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Q9BWL3

- CA043_HUMAN

UniProt

Q9BWL3 - CA043_HUMAN

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Protein
Uncharacterized protein C1orf43
Gene
C1orf43, NICE3, NS5ATP4, HSPC012
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf43
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 4
Short name:
HCV NS5A-transactivated protein 4
Protein NICE-3
S863-3
Gene namesi
Name:C1orf43
Synonyms:NICE3, NS5ATP4
ORF Names:HSPC012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29876. C1orf43.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Uncharacterized protein C1orf43
PRO_0000089256Add
BLAST

Proteomic databases

MaxQBiQ9BWL3.
PaxDbiQ9BWL3.
PRIDEiQ9BWL3.

PTM databases

PhosphoSiteiQ9BWL3.

Expressioni

Gene expression databases

ArrayExpressiQ9BWL3.
BgeeiQ9BWL3.
CleanExiHS_C1orf43.
GenevestigatoriQ9BWL3.

Organism-specific databases

HPAiHPA010725.
HPA047579.

Interactioni

Protein-protein interaction databases

BioGridi117416. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BWL3.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85443.
HOVERGENiHBG055226.
InParanoidiQ9BWL3.
OMAiHNAPKGL.
OrthoDBiEOG75F4DX.
PhylomeDBiQ9BWL3.
TreeFamiTF324880.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
InterProiIPR013328. DH_multihelical.
IPR010876. NICE-3_prd.
[Graphical view]
PANTHERiPTHR21425. PTHR21425. 1 hit.
PfamiPF07406. NICE-3. 1 hit.
[Graphical view]
ProDomiPD320812. NICE-3. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BWL3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV    50
GHNAPKDLKE EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY 100
LYRMKALDAI RTSEIPFHSE GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR 150
KALIDTLLDG YETARYGTGV FGQNEYLRYQ EALSELATAV KARIGSSQRH 200
HQSAAKDLTQ SPEVSPTTIQ VTYLPSSQKS KRAKHFLELK SFKDNYNTLE 250
STL 253
Length:253
Mass (Da):28,779
Last modified:June 1, 2001 - v1
Checksum:i0C8117E25C660C76
GO
Isoform 2 (identifier: Q9BWL3-2) [UniParc]FASTAAdd to Basket

Also known as: Nice-3

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.

Show »
Length:219
Mass (Da):24,819
Checksum:i03CCCB629898B7FE
GO
Isoform 3 (identifier: Q9BWL3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-253: Missing.

Show »
Length:189
Mass (Da):21,582
Checksum:i2115AE1540F8A227
GO
Isoform 4 (identifier: Q9BWL3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.
     96-114: SCYNYLYRMKALDAIRTSE → K

Show »
Length:201
Mass (Da):22,668
Checksum:iF93EB95DB17C4967
GO
Isoform 5 (identifier: Q9BWL3-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-114: SCYNYLYRMKALDAIRTSE → K
     170-170: V → G
     171-253: Missing.

Show »
Length:152
Mass (Da):17,203
Checksum:i78732B87F4E15912
GO

Sequence cautioni

The sequence CAH71276.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 5634Missing in isoform 2 and isoform 4.
VSP_014417Add
BLAST
Alternative sequencei96 – 11419SCYNY…IRTSE → K in isoform 4 and isoform 5.
VSP_014418Add
BLAST
Alternative sequencei170 – 1701V → G in isoform 5.
VSP_014419
Alternative sequencei171 – 25383Missing in isoform 5.
VSP_014420Add
BLAST
Alternative sequencei190 – 25364Missing in isoform 3.
VSP_014421Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391A → V in CAB65096. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243663 mRNA. Translation: CAB65094.1.
AJ243664 mRNA. Translation: CAB65095.1.
AJ243665 mRNA. Translation: CAB65096.1.
AF109185 mRNA. Translation: AAQ13494.1.
AF529365 mRNA. Translation: AAQ09599.1.
AF077036 mRNA. Translation: AAD27769.1.
AK290583 mRNA. Translation: BAF83272.1.
CR457131 mRNA. Translation: CAG33412.1.
AL590431 Genomic DNA. Translation: CAH71272.1.
AL590431 Genomic DNA. Translation: CAH71273.1.
AL590431 Genomic DNA. Translation: CAH71274.1.
AL590431 Genomic DNA. Translation: CAH71275.1.
AL590431 Genomic DNA. Translation: CAH71276.1. Sequence problems.
AL590431 Genomic DNA. Translation: CAH71277.1.
CH471121 Genomic DNA. Translation: EAW53221.1.
CH471121 Genomic DNA. Translation: EAW53223.1.
CH471121 Genomic DNA. Translation: EAW53224.1.
CH471121 Genomic DNA. Translation: EAW53226.1.
BC000152 mRNA. Translation: AAH00152.1.
BC001377 mRNA. Translation: AAH01377.1.
BC006514 mRNA. Translation: AAH06514.1.
BC008306 mRNA. Translation: AAH08306.1.
BC014391 mRNA. Translation: AAH14391.1.
BC088353 mRNA. Translation: AAH88353.1.
AL117463 mRNA. Translation: CAB55939.2.
CCDSiCCDS1061.1. [Q9BWL3-2]
CCDS1062.1. [Q9BWL3-4]
CCDS41404.1. [Q9BWL3-1]
PIRiT17249.
RefSeqiNP_001092086.1. NM_001098616.1. [Q9BWL3-1]
NP_056264.1. NM_015449.2. [Q9BWL3-2]
NP_620077.1. NM_138740.2. [Q9BWL3-4]
UniGeneiHs.287471.

Genome annotation databases

EnsembliENST00000350592; ENSP00000271925; ENSG00000143612. [Q9BWL3-2]
ENST00000362076; ENSP00000354496; ENSG00000143612. [Q9BWL3-4]
ENST00000368518; ENSP00000357504; ENSG00000143612. [Q9BWL3-3]
ENST00000368521; ENSP00000357507; ENSG00000143612. [Q9BWL3-1]
GeneIDi25912.
KEGGihsa:25912.
UCSCiuc001feh.2. human. [Q9BWL3-4]
uc001fei.2. human. [Q9BWL3-1]
uc009wos.1. human. [Q9BWL3-5]

Polymorphism databases

DMDMi68565268.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243663 mRNA. Translation: CAB65094.1 .
AJ243664 mRNA. Translation: CAB65095.1 .
AJ243665 mRNA. Translation: CAB65096.1 .
AF109185 mRNA. Translation: AAQ13494.1 .
AF529365 mRNA. Translation: AAQ09599.1 .
AF077036 mRNA. Translation: AAD27769.1 .
AK290583 mRNA. Translation: BAF83272.1 .
CR457131 mRNA. Translation: CAG33412.1 .
AL590431 Genomic DNA. Translation: CAH71272.1 .
AL590431 Genomic DNA. Translation: CAH71273.1 .
AL590431 Genomic DNA. Translation: CAH71274.1 .
AL590431 Genomic DNA. Translation: CAH71275.1 .
AL590431 Genomic DNA. Translation: CAH71276.1 . Sequence problems.
AL590431 Genomic DNA. Translation: CAH71277.1 .
CH471121 Genomic DNA. Translation: EAW53221.1 .
CH471121 Genomic DNA. Translation: EAW53223.1 .
CH471121 Genomic DNA. Translation: EAW53224.1 .
CH471121 Genomic DNA. Translation: EAW53226.1 .
BC000152 mRNA. Translation: AAH00152.1 .
BC001377 mRNA. Translation: AAH01377.1 .
BC006514 mRNA. Translation: AAH06514.1 .
BC008306 mRNA. Translation: AAH08306.1 .
BC014391 mRNA. Translation: AAH14391.1 .
BC088353 mRNA. Translation: AAH88353.1 .
AL117463 mRNA. Translation: CAB55939.2 .
CCDSi CCDS1061.1. [Q9BWL3-2 ]
CCDS1062.1. [Q9BWL3-4 ]
CCDS41404.1. [Q9BWL3-1 ]
PIRi T17249.
RefSeqi NP_001092086.1. NM_001098616.1. [Q9BWL3-1 ]
NP_056264.1. NM_015449.2. [Q9BWL3-2 ]
NP_620077.1. NM_138740.2. [Q9BWL3-4 ]
UniGenei Hs.287471.

3D structure databases

ProteinModelPortali Q9BWL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117416. 1 interaction.

PTM databases

PhosphoSitei Q9BWL3.

Polymorphism databases

DMDMi 68565268.

Proteomic databases

MaxQBi Q9BWL3.
PaxDbi Q9BWL3.
PRIDEi Q9BWL3.

Protocols and materials databases

DNASUi 25912.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000350592 ; ENSP00000271925 ; ENSG00000143612 . [Q9BWL3-2 ]
ENST00000362076 ; ENSP00000354496 ; ENSG00000143612 . [Q9BWL3-4 ]
ENST00000368518 ; ENSP00000357504 ; ENSG00000143612 . [Q9BWL3-3 ]
ENST00000368521 ; ENSP00000357507 ; ENSG00000143612 . [Q9BWL3-1 ]
GeneIDi 25912.
KEGGi hsa:25912.
UCSCi uc001feh.2. human. [Q9BWL3-4 ]
uc001fei.2. human. [Q9BWL3-1 ]
uc009wos.1. human. [Q9BWL3-5 ]

Organism-specific databases

CTDi 25912.
GeneCardsi GC01M154179.
H-InvDB HIX0019798.
HIX0028832.
HGNCi HGNC:29876. C1orf43.
HPAi HPA010725.
HPA047579.
neXtProti NX_Q9BWL3.
PharmGKBi PA134961848.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85443.
HOVERGENi HBG055226.
InParanoidi Q9BWL3.
OMAi HNAPKGL.
OrthoDBi EOG75F4DX.
PhylomeDBi Q9BWL3.
TreeFami TF324880.

Miscellaneous databases

GenomeRNAii 25912.
NextBioi 47400.

Gene expression databases

ArrayExpressi Q9BWL3.
Bgeei Q9BWL3.
CleanExi HS_C1orf43.
Genevestigatori Q9BWL3.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
InterProi IPR013328. DH_multihelical.
IPR010876. NICE-3_prd.
[Graphical view ]
PANTHERi PTHR21425. PTHR21425. 1 hit.
Pfami PF07406. NICE-3. 1 hit.
[Graphical view ]
ProDomi PD320812. NICE-3. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library."
    Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A., Mischke D.
    Genome Res. 11:341-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 37-253 (ISOFORM 1).
    Tissue: Keratinocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Aorta.
  3. "Cloning and identification of human gene 4 transactivated by hepatitis C virus NS5A protein."
    Liu Y., Cheng J., Wang G., Wang J., Zhang L., Chen J., Li L.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5).
    Tissue: Brain, Cervix, Kidney, Lung and Skin.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-253 (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiCA043_HUMAN
AccessioniPrimary (citable) accession number: Q9BWL3
Secondary accession number(s): A8K3G8
, D3DV72, D3DV74, Q5M801, Q5VU73, Q5VU83, Q96HP7, Q9UFU2, Q9UGL7, Q9UGL8, Q9Y2R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3

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