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Q9BW83

- IFT27_HUMAN

UniProt

Q9BW83 - IFT27_HUMAN

Protein

Intraflagellar transport protein 27 homolog

Gene

IFT27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Small GTPase-like component of the intraflagellar transport (IFT) complex B. Forms a subcomplex within the IFT complex B with IFT25 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPBy similarity
    Nucleotide bindingi64 – 685GTPBy similarity
    Nucleotide bindingi123 – 1264GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intraflagellar transport protein 27 homolog
    Alternative name(s):
    Putative GTP-binding protein RAY-like
    Rab-like protein 4
    Gene namesi
    Name:IFT27
    Synonyms:RABL4, RAYL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:18626. IFT27.

    Subcellular locationi

    GO - Cellular componenti

    1. intraciliary transport particle B Source: BHF-UCL
    2. motile cilium Source: BHF-UCL

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38609.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186Intraflagellar transport protein 27 homologPRO_0000082715Add
    BLAST

    Proteomic databases

    MaxQBiQ9BW83.
    PaxDbiQ9BW83.
    PRIDEiQ9BW83.

    PTM databases

    PhosphoSiteiQ9BW83.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BW83.
    BgeeiQ9BW83.
    CleanExiHS_RABL4.
    GenevestigatoriQ9BW83.

    Organism-specific databases

    HPAiHPA018418.

    Interactioni

    Subunit structurei

    Component of the IFT complex B, at least composed of IFT20, IFT25/HSPB11, IFT27, IFT52, IFT57, IFT74, IFT81, IFT88 and TRAF3IP1. Interacts with IFT25; the interaction is direct. Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi116210. 3 interactions.
    IntActiQ9BW83. 1 interaction.
    MINTiMINT-1456924.
    STRINGi9606.ENSP00000343593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BW83.
    SMRiQ9BW83. Positions 7-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOVERGENiHBG105393.
    KOiK07934.
    OMAiNGHQICI.
    OrthoDBiEOG75J0PC.
    PhylomeDBiQ9BW83.
    TreeFamiTF329292.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BW83-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVKLAAKCIL AGDPAVGKTA LAQIFRSDGA HFQKSYTLTT GMDLVVKTVP    50
    VPDTGDSVEL FIFDSAGKEL FSEMLDKLWE SPNVLCLVYD VTNEESFNNC 100
    SKWLEKARSQ APGISLPGVL VGNKTDLAGR RAVDSAEARA WALGQGLECF 150
    ETSVKEMENF EAPFHCLAKQ FHQLYREKVE VFRALA 186
    Length:186
    Mass (Da):20,480
    Last modified:June 1, 2001 - v1
    Checksum:i78CACF9ADF929B02
    GO
    Isoform 2 (identifier: Q9BW83-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-12: Missing.

    Show »
    Length:185
    Mass (Da):20,423
    Checksum:i74F6D5790343B58F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei12 – 121Missing in isoform 2. 1 PublicationVSP_021019

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022729 mRNA. Translation: CAA18787.1.
    CR456558 mRNA. Translation: CAG30444.1.
    BT006815 mRNA. Translation: AAP35461.1.
    Z80897 Genomic DNA. Translation: CAB62968.1.
    BC000566 mRNA. Translation: AAH00566.1.
    CCDSiCCDS13932.1. [Q9BW83-2]
    CCDS54523.1. [Q9BW83-1]
    RefSeqiNP_001171172.1. NM_001177701.2. [Q9BW83-1]
    NP_006851.1. NM_006860.4. [Q9BW83-2]
    XP_006724169.1. XM_006724106.1. [Q9BW83-1]
    UniGeneiHs.415172.

    Genome annotation databases

    EnsembliENST00000340630; ENSP00000343593; ENSG00000100360. [Q9BW83-2]
    ENST00000433985; ENSP00000393541; ENSG00000100360. [Q9BW83-1]
    GeneIDi11020.
    KEGGihsa:11020.
    UCSCiuc003apu.3. human. [Q9BW83-2]
    uc003apv.3. human. [Q9BW83-1]

    Polymorphism databases

    DMDMi20178058.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022729 mRNA. Translation: CAA18787.1 .
    CR456558 mRNA. Translation: CAG30444.1 .
    BT006815 mRNA. Translation: AAP35461.1 .
    Z80897 Genomic DNA. Translation: CAB62968.1 .
    BC000566 mRNA. Translation: AAH00566.1 .
    CCDSi CCDS13932.1. [Q9BW83-2 ]
    CCDS54523.1. [Q9BW83-1 ]
    RefSeqi NP_001171172.1. NM_001177701.2. [Q9BW83-1 ]
    NP_006851.1. NM_006860.4. [Q9BW83-2 ]
    XP_006724169.1. XM_006724106.1. [Q9BW83-1 ]
    UniGenei Hs.415172.

    3D structure databases

    ProteinModelPortali Q9BW83.
    SMRi Q9BW83. Positions 7-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116210. 3 interactions.
    IntActi Q9BW83. 1 interaction.
    MINTi MINT-1456924.
    STRINGi 9606.ENSP00000343593.

    PTM databases

    PhosphoSitei Q9BW83.

    Polymorphism databases

    DMDMi 20178058.

    Proteomic databases

    MaxQBi Q9BW83.
    PaxDbi Q9BW83.
    PRIDEi Q9BW83.

    Protocols and materials databases

    DNASUi 11020.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340630 ; ENSP00000343593 ; ENSG00000100360 . [Q9BW83-2 ]
    ENST00000433985 ; ENSP00000393541 ; ENSG00000100360 . [Q9BW83-1 ]
    GeneIDi 11020.
    KEGGi hsa:11020.
    UCSCi uc003apu.3. human. [Q9BW83-2 ]
    uc003apv.3. human. [Q9BW83-1 ]

    Organism-specific databases

    CTDi 11020.
    GeneCardsi GC22M037154.
    HGNCi HGNC:18626. IFT27.
    HPAi HPA018418.
    neXtProti NX_Q9BW83.
    PharmGKBi PA38609.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOVERGENi HBG105393.
    KOi K07934.
    OMAi NGHQICI.
    OrthoDBi EOG75J0PC.
    PhylomeDBi Q9BW83.
    TreeFami TF329292.

    Miscellaneous databases

    ChiTaRSi IFT27. human.
    GenomeRNAii 11020.
    NextBioi 41870.
    PROi Q9BW83.

    Gene expression databases

    ArrayExpressi Q9BW83.
    Bgeei Q9BW83.
    CleanExi HS_RABL4.
    Genevestigatori Q9BW83.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
      Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
      Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIFT27_HUMAN
    AccessioniPrimary (citable) accession number: Q9BW83
    Secondary accession number(s): O60897
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3