Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase 2-interacting protein

Gene

CINP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-interacting protein
Short name:
CDK2-interacting protein
Gene namesi
Name:CINP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23789. CINP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51550.
OpenTargetsiENSG00000100865.
PharmGKBiPA165478684.

Polymorphism and mutation databases

BioMutaiCINP.
DMDMi74733401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260551 – 212Cyclin-dependent kinase 2-interacting proteinAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDC7 but not by CDK2.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BW66.
MaxQBiQ9BW66.
PaxDbiQ9BW66.
PeptideAtlasiQ9BW66.
PRIDEiQ9BW66.

PTM databases

iPTMnetiQ9BW66.
PhosphoSitePlusiQ9BW66.

Expressioni

Gene expression databases

BgeeiENSG00000100865.
ExpressionAtlasiQ9BW66. baseline and differential.
GenevisibleiQ9BW66. HS.

Interactioni

Subunit structurei

Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATRIPQ8WXE13EBI-739784,EBI-747353
BLZF1Q9H2G95EBI-739784,EBI-2548012
C1orf109Q9NX049EBI-739784,EBI-8643161
FBF1Q8TES7-63EBI-739784,EBI-10244131
GOLGA2Q083793EBI-739784,EBI-618309
RELQ048643EBI-739784,EBI-307352
SYCE1Q8N0S23EBI-739784,EBI-6872807

Protein-protein interaction databases

BioGridi119604. 19 interactors.
DIPiDIP-49011N.
IntActiQ9BW66. 21 interactors.
STRINGi9606.ENSP00000442057.

Structurei

3D structure databases

ProteinModelPortaliQ9BW66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili73 – 107Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the CINP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWVU. Eukaryota.
ENOG4111M0E. LUCA.
GeneTreeiENSGT00390000015784.
HOGENOMiHOG000035137.
HOVERGENiHBG061504.
InParanoidiQ9BW66.
OMAiNYHYGEE.
OrthoDBiEOG091G0RIF.
PhylomeDBiQ9BW66.
TreeFamiTF329462.

Family and domain databases

InterProiIPR023250. Cyclin-dep_Kinase_2_interact.
[Graphical view]
PRINTSiPR02040. CDK2IP.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BW66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN
60 70 80 90 100
IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD
110 120 130 140 150
GLTKIQVKME KLSSTTKGIC ELENYHYGEE SKRPPLFHTW PTTHFYEVSH
160 170 180 190 200
KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL SYLSMWLHQP YVESDSRLHL
210
ESMLLETGHR AL
Length:212
Mass (Da):24,324
Last modified:June 1, 2001 - v1
Checksum:i3678E123B8C206B1
GO
Isoform 2 (identifier: Q9BW66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-118: TKIQVKMEKLSSTTKG → MRFRISSWRCTGRSCS
     119-212: Missing.

Note: No experimental confirmation available.
Show »
Length:118
Mass (Da):13,287
Checksum:iEBAB2978717852CE
GO
Isoform 3 (identifier: Q9BW66-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MEA → MNGTIYANECQQIRHPNS

Note: No experimental confirmation available.
Show »
Length:227
Mass (Da):26,051
Checksum:i9245BA7C5767DA0B
GO

Sequence cautioni

The sequence BU174070 differs from that shown. Reason: Frameshift at positions 183 and 197.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157R → K in AAF44747 (PubMed:16082200).Curated1
Sequence conflicti157R → K in AAF44748 (PubMed:16082200).Curated1
Sequence conflicti175D → N in AAF44747 (PubMed:16082200).Curated1
Sequence conflicti175D → N in AAF44748 (PubMed:16082200).Curated1
Sequence conflicti194 – 197SDSR → NDNK in AAF44747 (PubMed:16082200).Curated4
Sequence conflicti194 – 197SDSR → NDNK in AAF44748 (PubMed:16082200).Curated4
Sequence conflicti196S → R in BU174070 (PubMed:15489334).Curated1
Sequence conflicti202S → N in AAF44747 (PubMed:16082200).Curated1
Sequence conflicti202S → N in AAF44748 (PubMed:16082200).Curated1
Sequence conflicti210 – 212RAL → PSSLTS in BU174070 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039979164R → H.Corresponds to variant rs7011dbSNPEnsembl.1
Natural variantiVAR_039980177D → N in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0463861 – 3MEA → MNGTIYANECQQIRHPNS in isoform 3. 1 Publication3
Alternative sequenceiVSP_045342103 – 118TKIQV…STTKG → MRFRISSWRCTGRSCS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_045343119 – 212Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228148 mRNA. Translation: AAF44747.1.
AF228149 mRNA. Translation: AAF44748.1.
AK056112 mRNA. Translation: BAB71095.1.
DA167716 mRNA. No translation available.
CR457178 mRNA. Translation: CAG33459.1.
AL137229 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81785.1.
BC000600 mRNA. Translation: AAH00600.1.
BU174070 mRNA. No translation available.
CCDSiCCDS9972.1. [Q9BW66-1]
RefSeqiNP_001306975.1. NM_001320046.1. [Q9BW66-2]
NP_116019.1. NM_032630.2. [Q9BW66-1]
UniGeneiHs.129634.

Genome annotation databases

EnsembliENST00000216756; ENSP00000216756; ENSG00000100865. [Q9BW66-1]
ENST00000536961; ENSP00000442057; ENSG00000100865. [Q9BW66-3]
ENST00000541568; ENSP00000442377; ENSG00000100865. [Q9BW66-2]
ENST00000559514; ENSP00000453839; ENSG00000100865. [Q9BW66-1]
GeneIDi51550.
KEGGihsa:51550.
UCSCiuc001ylv.2. human. [Q9BW66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228148 mRNA. Translation: AAF44747.1.
AF228149 mRNA. Translation: AAF44748.1.
AK056112 mRNA. Translation: BAB71095.1.
DA167716 mRNA. No translation available.
CR457178 mRNA. Translation: CAG33459.1.
AL137229 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81785.1.
BC000600 mRNA. Translation: AAH00600.1.
BU174070 mRNA. No translation available.
CCDSiCCDS9972.1. [Q9BW66-1]
RefSeqiNP_001306975.1. NM_001320046.1. [Q9BW66-2]
NP_116019.1. NM_032630.2. [Q9BW66-1]
UniGeneiHs.129634.

3D structure databases

ProteinModelPortaliQ9BW66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119604. 19 interactors.
DIPiDIP-49011N.
IntActiQ9BW66. 21 interactors.
STRINGi9606.ENSP00000442057.

PTM databases

iPTMnetiQ9BW66.
PhosphoSitePlusiQ9BW66.

Polymorphism and mutation databases

BioMutaiCINP.
DMDMi74733401.

Proteomic databases

EPDiQ9BW66.
MaxQBiQ9BW66.
PaxDbiQ9BW66.
PeptideAtlasiQ9BW66.
PRIDEiQ9BW66.

Protocols and materials databases

DNASUi51550.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216756; ENSP00000216756; ENSG00000100865. [Q9BW66-1]
ENST00000536961; ENSP00000442057; ENSG00000100865. [Q9BW66-3]
ENST00000541568; ENSP00000442377; ENSG00000100865. [Q9BW66-2]
ENST00000559514; ENSP00000453839; ENSG00000100865. [Q9BW66-1]
GeneIDi51550.
KEGGihsa:51550.
UCSCiuc001ylv.2. human. [Q9BW66-1]

Organism-specific databases

CTDi51550.
DisGeNETi51550.
GeneCardsiCINP.
HGNCiHGNC:23789. CINP.
MIMi613362. gene.
neXtProtiNX_Q9BW66.
OpenTargetsiENSG00000100865.
PharmGKBiPA165478684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWVU. Eukaryota.
ENOG4111M0E. LUCA.
GeneTreeiENSGT00390000015784.
HOGENOMiHOG000035137.
HOVERGENiHBG061504.
InParanoidiQ9BW66.
OMAiNYHYGEE.
OrthoDBiEOG091G0RIF.
PhylomeDBiQ9BW66.
TreeFamiTF329462.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100865-MONOMER.

Miscellaneous databases

GenomeRNAii51550.
PROiQ9BW66.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100865.
ExpressionAtlasiQ9BW66. baseline and differential.
GenevisibleiQ9BW66. HS.

Family and domain databases

InterProiIPR023250. Cyclin-dep_Kinase_2_interact.
[Graphical view]
PRINTSiPR02040. CDK2IP.
ProtoNetiSearch...

Entry informationi

Entry nameiCINP_HUMAN
AccessioniPrimary (citable) accession number: Q9BW66
Secondary accession number(s): F5H7P3, F5H8A7, Q9NPF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.