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Q9BWF2 (TRAIP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase TRAIP

EC=6.3.2.-
Alternative name(s):
RING finger protein 206
TRAF-interacting protein
Gene names
Name:TRAIP
Synonyms:RNF206, TRIP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits activation of NF-kappa-B mediated by TNF By similarity. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity. Ref.5 Ref.6

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Binds TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 is part of the receptor-TRAF signaling complex By similarity. The C-terminus interacts with CYLD (Ref.4), however the interaction was not detected with the full-length protein. Interacts with POLK and POLN. Ref.4 Ref.6

Subcellular location

Cytoplasm. Cytoplasmperinuclear region. Nucleusnucleolus. Note: Occasionally observed at nuclear puncta. Ref.4 Ref.6

Post-translational modification

Autoubiquitinated By similarity.

Sequence similarities

Contains 1 RING-type zinc finger.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NCK1P163333EBI-1756205,EBI-389883

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469E3 ubiquitin-protein ligase TRAIP
PRO_0000056191

Regions

Zinc finger7 – 5044RING-type
Region211 – 469259Interaction with CYLD
Coiled coil70 – 177108 Potential
Coiled coil201 – 28080 Potential

Experimental info

Sequence conflict371W → S in AAB52993. Ref.1
Sequence conflict761A → R in AAB52993. Ref.1
Sequence conflict1571R → G in AAB52993. Ref.1
Sequence conflict1771R → L in AAB52993. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BWF2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: B9EF3808FBC5985B

FASTA46953,294
        10         20         30         40         50         60 
MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKRTIIN 

        70         80         90        100        110        120 
KLFFDLAQEE ENVLDAEFLK NELDNVRAQL SQKDKEKRDS QVIIDTLRDT LEERNATVVS 

       130        140        150        160        170        180 
LQQALGKAEM LCSTLKKQMK YLEQQQDETK QAQEEARRLR SKMKTMEQIE LLLQSQRPEV 

       190        200        210        220        230        240 
EEMIRDMGVG QSAVEQLAVY CVSLKKEYEN LKEARKASGE VADKLRKDLF SSRSKLQTVY 

       250        260        270        280        290        300 
SELDQAKLEL KSAQKDLQSA DKEIMSLKKK LTMLQETLNL PPVASETVDR LVLESPAPVE 

       310        320        330        340        350        360 
VNLKLRRPSF RDDIDLNATF DVDTPPARPS SSQHGYYEKL CLEKSHSPIQ DVPKKICKGP 

       370        380        390        400        410        420 
RKESQLSLGG QSCAGEPDEE LVGAFPIFVR NAILGQKQPK RPRSESSCSK DVVRTGFDGL 

       430        440        450        460 
GGRTKFIQPT DTVMIRPLPV KPKTKVKQRV RVKTVPSLFQ AKLDTFLWS 

« Hide

References

« Hide 'large scale' references
[1]"TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation."
Lee S.Y., Lee S.Y., Choi Y.
J. Exp. Med. 185:1275-1285(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymocyte.
[2]"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. expand/collapse author list , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor."
Regamey A., Hohl D., Liu J.W., Roger T., Kogerman P., Toftgaard R., Huber M.
J. Exp. Med. 198:1959-1964(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CYLD.
[5]"TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1."
Zhang M., Wang L., Zhao X., Zhao K., Meng H., Zhao W., Gao C.
J. Exp. Med. 209:1703-1711(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase eta."
Wallace H.A., Merkle J.A., Yu M.C., Berg T.G., Lee E., Bosco G., Lee L.A.
Development 141:1332-1341(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POLK AND POLN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77845 mRNA. Translation: AAB52993.1.
AB451320 mRNA. Translation: BAG70134.1.
AB451449 mRNA. Translation: BAG70263.1.
BC000310 mRNA. Translation: AAH00310.1.
BC019283 mRNA. Translation: AAH19283.1.
CCDSCCDS2806.1.
RefSeqNP_005870.2. NM_005879.2.
UniGeneHs.517972.

3D structure databases

ProteinModelPortalQ9BWF2.
SMRQ9BWF2. Positions 6-57, 97-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115581. 32 interactions.
IntActQ9BWF2. 14 interactions.
MINTMINT-6781129.
STRING9606.ENSP00000328203.

PTM databases

PhosphoSiteQ9BWF2.

Polymorphism databases

DMDM30580637.

Proteomic databases

MaxQBQ9BWF2.
PaxDbQ9BWF2.
PRIDEQ9BWF2.

Protocols and materials databases

DNASU10293.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331456; ENSP00000328203; ENSG00000183763.
GeneID10293.
KEGGhsa:10293.
UCSCuc003cxs.1. human.

Organism-specific databases

CTD10293.
GeneCardsGC03M049866.
HGNCHGNC:30764. TRAIP.
HPAHPA036261.
MIM605958. gene.
neXtProtNX_Q9BWF2.
PharmGKBPA142670705.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86944.
HOGENOMHOG000054214.
HOVERGENHBG059760.
InParanoidQ9BWF2.
KOK11985.
OMAKTMEQIE.
OrthoDBEOG7HXCQV.
PhylomeDBQ9BWF2.
TreeFamTF317309.

Enzyme and pathway databases

SignaLinkQ9BWF2.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ9BWF2.
BgeeQ9BWF2.
CleanExHS_TRAIP.
GenevestigatorQ9BWF2.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR009053. Prefoldin.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF46579. SSF46579. 1 hit.
PROSITEPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRAIP. human.
GeneWikiTRAF_interacting_protein.
GenomeRNAi10293.
NextBio35477924.
PROQ9BWF2.
SOURCESearch...

Entry information

Entry nameTRAIP_HUMAN
AccessionPrimary (citable) accession number: Q9BWF2
Secondary accession number(s): B5BU84, B5BUL3, O00467
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM