Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BW61

- DDA1_HUMAN

UniProt

Q9BW61 - DDA1_HUMAN

Protein

DET1- and DDB1-associated protein 1

Gene

DDA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.1 Publication

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DET1- and DDB1-associated protein 1
    Alternative name(s):
    Placenta cross-immune reaction antigen 1
    Short name:
    PCIA-1
    Gene namesi
    Name:DDA1
    Synonyms:C19orf58, PCIA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28360. DDA1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162383418.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 102101DET1- and DDB1-associated protein 1PRO_0000310270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei33 – 331Phosphoserine1 Publication
    Modified residuei95 – 951Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BW61.
    PaxDbiQ9BW61.
    PRIDEiQ9BW61.

    PTM databases

    PhosphoSiteiQ9BW61.

    Expressioni

    Gene expression databases

    BgeeiQ9BW61.
    CleanExiHS_DDA1.
    GenevestigatoriQ9BW61.

    Organism-specific databases

    HPAiHPA042134.

    Interactioni

    Subunit structurei

    Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.1 Publication

    Protein-protein interaction databases

    BioGridi122485. 74 interactions.
    DIPiDIP-53527N.
    IntActiQ9BW61. 48 interactions.
    STRINGi9606.ENSP00000352928.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BW61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DDA1 family.Curated

    Phylogenomic databases

    eggNOGiNOG264839.
    HOGENOMiHOG000006384.
    HOVERGENiHBG055081.
    InParanoidiQ9BW61.
    KOiK11792.
    OMAiRTDSQDM.
    OrthoDBiEOG7K3TP9.
    PhylomeDBiQ9BW61.
    TreeFamiTF323534.

    Family and domain databases

    InterProiIPR018276. Ub_ligase_Det1/DDB1-complexing.
    [Graphical view]
    PfamiPF10172. DDA1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BW61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE    50
    KTNILLRYLH QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE 100
    DT 102
    Length:102
    Mass (Da):11,835
    Last modified:June 1, 2001 - v1
    Checksum:i94E43C3528589F01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ090952 mRNA. Translation: AAZ41375.1.
    AY563006 mRNA. Translation: AAS66629.1.
    CH471106 Genomic DNA. Translation: EAW84593.1.
    BC000615 mRNA. Translation: AAH00615.1.
    CCDSiCCDS12357.1.
    RefSeqiNP_076955.1. NM_024050.5.
    UniGeneiHs.466154.

    Genome annotation databases

    EnsembliENST00000359866; ENSP00000352928; ENSG00000130311.
    ENST00000593466; ENSP00000473086; ENSG00000130311.
    ENST00000596582; ENSP00000472171; ENSG00000130311.
    GeneIDi79016.
    KEGGihsa:79016.
    UCSCiuc002ngd.3. human.

    Polymorphism databases

    DMDMi74733400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ090952 mRNA. Translation: AAZ41375.1 .
    AY563006 mRNA. Translation: AAS66629.1 .
    CH471106 Genomic DNA. Translation: EAW84593.1 .
    BC000615 mRNA. Translation: AAH00615.1 .
    CCDSi CCDS12357.1.
    RefSeqi NP_076955.1. NM_024050.5.
    UniGenei Hs.466154.

    3D structure databases

    ProteinModelPortali Q9BW61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122485. 74 interactions.
    DIPi DIP-53527N.
    IntActi Q9BW61. 48 interactions.
    STRINGi 9606.ENSP00000352928.

    PTM databases

    PhosphoSitei Q9BW61.

    Polymorphism databases

    DMDMi 74733400.

    Proteomic databases

    MaxQBi Q9BW61.
    PaxDbi Q9BW61.
    PRIDEi Q9BW61.

    Protocols and materials databases

    DNASUi 79016.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359866 ; ENSP00000352928 ; ENSG00000130311 .
    ENST00000593466 ; ENSP00000473086 ; ENSG00000130311 .
    ENST00000596582 ; ENSP00000472171 ; ENSG00000130311 .
    GeneIDi 79016.
    KEGGi hsa:79016.
    UCSCi uc002ngd.3. human.

    Organism-specific databases

    CTDi 79016.
    GeneCardsi GC19P017420.
    H-InvDB HIX0137478.
    HGNCi HGNC:28360. DDA1.
    HPAi HPA042134.
    neXtProti NX_Q9BW61.
    PharmGKBi PA162383418.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264839.
    HOGENOMi HOG000006384.
    HOVERGENi HBG055081.
    InParanoidi Q9BW61.
    KOi K11792.
    OMAi RTDSQDM.
    OrthoDBi EOG7K3TP9.
    PhylomeDBi Q9BW61.
    TreeFami TF323534.

    Miscellaneous databases

    GenomeRNAii 79016.
    NextBioi 67674.
    PROi Q9BW61.

    Gene expression databases

    Bgeei Q9BW61.
    CleanExi HS_DDA1.
    Genevestigatori Q9BW61.

    Family and domain databases

    InterProi IPR018276. Ub_ligase_Det1/DDB1-complexing.
    [Graphical view ]
    Pfami PF10172. DDA1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes."
      Pick E., Lau O.-S., Tsuge T., Menon S., Tong Y., Dohmae N., Plafker S.M., Deng X.W., Wei N.
      Mol. Cell. Biol. 27:4708-4719(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION IN A DDD COMPLEX WITH DET1 AND DDB1.
    2. "Identification of placenta cross-immune reaction antigen."
      Deng H.-X., Wei Y.-Q., Zhao X., Yang H.-S., Yang J.-L., Tian L.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33 AND SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDDA1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BW61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3