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Q9BW66

- CINP_HUMAN

UniProt

Q9BW66 - CINP_HUMAN

Protein

Cyclin-dependent kinase 2-interacting protein

Gene

CINP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA repair Source: UniProtKB-KW
    4. DNA replication Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA repair, DNA replication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 2-interacting protein
    Short name:
    CDK2-interacting protein
    Gene namesi
    Name:CINP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:23789. CINP.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165478684.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Cyclin-dependent kinase 2-interacting proteinPRO_0000326055Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Post-translational modificationi

    Phosphorylated by CDC7 but not by CDK2.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BW66.
    PaxDbiQ9BW66.
    PRIDEiQ9BW66.

    PTM databases

    PhosphoSiteiQ9BW66.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BW66.
    BgeeiQ9BW66.
    GenevestigatoriQ9BW66.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.3 Publications

    Protein-protein interaction databases

    BioGridi119604. 5 interactions.
    DIPiDIP-49011N.
    IntActiQ9BW66. 3 interactions.
    STRINGi9606.ENSP00000216756.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BW66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili73 – 10735Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CINP family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG43463.
    HOGENOMiHOG000035137.
    HOVERGENiHBG061504.
    InParanoidiQ9BW66.
    OMAiLHLESML.
    PhylomeDBiQ9BW66.
    TreeFamiTF329462.

    Family and domain databases

    InterProiIPR023250. Cyclin-dep_Kinase_2_interact.
    [Graphical view]
    PRINTSiPR02040. CDK2IP.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BW66-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN    50
    IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD 100
    GLTKIQVKME KLSSTTKGIC ELENYHYGEE SKRPPLFHTW PTTHFYEVSH 150
    KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL SYLSMWLHQP YVESDSRLHL 200
    ESMLLETGHR AL 212
    Length:212
    Mass (Da):24,324
    Last modified:June 1, 2001 - v1
    Checksum:i3678E123B8C206B1
    GO
    Isoform 2 (identifier: Q9BW66-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         103-118: TKIQVKMEKLSSTTKG → MRFRISSWRCTGRSCS
         119-212: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:118
    Mass (Da):13,287
    Checksum:iEBAB2978717852CE
    GO
    Isoform 3 (identifier: Q9BW66-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MEA → MNGTIYANECQQIRHPNS

    Note: No experimental confirmation available.

    Show »
    Length:227
    Mass (Da):26,051
    Checksum:i9245BA7C5767DA0B
    GO

    Sequence cautioni

    The sequence BU174070 differs from that shown. Reason: Frameshift at positions 183 and 197.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti157 – 1571R → K in AAF44747. (PubMed:16082200)Curated
    Sequence conflicti157 – 1571R → K in AAF44748. (PubMed:16082200)Curated
    Sequence conflicti175 – 1751D → N in AAF44747. (PubMed:16082200)Curated
    Sequence conflicti175 – 1751D → N in AAF44748. (PubMed:16082200)Curated
    Sequence conflicti194 – 1974SDSR → NDNK in AAF44747. (PubMed:16082200)Curated
    Sequence conflicti194 – 1974SDSR → NDNK in AAF44748. (PubMed:16082200)Curated
    Sequence conflicti196 – 1961S → R in BU174070. (PubMed:15489334)Curated
    Sequence conflicti202 – 2021S → N in AAF44747. (PubMed:16082200)Curated
    Sequence conflicti202 – 2021S → N in AAF44748. (PubMed:16082200)Curated
    Sequence conflicti210 – 2123RAL → PSSLTS in BU174070. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti164 – 1641R → H.
    Corresponds to variant rs7011 [ dbSNP | Ensembl ].
    VAR_039979
    Natural varianti177 – 1771D → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_039980

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 33MEA → MNGTIYANECQQIRHPNS in isoform 3. 1 PublicationVSP_046386
    Alternative sequencei103 – 11816TKIQV…STTKG → MRFRISSWRCTGRSCS in isoform 2. 1 PublicationVSP_045342Add
    BLAST
    Alternative sequencei119 – 21294Missing in isoform 2. 1 PublicationVSP_045343Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228148 mRNA. Translation: AAF44747.1.
    AF228149 mRNA. Translation: AAF44748.1.
    AK056112 mRNA. Translation: BAB71095.1.
    DA167716 mRNA. No translation available.
    CR457178 mRNA. Translation: CAG33459.1.
    AL137229 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81785.1.
    BC000600 mRNA. Translation: AAH00600.1.
    BU174070 mRNA. No translation available.
    CCDSiCCDS9972.1. [Q9BW66-1]
    RefSeqiNP_116019.1. NM_032630.2. [Q9BW66-1]
    XP_005267810.1. XM_005267753.1. [Q9BW66-2]
    UniGeneiHs.129634.

    Genome annotation databases

    EnsembliENST00000216756; ENSP00000216756; ENSG00000100865. [Q9BW66-1]
    ENST00000536961; ENSP00000442057; ENSG00000100865. [Q9BW66-3]
    ENST00000541568; ENSP00000442377; ENSG00000100865. [Q9BW66-2]
    ENST00000559514; ENSP00000453839; ENSG00000100865. [Q9BW66-1]
    GeneIDi51550.
    KEGGihsa:51550.
    UCSCiuc001ylv.1. human. [Q9BW66-1]

    Polymorphism databases

    DMDMi74733401.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228148 mRNA. Translation: AAF44747.1 .
    AF228149 mRNA. Translation: AAF44748.1 .
    AK056112 mRNA. Translation: BAB71095.1 .
    DA167716 mRNA. No translation available.
    CR457178 mRNA. Translation: CAG33459.1 .
    AL137229 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81785.1 .
    BC000600 mRNA. Translation: AAH00600.1 .
    BU174070 mRNA. No translation available.
    CCDSi CCDS9972.1. [Q9BW66-1 ]
    RefSeqi NP_116019.1. NM_032630.2. [Q9BW66-1 ]
    XP_005267810.1. XM_005267753.1. [Q9BW66-2 ]
    UniGenei Hs.129634.

    3D structure databases

    ProteinModelPortali Q9BW66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119604. 5 interactions.
    DIPi DIP-49011N.
    IntActi Q9BW66. 3 interactions.
    STRINGi 9606.ENSP00000216756.

    PTM databases

    PhosphoSitei Q9BW66.

    Polymorphism databases

    DMDMi 74733401.

    Proteomic databases

    MaxQBi Q9BW66.
    PaxDbi Q9BW66.
    PRIDEi Q9BW66.

    Protocols and materials databases

    DNASUi 51550.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216756 ; ENSP00000216756 ; ENSG00000100865 . [Q9BW66-1 ]
    ENST00000536961 ; ENSP00000442057 ; ENSG00000100865 . [Q9BW66-3 ]
    ENST00000541568 ; ENSP00000442377 ; ENSG00000100865 . [Q9BW66-2 ]
    ENST00000559514 ; ENSP00000453839 ; ENSG00000100865 . [Q9BW66-1 ]
    GeneIDi 51550.
    KEGGi hsa:51550.
    UCSCi uc001ylv.1. human. [Q9BW66-1 ]

    Organism-specific databases

    CTDi 51550.
    GeneCardsi GC14M102814.
    HGNCi HGNC:23789. CINP.
    MIMi 613362. gene.
    neXtProti NX_Q9BW66.
    PharmGKBi PA165478684.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43463.
    HOGENOMi HOG000035137.
    HOVERGENi HBG061504.
    InParanoidi Q9BW66.
    OMAi LHLESML.
    PhylomeDBi Q9BW66.
    TreeFami TF329462.

    Miscellaneous databases

    GenomeRNAii 51550.
    NextBioi 55331.
    PROi Q9BW66.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BW66.
    Bgeei Q9BW66.
    Genevestigatori Q9BW66.

    Family and domain databases

    InterProi IPR023250. Cyclin-dep_Kinase_2_interact.
    [Graphical view ]
    PRINTSi PR02040. CDK2IP.
    ProtoNeti Search...

    Publicationsi

    1. "A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes."
      Grishina I., Lattes B.
      Cell Cycle 4:1120-1126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, FUNCTION, INTERACTION WITH CDK2; CDC7; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7 AND ORC2, PHOSPHORYLATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Pancreatic carcinoma and Skin.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: FUNCTION, INTERACTION WITH ATRIP, SUBCELLULAR LOCATION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: INTERACTION WITH CEP152.
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-177.

    Entry informationi

    Entry nameiCINP_HUMAN
    AccessioniPrimary (citable) accession number: Q9BW66
    Secondary accession number(s): F5H7P3, F5H8A7, Q9NPF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3