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Q9BWH2

- FUND2_HUMAN

UniProt

Q9BWH2 - FUND2_HUMAN

Protein

FUN14 domain-containing protein 2

Gene

FUNDC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FUN14 domain-containing protein 2
    Alternative name(s):
    Cervical cancer proto-oncogene 3 protein
    Short name:
    HCC-3
    Hepatitis C virus core-binding protein 6
    Gene namesi
    Name:FUNDC2
    Synonyms:HCBP6
    ORF Names:DC44, HCC3, PD03104
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:24925. FUNDC2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: LIFEdb
    2. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134908797.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189FUN14 domain-containing protein 2PRO_0000314615Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BWH2.
    PaxDbiQ9BWH2.
    PRIDEiQ9BWH2.

    PTM databases

    PhosphoSiteiQ9BWH2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BWH2.
    BgeeiQ9BWH2.
    CleanExiHS_FUNDC2.
    GenevestigatoriQ9BWH2.

    Organism-specific databases

    HPAiHPA059129.

    Interactioni

    Protein-protein interaction databases

    BioGridi122440. 13 interactions.
    IntActiQ9BWH2. 16 interactions.
    MINTiMINT-1426834.
    STRINGi9606.ENSP00000358510.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BWH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FUN14 family.Curated

    Phylogenomic databases

    eggNOGiNOG249575.
    HOGENOMiHOG000232100.
    HOVERGENiHBG054805.
    OMAiTKKQPWW.
    PhylomeDBiQ9BWH2.
    TreeFamiTF300280.

    Family and domain databases

    InterProiIPR007014. FUN14.
    [Graphical view]
    PfamiPF04930. FUN14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BWH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN    50
    FESLDLAEFA KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI 100
    FQKVGKLAAT AVGGGFFLLQ LANHTGYIKV DWQRVEKDMK KAKEQLKIRK 150
    SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF GGFLLGMAS 189
    Length:189
    Mass (Da):20,676
    Last modified:March 1, 2004 - v2
    Checksum:i425CC27F23E240D9
    GO

    Sequence cautioni

    The sequence AAG44731.1 differs from that shown. Reason: Frameshift at position 69.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032594 mRNA. Translation: AAK51136.1.
    AF267862 mRNA. Translation: AAG44731.1. Frameshift.
    AJ272054 mRNA. Translation: CAC81242.1.
    AF320778 mRNA. Translation: AAN51931.1.
    AK313143 mRNA. Translation: BAG35962.1.
    BX470111 Genomic DNA. Translation: CAI41659.1.
    CH471172 Genomic DNA. Translation: EAW72643.1.
    CH471172 Genomic DNA. Translation: EAW72644.1.
    BC000255 mRNA. Translation: AAH00255.2.
    BC072685 mRNA. Translation: AAH72685.1.
    BC108657 mRNA. Translation: AAI08658.1.
    CCDSiCCDS14763.1.
    RefSeqiNP_076423.2. NM_023934.3.
    UniGeneiHs.356050.

    Genome annotation databases

    EnsembliENST00000369498; ENSP00000358510; ENSG00000165775.
    GeneIDi65991.
    KEGGihsa:65991.
    UCSCiuc004fmw.3. human.

    Polymorphism databases

    DMDMi74752400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032594 mRNA. Translation: AAK51136.1 .
    AF267862 mRNA. Translation: AAG44731.1 . Frameshift.
    AJ272054 mRNA. Translation: CAC81242.1 .
    AF320778 mRNA. Translation: AAN51931.1 .
    AK313143 mRNA. Translation: BAG35962.1 .
    BX470111 Genomic DNA. Translation: CAI41659.1 .
    CH471172 Genomic DNA. Translation: EAW72643.1 .
    CH471172 Genomic DNA. Translation: EAW72644.1 .
    BC000255 mRNA. Translation: AAH00255.2 .
    BC072685 mRNA. Translation: AAH72685.1 .
    BC108657 mRNA. Translation: AAI08658.1 .
    CCDSi CCDS14763.1.
    RefSeqi NP_076423.2. NM_023934.3.
    UniGenei Hs.356050.

    3D structure databases

    ProteinModelPortali Q9BWH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122440. 13 interactions.
    IntActi Q9BWH2. 16 interactions.
    MINTi MINT-1426834.
    STRINGi 9606.ENSP00000358510.

    PTM databases

    PhosphoSitei Q9BWH2.

    Polymorphism databases

    DMDMi 74752400.

    Proteomic databases

    MaxQBi Q9BWH2.
    PaxDbi Q9BWH2.
    PRIDEi Q9BWH2.

    Protocols and materials databases

    DNASUi 65991.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369498 ; ENSP00000358510 ; ENSG00000165775 .
    GeneIDi 65991.
    KEGGi hsa:65991.
    UCSCi uc004fmw.3. human.

    Organism-specific databases

    CTDi 65991.
    GeneCardsi GC0XP154254.
    H-InvDB HIX0029974.
    HGNCi HGNC:24925. FUNDC2.
    HPAi HPA059129.
    neXtProti NX_Q9BWH2.
    PharmGKBi PA134908797.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249575.
    HOGENOMi HOG000232100.
    HOVERGENi HBG054805.
    OMAi TKKQPWW.
    PhylomeDBi Q9BWH2.
    TreeFami TF300280.

    Miscellaneous databases

    ChiTaRSi FUNDC2. human.
    GeneWikii FUNDC2.
    GenomeRNAii 65991.
    NextBioi 67477.
    PROi Q9BWH2.

    Gene expression databases

    ArrayExpressi Q9BWH2.
    Bgeei Q9BWH2.
    CleanExi HS_FUNDC2.
    Genevestigatori Q9BWH2.

    Family and domain databases

    InterProi IPR007014. FUN14.
    [Graphical view ]
    Pfami PF04930. FUN14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein."
      Li K., Wang L., Cheng J., Zhang L., Duan H., Lu Y., Yang J., Liu Y., Xia X., Wang G., Dong J., Li L., Zhong Y., Hong Y., Chen J.
      Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16:351-353(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel gene from human dendritic cells."
      Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dendritic cell.
    3. "Study of 100 skeletal muscle full length mRNA (Telethon project B41)."
      Frigimelica E., Lanfranchi G.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    4. "Identification of a new oncogene in human cancers."
      Kim J.W.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Eye and Uterus.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFUND2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWH2
    Secondary accession number(s): B2R7W5
    , D3DWY5, Q8NHX8, Q9H2I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3