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Protein

FUN14 domain-containing protein 2

Gene

FUNDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FUN14 domain-containing protein 2
Alternative name(s):
Cervical cancer proto-oncogene 3 protein
Short name:
HCC-3
Hepatitis C virus core-binding protein 6
Gene namesi
Name:FUNDC2
Synonyms:HCBP6
ORF Names:DC44, HCC3, PD03104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24925. FUNDC2.

Subcellular locationi

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: GO_Central
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi65991.
OpenTargetsiENSG00000165775.
PharmGKBiPA134908797.

Polymorphism and mutation databases

BioMutaiFUNDC2.
DMDMi74752400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003146151 – 189FUN14 domain-containing protein 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWH2.
MaxQBiQ9BWH2.
PaxDbiQ9BWH2.
PeptideAtlasiQ9BWH2.
PRIDEiQ9BWH2.

PTM databases

iPTMnetiQ9BWH2.
PhosphoSitePlusiQ9BWH2.
SwissPalmiQ9BWH2.

Expressioni

Gene expression databases

BgeeiENSG00000165775.
CleanExiHS_FUNDC2.
ExpressionAtlasiQ9BWH2. baseline and differential.
GenevisibleiQ9BWH2. HS.

Organism-specific databases

HPAiHPA059129.

Interactioni

Protein-protein interaction databases

BioGridi122440. 26 interactors.
IntActiQ9BWH2. 18 interactors.
MINTiMINT-1426834.
STRINGi9606.ENSP00000358510.

Structurei

3D structure databases

ProteinModelPortaliQ9BWH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FUN14 family.Curated

Phylogenomic databases

eggNOGiKOG4099. Eukaryota.
ENOG41122V1. LUCA.
GeneTreeiENSGT00390000003926.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
InParanoidiQ9BWH2.
OMAiTKKQPWW.
OrthoDBiEOG091G15SP.
PhylomeDBiQ9BWH2.
TreeFamiTF300280.

Family and domain databases

InterProiIPR007014. FUN14.
[Graphical view]
PfamiPF04930. FUN14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN
60 70 80 90 100
FESLDLAEFA KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI
110 120 130 140 150
FQKVGKLAAT AVGGGFFLLQ LANHTGYIKV DWQRVEKDMK KAKEQLKIRK
160 170 180
SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF GGFLLGMAS
Length:189
Mass (Da):20,676
Last modified:March 1, 2004 - v2
Checksum:i425CC27F23E240D9
GO

Sequence cautioni

The sequence AAG44731 differs from that shown. Reason: Frameshift at position 69.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032594 mRNA. Translation: AAK51136.1.
AF267862 mRNA. Translation: AAG44731.1. Frameshift.
AJ272054 mRNA. Translation: CAC81242.1.
AF320778 mRNA. Translation: AAN51931.1.
AK313143 mRNA. Translation: BAG35962.1.
BX470111 Genomic DNA. Translation: CAI41659.1.
CH471172 Genomic DNA. Translation: EAW72643.1.
CH471172 Genomic DNA. Translation: EAW72644.1.
BC000255 mRNA. Translation: AAH00255.2.
BC072685 mRNA. Translation: AAH72685.1.
BC108657 mRNA. Translation: AAI08658.1.
CCDSiCCDS14763.1.
RefSeqiNP_076423.2. NM_023934.3.
UniGeneiHs.356050.

Genome annotation databases

EnsembliENST00000369498; ENSP00000358510; ENSG00000165775.
GeneIDi65991.
KEGGihsa:65991.
UCSCiuc004fmw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032594 mRNA. Translation: AAK51136.1.
AF267862 mRNA. Translation: AAG44731.1. Frameshift.
AJ272054 mRNA. Translation: CAC81242.1.
AF320778 mRNA. Translation: AAN51931.1.
AK313143 mRNA. Translation: BAG35962.1.
BX470111 Genomic DNA. Translation: CAI41659.1.
CH471172 Genomic DNA. Translation: EAW72643.1.
CH471172 Genomic DNA. Translation: EAW72644.1.
BC000255 mRNA. Translation: AAH00255.2.
BC072685 mRNA. Translation: AAH72685.1.
BC108657 mRNA. Translation: AAI08658.1.
CCDSiCCDS14763.1.
RefSeqiNP_076423.2. NM_023934.3.
UniGeneiHs.356050.

3D structure databases

ProteinModelPortaliQ9BWH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122440. 26 interactors.
IntActiQ9BWH2. 18 interactors.
MINTiMINT-1426834.
STRINGi9606.ENSP00000358510.

PTM databases

iPTMnetiQ9BWH2.
PhosphoSitePlusiQ9BWH2.
SwissPalmiQ9BWH2.

Polymorphism and mutation databases

BioMutaiFUNDC2.
DMDMi74752400.

Proteomic databases

EPDiQ9BWH2.
MaxQBiQ9BWH2.
PaxDbiQ9BWH2.
PeptideAtlasiQ9BWH2.
PRIDEiQ9BWH2.

Protocols and materials databases

DNASUi65991.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369498; ENSP00000358510; ENSG00000165775.
GeneIDi65991.
KEGGihsa:65991.
UCSCiuc004fmw.4. human.

Organism-specific databases

CTDi65991.
DisGeNETi65991.
GeneCardsiFUNDC2.
H-InvDBHIX0029974.
HGNCiHGNC:24925. FUNDC2.
HPAiHPA059129.
neXtProtiNX_Q9BWH2.
OpenTargetsiENSG00000165775.
PharmGKBiPA134908797.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4099. Eukaryota.
ENOG41122V1. LUCA.
GeneTreeiENSGT00390000003926.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
InParanoidiQ9BWH2.
OMAiTKKQPWW.
OrthoDBiEOG091G15SP.
PhylomeDBiQ9BWH2.
TreeFamiTF300280.

Miscellaneous databases

ChiTaRSiFUNDC2. human.
GeneWikiiFUNDC2.
GenomeRNAii65991.
PROiQ9BWH2.

Gene expression databases

BgeeiENSG00000165775.
CleanExiHS_FUNDC2.
ExpressionAtlasiQ9BWH2. baseline and differential.
GenevisibleiQ9BWH2. HS.

Family and domain databases

InterProiIPR007014. FUN14.
[Graphical view]
PfamiPF04930. FUN14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUND2_HUMAN
AccessioniPrimary (citable) accession number: Q9BWH2
Secondary accession number(s): B2R7W5
, D3DWY5, Q8NHX8, Q9H2I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.