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Q9BWH2

- FUND2_HUMAN

UniProt

Q9BWH2 - FUND2_HUMAN

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Protein
FUN14 domain-containing protein 2
Gene
FUNDC2, HCBP6, DC44, HCC3, PD03104
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FUN14 domain-containing protein 2
Alternative name(s):
Cervical cancer proto-oncogene 3 protein
Short name:
HCC-3
Hepatitis C virus core-binding protein 6
Gene namesi
Name:FUNDC2
Synonyms:HCBP6
ORF Names:DC44, HCC3, PD03104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:24925. FUNDC2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: LIFEdb
  2. nucleus Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189FUN14 domain-containing protein 2
PRO_0000314615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BWH2.
PaxDbiQ9BWH2.
PRIDEiQ9BWH2.

PTM databases

PhosphoSiteiQ9BWH2.

Expressioni

Gene expression databases

ArrayExpressiQ9BWH2.
BgeeiQ9BWH2.
CleanExiHS_FUNDC2.
GenevestigatoriQ9BWH2.

Organism-specific databases

HPAiHPA059129.

Interactioni

Protein-protein interaction databases

BioGridi122440. 13 interactions.
IntActiQ9BWH2. 16 interactions.
MINTiMINT-1426834.
STRINGi9606.ENSP00000358510.

Structurei

3D structure databases

ProteinModelPortaliQ9BWH2.

Family & Domainsi

Sequence similaritiesi

Belongs to the FUN14 family.

Phylogenomic databases

eggNOGiNOG249575.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
OMAiTKKQPWW.
PhylomeDBiQ9BWH2.
TreeFamiTF300280.

Family and domain databases

InterProiIPR007014. FUN14.
[Graphical view]
PfamiPF04930. FUN14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWH2-1 [UniParc]FASTAAdd to Basket

« Hide

METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN    50
FESLDLAEFA KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI 100
FQKVGKLAAT AVGGGFFLLQ LANHTGYIKV DWQRVEKDMK KAKEQLKIRK 150
SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF GGFLLGMAS 189
Length:189
Mass (Da):20,676
Last modified:March 1, 2004 - v2
Checksum:i425CC27F23E240D9
GO

Sequence cautioni

The sequence AAG44731.1 differs from that shown. Reason: Frameshift at position 69.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032594 mRNA. Translation: AAK51136.1.
AF267862 mRNA. Translation: AAG44731.1. Frameshift.
AJ272054 mRNA. Translation: CAC81242.1.
AF320778 mRNA. Translation: AAN51931.1.
AK313143 mRNA. Translation: BAG35962.1.
BX470111 Genomic DNA. Translation: CAI41659.1.
CH471172 Genomic DNA. Translation: EAW72643.1.
CH471172 Genomic DNA. Translation: EAW72644.1.
BC000255 mRNA. Translation: AAH00255.2.
BC072685 mRNA. Translation: AAH72685.1.
BC108657 mRNA. Translation: AAI08658.1.
CCDSiCCDS14763.1.
RefSeqiNP_076423.2. NM_023934.3.
UniGeneiHs.356050.

Genome annotation databases

EnsembliENST00000369498; ENSP00000358510; ENSG00000165775.
ENST00000598456; ENSP00000472692; ENSG00000268109.
GeneIDi65991.
KEGGihsa:65991.
UCSCiuc004fmw.3. human.

Polymorphism databases

DMDMi74752400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032594 mRNA. Translation: AAK51136.1 .
AF267862 mRNA. Translation: AAG44731.1 . Frameshift.
AJ272054 mRNA. Translation: CAC81242.1 .
AF320778 mRNA. Translation: AAN51931.1 .
AK313143 mRNA. Translation: BAG35962.1 .
BX470111 Genomic DNA. Translation: CAI41659.1 .
CH471172 Genomic DNA. Translation: EAW72643.1 .
CH471172 Genomic DNA. Translation: EAW72644.1 .
BC000255 mRNA. Translation: AAH00255.2 .
BC072685 mRNA. Translation: AAH72685.1 .
BC108657 mRNA. Translation: AAI08658.1 .
CCDSi CCDS14763.1.
RefSeqi NP_076423.2. NM_023934.3.
UniGenei Hs.356050.

3D structure databases

ProteinModelPortali Q9BWH2.
ModBasei Search...

Protein-protein interaction databases

BioGridi 122440. 13 interactions.
IntActi Q9BWH2. 16 interactions.
MINTi MINT-1426834.
STRINGi 9606.ENSP00000358510.

PTM databases

PhosphoSitei Q9BWH2.

Polymorphism databases

DMDMi 74752400.

Proteomic databases

MaxQBi Q9BWH2.
PaxDbi Q9BWH2.
PRIDEi Q9BWH2.

Protocols and materials databases

DNASUi 65991.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369498 ; ENSP00000358510 ; ENSG00000165775 .
ENST00000598456 ; ENSP00000472692 ; ENSG00000268109 .
GeneIDi 65991.
KEGGi hsa:65991.
UCSCi uc004fmw.3. human.

Organism-specific databases

CTDi 65991.
GeneCardsi GC0XP154254.
H-InvDB HIX0029974.
HGNCi HGNC:24925. FUNDC2.
HPAi HPA059129.
neXtProti NX_Q9BWH2.
PharmGKBi PA134908797.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249575.
HOGENOMi HOG000232100.
HOVERGENi HBG054805.
OMAi TKKQPWW.
PhylomeDBi Q9BWH2.
TreeFami TF300280.

Miscellaneous databases

ChiTaRSi FUNDC2. human.
GeneWikii FUNDC2.
GenomeRNAii 65991.
NextBioi 67477.
PROi Q9BWH2.

Gene expression databases

ArrayExpressi Q9BWH2.
Bgeei Q9BWH2.
CleanExi HS_FUNDC2.
Genevestigatori Q9BWH2.

Family and domain databases

InterProi IPR007014. FUN14.
[Graphical view ]
Pfami PF04930. FUN14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein."
    Li K., Wang L., Cheng J., Zhang L., Duan H., Lu Y., Yang J., Liu Y., Xia X., Wang G., Dong J., Li L., Zhong Y., Hong Y., Chen J.
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16:351-353(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel gene from human dendritic cells."
    Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  3. "Study of 100 skeletal muscle full length mRNA (Telethon project B41)."
    Frigimelica E., Lanfranchi G.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  4. "Identification of a new oncogene in human cancers."
    Kim J.W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Eye and Uterus.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFUND2_HUMAN
AccessioniPrimary (citable) accession number: Q9BWH2
Secondary accession number(s): B2R7W5
, D3DWY5, Q8NHX8, Q9H2I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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