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Protein

Protein FAM127B

Gene

FAM127B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31240-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM127B
Alternative name(s):
Mammalian retrotransposon derived protein 8A
Gene namesi
Name:FAM127B
Synonyms:CXX1B, MAR8A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24514. FAM127B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203950.
PharmGKBiPA162385915.

Polymorphism and mutation databases

BioMutaiFAM127B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003116931 – 113Protein FAM127BAdd BLAST113

Proteomic databases

EPDiQ9BWD3.
MaxQBiQ9BWD3.
PaxDbiQ9BWD3.
PeptideAtlasiQ9BWD3.
PRIDEiQ9BWD3.
TopDownProteomicsiQ9BWD3.

PTM databases

iPTMnetiQ9BWD3.
PhosphoSitePlusiQ9BWD3.

Expressioni

Gene expression databases

BgeeiENSG00000203950.
CleanExiHS_FAM127B.
GenevisibleiQ9BWD3. HS.

Organism-specific databases

HPAiHPA042173.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC102BA1A4H13EBI-741643,EBI-10171570
UBQLN1Q9UMX04EBI-741643,EBI-741480
UBQLN1Q9UMX0-23EBI-741643,EBI-10173939

Protein-protein interaction databases

BioGridi117530. 5 interactors.
IntActiQ9BWD3. 3 interactors.
STRINGi9606.ENSP00000375267.

Structurei

3D structure databases

ProteinModelPortaliQ9BWD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

eggNOGiENOG410IXM4. Eukaryota.
ENOG41113F5. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiQ9BWD3.
OMAiTEEHRWR.
OrthoDBiEOG091G02TH.
PhylomeDBiQ9BWD3.
TreeFamiTF337843.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGRVQLMKA LLAGPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY
60 70 80 90 100
MFVDENTFSN DALKVTFLIT RLTGPALQWV IPYIRKESPL LNDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,188
Last modified:December 4, 2007 - v3
Checksum:i65227B6D28946B9F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06016248S → C.1 PublicationCorresponds to variant rs2498776dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAD92617.2.
BC000393 mRNA. Translation: AAH00393.2.
BC019300 mRNA. Translation: AAH19300.1.
CCDSiCCDS43998.1.
RefSeqiNP_001071640.1. NM_001078172.1.
NP_001127793.1. NM_001134321.1.
UniGeneiHs.460924.

Genome annotation databases

EnsembliENST00000370775; ENSP00000375267; ENSG00000203950.
GeneIDi26071.
KEGGihsa:26071.
UCSCiuc004eyf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA. Translation: CAD92617.2.
BC000393 mRNA. Translation: AAH00393.2.
BC019300 mRNA. Translation: AAH19300.1.
CCDSiCCDS43998.1.
RefSeqiNP_001071640.1. NM_001078172.1.
NP_001127793.1. NM_001134321.1.
UniGeneiHs.460924.

3D structure databases

ProteinModelPortaliQ9BWD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117530. 5 interactors.
IntActiQ9BWD3. 3 interactors.
STRINGi9606.ENSP00000375267.

PTM databases

iPTMnetiQ9BWD3.
PhosphoSitePlusiQ9BWD3.

Polymorphism and mutation databases

BioMutaiFAM127B.

Proteomic databases

EPDiQ9BWD3.
MaxQBiQ9BWD3.
PaxDbiQ9BWD3.
PeptideAtlasiQ9BWD3.
PRIDEiQ9BWD3.
TopDownProteomicsiQ9BWD3.

Protocols and materials databases

DNASUi26071.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370775; ENSP00000375267; ENSG00000203950.
GeneIDi26071.
KEGGihsa:26071.
UCSCiuc004eyf.4. human.

Organism-specific databases

CTDi26071.
GeneCardsiFAM127B.
H-InvDBHIX0014311.
HGNCiHGNC:24514. FAM127B.
HPAiHPA042173.
neXtProtiNX_Q9BWD3.
OpenTargetsiENSG00000203950.
PharmGKBiPA162385915.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXM4. Eukaryota.
ENOG41113F5. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000049195.
HOVERGENiHBG052318.
InParanoidiQ9BWD3.
OMAiTEEHRWR.
OrthoDBiEOG091G02TH.
PhylomeDBiQ9BWD3.
TreeFamiTF337843.

Enzyme and pathway databases

BioCyciZFISH:G66-31240-MONOMER.

Miscellaneous databases

ChiTaRSiFAM127B. human.
GenomeRNAii26071.
PROiQ9BWD3.

Gene expression databases

BgeeiENSG00000203950.
CleanExiHS_FAM127B.
GenevisibleiQ9BWD3. HS.

Family and domain databases

InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF127B_HUMAN
AccessioniPrimary (citable) accession number: Q9BWD3
Secondary accession number(s): A2A2V9, Q8TBU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.