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Protein

HIRA-interacting protein 3

Gene

HIRIP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.1 Publication

GO - Biological processi

  • chromatin assembly or disassembly Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149929-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HIRA-interacting protein 3
Gene namesi
Name:HIRIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:4917. HIRIP3.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.

GO - Cellular componenti

  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8479.
OpenTargetsiENSG00000149929.
PharmGKBiPA29294.

Polymorphism and mutation databases

BioMutaiHIRIP3.
DMDMi116242511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839891 – 556HIRA-interacting protein 3Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei84PhosphothreonineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei358PhosphothreonineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei471PhosphothreonineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BW71.
MaxQBiQ9BW71.
PaxDbiQ9BW71.
PeptideAtlasiQ9BW71.
PRIDEiQ9BW71.

PTM databases

iPTMnetiQ9BW71.
PhosphoSitePlusiQ9BW71.

Expressioni

Tissue specificityi

Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart.1 Publication

Gene expression databases

BgeeiENSG00000149929.
CleanExiHS_HIRIP3.
GenevisibleiQ9BW71. HS.

Organism-specific databases

HPAiHPA051897.
HPA063205.

Interactioni

Subunit structurei

Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2.2 Publications

Protein-protein interaction databases

BioGridi114053. 33 interactors.
IntActiQ9BW71. 9 interactors.
MINTiMINT-1411245.
STRINGi9606.ENSP00000279392.

Structurei

3D structure databases

ProteinModelPortaliQ9BW71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 253Glu-richAdd BLAST125
Compositional biasi398 – 403Poly-Ser6

Phylogenomic databases

eggNOGiENOG410IZNK. Eukaryota.
ENOG4111SS6. LUCA.
GeneTreeiENSGT00390000014062.
HOGENOMiHOG000112903.
HOVERGENiHBG066199.
InParanoidiQ9BW71.
OMAiEENPRRA.
OrthoDBiEOG091G0CB9.
PhylomeDBiQ9BW71.
TreeFamiTF331753.

Family and domain databases

InterProiIPR019098. Histone_chaperone_domain_CHZ.
[Graphical view]
PfamiPF09649. CHZ. 1 hit.
[Graphical view]
SMARTiSM01082. CHZ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BW71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAREKEMQEF TRSFFRGRPD LSTLTHSIVR RRYLAHSGRS HLEPEEKQAL
60 70 80 90 100
KRLVEEELLK MQVDEAASRE DKLDLTKKGK RPPTPCSDPE RKRFRFNSES
110 120 130 140 150
ESGSEASSPD YFGPPAKNGV AAEVSPAKEE NPRRASKAVE ESSDEERQRD
160 170 180 190 200
LPAQRGEESS EEEEKGYKGK TRKKPVVKKQ APGKASVSRK QAREESEESE
210 220 230 240 250
AEPVQRTAKK VEGNKGTKSL KESEQESEEE ILAQKKEQRE EEVEEEEKEE
260 270 280 290 300
DEEKGDWKPR TRSNGRRKSA REERSCKQKS QAKRLLGDSD SEEEQKEAAS
310 320 330 340 350
SGDDSGRDRE PPVQRKSEDR TQLKGGKRLS GSSEDEEDSG KGEPTAKGSR
360 370 380 390 400
KMARLGSTSG EESDLEREVS DSEAGGGPQG ERKNRSSKKS SRKGRTRSSS
410 420 430 440 450
SSSDGSPEAK GGKAGSGRRG EDHPAVMRLK RYIRACGAHR NYKKLLGSCC
460 470 480 490 500
SHKERLSILR AELEALGMKG TPSLGKCRAL KEQREEAAEV ASLDVANIIS
510 520 530 540 550
GSGRPRRRTA WNPLGEAAPP GELYRRTLDS DEERPRPAPP DWSHMRGIIS

SDGESN
Length:556
Mass (Da):61,957
Last modified:October 17, 2006 - v3
Checksum:iACABE2E0032B8C13
GO
Isoform 2 (identifier: Q9BW71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-413: Missing.

Show »
Length:243
Mass (Da):27,612
Checksum:i6DE219CC60F3BAB8
GO
Isoform 3 (identifier: Q9BW71-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-175: ESGSEASSPD...GYKGKTRKKP → GWLRSPWRGP...GPEGAEGGGS
     176-556: Missing.

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):19,709
Checksum:i8E6D1E89AC91F6BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58L → P in CAA11273 (PubMed:9710638).Curated1
Sequence conflicti58L → P in CAA11274 (PubMed:9710638).Curated1
Sequence conflicti58L → P in CAA11275 (PubMed:9710638).Curated1
Sequence conflicti58L → P (PubMed:17391060).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051033496A → V.Corresponds to variant rs35431046dbSNPEnsembl.1
Natural variantiVAR_028115521G → W.Corresponds to variant rs11643314dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003877101 – 413Missing in isoform 2. 1 PublicationAdd BLAST313
Alternative sequenceiVSP_046024101 – 175ESGSE…TRKKP → GWLRSPWRGPPGCDEAEALH SGLWCPSKLQEAVGLLLLTQ GAPEYPPGRTGSARHEGYPF PREVSGPEGAEGGGS in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_046025176 – 556Missing in isoform 3. 1 PublicationAdd BLAST381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223349 mRNA. Translation: CAA11273.1.
AJ223350 mRNA. Translation: CAA11274.1.
AJ223351 mRNA. Translation: CAA11275.2.
BX393533 mRNA. No translation available.
AC093512 Genomic DNA. No translation available.
BC000588 mRNA. Translation: AAH00588.1.
CCDSiCCDS10664.1. [Q9BW71-1]
CCDS58449.1. [Q9BW71-3]
RefSeqiNP_001184252.1. NM_001197323.1. [Q9BW71-3]
NP_003600.2. NM_003609.4. [Q9BW71-1]
UniGeneiHs.567370.

Genome annotation databases

EnsembliENST00000279392; ENSP00000279392; ENSG00000149929. [Q9BW71-1]
ENST00000564026; ENSP00000456824; ENSG00000149929. [Q9BW71-3]
GeneIDi8479.
KEGGihsa:8479.
UCSCiuc002dve.4. human. [Q9BW71-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223349 mRNA. Translation: CAA11273.1.
AJ223350 mRNA. Translation: CAA11274.1.
AJ223351 mRNA. Translation: CAA11275.2.
BX393533 mRNA. No translation available.
AC093512 Genomic DNA. No translation available.
BC000588 mRNA. Translation: AAH00588.1.
CCDSiCCDS10664.1. [Q9BW71-1]
CCDS58449.1. [Q9BW71-3]
RefSeqiNP_001184252.1. NM_001197323.1. [Q9BW71-3]
NP_003600.2. NM_003609.4. [Q9BW71-1]
UniGeneiHs.567370.

3D structure databases

ProteinModelPortaliQ9BW71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114053. 33 interactors.
IntActiQ9BW71. 9 interactors.
MINTiMINT-1411245.
STRINGi9606.ENSP00000279392.

PTM databases

iPTMnetiQ9BW71.
PhosphoSitePlusiQ9BW71.

Polymorphism and mutation databases

BioMutaiHIRIP3.
DMDMi116242511.

Proteomic databases

EPDiQ9BW71.
MaxQBiQ9BW71.
PaxDbiQ9BW71.
PeptideAtlasiQ9BW71.
PRIDEiQ9BW71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279392; ENSP00000279392; ENSG00000149929. [Q9BW71-1]
ENST00000564026; ENSP00000456824; ENSG00000149929. [Q9BW71-3]
GeneIDi8479.
KEGGihsa:8479.
UCSCiuc002dve.4. human. [Q9BW71-1]

Organism-specific databases

CTDi8479.
DisGeNETi8479.
GeneCardsiHIRIP3.
HGNCiHGNC:4917. HIRIP3.
HPAiHPA051897.
HPA063205.
MIMi603365. gene.
neXtProtiNX_Q9BW71.
OpenTargetsiENSG00000149929.
PharmGKBiPA29294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZNK. Eukaryota.
ENOG4111SS6. LUCA.
GeneTreeiENSGT00390000014062.
HOGENOMiHOG000112903.
HOVERGENiHBG066199.
InParanoidiQ9BW71.
OMAiEENPRRA.
OrthoDBiEOG091G0CB9.
PhylomeDBiQ9BW71.
TreeFamiTF331753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149929-MONOMER.

Miscellaneous databases

GeneWikiiHIRIP3.
GenomeRNAii8479.
PROiQ9BW71.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149929.
CleanExiHS_HIRIP3.
GenevisibleiQ9BW71. HS.

Family and domain databases

InterProiIPR019098. Histone_chaperone_domain_CHZ.
[Graphical view]
PfamiPF09649. CHZ. 1 hit.
[Graphical view]
SMARTiSM01082. CHZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIRP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BW71
Secondary accession number(s): H3BSR3, O75707, O75708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.