Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BW61 (DDA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DET1- and DDB1-associated protein 1
Alternative name(s):
Placenta cross-immune reaction antigen 1
Short name=PCIA-1
Gene names
Name:DDA1
Synonyms:C19orf58, PCIA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length102 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins. Ref.1

Subunit structure

Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes. Ref.1

Sequence similarities

Belongs to the DDA1 family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.9
Chain2 – 102101DET1- and DDB1-associated protein 1
PRO_0000310270

Amino acid modifications

Modified residue21N-acetylalanine Ref.9
Modified residue331Phosphoserine Ref.6
Modified residue951Phosphoserine Ref.5 Ref.6 Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q9BW61 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 94E43C3528589F01

FASTA10211,835
        10         20         30         40         50         60 
MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE KTNILLRYLH 

        70         80         90        100 
QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE DT 

« Hide

References

« Hide 'large scale' references
[1]"Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes."
Pick E., Lau O.-S., Tsuge T., Menon S., Tong Y., Dohmae N., Plafker S.M., Deng X.W., Wei N.
Mol. Cell. Biol. 27:4708-4719(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION IN A DDD COMPLEX WITH DET1 AND DDB1.
[2]"Identification of placenta cross-immune reaction antigen."
Deng H.-X., Wei Y.-Q., Zhao X., Yang H.-S., Yang J.-L., Tian L.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33 AND SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ090952 mRNA. Translation: AAZ41375.1.
AY563006 mRNA. Translation: AAS66629.1.
CH471106 Genomic DNA. Translation: EAW84593.1.
BC000615 mRNA. Translation: AAH00615.1.
CCDSCCDS12357.1.
RefSeqNP_076955.1. NM_024050.5.
UniGeneHs.466154.

3D structure databases

ProteinModelPortalQ9BW61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122485. 74 interactions.
DIPDIP-53527N.
IntActQ9BW61. 48 interactions.
STRING9606.ENSP00000352928.

PTM databases

PhosphoSiteQ9BW61.

Polymorphism databases

DMDM74733400.

Proteomic databases

MaxQBQ9BW61.
PaxDbQ9BW61.
PRIDEQ9BW61.

Protocols and materials databases

DNASU79016.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359866; ENSP00000352928; ENSG00000130311.
ENST00000593466; ENSP00000473086; ENSG00000130311.
ENST00000596582; ENSP00000472171; ENSG00000130311.
GeneID79016.
KEGGhsa:79016.
UCSCuc002ngd.3. human.

Organism-specific databases

CTD79016.
GeneCardsGC19P017420.
H-InvDBHIX0137478.
HGNCHGNC:28360. DDA1.
HPAHPA042134.
neXtProtNX_Q9BW61.
PharmGKBPA162383418.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG264839.
HOGENOMHOG000006384.
HOVERGENHBG055081.
InParanoidQ9BW61.
KOK11792.
OMARTDSQDM.
OrthoDBEOG7K3TP9.
PhylomeDBQ9BW61.
TreeFamTF323534.

Gene expression databases

BgeeQ9BW61.
CleanExHS_DDA1.
GenevestigatorQ9BW61.

Family and domain databases

InterProIPR018276. Ub_ligase_Det1/DDB1-complexing.
[Graphical view]
PfamPF10172. DDA1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79016.
NextBio67674.
PROQ9BW61.

Entry information

Entry nameDDA1_HUMAN
AccessionPrimary (citable) accession number: Q9BW61
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM