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Q9BW66

- CINP_HUMAN

UniProt

Q9BW66 - CINP_HUMAN

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Protein

Cyclin-dependent kinase 2-interacting protein

Gene
CINP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA repair Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-interacting protein
Short name:
CDK2-interacting protein
Gene namesi
Name:CINP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:23789. CINP.

Subcellular locationi

Nucleus
Note: Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165478684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Cyclin-dependent kinase 2-interacting proteinPRO_0000326055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Post-translational modificationi

Phosphorylated by CDC7 but not by CDK2.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BW66.
PaxDbiQ9BW66.
PRIDEiQ9BW66.

PTM databases

PhosphoSiteiQ9BW66.

Expressioni

Gene expression databases

ArrayExpressiQ9BW66.
BgeeiQ9BW66.
GenevestigatoriQ9BW66.

Interactioni

Subunit structurei

Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.3 Publications

Protein-protein interaction databases

BioGridi119604. 5 interactions.
DIPiDIP-49011N.
IntActiQ9BW66. 3 interactions.
STRINGi9606.ENSP00000216756.

Structurei

3D structure databases

ProteinModelPortaliQ9BW66.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili73 – 10735 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the CINP family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG43463.
HOGENOMiHOG000035137.
HOVERGENiHBG061504.
InParanoidiQ9BW66.
OMAiLHLESML.
PhylomeDBiQ9BW66.
TreeFamiTF329462.

Family and domain databases

InterProiIPR023250. Cyclin-dep_Kinase_2_interact.
[Graphical view]
PRINTSiPR02040. CDK2IP.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BW66-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN    50
IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD 100
GLTKIQVKME KLSSTTKGIC ELENYHYGEE SKRPPLFHTW PTTHFYEVSH 150
KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL SYLSMWLHQP YVESDSRLHL 200
ESMLLETGHR AL 212
Length:212
Mass (Da):24,324
Last modified:June 1, 2001 - v1
Checksum:i3678E123B8C206B1
GO
Isoform 2 (identifier: Q9BW66-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-118: TKIQVKMEKLSSTTKG → MRFRISSWRCTGRSCS
     119-212: Missing.

Note: No experimental confirmation available.

Show »
Length:118
Mass (Da):13,287
Checksum:iEBAB2978717852CE
GO
Isoform 3 (identifier: Q9BW66-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MEA → MNGTIYANECQQIRHPNS

Note: No experimental confirmation available.

Show »
Length:227
Mass (Da):26,051
Checksum:i9245BA7C5767DA0B
GO

Sequence cautioni

The sequence BU174070 differs from that shown. Reason: Frameshift at positions 183 and 197.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti164 – 1641R → H.
Corresponds to variant rs7011 [ dbSNP | Ensembl ].
VAR_039979
Natural varianti177 – 1771D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_039980

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 33MEA → MNGTIYANECQQIRHPNS in isoform 3. VSP_046386
Alternative sequencei103 – 11816TKIQV…STTKG → MRFRISSWRCTGRSCS in isoform 2. VSP_045342Add
BLAST
Alternative sequencei119 – 21294Missing in isoform 2. VSP_045343Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571R → K in AAF44747. 1 Publication
Sequence conflicti157 – 1571R → K in AAF44748. 1 Publication
Sequence conflicti175 – 1751D → N in AAF44747. 1 Publication
Sequence conflicti175 – 1751D → N in AAF44748. 1 Publication
Sequence conflicti194 – 1974SDSR → NDNK in AAF44747. 1 Publication
Sequence conflicti194 – 1974SDSR → NDNK in AAF44748. 1 Publication
Sequence conflicti196 – 1961S → R in BU174070. 1 Publication
Sequence conflicti202 – 2021S → N in AAF44747. 1 Publication
Sequence conflicti202 – 2021S → N in AAF44748. 1 Publication
Sequence conflicti210 – 2123RAL → PSSLTS in BU174070. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228148 mRNA. Translation: AAF44747.1.
AF228149 mRNA. Translation: AAF44748.1.
AK056112 mRNA. Translation: BAB71095.1.
DA167716 mRNA. No translation available.
CR457178 mRNA. Translation: CAG33459.1.
AL137229 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81785.1.
BC000600 mRNA. Translation: AAH00600.1.
BU174070 mRNA. No translation available.
CCDSiCCDS9972.1. [Q9BW66-1]
RefSeqiNP_116019.1. NM_032630.2. [Q9BW66-1]
XP_005267810.1. XM_005267753.1. [Q9BW66-2]
UniGeneiHs.129634.

Genome annotation databases

EnsembliENST00000216756; ENSP00000216756; ENSG00000100865. [Q9BW66-1]
ENST00000536961; ENSP00000442057; ENSG00000100865. [Q9BW66-3]
ENST00000541568; ENSP00000442377; ENSG00000100865. [Q9BW66-2]
ENST00000559514; ENSP00000453839; ENSG00000100865. [Q9BW66-1]
GeneIDi51550.
KEGGihsa:51550.
UCSCiuc001ylv.1. human. [Q9BW66-1]

Polymorphism databases

DMDMi74733401.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228148 mRNA. Translation: AAF44747.1 .
AF228149 mRNA. Translation: AAF44748.1 .
AK056112 mRNA. Translation: BAB71095.1 .
DA167716 mRNA. No translation available.
CR457178 mRNA. Translation: CAG33459.1 .
AL137229 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81785.1 .
BC000600 mRNA. Translation: AAH00600.1 .
BU174070 mRNA. No translation available.
CCDSi CCDS9972.1. [Q9BW66-1 ]
RefSeqi NP_116019.1. NM_032630.2. [Q9BW66-1 ]
XP_005267810.1. XM_005267753.1. [Q9BW66-2 ]
UniGenei Hs.129634.

3D structure databases

ProteinModelPortali Q9BW66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119604. 5 interactions.
DIPi DIP-49011N.
IntActi Q9BW66. 3 interactions.
STRINGi 9606.ENSP00000216756.

PTM databases

PhosphoSitei Q9BW66.

Polymorphism databases

DMDMi 74733401.

Proteomic databases

MaxQBi Q9BW66.
PaxDbi Q9BW66.
PRIDEi Q9BW66.

Protocols and materials databases

DNASUi 51550.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216756 ; ENSP00000216756 ; ENSG00000100865 . [Q9BW66-1 ]
ENST00000536961 ; ENSP00000442057 ; ENSG00000100865 . [Q9BW66-3 ]
ENST00000541568 ; ENSP00000442377 ; ENSG00000100865 . [Q9BW66-2 ]
ENST00000559514 ; ENSP00000453839 ; ENSG00000100865 . [Q9BW66-1 ]
GeneIDi 51550.
KEGGi hsa:51550.
UCSCi uc001ylv.1. human. [Q9BW66-1 ]

Organism-specific databases

CTDi 51550.
GeneCardsi GC14M102814.
HGNCi HGNC:23789. CINP.
MIMi 613362. gene.
neXtProti NX_Q9BW66.
PharmGKBi PA165478684.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43463.
HOGENOMi HOG000035137.
HOVERGENi HBG061504.
InParanoidi Q9BW66.
OMAi LHLESML.
PhylomeDBi Q9BW66.
TreeFami TF329462.

Miscellaneous databases

GenomeRNAii 51550.
NextBioi 55331.
PROi Q9BW66.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BW66.
Bgeei Q9BW66.
Genevestigatori Q9BW66.

Family and domain databases

InterProi IPR023250. Cyclin-dep_Kinase_2_interact.
[Graphical view ]
PRINTSi PR02040. CDK2IP.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes."
    Grishina I., Lattes B.
    Cell Cycle 4:1120-1126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, FUNCTION, INTERACTION WITH CDK2; CDC7; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7 AND ORC2, PHOSPHORYLATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Pancreatic carcinoma and Skin.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: FUNCTION, INTERACTION WITH ATRIP, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: INTERACTION WITH CEP152.
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-177.

Entry informationi

Entry nameiCINP_HUMAN
AccessioniPrimary (citable) accession number: Q9BW66
Secondary accession number(s): F5H7P3, F5H8A7, Q9NPF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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