Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM127B

Gene

FAM127B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM127B
Alternative name(s):
Mammalian retrotransposon derived protein 8A
Gene namesi
Name:FAM127B
Synonyms:CXX1B, MAR8A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24514. FAM127B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385915.

Polymorphism and mutation databases

BioMutaiFAM127B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Protein FAM127BPRO_0000311693Add
BLAST

Proteomic databases

MaxQBiQ9BWD3.
PaxDbiQ9BWD3.
PRIDEiQ9BWD3.

PTM databases

PhosphoSiteiQ9BWD3.

Expressioni

Gene expression databases

BgeeiQ9BWD3.
CleanExiHS_FAM127B.
GenevisibleiQ9BWD3. HS.

Organism-specific databases

HPAiHPA042173.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC102BA1A4H13EBI-741643,EBI-10171570
UBQLN1Q9UMX04EBI-741643,EBI-741480
UBQLN1Q9UMX0-23EBI-741643,EBI-10173939

Protein-protein interaction databases

BioGridi117530. 5 interactions.
IntActiQ9BWD3. 2 interactions.
STRINGi9606.ENSP00000375267.

Structurei

3D structure databases

ProteinModelPortaliQ9BWD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

eggNOGiNOG294112.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiQ9BWD3.
OMAiTEEHRWR.
OrthoDBiEOG722JBJ.
PhylomeDBiQ9BWD3.
TreeFamiTF337843.

Sequencei

Sequence statusi: Complete.

Q9BWD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGRVQLMKA LLAGPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY
60 70 80 90 100
MFVDENTFSN DALKVTFLIT RLTGPALQWV IPYIRKESPL LNDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,188
Last modified:December 4, 2007 - v3
Checksum:i65227B6D28946B9F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481S → C.1 Publication
Corresponds to variant rs2498776 [ dbSNP | Ensembl ].
VAR_060162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAD92617.2.
BC000393 mRNA. Translation: AAH00393.2.
BC019300 mRNA. Translation: AAH19300.1.
CCDSiCCDS43998.1.
RefSeqiNP_001071640.1. NM_001078172.1.
NP_001127793.1. NM_001134321.1.
UniGeneiHs.460924.

Genome annotation databases

EnsembliENST00000370775; ENSP00000375267; ENSG00000203950.
GeneIDi26071.
KEGGihsa:26071.
UCSCiuc004eyf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAD92617.2.
BC000393 mRNA. Translation: AAH00393.2.
BC019300 mRNA. Translation: AAH19300.1.
CCDSiCCDS43998.1.
RefSeqiNP_001071640.1. NM_001078172.1.
NP_001127793.1. NM_001134321.1.
UniGeneiHs.460924.

3D structure databases

ProteinModelPortaliQ9BWD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117530. 5 interactions.
IntActiQ9BWD3. 2 interactions.
STRINGi9606.ENSP00000375267.

PTM databases

PhosphoSiteiQ9BWD3.

Polymorphism and mutation databases

BioMutaiFAM127B.

Proteomic databases

MaxQBiQ9BWD3.
PaxDbiQ9BWD3.
PRIDEiQ9BWD3.

Protocols and materials databases

DNASUi26071.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370775; ENSP00000375267; ENSG00000203950.
GeneIDi26071.
KEGGihsa:26071.
UCSCiuc004eyf.3. human.

Organism-specific databases

CTDi26071.
GeneCardsiGC0XM134184.
H-InvDBHIX0014311.
HGNCiHGNC:24514. FAM127B.
HPAiHPA042173.
neXtProtiNX_Q9BWD3.
PharmGKBiPA162385915.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG294112.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiQ9BWD3.
OMAiTEEHRWR.
OrthoDBiEOG722JBJ.
PhylomeDBiQ9BWD3.
TreeFamiTF337843.

Miscellaneous databases

ChiTaRSiFAM127B. human.
GenomeRNAii26071.
NextBioi47979.
PROiQ9BWD3.

Gene expression databases

BgeeiQ9BWD3.
CleanExiHS_FAM127B.
GenevisibleiQ9BWD3. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-48.
    Tissue: Lung.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF127B_HUMAN
AccessioniPrimary (citable) accession number: Q9BWD3
Secondary accession number(s): A2A2V9, Q8TBU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 22, 2015
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.