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Q9BWF2

- TRAIP_HUMAN

UniProt

Q9BWF2 - TRAIP_HUMAN

Protein

E3 ubiquitin-protein ligase TRAIP

Gene

TRAIP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Inhibits activation of NF-kappa-B mediated by TNF By similarity. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity.By similarity2 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 5044RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. receptor signaling protein activity Source: Ensembl
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. protein ubiquitination Source: UniProtKB-UniPathway
    4. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ9BWF2.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRAIP (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 206
    TRAF-interacting protein
    Gene namesi
    Name:TRAIP
    Synonyms:RNF206, TRIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30764. TRAIP.

    Subcellular locationi

    Cytoplasm. Cytoplasmperinuclear region. Nucleusnucleolus
    Note: Occasionally observed at nuclear puncta.

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670705.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469E3 ubiquitin-protein ligase TRAIPPRO_0000056191Add
    BLAST

    Post-translational modificationi

    Autoubiquitinated.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9BWF2.
    PaxDbiQ9BWF2.
    PRIDEiQ9BWF2.

    PTM databases

    PhosphoSiteiQ9BWF2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BWF2.
    BgeeiQ9BWF2.
    CleanExiHS_TRAIP.
    GenevestigatoriQ9BWF2.

    Organism-specific databases

    HPAiHPA036261.

    Interactioni

    Subunit structurei

    Binds TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 is part of the receptor-TRAF signaling complex By similarity. The C-terminus interacts with CYLD (PubMed:14676304), however the interaction was not detected with the full-length protein. Interacts with POLK and POLN.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163333EBI-1756205,EBI-389883

    Protein-protein interaction databases

    BioGridi115581. 32 interactions.
    IntActiQ9BWF2. 14 interactions.
    MINTiMINT-6781129.
    STRINGi9606.ENSP00000328203.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BWF2.
    SMRiQ9BWF2. Positions 6-57, 97-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni211 – 469259Interaction with CYLDAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili70 – 177108Sequence AnalysisAdd
    BLAST
    Coiled coili201 – 28080Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 5044RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG86944.
    HOGENOMiHOG000054214.
    HOVERGENiHBG059760.
    InParanoidiQ9BWF2.
    KOiK11985.
    OMAiKTMEQIE.
    OrthoDBiEOG7HXCQV.
    PhylomeDBiQ9BWF2.
    TreeFamiTF317309.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR009053. Prefoldin.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF46579. SSF46579. 1 hit.
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BWF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR    50
    IQVGKRTIIN KLFFDLAQEE ENVLDAEFLK NELDNVRAQL SQKDKEKRDS 100
    QVIIDTLRDT LEERNATVVS LQQALGKAEM LCSTLKKQMK YLEQQQDETK 150
    QAQEEARRLR SKMKTMEQIE LLLQSQRPEV EEMIRDMGVG QSAVEQLAVY 200
    CVSLKKEYEN LKEARKASGE VADKLRKDLF SSRSKLQTVY SELDQAKLEL 250
    KSAQKDLQSA DKEIMSLKKK LTMLQETLNL PPVASETVDR LVLESPAPVE 300
    VNLKLRRPSF RDDIDLNATF DVDTPPARPS SSQHGYYEKL CLEKSHSPIQ 350
    DVPKKICKGP RKESQLSLGG QSCAGEPDEE LVGAFPIFVR NAILGQKQPK 400
    RPRSESSCSK DVVRTGFDGL GGRTKFIQPT DTVMIRPLPV KPKTKVKQRV 450
    RVKTVPSLFQ AKLDTFLWS 469
    Length:469
    Mass (Da):53,294
    Last modified:June 1, 2001 - v1
    Checksum:iB9EF3808FBC5985B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371W → S in AAB52993. (PubMed:9104814)Curated
    Sequence conflicti76 – 761A → R in AAB52993. (PubMed:9104814)Curated
    Sequence conflicti157 – 1571R → G in AAB52993. (PubMed:9104814)Curated
    Sequence conflicti177 – 1771R → L in AAB52993. (PubMed:9104814)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77845 mRNA. Translation: AAB52993.1.
    AB451320 mRNA. Translation: BAG70134.1.
    AB451449 mRNA. Translation: BAG70263.1.
    BC000310 mRNA. Translation: AAH00310.1.
    BC019283 mRNA. Translation: AAH19283.1.
    CCDSiCCDS2806.1.
    RefSeqiNP_005870.2. NM_005879.2.
    UniGeneiHs.517972.

    Genome annotation databases

    EnsembliENST00000331456; ENSP00000328203; ENSG00000183763.
    GeneIDi10293.
    KEGGihsa:10293.
    UCSCiuc003cxs.1. human.

    Polymorphism databases

    DMDMi30580637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77845 mRNA. Translation: AAB52993.1 .
    AB451320 mRNA. Translation: BAG70134.1 .
    AB451449 mRNA. Translation: BAG70263.1 .
    BC000310 mRNA. Translation: AAH00310.1 .
    BC019283 mRNA. Translation: AAH19283.1 .
    CCDSi CCDS2806.1.
    RefSeqi NP_005870.2. NM_005879.2.
    UniGenei Hs.517972.

    3D structure databases

    ProteinModelPortali Q9BWF2.
    SMRi Q9BWF2. Positions 6-57, 97-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115581. 32 interactions.
    IntActi Q9BWF2. 14 interactions.
    MINTi MINT-6781129.
    STRINGi 9606.ENSP00000328203.

    PTM databases

    PhosphoSitei Q9BWF2.

    Polymorphism databases

    DMDMi 30580637.

    Proteomic databases

    MaxQBi Q9BWF2.
    PaxDbi Q9BWF2.
    PRIDEi Q9BWF2.

    Protocols and materials databases

    DNASUi 10293.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331456 ; ENSP00000328203 ; ENSG00000183763 .
    GeneIDi 10293.
    KEGGi hsa:10293.
    UCSCi uc003cxs.1. human.

    Organism-specific databases

    CTDi 10293.
    GeneCardsi GC03M049866.
    HGNCi HGNC:30764. TRAIP.
    HPAi HPA036261.
    MIMi 605958. gene.
    neXtProti NX_Q9BWF2.
    PharmGKBi PA142670705.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86944.
    HOGENOMi HOG000054214.
    HOVERGENi HBG059760.
    InParanoidi Q9BWF2.
    KOi K11985.
    OMAi KTMEQIE.
    OrthoDBi EOG7HXCQV.
    PhylomeDBi Q9BWF2.
    TreeFami TF317309.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    SignaLinki Q9BWF2.

    Miscellaneous databases

    ChiTaRSi TRAIP. human.
    GeneWikii TRAF_interacting_protein.
    GenomeRNAii 10293.
    NextBioi 35477924.
    PROi Q9BWF2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BWF2.
    Bgeei Q9BWF2.
    CleanExi HS_TRAIP.
    Genevestigatori Q9BWF2.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR009053. Prefoldin.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46579. SSF46579. 1 hit.
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation."
      Lee S.Y., Lee S.Y., Choi Y.
      J. Exp. Med. 185:1275-1285(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymocyte.
    2. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor."
      Regamey A., Hohl D., Liu J.W., Roger T., Kogerman P., Toftgaard R., Huber M.
      J. Exp. Med. 198:1959-1964(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CYLD.
    5. "TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1."
      Zhang M., Wang L., Zhao X., Zhao K., Meng H., Zhao W., Gao C.
      J. Exp. Med. 209:1703-1711(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase eta."
      Wallace H.A., Merkle J.A., Yu M.C., Berg T.G., Lee E., Bosco G., Lee L.A.
      Development 141:1332-1341(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POLK AND POLN.

    Entry informationi

    Entry nameiTRAIP_HUMAN
    AccessioniPrimary (citable) accession number: Q9BWF2
    Secondary accession number(s): B5BU84, B5BUL3, O00467
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3