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Protein

Single-stranded DNA-binding protein 4

Gene

SSBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 4
Gene namesi
Name:SSBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15676. SSBP4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130511.
PharmGKBiPA38018.

Polymorphism and mutation databases

BioMutaiSSBP4.
DMDMi27734580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238321 – 385Single-stranded DNA-binding protein 4Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei355PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BWG4.
MaxQBiQ9BWG4.
PaxDbiQ9BWG4.
PeptideAtlasiQ9BWG4.
PRIDEiQ9BWG4.

PTM databases

iPTMnetiQ9BWG4.
PhosphoSitePlusiQ9BWG4.

Expressioni

Gene expression databases

BgeeiENSG00000130511.
CleanExiHS_SSBP4.
ExpressionAtlasiQ9BWG4. baseline and differential.
GenevisibleiQ9BWG4. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128006. 24 interactors.
IntActiQ9BWG4. 7 interactors.
MINTiMINT-1472242.
STRINGi9606.ENSP00000270061.

Structurei

3D structure databases

ProteinModelPortaliQ9BWG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 49LisHPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 279Pro-richAdd BLAST155

Phylogenomic databases

eggNOGiKOG4594. Eukaryota.
ENOG410XPQX. LUCA.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiQ9BWG4.
OMAiMASGPMA.
OrthoDBiEOG091G111C.
PhylomeDBiQ9BWG4.
TreeFamiTF318961.

Family and domain databases

InterProiView protein in InterPro
IPR006594. LisH.
IPR008116. SSDP_DNA-bd.
PRINTSiPR01743. SSDNABINDING.
SMARTiView protein in SMART
SM00667. LisH. 1 hit.
PROSITEiView protein in PROSITE
PS50896. LISH. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYAKGGKGSA VPSDSQAREK LALYVYEYLL HIGAQKSAQT FLSEIRWEKN
60 70 80 90 100
ITLGEPPGFL HSWWCVFWDL YCAAPDRREA CEHSGEAKAF QDYSAAAAPS
110 120 130 140 150
PVMGSMAPGD TMAAGSMAAG FFQGPPGSQP SPHNPNAPMM GPHGQPFMSP
160 170 180 190 200
RFPGGPRPTL RMPSQPPAGL PGSQPLLPGA MEPSPRAQGH PSMGGPMQRV
210 220 230 240 250
TPPRGMASVG PQSYGGGMRP PPNSLAGPGL PAMNMGPGVR GPWASPSGNS
260 270 280 290 300
IPYSSSSPGS YTGPPGGGGP PGTPIMPSPG DSTNSSENMY TIMNPIGQGA
310 320 330 340 350
GRANFPLGPG PEGPMAAMSA MEPHHVNGSL GSGDMDGLPK SSPGAVAGLS
360 370 380
NAPGTPRDDG EMAAAGTFLH PFPSESYSPG MTMSV
Length:385
Mass (Da):39,388
Last modified:June 1, 2001 - v1
Checksum:iF55FD3470B810742
GO
Isoform 2 (identifier: Q9BWG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-144: Missing.

Show »
Length:363
Mass (Da):37,214
Checksum:i001C3AACC1A38F1F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054113123 – 144Missing in isoform 2. CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026292
, AY026276, AY026277, AY026278, AY026279, AY026280, AY026281, AY026282, AY026283, AY026284, AY026285, AY026286, AY026287, AY026288, AY026289, AY026290, AY026291 Genomic DNA. Translation: AAK20020.1.
AC008397 Genomic DNA. No translation available.
BC000274 mRNA. Translation: AAH00274.1.
CCDSiCCDS12378.1. [Q9BWG4-1]
CCDS32960.1. [Q9BWG4-2]
RefSeqiNP_001009998.1. NM_001009998.3. [Q9BWG4-2]
NP_116016.1. NM_032627.4. [Q9BWG4-1]
UniGeneiHs.515259.

Genome annotation databases

EnsembliENST00000270061; ENSP00000270061; ENSG00000130511. [Q9BWG4-1]
ENST00000348495; ENSP00000252807; ENSG00000130511. [Q9BWG4-2]
GeneIDi170463.
KEGGihsa:170463.
UCSCiuc002niy.4. human. [Q9BWG4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSSBP4_HUMAN
AccessioniPrimary (citable) accession number: Q9BWG4
Secondary accession number(s): Q9BWW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot