Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized protein C1orf43

Gene

C1orf43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf43
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 4
Short name:
HCV NS5A-transactivated protein 4
Protein NICE-3
S863-3
Gene namesi
Name:C1orf43
Synonyms:NICE3, NS5ATP4
ORF Names:HSPC012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143612.18
HGNCiHGNC:29876 C1orf43
MIMi617428 gene
neXtProtiNX_Q9BWL3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143612
PharmGKBiPA134961848

Polymorphism and mutation databases

BioMutaiC1orf43
DMDMi68565268

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892561 – 253Uncharacterized protein C1orf43Add BLAST253

Proteomic databases

EPDiQ9BWL3
MaxQBiQ9BWL3
PaxDbiQ9BWL3
PeptideAtlasiQ9BWL3
PRIDEiQ9BWL3

PTM databases

iPTMnetiQ9BWL3
PhosphoSitePlusiQ9BWL3

Expressioni

Gene expression databases

BgeeiENSG00000143612
CleanExiHS_C1orf43
ExpressionAtlasiQ9BWL3 baseline and differential
GenevisibleiQ9BWL3 HS

Organism-specific databases

HPAiHPA010725

Interactioni

Protein-protein interaction databases

BioGridi11741636 interactors.
STRINGi9606.ENSP00000357507

Structurei

3D structure databases

ProteinModelPortaliQ9BWL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJYI Eukaryota
ENOG410XP22 LUCA
GeneTreeiENSGT00510000047366
HOVERGENiHBG055226
InParanoidiQ9BWL3
OMAiEADHHQS
OrthoDBiEOG091G0HJ0
PhylomeDBiQ9BWL3
TreeFamiTF324880

Family and domain databases

InterProiView protein in InterPro
IPR010876 NICE-3_prd
PANTHERiPTHR21425 PTHR21425, 1 hit
PfamiView protein in Pfam
PF07406 NICE-3, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD320812 NICE-3, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV
60 70 80 90 100
GHNAPKDLKE EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY
110 120 130 140 150
LYRMKALDAI RTSEIPFHSE GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR
160 170 180 190 200
KALIDTLLDG YETARYGTGV FGQNEYLRYQ EALSELATAV KARIGSSQRH
210 220 230 240 250
HQSAAKDLTQ SPEVSPTTIQ VTYLPSSQKS KRAKHFLELK SFKDNYNTLE

STL
Length:253
Mass (Da):28,779
Last modified:June 1, 2001 - v1
Checksum:i0C8117E25C660C76
GO
Isoform 2 (identifier: Q9BWL3-2) [UniParc]FASTAAdd to basket
Also known as: Nice-3

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.

Show »
Length:219
Mass (Da):24,819
Checksum:i03CCCB629898B7FE
GO
Isoform 3 (identifier: Q9BWL3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-253: Missing.

Show »
Length:189
Mass (Da):21,582
Checksum:i2115AE1540F8A227
GO
Isoform 4 (identifier: Q9BWL3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-56: Missing.
     96-114: SCYNYLYRMKALDAIRTSE → K

Show »
Length:201
Mass (Da):22,668
Checksum:iF93EB95DB17C4967
GO
Isoform 5 (identifier: Q9BWL3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-114: SCYNYLYRMKALDAIRTSE → K
     170-170: V → G
     171-253: Missing.

Show »
Length:152
Mass (Da):17,203
Checksum:i78732B87F4E15912
GO

Sequence cautioni

The sequence CAH71276 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39A → V in CAB65096 (PubMed:11230159).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01441723 – 56Missing in isoform 2 and isoform 4. 4 PublicationsAdd BLAST34
Alternative sequenceiVSP_01441896 – 114SCYNY…IRTSE → K in isoform 4 and isoform 5. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_014419170V → G in isoform 5. 1 Publication1
Alternative sequenceiVSP_014420171 – 253Missing in isoform 5. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_014421190 – 253Missing in isoform 3. 2 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243663 mRNA Translation: CAB65094.1
AJ243664 mRNA Translation: CAB65095.1
AJ243665 mRNA Translation: CAB65096.1
AF109185 mRNA Translation: AAQ13494.1
AF529365 mRNA Translation: AAQ09599.1
AF077036 mRNA Translation: AAD27769.1
AK290583 mRNA Translation: BAF83272.1
CR457131 mRNA Translation: CAG33412.1
AL590431 Genomic DNA Translation: CAH71272.1
AL590431 Genomic DNA Translation: CAH71273.1
AL590431 Genomic DNA Translation: CAH71274.1
AL590431 Genomic DNA Translation: CAH71275.1
AL590431 Genomic DNA Translation: CAH71276.1 Sequence problems.
AL590431 Genomic DNA Translation: CAH71277.1
CH471121 Genomic DNA Translation: EAW53221.1
CH471121 Genomic DNA Translation: EAW53223.1
CH471121 Genomic DNA Translation: EAW53224.1
CH471121 Genomic DNA Translation: EAW53226.1
BC000152 mRNA Translation: AAH00152.1
BC001377 mRNA Translation: AAH01377.1
BC006514 mRNA Translation: AAH06514.1
BC008306 mRNA Translation: AAH08306.1
BC014391 mRNA Translation: AAH14391.1
BC088353 mRNA Translation: AAH88353.1
AL117463 mRNA Translation: CAB55939.2
CCDSiCCDS1061.1 [Q9BWL3-2]
CCDS1062.1 [Q9BWL3-4]
CCDS41404.1 [Q9BWL3-1]
CCDS76220.1 [Q9BWL3-3]
PIRiT17249
RefSeqiNP_001092086.1, NM_001098616.2 [Q9BWL3-1]
NP_001284646.1, NM_001297717.1 [Q9BWL3-5]
NP_001284647.1, NM_001297718.1
NP_001284649.1, NM_001297720.1
NP_001284650.1, NM_001297721.1
NP_001284652.1, NM_001297723.1 [Q9BWL3-3]
NP_056264.1, NM_015449.3 [Q9BWL3-2]
NP_620077.1, NM_138740.3 [Q9BWL3-4]
UniGeneiHs.287471

Genome annotation databases

EnsembliENST00000350592; ENSP00000271925; ENSG00000143612 [Q9BWL3-2]
ENST00000362076; ENSP00000354496; ENSG00000143612 [Q9BWL3-4]
ENST00000368518; ENSP00000357504; ENSG00000143612 [Q9BWL3-3]
ENST00000368521; ENSP00000357507; ENSG00000143612 [Q9BWL3-1]
GeneIDi25912
KEGGihsa:25912
UCSCiuc001feg.3 human [Q9BWL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCA043_HUMAN
AccessioniPrimary (citable) accession number: Q9BWL3
Secondary accession number(s): A8K3G8
, D3DV72, D3DV74, Q5M801, Q5VU73, Q5VU83, Q96HP7, Q9UFU2, Q9UGL7, Q9UGL8, Q9Y2R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome