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Protein

Coiled-coil domain-containing protein 94

Gene

CCDC94

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 94
Gene namesi
Name:CCDC94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25518. CCDC94.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596461.

Polymorphism and mutation databases

BioMutaiCCDC94.
DMDMi74733407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Coiled-coil domain-containing protein 94PRO_0000234018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111PhosphoserineCombined sources
Modified residuei213 – 2131PhosphoserineCombined sources
Modified residuei220 – 2201PhosphoserineCombined sources
Modified residuei316 – 3161PhosphoserineBy similarity
Modified residuei319 – 3191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BW85.
MaxQBiQ9BW85.
PaxDbiQ9BW85.
PeptideAtlasiQ9BW85.
PRIDEiQ9BW85.

PTM databases

iPTMnetiQ9BW85.
PhosphoSiteiQ9BW85.

Expressioni

Gene expression databases

BgeeiENSG00000105248.
CleanExiHS_CCDC94.
ExpressionAtlasiQ9BW85. baseline and differential.
GenevisibleiQ9BW85. HS.

Organism-specific databases

HPAiHPA043606.
HPA055675.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-10300345,EBI-739624
GOLGA2Q083793EBI-10300345,EBI-618309
JADE1Q6IE813EBI-10300345,EBI-954672
MAD1L1Q9Y6D93EBI-10300345,EBI-742610
TFCP2Q128003EBI-10300345,EBI-717422
TRIM27P143733EBI-10300345,EBI-719493

Protein-protein interaction databases

BioGridi120827. 40 interactions.
IntActiQ9BW85. 17 interactions.
STRINGi9606.ENSP00000262962.

Structurei

3D structure databases

ProteinModelPortaliQ9BW85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili105 – 206102Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CWC16 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2989. Eukaryota.
COG5134. LUCA.
GeneTreeiENSGT00530000063615.
HOGENOMiHOG000160812.
HOVERGENiHBG053135.
InParanoidiQ9BW85.
OMAiKRKVESW.
OrthoDBiEOG091G0JDG.
PhylomeDBiQ9BW85.
TreeFamiTF315070.

Family and domain databases

InterProiIPR007590. CWC16.
[Graphical view]
PANTHERiPTHR12111. PTHR12111. 1 hit.
PfamiPF04502. DUF572. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BW85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERKVLNKY YPPDFDPSKI PKLKLPKDRQ YVVRLMAPFN MRCKTCGEYI
60 70 80 90 100
YKGKKFNARK ETVQNEVYLG LPIFRFYIKC TRCLAEITFK TDPENTDYTM
110 120 130 140 150
EHGATRNFQA EKLLEEEEKR VQKEREDEEL NNPMKVLENR TKDSKLEMEV
160 170 180 190 200
LENLQELKDL NQRQAHVDFE AMLRQHRLSE EERRRQQQEE DEQETAALLE
210 220 230 240 250
EARKRRLLED SDSEDEAAPS PLQPALRPNP TAILDEAPKP KRKVEVWEQS
260 270 280 290 300
VGSLGSRPPL SRLVVVKKAK ADPDCSNGQP QAAPTPGAPQ NRKEANPTPL
310 320
TPGASSLSQL GAYLDSDDSN GSN
Length:323
Mass (Da):37,086
Last modified:June 1, 2001 - v1
Checksum:i8E1BB92C4A008BB5
GO

Sequence cautioni

The sequence AAC72949 differs from that shown. Reason: Frameshift at position 285. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051T → A in BAA91572 (PubMed:14702039).Curated
Sequence conflicti247 – 2471W → R in BAB14757 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001236 mRNA. Translation: BAA91572.1.
AK023988 mRNA. Translation: BAB14757.1.
AF091080 mRNA. Translation: AAC72949.1. Frameshift.
BC000561 mRNA. Translation: AAH00561.1.
BC019096 mRNA. Translation: AAH19096.1.
CCDSiCCDS12124.1.
RefSeqiNP_060544.2. NM_018074.4.
UniGeneiHs.21811.

Genome annotation databases

EnsembliENST00000262962; ENSP00000262962; ENSG00000105248.
GeneIDi55702.
KEGGihsa:55702.
UCSCiuc002lzv.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001236 mRNA. Translation: BAA91572.1.
AK023988 mRNA. Translation: BAB14757.1.
AF091080 mRNA. Translation: AAC72949.1. Frameshift.
BC000561 mRNA. Translation: AAH00561.1.
BC019096 mRNA. Translation: AAH19096.1.
CCDSiCCDS12124.1.
RefSeqiNP_060544.2. NM_018074.4.
UniGeneiHs.21811.

3D structure databases

ProteinModelPortaliQ9BW85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120827. 40 interactions.
IntActiQ9BW85. 17 interactions.
STRINGi9606.ENSP00000262962.

PTM databases

iPTMnetiQ9BW85.
PhosphoSiteiQ9BW85.

Polymorphism and mutation databases

BioMutaiCCDC94.
DMDMi74733407.

Proteomic databases

EPDiQ9BW85.
MaxQBiQ9BW85.
PaxDbiQ9BW85.
PeptideAtlasiQ9BW85.
PRIDEiQ9BW85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262962; ENSP00000262962; ENSG00000105248.
GeneIDi55702.
KEGGihsa:55702.
UCSCiuc002lzv.5. human.

Organism-specific databases

CTDi55702.
GeneCardsiCCDC94.
HGNCiHGNC:25518. CCDC94.
HPAiHPA043606.
HPA055675.
neXtProtiNX_Q9BW85.
PharmGKBiPA144596461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2989. Eukaryota.
COG5134. LUCA.
GeneTreeiENSGT00530000063615.
HOGENOMiHOG000160812.
HOVERGENiHBG053135.
InParanoidiQ9BW85.
OMAiKRKVESW.
OrthoDBiEOG091G0JDG.
PhylomeDBiQ9BW85.
TreeFamiTF315070.

Miscellaneous databases

GenomeRNAii55702.
PROiQ9BW85.

Gene expression databases

BgeeiENSG00000105248.
CleanExiHS_CCDC94.
ExpressionAtlasiQ9BW85. baseline and differential.
GenevisibleiQ9BW85. HS.

Family and domain databases

InterProiIPR007590. CWC16.
[Graphical view]
PANTHERiPTHR12111. PTHR12111. 1 hit.
PfamiPF04502. DUF572. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCD94_HUMAN
AccessioniPrimary (citable) accession number: Q9BW85
Secondary accession number(s): O75270, Q9H862, Q9NW16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.