ID FUND2_HUMAN Reviewed; 189 AA. AC Q9BWH2; B2R7W5; D3DWY5; Q8NHX8; Q9H2I6; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2004, sequence version 2. DT 27-MAR-2024, entry version 160. DE RecName: Full=FUN14 domain-containing protein 2 {ECO:0000305}; DE AltName: Full=Cervical cancer proto-oncogene 3 protein; DE Short=HCC-3; DE AltName: Full=Hepatitis C virus core-binding protein 6; GN Name=FUNDC2 {ECO:0000312|HGNC:HGNC:24925}; Synonyms=HCBP6; GN ORFNames=DC44, HCC3, PD03104; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=12665903; RA Li K., Wang L., Cheng J., Zhang L., Duan H., Lu Y., Yang J., Liu Y., RA Xia X., Wang G., Dong J., Li L., Zhong Y., Hong Y., Chen J.; RT "Screening and cloning gene of hepatocyte protein interacting with RT hepatitis C virus core protein."; RL Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16:351-353(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Dendritic cell; RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.; RT "A novel gene from human dendritic cells."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skeletal muscle; RA Frigimelica E., Lanfranchi G.; RT "Study of 100 skeletal muscle full length mRNA (Telethon project B41)."; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kim J.W.; RT "Identification of a new oncogene in human cancers."; RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, Eye, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-151, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [12] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53 AND SER-151, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [13] RP FUNCTION. RX PubMed=25855506; DOI=10.1002/jcb.25188; RA Gao L.L., Li M., Wang Q., Liu S.A., Zhang J.Q., Cheng J.; RT "HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the RT SREBP1c/FASN Pathway."; RL J. Cell. Biochem. 116:2375-2384(2015). RN [14] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=29187281; DOI=10.5483/bmbrep.2018.51.1.184; RA Yang X., Han M., Liu S., Yuan X., Liu X., Feng S., Zhou L., Li Y., Lu H., RA Cheng J., Lin S.; RT "HCBP6 upregulates human SREBP1c expression by binding to C/EBPbeta-binding RT site in the SREBP1c promoter."; RL BMB Rep. 51:33-38(2018). RN [15] RP TISSUE SPECIFICITY. RX PubMed=30576423; DOI=10.1093/cvr/cvy311; RA Ma Q., Zhang W., Zhu C., Liu J., Chen Q.; RT "FUNDC2 regulates platelet activation through AKT/GSK-3beta/cGMP axis."; RL Cardiovasc. Res. 115:1672-1679(2019). RN [16] RP SUBCELLULAR LOCATION, TOPOLOGY, AND FUNCTION. RX PubMed=29786068; DOI=10.1038/s41418-018-0121-8; RA Ma Q., Zhu C., Zhang W., Ta N., Zhang R., Liu L., Feng D., Cheng H., RA Liu J., Chen Q.; RT "Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via RT AKT signaling pathway."; RL Cell Death Differ. 26:321-331(2019). CC -!- FUNCTION: Binds directly and specifically 1,2-Diacyl-sn-glycero-3- CC phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the CC recruitment of PIP3 to mitochondria and may play a role in the CC regulation of the platelet activation via AKT/GSK3B/cGMP signaling CC pathways (PubMed:29786068). May act as transcription factor that CC regulates SREBP1 (isoform SREBP-1C) expression in order to modulate CC triglyceride (TG) homeostasis in hepatocytes (PubMed:29187281, CC PubMed:25855506). {ECO:0000269|PubMed:25855506, CC ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}. CC -!- INTERACTION: CC Q9BWH2; Q13520: AQP6; NbExp=3; IntAct=EBI-714482, EBI-13059134; CC Q9BWH2; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-714482, EBI-11343438; CC Q9BWH2; P11912: CD79A; NbExp=3; IntAct=EBI-714482, EBI-7797864; CC Q9BWH2; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-714482, EBI-7062247; CC Q9BWH2; Q5RI15: COX20; NbExp=3; IntAct=EBI-714482, EBI-2834035; CC Q9BWH2; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-714482, EBI-17233035; CC Q9BWH2; P00387: CYB5R3; NbExp=3; IntAct=EBI-714482, EBI-1046040; CC Q9BWH2; Q15125: EBP; NbExp=3; IntAct=EBI-714482, EBI-3915253; CC Q9BWH2; P34910-2: EVI2B; NbExp=3; IntAct=EBI-714482, EBI-17640610; CC Q9BWH2; Q92915-2: FGF14; NbExp=3; IntAct=EBI-714482, EBI-12836320; CC Q9BWH2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-714482, EBI-13345167; CC Q9BWH2; P48051: KCNJ6; NbExp=3; IntAct=EBI-714482, EBI-12017638; CC Q9BWH2; P43628: KIR2DL3; NbExp=3; IntAct=EBI-714482, EBI-8632435; CC Q9BWH2; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-714482, EBI-373355; CC Q9BWH2; O14880: MGST3; NbExp=3; IntAct=EBI-714482, EBI-724754; CC Q9BWH2; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-714482, EBI-7545592; CC Q9BWH2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-714482, EBI-10192441; CC Q9BWH2; Q8N3Y7: SDR16C5; NbExp=3; IntAct=EBI-714482, EBI-3923480; CC Q9BWH2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-714482, EBI-18159983; CC Q9BWH2; Q8TF71: SLC16A10; NbExp=3; IntAct=EBI-714482, EBI-17858931; CC Q9BWH2; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-714482, EBI-3907610; CC Q9BWH2; P27105: STOM; NbExp=3; IntAct=EBI-714482, EBI-1211440; CC Q9BWH2; Q8N9I0: SYT2; NbExp=3; IntAct=EBI-714482, EBI-8032987; CC Q9BWH2; Q6P9G4: TMEM154; NbExp=3; IntAct=EBI-714482, EBI-13329239; CC Q9BWH2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-714482, EBI-6447886; CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane CC {ECO:0000269|PubMed:29786068}; Multi-pass membrane protein CC {ECO:0000255}. Nucleus {ECO:0000305|PubMed:29187281}. CC -!- TISSUE SPECIFICITY: Highly expressed in platelets (at protein level). CC {ECO:0000269|PubMed:30576423}. CC -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAG44731.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY032594; AAK51136.1; -; mRNA. DR EMBL; AF267862; AAG44731.1; ALT_FRAME; mRNA. DR EMBL; AJ272054; CAC81242.1; -; mRNA. DR EMBL; AF320778; AAN51931.1; -; mRNA. DR EMBL; AK313143; BAG35962.1; -; mRNA. DR EMBL; BX470111; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471172; EAW72643.1; -; Genomic_DNA. DR EMBL; CH471172; EAW72644.1; -; Genomic_DNA. DR EMBL; BC000255; AAH00255.2; -; mRNA. DR EMBL; BC072685; AAH72685.1; -; mRNA. DR EMBL; BC108657; AAI08658.1; -; mRNA. DR CCDS; CCDS14763.1; -. DR RefSeq; NP_076423.2; NM_023934.3. DR AlphaFoldDB; Q9BWH2; -. DR BioGRID; 122440; 104. DR IntAct; Q9BWH2; 59. DR MINT; Q9BWH2; -. DR STRING; 9606.ENSP00000358510; -. DR GlyGen; Q9BWH2; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9BWH2; -. DR PhosphoSitePlus; Q9BWH2; -. DR SwissPalm; Q9BWH2; -. DR BioMuta; FUNDC2; -. DR DMDM; 74752400; -. DR EPD; Q9BWH2; -. DR jPOST; Q9BWH2; -. DR MassIVE; Q9BWH2; -. DR MaxQB; Q9BWH2; -. DR PaxDb; 9606-ENSP00000358510; -. DR PeptideAtlas; Q9BWH2; -. DR ProteomicsDB; 79278; -. DR Pumba; Q9BWH2; -. DR Antibodypedia; 31390; 111 antibodies from 17 providers. DR DNASU; 65991; -. DR Ensembl; ENST00000369498.8; ENSP00000358510.3; ENSG00000165775.18. DR GeneID; 65991; -. DR KEGG; hsa:65991; -. DR MANE-Select; ENST00000369498.8; ENSP00000358510.3; NM_023934.4; NP_076423.2. DR UCSC; uc004fmw.4; human. DR AGR; HGNC:24925; -. DR CTD; 65991; -. DR DisGeNET; 65991; -. DR GeneCards; FUNDC2; -. DR HGNC; HGNC:24925; FUNDC2. DR HPA; ENSG00000165775; Tissue enhanced (tongue). DR MalaCards; FUNDC2; -. DR MIM; 301042; gene. DR neXtProt; NX_Q9BWH2; -. DR OpenTargets; ENSG00000165775; -. DR PharmGKB; PA134908797; -. DR VEuPathDB; HostDB:ENSG00000165775; -. DR eggNOG; KOG4099; Eukaryota. DR GeneTree; ENSGT00940000154783; -. DR HOGENOM; CLU_095425_2_0_1; -. DR InParanoid; Q9BWH2; -. DR OMA; KICKNDQ; -. DR OrthoDB; 4918003at2759; -. DR PhylomeDB; Q9BWH2; -. DR TreeFam; TF300280; -. DR PathwayCommons; Q9BWH2; -. DR SignaLink; Q9BWH2; -. DR BioGRID-ORCS; 65991; 15 hits in 780 CRISPR screens. DR ChiTaRS; FUNDC2; human. DR GeneWiki; FUNDC2; -. DR GenomeRNAi; 65991; -. DR Pharos; Q9BWH2; Tbio. DR PRO; PR:Q9BWH2; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; Q9BWH2; Protein. DR Bgee; ENSG00000165775; Expressed in apex of heart and 127 other cell types or tissues. DR ExpressionAtlas; Q9BWH2; baseline and differential. DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005739; C:mitochondrion; IDA:LIFEdb. DR GO; GO:0005634; C:nucleus; HDA:UniProtKB. DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB. DR GO; GO:0035356; P:intracellular triglyceride homeostasis; IMP:UniProtKB. DR GO; GO:0010543; P:regulation of platelet activation; ISS:UniProtKB. DR InterPro; IPR007014; FUN14. DR PANTHER; PTHR21346; FUN14 DOMAIN CONTAINING; 1. DR PANTHER; PTHR21346:SF5; FUN14 DOMAIN-CONTAINING PROTEIN 2; 1. DR Pfam; PF04930; FUN14; 1. DR Genevisible; Q9BWH2; HS. PE 1: Evidence at protein level; KW Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleus; KW Phosphoprotein; Reference proteome; Transcription; KW Transcription regulation; Transmembrane; Transmembrane helix. FT CHAIN 1..189 FT /note="FUN14 domain-containing protein 2" FT /id="PRO_0000314615" FT TOPO_DOM 1..80 FT /note="Cytoplasmic" FT /evidence="ECO:0000305|PubMed:29786068" FT TRANSMEM 81..101 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 102..107 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000305|PubMed:29786068" FT TRANSMEM 108..128 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 129..164 FT /note="Cytoplasmic" FT /evidence="ECO:0000305|PubMed:29786068" FT TRANSMEM 165..185 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 186..189 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000305|PubMed:29786068" FT MOD_RES 10 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 53 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 151 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" SQ SEQUENCE 189 AA; 20676 MW; 425CC27F23E240D9 CRC64; METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN FESLDLAEFA KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI FQKVGKLAAT AVGGGFFLLQ LANHTGYIKV DWQRVEKDMK KAKEQLKIRK SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF GGFLLGMAS //