UniProtKB - Q9BWD1 (THIC_HUMAN)
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Protein
Acetyl-CoA acetyltransferase, cytosolic
Gene
ACAT2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 92 | Acyl-thioester intermediate | 1 | |
Active sitei | 353 | Proton acceptor | 1 | |
Active sitei | 383 | Proton acceptor | 1 |
GO - Molecular functioni
- acetyl-CoA C-acetyltransferase activity Source: BHF-UCL
GO - Biological processi
- cholesterol biosynthetic process Source: Reactome
- fatty acid beta-oxidation Source: GO_Central
- lipid metabolic process Source: ProtInc
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000120437-MONOMER. |
BRENDAi | 2.3.1.9. 2681. |
Reactomei | R-HSA-191273. Cholesterol biosynthesis. |
Chemistry databases
SwissLipidsi | SLP:000001266. |
Names & Taxonomyi
Protein namesi | Recommended name: Acetyl-CoA acetyltransferase, cytosolic (EC:2.3.1.9)Alternative name(s): Acetyl-CoA transferase-like protein Cytosolic acetoacetyl-CoA thiolase |
Gene namesi | Name:ACAT2 Synonyms:ACTL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000120437.8. |
HGNCi | HGNC:94. ACAT2. |
MIMi | 100678. gene+phenotype. |
neXtProti | NX_Q9BWD1. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 39. |
MalaCardsi | ACAT2. |
MIMi | 100678. gene+phenotype. |
OpenTargetsi | ENSG00000120437. |
PharmGKBi | PA19. |
Chemistry databases
DrugBanki | DB01992. Coenzyme A. DB01915. S-Hydroxycysteine. |
Polymorphism and mutation databases
BioMutai | ACAT2. |
DMDMi | 52000838. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206409 | 1 – 397 | Acetyl-CoA acetyltransferase, cytosolicAdd BLAST | 397 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 200 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 233 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 235 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9BWD1. |
MaxQBi | Q9BWD1. |
PaxDbi | Q9BWD1. |
PeptideAtlasi | Q9BWD1. |
PRIDEi | Q9BWD1. |
2D gel databases
OGPi | Q9BWD1. |
REPRODUCTION-2DPAGEi | IPI00291419. |
PTM databases
iPTMneti | Q9BWD1. |
PhosphoSitePlusi | Q9BWD1. |
SwissPalmi | Q9BWD1. |
Expressioni
Gene expression databases
Bgeei | ENSG00000120437. |
CleanExi | HS_ACAT2. |
Genevisiblei | Q9BWD1. HS. |
Organism-specific databases
HPAi | CAB021106. HPA025736. HPA025765. HPA025811. |
Interactioni
Subunit structurei
Homotetramer.
Binary interactionsi
Protein-protein interaction databases
BioGridi | 106557. 39 interactors. |
IntActi | Q9BWD1. 16 interactors. |
STRINGi | 9606.ENSP00000356015. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 8 – 15 | Combined sources | 8 | |
Turni | 24 – 27 | Combined sources | 4 | |
Helixi | 30 – 45 | Combined sources | 16 | |
Helixi | 49 – 51 | Combined sources | 3 | |
Beta strandi | 54 – 58 | Combined sources | 5 | |
Helixi | 69 – 76 | Combined sources | 8 | |
Beta strandi | 85 – 88 | Combined sources | 4 | |
Helixi | 91 – 93 | Combined sources | 3 | |
Helixi | 94 – 107 | Combined sources | 14 | |
Beta strandi | 112 – 122 | Combined sources | 11 | |
Beta strandi | 136 – 138 | Combined sources | 3 | |
Helixi | 145 – 149 | Combined sources | 5 | |
Turni | 154 – 156 | Combined sources | 3 | |
Helixi | 160 – 171 | Combined sources | 12 | |
Helixi | 175 – 194 | Combined sources | 20 | |
Turni | 195 – 201 | Combined sources | 7 | |
Beta strandi | 205 – 209 | Combined sources | 5 | |
Beta strandi | 212 – 216 | Combined sources | 5 | |
Helixi | 228 – 232 | Combined sources | 5 | |
Turni | 240 – 243 | Combined sources | 4 | |
Helixi | 248 – 250 | Combined sources | 3 | |
Beta strandi | 255 – 265 | Combined sources | 11 | |
Helixi | 266 – 271 | Combined sources | 6 | |
Beta strandi | 277 – 287 | Combined sources | 11 | |
Helixi | 290 – 295 | Combined sources | 6 | |
Helixi | 297 – 308 | Combined sources | 12 | |
Helixi | 312 – 314 | Combined sources | 3 | |
Beta strandi | 317 – 320 | Combined sources | 4 | |
Helixi | 325 – 335 | Combined sources | 11 | |
Helixi | 339 – 341 | Combined sources | 3 | |
Helixi | 348 – 351 | Combined sources | 4 | |
Turni | 355 – 357 | Combined sources | 3 | |
Helixi | 358 – 373 | Combined sources | 16 | |
Beta strandi | 377 – 384 | Combined sources | 8 | |
Turni | 385 – 387 | Combined sources | 3 | |
Beta strandi | 388 – 396 | Combined sources | 9 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WL4 | X-ray | 1.55 | A | 1-397 | [»] | |
1WL5 | X-ray | 2.26 | A | 1-397 | [»] | |
ProteinModelPortali | Q9BWD1. | |||||
SMRi | Q9BWD1. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BWD1. |
Family & Domainsi
Sequence similaritiesi
Belongs to the thiolase family.Curated
Phylogenomic databases
eggNOGi | KOG1391. Eukaryota. COG0183. LUCA. |
GeneTreei | ENSGT00390000009412. |
HOGENOMi | HOG000012238. |
HOVERGENi | HBG003112. |
InParanoidi | Q9BWD1. |
KOi | K00626. |
OMAi | ICPSIAI. |
OrthoDBi | EOG091G09C6. |
PhylomeDBi | Q9BWD1. |
TreeFami | TF300650. |
Family and domain databases
CDDi | cd00751. thiolase. 1 hit. |
Gene3Di | 3.40.47.10. 4 hits. |
InterProi | View protein in InterPro IPR002155. Thiolase. IPR016039. Thiolase-like. IPR020610. Thiolase_AS. IPR020617. Thiolase_C. IPR020613. Thiolase_CS. IPR020616. Thiolase_N. |
Pfami | View protein in Pfam PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit. |
PIRSFi | PIRSF000429. Ac-CoA_Ac_transf. 1 hit. |
SUPFAMi | SSF53901. SSF53901. 2 hits. |
TIGRFAMsi | TIGR01930. AcCoA-C-Actrans. 1 hit. |
PROSITEi | View protein in PROSITE PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BWD1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MNAGSDPVVI VSAARTIIGS FNGALAAVPV QDLGSTVIKE VLKRATVAPE
60 70 80 90 100
DVSEVIFGHV LAAGCGQNPV RQASVGAGIP YSVPAWSCQM ICGSGLKAVC
110 120 130 140 150
LAVQSIGIGD SSIVVAGGME NMSKAPHLAY LRTGVKIGEM PLTDSILCDG
160 170 180 190 200
LTDAFHNCHM GITAENVAKK WQVSREDQDK VAVLSQNRTE NAQKAGHFDK
210 220 230 240 250
EIVPVLVSTR KGLIEVKTDE FPRHGSNIEA MSKLKPYFLT DGTGTVTPAN
260 270 280 290 300
ASGINDGAAA VVLMKKSEAD KRGLTPLARI VSWSQVGVEP SIMGIGPIPA
310 320 330 340 350
IKQAVTKAGW SLEDVDIFEI NEAFAAVSAA IVKELGLNPE KVNIEGGAIA
360 370 380 390
LGHPLGASGC RILVTLLHTL ERMGRSRGVA ALCIGGGMGI AMCVQRE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 169 | K → T in AAB30856 (PubMed:7911016).Curated | 1 | |
Sequence conflicti | 262 | V → A in AAB30856 (PubMed:7911016).Curated | 1 | |
Sequence conflicti | 375 | R → G in AAM00223 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019686 | 211 | K → R1 PublicationCorresponds to variant dbSNP:rs25683Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056217 | 1 – 19 | MNAGS…RTIIG → MGSHPVLRIWGNRRATAASL GRSGGRLSSPRLLRVVAPTL TFAQTSRC in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S70154 mRNA. Translation: AAB30856.1. AF356877 mRNA. Translation: AAM00223.1. AK294273 mRNA. Translation: BAH11719.1. AL135914 Genomic DNA. No translation available. CH471051 Genomic DNA. Translation: EAW47619.1. CH471051 Genomic DNA. Translation: EAW47620.1. BC000408 mRNA. Translation: AAH00408.1. |
CCDSi | CCDS5268.1. [Q9BWD1-1] |
PIRi | JC2378. |
RefSeqi | NP_001290182.1. NM_001303253.1. [Q9BWD1-2] NP_005882.2. NM_005891.2. [Q9BWD1-1] |
UniGenei | Hs.571037. |
Genome annotation databases
Ensembli | ENST00000367048; ENSP00000356015; ENSG00000120437. [Q9BWD1-1] |
GeneIDi | 39. |
KEGGi | hsa:39. |
UCSCi | uc010kjy.4. human. [Q9BWD1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | THIC_HUMAN | |
Accessioni | Q9BWD1Primary (citable) accession number: Q9BWD1 Secondary accession number(s): B7Z233 Q8TDM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | September 13, 2004 | |
Last modified: | March 28, 2018 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |