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Protein

Katanin p60 ATPase-containing subunit A-like 1

Gene

KATNAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi248 – 255ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS02412-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A-like 1UniRule annotation (EC:3.6.4.3UniRule annotation)
Short name:
Katanin p60 subunit A-like 1UniRule annotation
Alternative name(s):
p60 katanin-like 1UniRule annotation
Gene namesi
Name:KATNAL1UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:28361. KATNAL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi84056.
OpenTargetsiENSG00000102781.
PharmGKBiPA134951885.

Polymorphism and mutation databases

BioMutaiKATNAL1.
DMDMi60390214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846011 – 490Katanin p60 ATPase-containing subunit A-like 1Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei174PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BW62.
MaxQBiQ9BW62.
PaxDbiQ9BW62.
PeptideAtlasiQ9BW62.
PRIDEiQ9BW62.

PTM databases

iPTMnetiQ9BW62.
PhosphoSitePlusiQ9BW62.

Expressioni

Tissue specificityi

Expressed in testis, restricted to Sertoli cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000102781.
CleanExiHS_KATNAL1.
ExpressionAtlasiQ9BW62. baseline and differential.
GenevisibleiQ9BW62. HS.

Organism-specific databases

HPAiHPA046205.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-743591,EBI-743591
C1orf109Q9NX045EBI-743591,EBI-8643161
CEP57L1Q8IYX85EBI-743591,EBI-1104570
CEP57L1Q8IYX8-23EBI-743591,EBI-10181988
COX17Q140614EBI-743591,EBI-711311
KATNBL1Q9H0795EBI-743591,EBI-715394
KLC4Q9NSK05EBI-743591,EBI-949319
SIAH1Q8IUQ43EBI-743591,EBI-747107
ZNF69Q9UC073EBI-743591,EBI-10320266

Protein-protein interaction databases

BioGridi123851. 11 interactors.
IntActiQ9BW62. 14 interactors.
MINTiMINT-1463957.
STRINGi9606.ENSP00000369989.

Structurei

3D structure databases

ProteinModelPortaliQ9BW62.
SMRiQ9BW62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0738. Eukaryota.
ENOG410XPN7. LUCA.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ9BW62.
KOiK07767.
OMAiGVMQQIQ.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ9BW62.
TreeFamiTF323170.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03023. Katanin_p60_A1. 1 hit.
MF_03024. Katanin_p60_AL1. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR028594. Katnal1_chordates.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BW62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAEICDNA KKGREYALLG NYDSSMVYYQ GVMQQIQRHC QSVRDPAIKG
60 70 80 90 100
KWQQVRQELL EEYEQVKSIV STLESFKIDK PPDFPVSCQD EPFRDPAVWP
110 120 130 140 150
PPVPAEHRAP PQIRRPNREV RPLRKEMAGV GARGPVGRAH PISKSEKPST
160 170 180 190 200
SRDKDYRARG RDDKGRKNMQ DGASDGEMPK FDGAGYDKDL VEALERDIVS
210 220 230 240 250
RNPSIHWDDI ADLEEAKKLL REAVVLPMWM PDFFKGIRRP WKGVLMVGPP
260 270 280 290 300
GTGKTMLAKA VATECGTTFF NVSSSTLTSK YRGESEKLVR LLFEMARFYA
310 320 330 340 350
PTTIFIDEID SICSRRGTSD EHEASRRVKS ELLIQMDGVG GALENDDPSK
360 370 380 390 400
MVMVLAATNF PWDIDEALRR RLEKRIYIPL PTAKGRAELL KINLREVELD
410 420 430 440 450
PDIQLEDIAE KIEGYSGADI TNVCRDASLM AMRRRINGLS PEEIRALSKE
460 470 480 490
ELQMPVTKGD FELALKKIAK SVSAADLEKY EKWMVEFGSA
Length:490
Mass (Da):55,392
Last modified:June 1, 2001 - v1
Checksum:iCB8E51A77E5CB487
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291439 mRNA. Translation: BAF84128.1.
AL356750 Genomic DNA. Translation: CAI13718.1.
CH471075 Genomic DNA. Translation: EAX08452.1.
BC000612 mRNA. Translation: AAH00612.1.
CCDSiCCDS31956.1.
RefSeqiNP_001014402.1. NM_001014380.2.
NP_115492.1. NM_032116.4.
XP_005266631.1. XM_005266574.2.
UniGeneiHs.243596.

Genome annotation databases

EnsembliENST00000380615; ENSP00000369989; ENSG00000102781.
ENST00000380617; ENSP00000369991; ENSG00000102781.
GeneIDi84056.
KEGGihsa:84056.
UCSCiuc001uss.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291439 mRNA. Translation: BAF84128.1.
AL356750 Genomic DNA. Translation: CAI13718.1.
CH471075 Genomic DNA. Translation: EAX08452.1.
BC000612 mRNA. Translation: AAH00612.1.
CCDSiCCDS31956.1.
RefSeqiNP_001014402.1. NM_001014380.2.
NP_115492.1. NM_032116.4.
XP_005266631.1. XM_005266574.2.
UniGeneiHs.243596.

3D structure databases

ProteinModelPortaliQ9BW62.
SMRiQ9BW62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123851. 11 interactors.
IntActiQ9BW62. 14 interactors.
MINTiMINT-1463957.
STRINGi9606.ENSP00000369989.

PTM databases

iPTMnetiQ9BW62.
PhosphoSitePlusiQ9BW62.

Polymorphism and mutation databases

BioMutaiKATNAL1.
DMDMi60390214.

Proteomic databases

EPDiQ9BW62.
MaxQBiQ9BW62.
PaxDbiQ9BW62.
PeptideAtlasiQ9BW62.
PRIDEiQ9BW62.

Protocols and materials databases

DNASUi84056.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380615; ENSP00000369989; ENSG00000102781.
ENST00000380617; ENSP00000369991; ENSG00000102781.
GeneIDi84056.
KEGGihsa:84056.
UCSCiuc001uss.5. human.

Organism-specific databases

CTDi84056.
DisGeNETi84056.
GeneCardsiKATNAL1.
HGNCiHGNC:28361. KATNAL1.
HPAiHPA046205.
MIMi614764. gene.
neXtProtiNX_Q9BW62.
OpenTargetsiENSG00000102781.
PharmGKBiPA134951885.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0738. Eukaryota.
ENOG410XPN7. LUCA.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ9BW62.
KOiK07767.
OMAiGVMQQIQ.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ9BW62.
TreeFamiTF323170.

Enzyme and pathway databases

BioCyciZFISH:HS02412-MONOMER.

Miscellaneous databases

GenomeRNAii84056.
PROiQ9BW62.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102781.
CleanExiHS_KATNAL1.
ExpressionAtlasiQ9BW62. baseline and differential.
GenevisibleiQ9BW62. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03023. Katanin_p60_A1. 1 hit.
MF_03024. Katanin_p60_AL1. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR028594. Katnal1_chordates.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATL1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW62
Secondary accession number(s): A8K5X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.