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Protein

Coiled-coil domain-containing protein 106

Gene

CCDC106

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the degradation of p53/TP53 protein and inhibits its transactivity.1 Publication

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173581-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 106
Gene namesi
Name:CCDC106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30181. CCDC106.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173581.
PharmGKBiPA145008652.

Polymorphism and mutation databases

BioMutaiCCDC106.
DMDMi74733424.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743431 – 280Coiled-coil domain-containing protein 106Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWC9.
MaxQBiQ9BWC9.
PaxDbiQ9BWC9.
PeptideAtlasiQ9BWC9.
PRIDEiQ9BWC9.

PTM databases

iPTMnetiQ9BWC9.
PhosphoSitePlusiQ9BWC9.

Expressioni

Gene expression databases

BgeeiENSG00000173581.
CleanExiHS_CCDC106.
ExpressionAtlasiQ9BWC9. baseline and differential.
GenevisibleiQ9BWC9. HS.

Organism-specific databases

HPAiHPA041925.
HPA043219.

Interactioni

Subunit structurei

Interacts with p53/TP53.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF4P188486EBI-711501,EBI-492498
ATF4Q96AQ33EBI-711501,EBI-740263
FAM9BQ8IZU03EBI-711501,EBI-10175124
TP53P046373EBI-711501,EBI-366083

Protein-protein interaction databases

BioGridi118952. 18 interactors.
IntActiQ9BWC9. 15 interactors.
MINTiMINT-7681160.
STRINGi9606.ENSP00000309681.

Structurei

3D structure databases

ProteinModelPortaliQ9BWC9.
SMRiQ9BWC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 101Sequence analysisAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi151 – 164Bipartite nuclear localization signalAdd BLAST14

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IZAC. Eukaryota.
ENOG410ZRF6. LUCA.
GeneTreeiENSGT00390000013183.
HOGENOMiHOG000111376.
HOVERGENiHBG055157.
InParanoidiQ9BWC9.
OMAiNWRARRE.
OrthoDBiEOG091G09M7.
PhylomeDBiQ9BWC9.
TreeFamiTF331729.

Family and domain databases

InterProiIPR031591. CCDC106.
[Graphical view]
PfamiPF15794. CCDC106. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BWC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA
60 70 80 90 100
ASSALALMNS VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA
110 120 130 140 150
RMEAEDHCRM KPGPRRMEGD SRGGAGGEAS DPESAASSLS GASEEGSASE
160 170 180 190 200
RRRQKQKGGA SRRRFGKPKA RERQRVKDAD GVLCRYKKIL GTFQKLKSMS
210 220 230 240 250
RAFEHHRVDR NTVALTTPIA ELLIVAPEKL AEVGEFDPSK ERLLEYSRRC
260 270 280
FLALDDETLK KVQALKKSKL LLPITYRFKR
Length:280
Mass (Da):32,032
Last modified:June 1, 2001 - v1
Checksum:i8A380144441AEA33
GO

Sequence cautioni

The sequence AAB50227 differs from that shown. Reason: Erroneous termination at position 154. Translated as Gln.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU354321 mRNA. Translation: ADC34060.1.
GU354322 mRNA. Translation: ADC34061.1.
GU354323 mRNA. Translation: ADC34062.1.
U79303 mRNA. Translation: AAB50227.1. Sequence problems.
AK097095 mRNA. Translation: BAG53421.1.
BC000412 mRNA. Translation: AAH00412.1.
BC008956 mRNA. Translation: AAH08956.1.
CR450308 mRNA. Translation: CAG29304.1.
CCDSiCCDS33118.1.
RefSeqiNP_037433.2. NM_013301.2.
XP_005258884.1. XM_005258827.2.
XP_005258885.1. XM_005258828.2.
UniGeneiHs.82482.

Genome annotation databases

EnsembliENST00000308964; ENSP00000309681; ENSG00000173581.
ENST00000586790; ENSP00000465757; ENSG00000173581.
ENST00000588740; ENSP00000468539; ENSG00000173581.
ENST00000591578; ENSP00000466870; ENSG00000173581.
GeneIDi29903.
KEGGihsa:29903.
UCSCiuc002qlr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU354321 mRNA. Translation: ADC34060.1.
GU354322 mRNA. Translation: ADC34061.1.
GU354323 mRNA. Translation: ADC34062.1.
U79303 mRNA. Translation: AAB50227.1. Sequence problems.
AK097095 mRNA. Translation: BAG53421.1.
BC000412 mRNA. Translation: AAH00412.1.
BC008956 mRNA. Translation: AAH08956.1.
CR450308 mRNA. Translation: CAG29304.1.
CCDSiCCDS33118.1.
RefSeqiNP_037433.2. NM_013301.2.
XP_005258884.1. XM_005258827.2.
XP_005258885.1. XM_005258828.2.
UniGeneiHs.82482.

3D structure databases

ProteinModelPortaliQ9BWC9.
SMRiQ9BWC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118952. 18 interactors.
IntActiQ9BWC9. 15 interactors.
MINTiMINT-7681160.
STRINGi9606.ENSP00000309681.

PTM databases

iPTMnetiQ9BWC9.
PhosphoSitePlusiQ9BWC9.

Polymorphism and mutation databases

BioMutaiCCDC106.
DMDMi74733424.

Proteomic databases

EPDiQ9BWC9.
MaxQBiQ9BWC9.
PaxDbiQ9BWC9.
PeptideAtlasiQ9BWC9.
PRIDEiQ9BWC9.

Protocols and materials databases

DNASUi29903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308964; ENSP00000309681; ENSG00000173581.
ENST00000586790; ENSP00000465757; ENSG00000173581.
ENST00000588740; ENSP00000468539; ENSG00000173581.
ENST00000591578; ENSP00000466870; ENSG00000173581.
GeneIDi29903.
KEGGihsa:29903.
UCSCiuc002qlr.4. human.

Organism-specific databases

CTDi29903.
GeneCardsiCCDC106.
HGNCiHGNC:30181. CCDC106.
HPAiHPA041925.
HPA043219.
MIMi613478. gene.
neXtProtiNX_Q9BWC9.
OpenTargetsiENSG00000173581.
PharmGKBiPA145008652.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZAC. Eukaryota.
ENOG410ZRF6. LUCA.
GeneTreeiENSGT00390000013183.
HOGENOMiHOG000111376.
HOVERGENiHBG055157.
InParanoidiQ9BWC9.
OMAiNWRARRE.
OrthoDBiEOG091G09M7.
PhylomeDBiQ9BWC9.
TreeFamiTF331729.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173581-MONOMER.

Miscellaneous databases

ChiTaRSiCCDC106. human.
GenomeRNAii29903.
PROiQ9BWC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173581.
CleanExiHS_CCDC106.
ExpressionAtlasiQ9BWC9. baseline and differential.
GenevisibleiQ9BWC9. HS.

Family and domain databases

InterProiIPR031591. CCDC106.
[Graphical view]
PfamiPF15794. CCDC106. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCC106_HUMAN
AccessioniPrimary (citable) accession number: Q9BWC9
Secondary accession number(s): B3KUF9, D3K183, Q99786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.