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Protein

Splicing factor 3B subunit 5

Gene

SF3B5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 3B subunit 5
Short name:
SF3b5
Alternative name(s):
Pre-mRNA-splicing factor SF3b 10 kDa subunit
Gene namesi
Name:SF3B5
Synonyms:SF3B10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21083. SF3B5.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: LIFEdb
  • precatalytic spliceosome Source: GO_Central
  • U12-type spliceosomal complex Source: UniProtKB
  • U2 snRNP Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951632.

Polymorphism and mutation databases

BioMutaiSF3B5.
DMDMi20140757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 8685Splicing factor 3B subunit 5PRO_0000220757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineCombined sources
Modified residuei9 – 91PhosphoserineCombined sources
Modified residuei17 – 171N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BWJ5.
MaxQBiQ9BWJ5.
PaxDbiQ9BWJ5.
PeptideAtlasiQ9BWJ5.
PRIDEiQ9BWJ5.
TopDownProteomicsiQ9BWJ5.

PTM databases

iPTMnetiQ9BWJ5.
PhosphoSiteiQ9BWJ5.

Expressioni

Gene expression databases

BgeeiENSG00000169976.
CleanExiHS_SF3B5.
GenevisibleiQ9BWJ5. HS.

Organism-specific databases

HPAiHPA054408.

Interactioni

Subunit structurei

Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.3 Publications

Protein-protein interaction databases

BioGridi123645. 33 interactions.
IntActiQ9BWJ5. 7 interactions.
MINTiMINT-3062697.
STRINGi9606.ENSP00000356541.

Structurei

3D structure databases

ProteinModelPortaliQ9BWJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SF3B5 family.Curated

Phylogenomic databases

eggNOGiKOG3485. Eukaryota.
ENOG4111NTV. LUCA.
GeneTreeiENSGT00390000013215.
HOVERGENiHBG054589.
InParanoidiQ9BWJ5.
KOiK12832.
OMAiGNPPETQ.
OrthoDBiEOG091G0ZLI.
PhylomeDBiQ9BWJ5.
TreeFamiTF300117.

Family and domain databases

InterProiIPR009846. SF3b5/RDS3-10.
IPR017089. Splicing_factor_3B_subunit_5.
[Graphical view]
PANTHERiPTHR20978. PTHR20978. 1 hit.
PfamiPF07189. SF3b10. 1 hit.
[Graphical view]
PIRSFiPIRSF037010. Splicing_factor_3B_subunit_5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BWJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRYTIHSQ LEHLQSKYIG TGHADTTKWE WLVNQHRDSY CSYMGHFDLL
60 70 80
NYFAIAENES KARVRFNLME KMLQPCGPPA DKPEEN
Length:86
Mass (Da):10,135
Last modified:June 1, 2001 - v1
Checksum:iB8A209EA9F548E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312079 mRNA. Translation: BAG35015.1.
AL031390 Genomic DNA. Translation: CAI19755.1.
CH471051 Genomic DNA. Translation: EAW47851.1.
BC000198 mRNA. Translation: AAH00198.1.
BK000562 Genomic DNA. Translation: DAA00073.1.
CCDSiCCDS5204.1.
RefSeqiNP_112577.1. NM_031287.2.
UniGeneiHs.110695.

Genome annotation databases

EnsembliENST00000367569; ENSP00000356541; ENSG00000169976.
GeneIDi83443.
KEGGihsa:83443.
UCSCiuc003qkr.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312079 mRNA. Translation: BAG35015.1.
AL031390 Genomic DNA. Translation: CAI19755.1.
CH471051 Genomic DNA. Translation: EAW47851.1.
BC000198 mRNA. Translation: AAH00198.1.
BK000562 Genomic DNA. Translation: DAA00073.1.
CCDSiCCDS5204.1.
RefSeqiNP_112577.1. NM_031287.2.
UniGeneiHs.110695.

3D structure databases

ProteinModelPortaliQ9BWJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123645. 33 interactions.
IntActiQ9BWJ5. 7 interactions.
MINTiMINT-3062697.
STRINGi9606.ENSP00000356541.

PTM databases

iPTMnetiQ9BWJ5.
PhosphoSiteiQ9BWJ5.

Polymorphism and mutation databases

BioMutaiSF3B5.
DMDMi20140757.

Proteomic databases

EPDiQ9BWJ5.
MaxQBiQ9BWJ5.
PaxDbiQ9BWJ5.
PeptideAtlasiQ9BWJ5.
PRIDEiQ9BWJ5.
TopDownProteomicsiQ9BWJ5.

Protocols and materials databases

DNASUi83443.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367569; ENSP00000356541; ENSG00000169976.
GeneIDi83443.
KEGGihsa:83443.
UCSCiuc003qkr.2. human.

Organism-specific databases

CTDi83443.
GeneCardsiSF3B5.
HGNCiHGNC:21083. SF3B5.
HPAiHPA054408.
neXtProtiNX_Q9BWJ5.
PharmGKBiPA134951632.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3485. Eukaryota.
ENOG4111NTV. LUCA.
GeneTreeiENSGT00390000013215.
HOVERGENiHBG054589.
InParanoidiQ9BWJ5.
KOiK12832.
OMAiGNPPETQ.
OrthoDBiEOG091G0ZLI.
PhylomeDBiQ9BWJ5.
TreeFamiTF300117.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

GeneWikiiSF3B5.
GenomeRNAii83443.
PROiQ9BWJ5.

Gene expression databases

BgeeiENSG00000169976.
CleanExiHS_SF3B5.
GenevisibleiQ9BWJ5. HS.

Family and domain databases

InterProiIPR009846. SF3b5/RDS3-10.
IPR017089. Splicing_factor_3B_subunit_5.
[Graphical view]
PANTHERiPTHR20978. PTHR20978. 1 hit.
PfamiPF07189. SF3b10. 1 hit.
[Graphical view]
PIRSFiPIRSF037010. Splicing_factor_3B_subunit_5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSF3B5_HUMAN
AccessioniPrimary (citable) accession number: Q9BWJ5
Secondary accession number(s): B2R568, Q7RTV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.