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Protein
Submitted name:

MCM2 protein

Gene

MCM2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
MCM2 proteinImported
Gene namesi
Name:MCM2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ9BWF4.
PeptideAtlasiQ9BWF4.

Expressioni

Gene expression databases

BgeeiENSG00000073111.

Interactioni

Protein-protein interaction databases

IntActiQ9BWF4. 2 interactors.
STRINGi9606.ENSP00000265056.

Structurei

3D structure databases

ProteinModelPortaliQ9BWF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 137MCMInterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0477. Eukaryota.
COG1241. LUCA.
HOVERGENiHBG104907.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR031327. MCM.
IPR008045. MCM2.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11630:SF89. PTHR11630:SF89. 1 hit.
PfamiView protein in Pfam
PF00493. MCM. 1 hit.
PRINTSiPR01657. MCMFAMILY.
SMARTiView protein in SMART
SM00350. MCM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9BWF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AIFTTGQGAS AVGLTAYVQR HPVSREWTLE AGALVLADRG VCLIDEFDKM
60 70 80 90 100
NDQDRTSIHE AMEQQSISIS KAGIVTSLQA RCTVIAAANP IGGRYDPSLT
110 120 130 140 150
FSENVDLTEP IISRFDILCV VRDTVDPVQD EMLARFVVGS HVRHHPSNKE
160 170 180 190 200
EEGLANGSAA EPAMPNTYGV EPLPQEVLKK YIIYAKERVH PKLNQMDQDK
210 220 230 240 250
VAKMYSDLRK ESMATGSIPI TVRHIESMIR MAEAHARIHL RDYVIEDDVN
260 270 280 290 300
MAIRVMLESF IDTQKFSVMR SMRKTFARYL SFRRDNNELL LFILKQLVAE
310 320 330 340 350
QVTYQRNRFG AQQDTIEVPE KDLVDKARQI NIHNLSAFYD SELFRMNKFS
360
HDLKRKMILQ QF
Length:362
Mass (Da):41,264
Last modified:March 1, 2004 - v2
Checksum:iB2F1BDA960A8A979
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000300 mRNA. Translation: AAH00300.2.
UniGeneiHs.477481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000300 mRNA. Translation: AAH00300.2.
UniGeneiHs.477481.

3D structure databases

ProteinModelPortaliQ9BWF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BWF4. 2 interactors.
STRINGi9606.ENSP00000265056.

Proteomic databases

PaxDbiQ9BWF4.
PeptideAtlasiQ9BWF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0477. Eukaryota.
COG1241. LUCA.
HOVERGENiHBG104907.

Miscellaneous databases

ChiTaRSiMCM2. human.

Gene expression databases

BgeeiENSG00000073111.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR031327. MCM.
IPR008045. MCM2.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11630:SF89. PTHR11630:SF89. 1 hit.
PfamiView protein in Pfam
PF00493. MCM. 1 hit.
PRINTSiPR01657. MCMFAMILY.
SMARTiView protein in SMART
SM00350. MCM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9BWF4_HUMAN
AccessioniPrimary (citable) accession number: Q9BWF4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: March 1, 2004
Last modified: March 15, 2017
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.