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Protein

ADP-ribose pyrophosphatase, mitochondrial

Gene

NUDT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

Catalytic activityi

ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese

Enzyme and pathway databases

BioCyciZFISH:HS10140-MONOMER.
ReactomeiR-HSA-2393930. Phosphate bond hydrolysis by NUDT proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribose pyrophosphatase, mitochondrial (EC:3.6.1.13)
Alternative name(s):
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
Adenosine diphosphoribose pyrophosphatase
Short name:
ADPR-PPase
Nucleoside diphosphate-linked moiety X motif 9
Short name:
Nudix motif 9
Gene namesi
Name:NUDT9
Synonyms:NUDT10
ORF Names:PSEC0099, UNQ3012/PRO9771
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:8056. NUDT9.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intracellular Source: UniProtKB
  • mitochondrial matrix Source: Reactome
  • mitochondrion Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170502.
PharmGKBiPA31842.

Polymorphism and mutation databases

BioMutaiNUDT9.
DMDMi20455184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
ChainiPRO_000001995047 – 350ADP-ribose pyrophosphatase, mitochondrialAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BW91.
MaxQBiQ9BW91.
PaxDbiQ9BW91.
PeptideAtlasiQ9BW91.
PRIDEiQ9BW91.

PTM databases

iPTMnetiQ9BW91.
PhosphoSitePlusiQ9BW91.

Expressioni

Tissue specificityi

Ubiquitously expressed but isoform 1 is the most predominant isoform.1 Publication

Inductioni

Isoform 1 is inhibited by fluoride and N-acetyl-p-benzoquinoneimine.1 Publication

Gene expression databases

BgeeiENSG00000170502.
CleanExiHS_NUDT10.
HS_NUDT9.
ExpressionAtlasiQ9BW91. baseline and differential.
GenevisibleiQ9BW91. HS.

Organism-specific databases

HPAiHPA036917.
HPA044866.

Interactioni

Subunit structurei

Monomer. Interacts with GLOD4.2 Publications

Protein-protein interaction databases

BioGridi119744. 14 interactors.
IntActiQ9BW91. 2 interactors.
STRINGi9606.ENSP00000303575.

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 66Combined sources3
Helixi82 – 84Combined sources3
Beta strandi97 – 100Combined sources4
Helixi102 – 105Combined sources4
Beta strandi126 – 128Combined sources3
Beta strandi155 – 160Combined sources6
Beta strandi163 – 178Combined sources16
Turni190 – 192Combined sources3
Beta strandi197 – 203Combined sources7
Turni205 – 207Combined sources3
Beta strandi209 – 211Combined sources3
Helixi223 – 235Combined sources13
Helixi238 – 240Combined sources3
Helixi245 – 256Combined sources12
Turni257 – 259Combined sources3
Beta strandi260 – 268Combined sources9
Beta strandi276 – 292Combined sources17
Turni293 – 297Combined sources5
Beta strandi307 – 313Combined sources7
Helixi324 – 335Combined sources12
Helixi345 – 347Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q33X-ray1.81A59-350[»]
1QVJX-ray1.91A59-350[»]
ProteinModelPortaliQ9BW91.
SMRiQ9BW91.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BW91.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 334Nudix hydrolasePROSITE-ProRule annotationAdd BLAST157

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi215 – 237Nudix boxAdd BLAST23

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudF subfamily.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4195. Eukaryota.
ENOG410XPYY. LUCA.
GeneTreeiENSGT00390000017405.
HOGENOMiHOG000130166.
HOVERGENiHBG052693.
InParanoidiQ9BW91.
KOiK13988.
OMAiQISESNF.
OrthoDBiEOG091G0H75.
PhylomeDBiQ9BW91.
TreeFamiTF106351.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BW91-1) [UniParc]FASTAAdd to basket
Also known as: NUDT9a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRLLGKAL AAVSLSLALA SVTIRSSRCR GIQAFRNSFS SSWFHLNTNV
60 70 80 90 100
MSGSNGSKEN SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYKPVEYT
110 120 130 140 150
AVSVLAGPRW ADPQISESNF SPKFNEKDGH VERKSKNGLY EIENGRPRNP
160 170 180 190 200
AGRTGLVGRG LLGRWGPNHA ADPIITRWKR DSSGNKIMHP VSGKHILQFV
210 220 230 240 250
AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ KTSAEKREIE
260 270 280 290 300
EKLHKLFSQD HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGEIMDNLML
310 320 330 340 350
EAGDDAGKVK WVDINDKLKL YASHSQFIKL VAEKRDAHWS EDSEADCHAL
Length:350
Mass (Da):39,125
Last modified:June 1, 2001 - v1
Checksum:i2EA5B24B88FB3420
GO
Isoform 2 (identifier: Q9BW91-2) [UniParc]FASTAAdd to basket
Also known as: NUDT9b

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:300
Mass (Da):33,776
Checksum:i531993C757A82E49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118S → G in AAM46068 (Ref. 4) Curated1
Sequence conflicti293E → V in BAC11601 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0105521 – 50Missing in isoform 2. 3 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026252 mRNA. Translation: AAK07671.1.
AY359123 mRNA. Translation: AAQ89480.1.
AF273028 mRNA. Translation: AAM46068.1.
AK074845 mRNA. Translation: BAC11239.1.
AK075408 mRNA. Translation: BAC11601.1.
BC000542 mRNA. Translation: AAH00542.1.
CCDSiCCDS3620.1. [Q9BW91-1]
CCDS3621.1. [Q9BW91-2]
RefSeqiNP_001234940.1. NM_001248011.1.
NP_076952.1. NM_024047.4. [Q9BW91-1]
NP_932155.1. NM_198038.2. [Q9BW91-2]
XP_011530334.1. XM_011532032.2. [Q9BW91-2]
UniGeneiHs.149500.

Genome annotation databases

EnsembliENST00000302174; ENSP00000303575; ENSG00000170502. [Q9BW91-1]
ENST00000473942; ENSP00000421811; ENSG00000170502. [Q9BW91-2]
GeneIDi53343.
KEGGihsa:53343.
UCSCiuc003hqq.4. human. [Q9BW91-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026252 mRNA. Translation: AAK07671.1.
AY359123 mRNA. Translation: AAQ89480.1.
AF273028 mRNA. Translation: AAM46068.1.
AK074845 mRNA. Translation: BAC11239.1.
AK075408 mRNA. Translation: BAC11601.1.
BC000542 mRNA. Translation: AAH00542.1.
CCDSiCCDS3620.1. [Q9BW91-1]
CCDS3621.1. [Q9BW91-2]
RefSeqiNP_001234940.1. NM_001248011.1.
NP_076952.1. NM_024047.4. [Q9BW91-1]
NP_932155.1. NM_198038.2. [Q9BW91-2]
XP_011530334.1. XM_011532032.2. [Q9BW91-2]
UniGeneiHs.149500.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q33X-ray1.81A59-350[»]
1QVJX-ray1.91A59-350[»]
ProteinModelPortaliQ9BW91.
SMRiQ9BW91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119744. 14 interactors.
IntActiQ9BW91. 2 interactors.
STRINGi9606.ENSP00000303575.

PTM databases

iPTMnetiQ9BW91.
PhosphoSitePlusiQ9BW91.

Polymorphism and mutation databases

BioMutaiNUDT9.
DMDMi20455184.

Proteomic databases

EPDiQ9BW91.
MaxQBiQ9BW91.
PaxDbiQ9BW91.
PeptideAtlasiQ9BW91.
PRIDEiQ9BW91.

Protocols and materials databases

DNASUi53343.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302174; ENSP00000303575; ENSG00000170502. [Q9BW91-1]
ENST00000473942; ENSP00000421811; ENSG00000170502. [Q9BW91-2]
GeneIDi53343.
KEGGihsa:53343.
UCSCiuc003hqq.4. human. [Q9BW91-1]

Organism-specific databases

CTDi53343.
GeneCardsiNUDT9.
HGNCiHGNC:8056. NUDT9.
HPAiHPA036917.
HPA044866.
MIMi606022. gene.
neXtProtiNX_Q9BW91.
OpenTargetsiENSG00000170502.
PharmGKBiPA31842.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4195. Eukaryota.
ENOG410XPYY. LUCA.
GeneTreeiENSGT00390000017405.
HOGENOMiHOG000130166.
HOVERGENiHBG052693.
InParanoidiQ9BW91.
KOiK13988.
OMAiQISESNF.
OrthoDBiEOG091G0H75.
PhylomeDBiQ9BW91.
TreeFamiTF106351.

Enzyme and pathway databases

BioCyciZFISH:HS10140-MONOMER.
ReactomeiR-HSA-2393930. Phosphate bond hydrolysis by NUDT proteins.

Miscellaneous databases

EvolutionaryTraceiQ9BW91.
GeneWikiiNUDT9.
GenomeRNAii53343.
PROiQ9BW91.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170502.
CleanExiHS_NUDT10.
HS_NUDT9.
ExpressionAtlasiQ9BW91. baseline and differential.
GenevisibleiQ9BW91. HS.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDT9_HUMAN
AccessioniPrimary (citable) accession number: Q9BW91
Secondary accession number(s): Q8NBN1, Q8NCB9, Q8NG25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.