Xu Y.Y., Liu Y.Q., Song L., Ye J., Sheng H., Gao Y., Zhang C.L., Wei Y.J., Zhang J., Song L., Jiang Y.X., Zhao Z.W., Ding J.F., Liu L.S., Gao R.L. expand/collapse author list , Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Aorta.
[3]"Cloning and identification of human gene 4 transactivated by hepatitis C virus NS5A protein."
Liu Y., Cheng J., Wang G., Wang J., Zhang L., Chen J., Li L.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Umbilical cord blood.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5).
Tissue: Brain, Cervix, Kidney, Lung and Skin.
[10]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-253 (ISOFORM 1).
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ243663 mRNA. Translation: CAB65094.1.
AJ243664 mRNA. Translation: CAB65095.1.
AJ243665 mRNA. Translation: CAB65096.1.
AF109185 mRNA. Translation: AAQ13494.1.
AF529365 mRNA. Translation: AAQ09599.1.
AF077036 mRNA. Translation: AAD27769.1.
AK290583 mRNA. Translation: BAF83272.1.
CR457131 mRNA. Translation: CAG33412.1.
AL590431 Genomic DNA. Translation: CAH71272.1.
AL590431 Genomic DNA. Translation: CAH71273.1.
AL590431 Genomic DNA. Translation: CAH71274.1.
AL590431 Genomic DNA. Translation: CAH71275.1.
AL590431 Genomic DNA. Translation: CAH71276.1. Sequence problems.
AL590431 Genomic DNA. Translation: CAH71277.1.
CH471121 Genomic DNA. Translation: EAW53221.1.
CH471121 Genomic DNA. Translation: EAW53223.1.
CH471121 Genomic DNA. Translation: EAW53224.1.
CH471121 Genomic DNA. Translation: EAW53226.1.
BC000152 mRNA. Translation: AAH00152.1.
BC001377 mRNA. Translation: AAH01377.1.
BC006514 mRNA. Translation: AAH06514.1.
BC008306 mRNA. Translation: AAH08306.1.
BC014391 mRNA. Translation: AAH14391.1.
BC088353 mRNA. Translation: AAH88353.1.
AL117463 mRNA. Translation: CAB55939.2.
PIRT17249.
RefSeqNP_001092086.1. NM_001098616.1.
NP_056264.1. NM_015449.2.
NP_620077.1. NM_138740.2.
UniGeneHs.287471.

3D structure databases

ProteinModelPortalQ9BWL3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117416. 1 interaction.

PTM databases

PhosphoSiteQ9BWL3.

Polymorphism databases

DMDM68565268.

Proteomic databases

PaxDbQ9BWL3.
PRIDEQ9BWL3.

Protocols and materials databases

DNASU25912.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000350592; ENSP00000271925; ENSG00000143612. [Q9BWL3-2]
ENST00000362076; ENSP00000354496; ENSG00000143612. [Q9BWL3-4]
ENST00000368518; ENSP00000357504; ENSG00000143612. [Q9BWL3-3]
ENST00000368521; ENSP00000357507; ENSG00000143612. [Q9BWL3-1]
GeneID25912.
KEGGhsa:25912.
UCSCuc001feh.2. human. [Q9BWL3-4]
uc001fei.2. human. [Q9BWL3-1]
uc009wos.1. human. [Q9BWL3-5]

Organism-specific databases

CTD25912.
GeneCardsGC01M154179.
H-InvDBHIX0019798.
HIX0028832.
HGNCHGNC:29876. C1orf43.
HPAHPA010725.
HPA047579.
neXtProtNX_Q9BWL3.
PharmGKBPA134961848.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85443.
HOVERGENHBG055226.
InParanoidQ9BWL3.
OMAFAMRSRR.
OrthoDBEOG75F4DX.
PhylomeDBQ9BWL3.
TreeFamTF324880.

Gene expression databases

ArrayExpressQ9BWL3.
BgeeQ9BWL3.
CleanExHS_C1orf43.
GenevestigatorQ9BWL3.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
InterProIPR013328. DH_multihelical.
IPR010876. NICE-3_prd.
[Graphical view]
PANTHERPTHR21425. PTHR21425. 1 hit.
PfamPF07406. NICE-3. 1 hit.
[Graphical view]
ProDomPD320812. NICE-3. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GenomeRNAi25912.
NextBio47400.

Entry information

Entry nameCA043_HUMAN
AccessionPrimary (citable) accession number: Q9BWL3
Secondary accession number(s): A8K3G8 expand/collapse secondary AC list , D3DV72, D3DV74, Q5M801, Q5VU73, Q5VU83, Q96HP7, Q9UFU2, Q9UGL7, Q9UGL8, Q9Y2R6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: March 19, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM