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Protein

Coiled-coil domain-containing protein 106

Gene

CCDC106

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the degradation of p53/TP53 protein and inhibits its transactivity.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 106
Gene namesi
Name:CCDC106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000173581.7.
HGNCiHGNC:30181. CCDC106.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173581.
PharmGKBiPA145008652.

Polymorphism and mutation databases

BioMutaiCCDC106.
DMDMi74733424.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743431 – 280Coiled-coil domain-containing protein 106Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWC9.
MaxQBiQ9BWC9.
PaxDbiQ9BWC9.
PeptideAtlasiQ9BWC9.
PRIDEiQ9BWC9.

PTM databases

iPTMnetiQ9BWC9.
PhosphoSitePlusiQ9BWC9.

Expressioni

Gene expression databases

BgeeiENSG00000173581.
CleanExiHS_CCDC106.
ExpressionAtlasiQ9BWC9. baseline and differential.
GenevisibleiQ9BWC9. HS.

Organism-specific databases

HPAiHPA041925.
HPA043219.

Interactioni

Subunit structurei

Interacts with p53/TP53.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118952. 20 interactors.
IntActiQ9BWC9. 16 interactors.
MINTiMINT-7681160.

Structurei

3D structure databases

ProteinModelPortaliQ9BWC9.
SMRiQ9BWC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 101Sequence analysisAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi151 – 164Bipartite nuclear localization signalAdd BLAST14

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IZAC. Eukaryota.
ENOG410ZRF6. LUCA.
GeneTreeiENSGT00390000013183.
HOGENOMiHOG000111376.
HOVERGENiHBG055157.
InParanoidiQ9BWC9.
OMAiPFDEAPH.
OrthoDBiEOG091G09M7.
PhylomeDBiQ9BWC9.
TreeFamiTF331729.

Family and domain databases

InterProiView protein in InterPro
IPR031591. CCDC106.
PfamiView protein in Pfam
PF15794. CCDC106. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BWC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA
60 70 80 90 100
ASSALALMNS VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA
110 120 130 140 150
RMEAEDHCRM KPGPRRMEGD SRGGAGGEAS DPESAASSLS GASEEGSASE
160 170 180 190 200
RRRQKQKGGA SRRRFGKPKA RERQRVKDAD GVLCRYKKIL GTFQKLKSMS
210 220 230 240 250
RAFEHHRVDR NTVALTTPIA ELLIVAPEKL AEVGEFDPSK ERLLEYSRRC
260 270 280
FLALDDETLK KVQALKKSKL LLPITYRFKR
Length:280
Mass (Da):32,032
Last modified:June 1, 2001 - v1
Checksum:i8A380144441AEA33
GO

Sequence cautioni

Q9BWC9: The sequence AAB50227 differs from that shown. Reason: Erroneous termination at position 154. Translated as Gln.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU354321 mRNA. Translation: ADC34060.1.
GU354322 mRNA. Translation: ADC34061.1.
GU354323 mRNA. Translation: ADC34062.1.
U79303 mRNA. Translation: AAB50227.1. Sequence problems.
AK097095 mRNA. Translation: BAG53421.1.
BC000412 mRNA. Translation: AAH00412.1.
BC008956 mRNA. Translation: AAH08956.1.
CR450308 mRNA. Translation: CAG29304.1.
CCDSiCCDS33118.1.
RefSeqiNP_037433.2. NM_013301.2.
XP_005258884.1. XM_005258827.2.
XP_005258885.1. XM_005258828.2.
UniGeneiHs.82482.

Genome annotation databases

EnsembliENST00000308964; ENSP00000309681; ENSG00000173581.
ENST00000586790; ENSP00000465757; ENSG00000173581.
ENST00000588740; ENSP00000468539; ENSG00000173581.
ENST00000591578; ENSP00000466870; ENSG00000173581.
GeneIDi29903.
KEGGihsa:29903.
UCSCiuc002qlr.4. human.

Similar proteinsi

Entry informationi

Entry nameiCC106_HUMAN
AccessioniPrimary (citable) accession number: Q9BWC9
Secondary accession number(s): B3KUF9, D3K183, Q99786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot