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Protein

Single-stranded DNA-binding protein 4

Gene

SSBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 4
Gene namesi
Name:SSBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15676. SSBP4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38018.

Polymorphism and mutation databases

BioMutaiSSBP4.
DMDMi27734580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Single-stranded DNA-binding protein 4PRO_0000123832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei341 – 3411PhosphoserineCombined sources
Modified residuei342 – 3421PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei355 – 3551PhosphothreonineCombined sources
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BWG4.
MaxQBiQ9BWG4.
PaxDbiQ9BWG4.
PeptideAtlasiQ9BWG4.
PRIDEiQ9BWG4.

PTM databases

iPTMnetiQ9BWG4.
PhosphoSiteiQ9BWG4.

Expressioni

Gene expression databases

BgeeiENSG00000130511.
CleanExiHS_SSBP4.
ExpressionAtlasiQ9BWG4. baseline and differential.
GenevisibleiQ9BWG4. HS.

Organism-specific databases

HPAiHPA049081.

Interactioni

Protein-protein interaction databases

BioGridi128006. 22 interactions.
IntActiQ9BWG4. 4 interactions.
MINTiMINT-1472242.
STRINGi9606.ENSP00000270061.

Structurei

3D structure databases

ProteinModelPortaliQ9BWG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 4933LisHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi125 – 279155Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4594. Eukaryota.
ENOG410XPQX. LUCA.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiQ9BWG4.
OMAiMASGPMA.
OrthoDBiEOG091G111C.
PhylomeDBiQ9BWG4.
TreeFamiTF318961.

Family and domain databases

InterProiIPR006594. LisH.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYAKGGKGSA VPSDSQAREK LALYVYEYLL HIGAQKSAQT FLSEIRWEKN
60 70 80 90 100
ITLGEPPGFL HSWWCVFWDL YCAAPDRREA CEHSGEAKAF QDYSAAAAPS
110 120 130 140 150
PVMGSMAPGD TMAAGSMAAG FFQGPPGSQP SPHNPNAPMM GPHGQPFMSP
160 170 180 190 200
RFPGGPRPTL RMPSQPPAGL PGSQPLLPGA MEPSPRAQGH PSMGGPMQRV
210 220 230 240 250
TPPRGMASVG PQSYGGGMRP PPNSLAGPGL PAMNMGPGVR GPWASPSGNS
260 270 280 290 300
IPYSSSSPGS YTGPPGGGGP PGTPIMPSPG DSTNSSENMY TIMNPIGQGA
310 320 330 340 350
GRANFPLGPG PEGPMAAMSA MEPHHVNGSL GSGDMDGLPK SSPGAVAGLS
360 370 380
NAPGTPRDDG EMAAAGTFLH PFPSESYSPG MTMSV
Length:385
Mass (Da):39,388
Last modified:June 1, 2001 - v1
Checksum:iF55FD3470B810742
GO
Isoform 2 (identifier: Q9BWG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-144: Missing.

Show »
Length:363
Mass (Da):37,214
Checksum:i001C3AACC1A38F1F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei123 – 14422Missing in isoform 2. CuratedVSP_054113Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026292
, AY026276, AY026277, AY026278, AY026279, AY026280, AY026281, AY026282, AY026283, AY026284, AY026285, AY026286, AY026287, AY026288, AY026289, AY026290, AY026291 Genomic DNA. Translation: AAK20020.1.
AC008397 Genomic DNA. No translation available.
BC000274 mRNA. Translation: AAH00274.1.
CCDSiCCDS12378.1. [Q9BWG4-1]
CCDS32960.1. [Q9BWG4-2]
RefSeqiNP_001009998.1. NM_001009998.3. [Q9BWG4-2]
NP_116016.1. NM_032627.4. [Q9BWG4-1]
UniGeneiHs.515259.

Genome annotation databases

EnsembliENST00000270061; ENSP00000270061; ENSG00000130511. [Q9BWG4-1]
ENST00000348495; ENSP00000252807; ENSG00000130511. [Q9BWG4-2]
GeneIDi170463.
KEGGihsa:170463.
UCSCiuc002niy.4. human. [Q9BWG4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026292
, AY026276, AY026277, AY026278, AY026279, AY026280, AY026281, AY026282, AY026283, AY026284, AY026285, AY026286, AY026287, AY026288, AY026289, AY026290, AY026291 Genomic DNA. Translation: AAK20020.1.
AC008397 Genomic DNA. No translation available.
BC000274 mRNA. Translation: AAH00274.1.
CCDSiCCDS12378.1. [Q9BWG4-1]
CCDS32960.1. [Q9BWG4-2]
RefSeqiNP_001009998.1. NM_001009998.3. [Q9BWG4-2]
NP_116016.1. NM_032627.4. [Q9BWG4-1]
UniGeneiHs.515259.

3D structure databases

ProteinModelPortaliQ9BWG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128006. 22 interactions.
IntActiQ9BWG4. 4 interactions.
MINTiMINT-1472242.
STRINGi9606.ENSP00000270061.

PTM databases

iPTMnetiQ9BWG4.
PhosphoSiteiQ9BWG4.

Polymorphism and mutation databases

BioMutaiSSBP4.
DMDMi27734580.

Proteomic databases

EPDiQ9BWG4.
MaxQBiQ9BWG4.
PaxDbiQ9BWG4.
PeptideAtlasiQ9BWG4.
PRIDEiQ9BWG4.

Protocols and materials databases

DNASUi170463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270061; ENSP00000270061; ENSG00000130511. [Q9BWG4-1]
ENST00000348495; ENSP00000252807; ENSG00000130511. [Q9BWG4-2]
GeneIDi170463.
KEGGihsa:170463.
UCSCiuc002niy.4. human. [Q9BWG4-1]

Organism-specific databases

CTDi170463.
GeneCardsiSSBP4.
HGNCiHGNC:15676. SSBP4.
HPAiHPA049081.
MIMi607391. gene.
neXtProtiNX_Q9BWG4.
PharmGKBiPA38018.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4594. Eukaryota.
ENOG410XPQX. LUCA.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiQ9BWG4.
OMAiMASGPMA.
OrthoDBiEOG091G111C.
PhylomeDBiQ9BWG4.
TreeFamiTF318961.

Miscellaneous databases

GenomeRNAii170463.
PROiQ9BWG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130511.
CleanExiHS_SSBP4.
ExpressionAtlasiQ9BWG4. baseline and differential.
GenevisibleiQ9BWG4. HS.

Family and domain databases

InterProiIPR006594. LisH.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSBP4_HUMAN
AccessioniPrimary (citable) accession number: Q9BWG4
Secondary accession number(s): Q9BWW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.