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Protein

Uncharacterized protein C1orf43

Gene

C1orf43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143612-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf43
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 4
Short name:
HCV NS5A-transactivated protein 4
Protein NICE-3
S863-3
Gene namesi
Name:C1orf43
Synonyms:NICE3, NS5ATP4
ORF Names:HSPC012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29876. C1orf43.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143612.
PharmGKBiPA134961848.

Polymorphism and mutation databases

BioMutaiC1orf43.
DMDMi68565268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892561 – 253Uncharacterized protein C1orf43Add BLAST253

Proteomic databases

EPDiQ9BWL3.
MaxQBiQ9BWL3.
PaxDbiQ9BWL3.
PeptideAtlasiQ9BWL3.
PRIDEiQ9BWL3.

PTM databases

iPTMnetiQ9BWL3.
PhosphoSitePlusiQ9BWL3.

Expressioni

Gene expression databases

BgeeiENSG00000143612.
CleanExiHS_C1orf43.
ExpressionAtlasiQ9BWL3. baseline and differential.
GenevisibleiQ9BWL3. HS.

Organism-specific databases

HPAiHPA010725.

Interactioni

Protein-protein interaction databases

BioGridi117416. 26 interactors.
STRINGi9606.ENSP00000357507.

Structurei

3D structure databases

ProteinModelPortaliQ9BWL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJYI. Eukaryota.
ENOG410XP22. LUCA.
GeneTreeiENSGT00510000047366.
HOVERGENiHBG055226.
InParanoidiQ9BWL3.
OMAiYLHYQEA.
OrthoDBiEOG091G0HJ0.
PhylomeDBiQ9BWL3.
TreeFamiTF324880.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
InterProiIPR013328. 6PGD_dom_2.
IPR010876. NICE-3_prd.
[Graphical view]
PANTHERiPTHR21425. PTHR21425. 1 hit.
PfamiPF07406. NICE-3. 1 hit.
[Graphical view]
ProDomiPD320812. NICE-3. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV
60 70 80 90 100
GHNAPKDLKE EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY
110 120 130 140 150
LYRMKALDAI RTSEIPFHSE GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR
160 170 180 190 200
KALIDTLLDG YETARYGTGV FGQNEYLRYQ EALSELATAV KARIGSSQRH
210 220 230 240 250
HQSAAKDLTQ SPEVSPTTIQ VTYLPSSQKS KRAKHFLELK SFKDNYNTLE

STL
Length:253
Mass (Da):28,779
Last modified:June 1, 2001 - v1
Checksum:i0C8117E25C660C76
GO
Isoform 2 (identifier: Q9BWL3-2) [UniParc]FASTAAdd to basket
Also known as: Nice-3

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.

Show »
Length:219
Mass (Da):24,819
Checksum:i03CCCB629898B7FE
GO
Isoform 3 (identifier: Q9BWL3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-253: Missing.

Show »
Length:189
Mass (Da):21,582
Checksum:i2115AE1540F8A227
GO
Isoform 4 (identifier: Q9BWL3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.
     96-114: SCYNYLYRMKALDAIRTSE → K

Show »
Length:201
Mass (Da):22,668
Checksum:iF93EB95DB17C4967
GO
Isoform 5 (identifier: Q9BWL3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-114: SCYNYLYRMKALDAIRTSE → K
     170-170: V → G
     171-253: Missing.

Show »
Length:152
Mass (Da):17,203
Checksum:i78732B87F4E15912
GO

Sequence cautioni

The sequence CAH71276 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39A → V in CAB65096 (PubMed:11230159).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01441723 – 56Missing in isoform 2 and isoform 4. 4 PublicationsAdd BLAST34
Alternative sequenceiVSP_01441896 – 114SCYNY…IRTSE → K in isoform 4 and isoform 5. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_014419170V → G in isoform 5. 1 Publication1
Alternative sequenceiVSP_014420171 – 253Missing in isoform 5. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_014421190 – 253Missing in isoform 3. 2 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243663 mRNA. Translation: CAB65094.1.
AJ243664 mRNA. Translation: CAB65095.1.
AJ243665 mRNA. Translation: CAB65096.1.
AF109185 mRNA. Translation: AAQ13494.1.
AF529365 mRNA. Translation: AAQ09599.1.
AF077036 mRNA. Translation: AAD27769.1.
AK290583 mRNA. Translation: BAF83272.1.
CR457131 mRNA. Translation: CAG33412.1.
AL590431 Genomic DNA. Translation: CAH71272.1.
AL590431 Genomic DNA. Translation: CAH71273.1.
AL590431 Genomic DNA. Translation: CAH71274.1.
AL590431 Genomic DNA. Translation: CAH71275.1.
AL590431 Genomic DNA. Translation: CAH71276.1. Sequence problems.
AL590431 Genomic DNA. Translation: CAH71277.1.
CH471121 Genomic DNA. Translation: EAW53221.1.
CH471121 Genomic DNA. Translation: EAW53223.1.
CH471121 Genomic DNA. Translation: EAW53224.1.
CH471121 Genomic DNA. Translation: EAW53226.1.
BC000152 mRNA. Translation: AAH00152.1.
BC001377 mRNA. Translation: AAH01377.1.
BC006514 mRNA. Translation: AAH06514.1.
BC008306 mRNA. Translation: AAH08306.1.
BC014391 mRNA. Translation: AAH14391.1.
BC088353 mRNA. Translation: AAH88353.1.
AL117463 mRNA. Translation: CAB55939.2.
CCDSiCCDS1061.1. [Q9BWL3-2]
CCDS1062.1. [Q9BWL3-4]
CCDS41404.1. [Q9BWL3-1]
CCDS76220.1. [Q9BWL3-3]
PIRiT17249.
RefSeqiNP_001092086.1. NM_001098616.2. [Q9BWL3-1]
NP_001284646.1. NM_001297717.1. [Q9BWL3-5]
NP_001284647.1. NM_001297718.1.
NP_001284649.1. NM_001297720.1.
NP_001284650.1. NM_001297721.1.
NP_001284652.1. NM_001297723.1. [Q9BWL3-3]
NP_056264.1. NM_015449.3. [Q9BWL3-2]
NP_620077.1. NM_138740.3. [Q9BWL3-4]
UniGeneiHs.287471.

Genome annotation databases

EnsembliENST00000350592; ENSP00000271925; ENSG00000143612. [Q9BWL3-2]
ENST00000362076; ENSP00000354496; ENSG00000143612. [Q9BWL3-4]
ENST00000368518; ENSP00000357504; ENSG00000143612. [Q9BWL3-3]
ENST00000368521; ENSP00000357507; ENSG00000143612. [Q9BWL3-1]
GeneIDi25912.
KEGGihsa:25912.
UCSCiuc001feg.3. human. [Q9BWL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243663 mRNA. Translation: CAB65094.1.
AJ243664 mRNA. Translation: CAB65095.1.
AJ243665 mRNA. Translation: CAB65096.1.
AF109185 mRNA. Translation: AAQ13494.1.
AF529365 mRNA. Translation: AAQ09599.1.
AF077036 mRNA. Translation: AAD27769.1.
AK290583 mRNA. Translation: BAF83272.1.
CR457131 mRNA. Translation: CAG33412.1.
AL590431 Genomic DNA. Translation: CAH71272.1.
AL590431 Genomic DNA. Translation: CAH71273.1.
AL590431 Genomic DNA. Translation: CAH71274.1.
AL590431 Genomic DNA. Translation: CAH71275.1.
AL590431 Genomic DNA. Translation: CAH71276.1. Sequence problems.
AL590431 Genomic DNA. Translation: CAH71277.1.
CH471121 Genomic DNA. Translation: EAW53221.1.
CH471121 Genomic DNA. Translation: EAW53223.1.
CH471121 Genomic DNA. Translation: EAW53224.1.
CH471121 Genomic DNA. Translation: EAW53226.1.
BC000152 mRNA. Translation: AAH00152.1.
BC001377 mRNA. Translation: AAH01377.1.
BC006514 mRNA. Translation: AAH06514.1.
BC008306 mRNA. Translation: AAH08306.1.
BC014391 mRNA. Translation: AAH14391.1.
BC088353 mRNA. Translation: AAH88353.1.
AL117463 mRNA. Translation: CAB55939.2.
CCDSiCCDS1061.1. [Q9BWL3-2]
CCDS1062.1. [Q9BWL3-4]
CCDS41404.1. [Q9BWL3-1]
CCDS76220.1. [Q9BWL3-3]
PIRiT17249.
RefSeqiNP_001092086.1. NM_001098616.2. [Q9BWL3-1]
NP_001284646.1. NM_001297717.1. [Q9BWL3-5]
NP_001284647.1. NM_001297718.1.
NP_001284649.1. NM_001297720.1.
NP_001284650.1. NM_001297721.1.
NP_001284652.1. NM_001297723.1. [Q9BWL3-3]
NP_056264.1. NM_015449.3. [Q9BWL3-2]
NP_620077.1. NM_138740.3. [Q9BWL3-4]
UniGeneiHs.287471.

3D structure databases

ProteinModelPortaliQ9BWL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117416. 26 interactors.
STRINGi9606.ENSP00000357507.

PTM databases

iPTMnetiQ9BWL3.
PhosphoSitePlusiQ9BWL3.

Polymorphism and mutation databases

BioMutaiC1orf43.
DMDMi68565268.

Proteomic databases

EPDiQ9BWL3.
MaxQBiQ9BWL3.
PaxDbiQ9BWL3.
PeptideAtlasiQ9BWL3.
PRIDEiQ9BWL3.

Protocols and materials databases

DNASUi25912.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350592; ENSP00000271925; ENSG00000143612. [Q9BWL3-2]
ENST00000362076; ENSP00000354496; ENSG00000143612. [Q9BWL3-4]
ENST00000368518; ENSP00000357504; ENSG00000143612. [Q9BWL3-3]
ENST00000368521; ENSP00000357507; ENSG00000143612. [Q9BWL3-1]
GeneIDi25912.
KEGGihsa:25912.
UCSCiuc001feg.3. human. [Q9BWL3-1]

Organism-specific databases

CTDi25912.
GeneCardsiC1orf43.
H-InvDBHIX0019798.
HIX0028832.
HGNCiHGNC:29876. C1orf43.
HPAiHPA010725.
neXtProtiNX_Q9BWL3.
OpenTargetsiENSG00000143612.
PharmGKBiPA134961848.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJYI. Eukaryota.
ENOG410XP22. LUCA.
GeneTreeiENSGT00510000047366.
HOVERGENiHBG055226.
InParanoidiQ9BWL3.
OMAiYLHYQEA.
OrthoDBiEOG091G0HJ0.
PhylomeDBiQ9BWL3.
TreeFamiTF324880.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143612-MONOMER.

Miscellaneous databases

ChiTaRSiC1orf43. human.
GenomeRNAii25912.
PROiQ9BWL3.

Gene expression databases

BgeeiENSG00000143612.
CleanExiHS_C1orf43.
ExpressionAtlasiQ9BWL3. baseline and differential.
GenevisibleiQ9BWL3. HS.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
InterProiIPR013328. 6PGD_dom_2.
IPR010876. NICE-3_prd.
[Graphical view]
PANTHERiPTHR21425. PTHR21425. 1 hit.
PfamiPF07406. NICE-3. 1 hit.
[Graphical view]
ProDomiPD320812. NICE-3. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCA043_HUMAN
AccessioniPrimary (citable) accession number: Q9BWL3
Secondary accession number(s): A8K3G8
, D3DV72, D3DV74, Q5M801, Q5VU73, Q5VU83, Q96HP7, Q9UFU2, Q9UGL7, Q9UGL8, Q9Y2R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.