Q9BWF2 (TRAIP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TRAF-interacting protein

Alternative name(s):
RING finger protein 206

Gene names

Name:	TRAIP
Synonyms:	RNF206, TRIP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits activation of NF-kappa-B mediated by TNF By similarity.
Subunit structure	Binds TRAF1 and TRAF2 and is part of the receptor-TRAF signaling complex By similarity. Interacts with CYLD. Ref.3
Subcellular location	Cytoplasm. Cytoplasm › perinuclear region Ref.3.
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.1. Source: ProtInc induction of apoptosis Traceable author statement Ref.1. Source: ProtInc signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	receptor signaling protein activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	3	EBI-1756205,EBI-389883

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	TRAF-interacting protein		PRO_0000056191
Regions
	Zinc finger	7 – 50	44	RING-type
	Region	211 – 469	259	Interaction with CYLD
	Coiled coil	70 – 177	108	Potential
	Coiled coil	201 – 280	80	Potential
Experimental info
	Sequence conflict	37	1	W → S in AAB52993. Ref.1
	Sequence conflict	76	1	A → R in AAB52993. Ref.1
	Sequence conflict	157	1	R → G in AAB52993. Ref.1
	Sequence conflict	177	1	R → L in AAB52993. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BWF2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B9EF3808FBC5985B	FASTA	469	53,294
	10 20 30 40 50 60 MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKRTIIN 70 80 90 100 110 120 KLFFDLAQEE ENVLDAEFLK NELDNVRAQL SQKDKEKRDS QVIIDTLRDT LEERNATVVS 130 140 150 160 170 180 LQQALGKAEM LCSTLKKQMK YLEQQQDETK QAQEEARRLR SKMKTMEQIE LLLQSQRPEV 190 200 210 220 230 240 EEMIRDMGVG QSAVEQLAVY CVSLKKEYEN LKEARKASGE VADKLRKDLF SSRSKLQTVY 250 260 270 280 290 300 SELDQAKLEL KSAQKDLQSA DKEIMSLKKK LTMLQETLNL PPVASETVDR LVLESPAPVE 310 320 330 340 350 360 VNLKLRRPSF RDDIDLNATF DVDTPPARPS SSQHGYYEKL CLEKSHSPIQ DVPKKICKGP 370 380 390 400 410 420 RKESQLSLGG QSCAGEPDEE LVGAFPIFVR NAILGQKQPK RPRSESSCSK DVVRTGFDGL 430 440 450 460 GGRTKFIQPT DTVMIRPLPV KPKTKVKQRV RVKTVPSLFQ AKLDTFLWS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation." Lee S.Y., Lee S.Y., Choi Y. J. Exp. Med. 185:1275-1285(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thymocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor." Regamey A., Hohl D., Liu J.W., Roger T., Kogerman P., Toftgaard R., Huber M. J. Exp. Med. 198:1959-1964(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CYLD.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U77845 mRNA. Translation: AAB52993.1. BC000310 mRNA. Translation: AAH00310.1. BC019283 mRNA. Translation: AAH19283.1.
IPI	IPI00306611.
RefSeq	NP_005870.2. NM_005879.2.
UniGene	Hs.517972.
3D structure databases
ProteinModelPortal	Q9BWF2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BWF2. 14 interactions.
MINT	MINT-6781129.
STRING	9606.ENSP00000328203.
PTM databases
PhosphoSite	Q9BWF2.
Polymorphism databases
DMDM	30580637.
Proteomic databases
PaxDb	Q9BWF2.
PRIDE	Q9BWF2.
Protocols and materials databases
DNASU	10293.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331456; ENSP00000328203; ENSG00000183763.
GeneID	10293.
KEGG	hsa:10293.
UCSC	uc003cxs.1. human.
Organism-specific databases
CTD	10293.
GeneCards	GC03M049866.
HGNC	HGNC:30764. TRAIP.
HPA	HPA036261.
MIM	605958. gene.
neXtProt	NX_Q9BWF2.
PharmGKB	PA142670705.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86944.
HOGENOM	HOG000054214.
HOVERGEN	HBG059760.
InParanoid	Q9BWF2.
KO	K11985.
OMA	KTMEQIE.
OrthoDB	EOG41VK2T.
PhylomeDB	Q9BWF2.
Enzyme and pathway databases
SignaLink	Q9BWF2.
Gene expression databases
ArrayExpress	Q9BWF2.
Bgee	Q9BWF2.
CleanEx	HS_TRAIP.
Genevestigator	Q9BWF2.
GermOnline	ENSG00000183763. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR009053. Prefoldin. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF13639. zf-RING_2. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF46579. Prefoldin. 1 hit.
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRAIP. human.
GenomeRNAi	10293.
NextBio	39006.
SOURCE	Search...

Entry information

Entry name

TRAIP_HUMAN

Accession

Primary (citable) accession number: Q9BWF2
Secondary accession number(s): O00467

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.