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Protein

DET1- and DDB1-associated protein 1

Gene

DDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DET1- and DDB1-associated protein 1
Alternative name(s):
Placenta cross-immune reaction antigen 1
Short name:
PCIA-1
Gene namesi
Name:DDA1
Synonyms:C19orf58, PCIA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28360. DDA1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79016.
OpenTargetsiENSG00000130311.
PharmGKBiPA162383418.

Polymorphism and mutation databases

BioMutaiDDA1.
DMDMi74733400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003102702 – 102DET1- and DDB1-associated protein 1Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BW61.
MaxQBiQ9BW61.
PaxDbiQ9BW61.
PeptideAtlasiQ9BW61.
PRIDEiQ9BW61.
TopDownProteomicsiQ9BW61.

PTM databases

iPTMnetiQ9BW61.
PhosphoSitePlusiQ9BW61.

Expressioni

Gene expression databases

BgeeiENSG00000130311.
CleanExiHS_DDA1.
ExpressionAtlasiQ9BW61. baseline and differential.
GenevisibleiQ9BW61. HS.

Organism-specific databases

HPAiHPA042134.
HPA055272.

Interactioni

Subunit structurei

Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-2510241,EBI-741181
CMTM5Q96DZ93EBI-2510241,EBI-2548702

Protein-protein interaction databases

BioGridi122485. 86 interactors.
DIPiDIP-53527N.
IntActiQ9BW61. 59 interactors.
STRINGi9606.ENSP00000352928.

Structurei

3D structure databases

ProteinModelPortaliQ9BW61.
SMRiQ9BW61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDA1 family.Curated

Phylogenomic databases

eggNOGiKOG4816. Eukaryota.
ENOG41120QM. LUCA.
GeneTreeiENSGT00390000007029.
HOGENOMiHOG000006384.
HOVERGENiHBG055081.
InParanoidiQ9BW61.
KOiK11792.
OMAiRTDSQDM.
OrthoDBiEOG091G129W.
PhylomeDBiQ9BW61.
TreeFamiTF323534.

Family and domain databases

InterProiIPR033575. DDA1.
IPR018276. Ub_ligase_Det1/DDB1-complexing.
[Graphical view]
PANTHERiPTHR31879. PTHR31879. 1 hit.
PfamiPF10172. DDA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BW61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE
60 70 80 90 100
KTNILLRYLH QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE

DT
Length:102
Mass (Da):11,835
Last modified:June 1, 2001 - v1
Checksum:i94E43C3528589F01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ090952 mRNA. Translation: AAZ41375.1.
AY563006 mRNA. Translation: AAS66629.1.
CH471106 Genomic DNA. Translation: EAW84593.1.
BC000615 mRNA. Translation: AAH00615.1.
CCDSiCCDS12357.1.
RefSeqiNP_076955.1. NM_024050.5.
UniGeneiHs.466154.

Genome annotation databases

EnsembliENST00000359866; ENSP00000352928; ENSG00000130311.
ENST00000593466; ENSP00000473086; ENSG00000130311.
ENST00000596582; ENSP00000472171; ENSG00000130311.
GeneIDi79016.
KEGGihsa:79016.
UCSCiuc002ngd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ090952 mRNA. Translation: AAZ41375.1.
AY563006 mRNA. Translation: AAS66629.1.
CH471106 Genomic DNA. Translation: EAW84593.1.
BC000615 mRNA. Translation: AAH00615.1.
CCDSiCCDS12357.1.
RefSeqiNP_076955.1. NM_024050.5.
UniGeneiHs.466154.

3D structure databases

ProteinModelPortaliQ9BW61.
SMRiQ9BW61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122485. 86 interactors.
DIPiDIP-53527N.
IntActiQ9BW61. 59 interactors.
STRINGi9606.ENSP00000352928.

PTM databases

iPTMnetiQ9BW61.
PhosphoSitePlusiQ9BW61.

Polymorphism and mutation databases

BioMutaiDDA1.
DMDMi74733400.

Proteomic databases

EPDiQ9BW61.
MaxQBiQ9BW61.
PaxDbiQ9BW61.
PeptideAtlasiQ9BW61.
PRIDEiQ9BW61.
TopDownProteomicsiQ9BW61.

Protocols and materials databases

DNASUi79016.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359866; ENSP00000352928; ENSG00000130311.
ENST00000593466; ENSP00000473086; ENSG00000130311.
ENST00000596582; ENSP00000472171; ENSG00000130311.
GeneIDi79016.
KEGGihsa:79016.
UCSCiuc002ngd.4. human.

Organism-specific databases

CTDi79016.
DisGeNETi79016.
GeneCardsiDDA1.
H-InvDBHIX0137478.
HGNCiHGNC:28360. DDA1.
HPAiHPA042134.
HPA055272.
neXtProtiNX_Q9BW61.
OpenTargetsiENSG00000130311.
PharmGKBiPA162383418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4816. Eukaryota.
ENOG41120QM. LUCA.
GeneTreeiENSGT00390000007029.
HOGENOMiHOG000006384.
HOVERGENiHBG055081.
InParanoidiQ9BW61.
KOiK11792.
OMAiRTDSQDM.
OrthoDBiEOG091G129W.
PhylomeDBiQ9BW61.
TreeFamiTF323534.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130311-MONOMER.

Miscellaneous databases

ChiTaRSiDDA1. human.
GenomeRNAii79016.
PROiQ9BW61.

Gene expression databases

BgeeiENSG00000130311.
CleanExiHS_DDA1.
ExpressionAtlasiQ9BW61. baseline and differential.
GenevisibleiQ9BW61. HS.

Family and domain databases

InterProiIPR033575. DDA1.
IPR018276. Ub_ligase_Det1/DDB1-complexing.
[Graphical view]
PANTHERiPTHR31879. PTHR31879. 1 hit.
PfamiPF10172. DDA1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.