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Protein

Sodium channel modifier 1

Gene

SCNM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 74Matrin-typeAdd BLAST33

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163156-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel modifier 1
Gene namesi
Name:SCNM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23136. SCNM1.

Subcellular locationi

  • Nucleus By similarity
  • Nucleus speckle By similarity

  • Note: Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79005.
OpenTargetsiENSG00000163156.
PharmGKBiPA134958437.

Polymorphism and mutation databases

BioMutaiSCNM1.
DMDMi74752399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596351 – 230Sodium channel modifier 1Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei183PhosphoserineBy similarity1
Modified residuei219PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWG6.
MaxQBiQ9BWG6.
PaxDbiQ9BWG6.
PeptideAtlasiQ9BWG6.
PRIDEiQ9BWG6.

PTM databases

iPTMnetiQ9BWG6.
PhosphoSitePlusiQ9BWG6.

Expressioni

Gene expression databases

BgeeiENSG00000163156.
CleanExiHS_SCNM1.
GenevisibleiQ9BWG6. HS.

Organism-specific databases

HPAiHPA052439.
HPA054324.

Interactioni

Subunit structurei

Interacts with LUC7L2 and SNRNP70, which suggests a role as a spliceosome component.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122476. 55 interactors.
IntActiQ9BWG6. 106 interactors.
MINTiMINT-1460700.
STRINGi9606.ENSP00000357901.

Structurei

3D structure databases

ProteinModelPortaliQ9BWG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 230Required for interaction with LUC7L2By similarityAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi4 – 20Bipartite nuclear localization signalSequence analysisAdd BLAST17

Sequence similaritiesi

Contains 1 matrin-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 74Matrin-typeAdd BLAST33

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IW6J. Eukaryota.
ENOG4112DAT. LUCA.
GeneTreeiENSGT00390000010811.
HOGENOMiHOG000033694.
HOVERGENiHBG093936.
InParanoidiQ9BWG6.
OMAiGWIPDGQ.
OrthoDBiEOG091G0Y5A.
PhylomeDBiQ9BWG6.
TreeFamiTF332168.

Family and domain databases

InterProiIPR033570. SCNM1.
IPR031625. SCNM1_acidic.
IPR031622. Znf-SCNM1.
[Graphical view]
PANTHERiPTHR32297. PTHR32297. 1 hit.
PfamiPF15805. SCNM1_acidic. 1 hit.
PF15803. zf-SCNM1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR
60 70 80 90 100
PVLDTLAMLT AHRAGKKHLS SLQLFYGKKQ PGKERKQNPK HQNELRREET
110 120 130 140 150
KAEAPLLTQT RLITQSALHR APHYNSCCRR KYRPEAPGPS VSLSPMPPSE
160 170 180 190 200
VKLQSGKISR EPEPAAGPQA EESATVSAPA PMSPTRRRAL DHYLTLRSSG
210 220 230
WIPDGRGRWV KDENVEFDSD EEEPPDLPLD
Length:230
Mass (Da):25,949
Last modified:June 1, 2001 - v1
Checksum:i001576EA78C61C85
GO
Isoform 2 (identifier: Q9BWG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-36: Missing.

Show »
Length:195
Mass (Da):21,887
Checksum:i010E51E98394DA83
GO
Isoform 3 (identifier: Q9BWG6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-162: PEAPGPSVSLSPMPPSEVKLQSGKISREP → YGTGKPEVGRLRRRQMALKEFSSVYSEEY
     163-230: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,886
Checksum:i93C4D90FF7F664D6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0214892 – 36Missing in isoform 2. CuratedAdd BLAST35
Alternative sequenceiVSP_053982134 – 162PEAPG…ISREP → YGTGKPEVGRLRRRQMALKE FSSVYSEEY in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_053983163 – 230Missing in isoform 3. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056322 mRNA. Translation: BAB71149.1.
AK301644 mRNA. Translation: BAG63123.1.
AL592424 Genomic DNA. Translation: CAI16381.1.
AL592424 Genomic DNA. Translation: CAI16382.1.
BC000264 mRNA. Translation: AAH00264.1.
CCDSiCCDS55636.1. [Q9BWG6-2]
CCDS987.1. [Q9BWG6-1]
RefSeqiNP_001191777.1. NM_001204848.1. [Q9BWG6-2]
NP_001191785.1. NM_001204856.1. [Q9BWG6-2]
NP_076946.1. NM_024041.3. [Q9BWG6-1]
UniGeneiHs.732060.

Genome annotation databases

EnsembliENST00000368902; ENSP00000357898; ENSG00000163156. [Q9BWG6-2]
ENST00000368905; ENSP00000357901; ENSG00000163156. [Q9BWG6-1]
ENST00000602841; ENSP00000473282; ENSG00000163156. [Q9BWG6-2]
GeneIDi100534012.
79005.
KEGGihsa:100534012.
hsa:79005.
UCSCiuc001ewz.4. human. [Q9BWG6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056322 mRNA. Translation: BAB71149.1.
AK301644 mRNA. Translation: BAG63123.1.
AL592424 Genomic DNA. Translation: CAI16381.1.
AL592424 Genomic DNA. Translation: CAI16382.1.
BC000264 mRNA. Translation: AAH00264.1.
CCDSiCCDS55636.1. [Q9BWG6-2]
CCDS987.1. [Q9BWG6-1]
RefSeqiNP_001191777.1. NM_001204848.1. [Q9BWG6-2]
NP_001191785.1. NM_001204856.1. [Q9BWG6-2]
NP_076946.1. NM_024041.3. [Q9BWG6-1]
UniGeneiHs.732060.

3D structure databases

ProteinModelPortaliQ9BWG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122476. 55 interactors.
IntActiQ9BWG6. 106 interactors.
MINTiMINT-1460700.
STRINGi9606.ENSP00000357901.

PTM databases

iPTMnetiQ9BWG6.
PhosphoSitePlusiQ9BWG6.

Polymorphism and mutation databases

BioMutaiSCNM1.
DMDMi74752399.

Proteomic databases

EPDiQ9BWG6.
MaxQBiQ9BWG6.
PaxDbiQ9BWG6.
PeptideAtlasiQ9BWG6.
PRIDEiQ9BWG6.

Protocols and materials databases

DNASUi79005.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368902; ENSP00000357898; ENSG00000163156. [Q9BWG6-2]
ENST00000368905; ENSP00000357901; ENSG00000163156. [Q9BWG6-1]
ENST00000602841; ENSP00000473282; ENSG00000163156. [Q9BWG6-2]
GeneIDi100534012.
79005.
KEGGihsa:100534012.
hsa:79005.
UCSCiuc001ewz.4. human. [Q9BWG6-1]

Organism-specific databases

CTDi100534012.
79005.
DisGeNETi79005.
GeneCardsiSCNM1.
HGNCiHGNC:23136. SCNM1.
HPAiHPA052439.
HPA054324.
MIMi608095. gene.
neXtProtiNX_Q9BWG6.
OpenTargetsiENSG00000163156.
PharmGKBiPA134958437.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW6J. Eukaryota.
ENOG4112DAT. LUCA.
GeneTreeiENSGT00390000010811.
HOGENOMiHOG000033694.
HOVERGENiHBG093936.
InParanoidiQ9BWG6.
OMAiGWIPDGQ.
OrthoDBiEOG091G0Y5A.
PhylomeDBiQ9BWG6.
TreeFamiTF332168.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163156-MONOMER.

Miscellaneous databases

PROiQ9BWG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163156.
CleanExiHS_SCNM1.
GenevisibleiQ9BWG6. HS.

Family and domain databases

InterProiIPR033570. SCNM1.
IPR031625. SCNM1_acidic.
IPR031622. Znf-SCNM1.
[Graphical view]
PANTHERiPTHR32297. PTHR32297. 1 hit.
PfamiPF15805. SCNM1_acidic. 1 hit.
PF15803. zf-SCNM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCNM1_HUMAN
AccessioniPrimary (citable) accession number: Q9BWG6
Secondary accession number(s): B4DWR1, Q5JR74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.