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Q9BW61

- DDA1_HUMAN

UniProt

Q9BW61 - DDA1_HUMAN

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Protein

DET1- and DDB1-associated protein 1

Gene

DDA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.1 Publication

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DET1- and DDB1-associated protein 1
Alternative name(s):
Placenta cross-immune reaction antigen 1
Short name:
PCIA-1
Gene namesi
Name:DDA1
Synonyms:C19orf58, PCIA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28360. DDA1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 102101DET1- and DDB1-associated protein 1PRO_0000310270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei33 – 331Phosphoserine1 Publication
Modified residuei95 – 951Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BW61.
PaxDbiQ9BW61.
PRIDEiQ9BW61.

PTM databases

PhosphoSiteiQ9BW61.

Expressioni

Gene expression databases

BgeeiQ9BW61.
CleanExiHS_DDA1.
GenevestigatoriQ9BW61.

Organism-specific databases

HPAiHPA042134.

Interactioni

Subunit structurei

Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.1 Publication

Protein-protein interaction databases

BioGridi122485. 76 interactions.
DIPiDIP-53527N.
IntActiQ9BW61. 49 interactions.
STRINGi9606.ENSP00000352928.

Structurei

3D structure databases

ProteinModelPortaliQ9BW61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDA1 family.Curated

Phylogenomic databases

eggNOGiNOG264839.
GeneTreeiENSGT00390000007029.
HOGENOMiHOG000006384.
HOVERGENiHBG055081.
InParanoidiQ9BW61.
KOiK11792.
OMAiRTDSQDM.
OrthoDBiEOG7K3TP9.
PhylomeDBiQ9BW61.
TreeFamiTF323534.

Family and domain databases

InterProiIPR018276. Ub_ligase_Det1/DDB1-complexing.
[Graphical view]
PfamiPF10172. DDA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BW61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE
60 70 80 90 100
KTNILLRYLH QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE

DT
Length:102
Mass (Da):11,835
Last modified:June 1, 2001 - v1
Checksum:i94E43C3528589F01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ090952 mRNA. Translation: AAZ41375.1.
AY563006 mRNA. Translation: AAS66629.1.
CH471106 Genomic DNA. Translation: EAW84593.1.
BC000615 mRNA. Translation: AAH00615.1.
CCDSiCCDS12357.1.
RefSeqiNP_076955.1. NM_024050.5.
UniGeneiHs.466154.

Genome annotation databases

EnsembliENST00000359866; ENSP00000352928; ENSG00000130311.
ENST00000593466; ENSP00000473086; ENSG00000130311.
ENST00000596582; ENSP00000472171; ENSG00000130311.
GeneIDi79016.
KEGGihsa:79016.
UCSCiuc002ngd.3. human.

Polymorphism databases

DMDMi74733400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ090952 mRNA. Translation: AAZ41375.1 .
AY563006 mRNA. Translation: AAS66629.1 .
CH471106 Genomic DNA. Translation: EAW84593.1 .
BC000615 mRNA. Translation: AAH00615.1 .
CCDSi CCDS12357.1.
RefSeqi NP_076955.1. NM_024050.5.
UniGenei Hs.466154.

3D structure databases

ProteinModelPortali Q9BW61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122485. 76 interactions.
DIPi DIP-53527N.
IntActi Q9BW61. 49 interactions.
STRINGi 9606.ENSP00000352928.

PTM databases

PhosphoSitei Q9BW61.

Polymorphism databases

DMDMi 74733400.

Proteomic databases

MaxQBi Q9BW61.
PaxDbi Q9BW61.
PRIDEi Q9BW61.

Protocols and materials databases

DNASUi 79016.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359866 ; ENSP00000352928 ; ENSG00000130311 .
ENST00000593466 ; ENSP00000473086 ; ENSG00000130311 .
ENST00000596582 ; ENSP00000472171 ; ENSG00000130311 .
GeneIDi 79016.
KEGGi hsa:79016.
UCSCi uc002ngd.3. human.

Organism-specific databases

CTDi 79016.
GeneCardsi GC19P017420.
H-InvDB HIX0137478.
HGNCi HGNC:28360. DDA1.
HPAi HPA042134.
neXtProti NX_Q9BW61.
PharmGKBi PA162383418.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG264839.
GeneTreei ENSGT00390000007029.
HOGENOMi HOG000006384.
HOVERGENi HBG055081.
InParanoidi Q9BW61.
KOi K11792.
OMAi RTDSQDM.
OrthoDBi EOG7K3TP9.
PhylomeDBi Q9BW61.
TreeFami TF323534.

Miscellaneous databases

GenomeRNAii 79016.
NextBioi 67674.
PROi Q9BW61.

Gene expression databases

Bgeei Q9BW61.
CleanExi HS_DDA1.
Genevestigatori Q9BW61.

Family and domain databases

InterProi IPR018276. Ub_ligase_Det1/DDB1-complexing.
[Graphical view ]
Pfami PF10172. DDA1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes."
    Pick E., Lau O.-S., Tsuge T., Menon S., Tong Y., Dohmae N., Plafker S.M., Deng X.W., Wei N.
    Mol. Cell. Biol. 27:4708-4719(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION IN A DDD COMPLEX WITH DET1 AND DDB1.
  2. "Identification of placenta cross-immune reaction antigen."
    Deng H.-X., Wei Y.-Q., Zhao X., Yang H.-S., Yang J.-L., Tian L.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33 AND SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDDA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3