UniProtKB - Q9BW30 (TPPP3_HUMAN)
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Protein
Tubulin polymerization-promoting protein family member 3
Gene
TPPP3
Organism
Homo sapiens (Human)
Status
Functioni
Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.2 Publications
GO - Molecular functioni
- tubulin binding Source: UniProtKB
GO - Biological processi
- microtubule bundle formation Source: UniProtKB
- microtubule polymerization Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin polymerization-promoting protein family member 3Alternative name(s): TPPP/p20 |
Gene namesi | Name:TPPP3 ORF Names:CGI-38 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159713.10. |
HGNCi | HGNC:24162. TPPP3. |
MIMi | 616957. gene. |
neXtProti | NX_Q9BW30. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51673. |
OpenTargetsi | ENSG00000159713. |
PharmGKBi | PA162406823. |
Polymorphism and mutation databases
DMDMi | 28380040. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000221138 | 2 – 176 | Tubulin polymerization-promoting protein family member 3Add BLAST | 175 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | Q9BW30. |
PaxDbi | Q9BW30. |
PeptideAtlasi | Q9BW30. |
PRIDEi | Q9BW30. |
PTM databases
iPTMneti | Q9BW30. |
PhosphoSitePlusi | Q9BW30. |
Expressioni
Gene expression databases
Bgeei | ENSG00000159713. |
CleanExi | HS_TPPP3. |
ExpressionAtlasi | Q9BW30. baseline and differential. |
Genevisiblei | Q9BW30. HS. |
Organism-specific databases
HPAi | HPA047629. |
Interactioni
GO - Molecular functioni
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 119673. 1 interactor. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 3 – 6 | Combined sources | 4 | |
Helixi | 9 – 18 | Combined sources | 10 | |
Beta strandi | 19 – 21 | Combined sources | 3 | |
Beta strandi | 28 – 31 | Combined sources | 4 | |
Helixi | 32 – 41 | Combined sources | 10 | |
Beta strandi | 47 – 50 | Combined sources | 4 | |
Helixi | 52 – 62 | Combined sources | 11 | |
Beta strandi | 68 – 71 | Combined sources | 4 | |
Helixi | 72 – 86 | Combined sources | 15 | |
Helixi | 92 – 101 | Combined sources | 10 | |
Turni | 102 – 105 | Combined sources | 4 | |
Beta strandi | 108 – 112 | Combined sources | 5 | |
Beta strandi | 126 – 129 | Combined sources | 4 | |
Beta strandi | 141 – 143 | Combined sources | 3 | |
Turni | 146 – 150 | Combined sources | 5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JRF | NMR | - | A | 1-176 | [»] | |
ProteinModelPortali | Q9BW30. | |||||
SMRi | Q9BW30. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BW30. |
Family & Domainsi
Sequence similaritiesi
Belongs to the TPPP family.Curated
Phylogenomic databases
eggNOGi | KOG4070. Eukaryota. ENOG4111H9J. LUCA. |
GeneTreei | ENSGT00390000014993. |
HOGENOMi | HOG000260314. |
HOVERGENi | HBG036683. |
InParanoidi | Q9BW30. |
OMAi | EPTNVGV. |
OrthoDBi | EOG091G0PC4. |
PhylomeDBi | Q9BW30. |
TreeFami | TF314440. |
Family and domain databases
InterProi | View protein in InterPro IPR011992. EF-hand-dom_pair. IPR008907. P25-alpha. IPR030795. TPPP3. |
PANTHERi | PTHR12932. PTHR12932. 1 hit. PTHR12932:SF16. PTHR12932:SF16. 1 hit. |
Pfami | View protein in Pfam PF05517. p25-alpha. 1 hit. |
SUPFAMi | SSF47473. SSF47473. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9BW30-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASTDMAGL EESFRKFAIH GDPKASGQEM NGKNWAKLCK DCKVADGKSV
60 70 80 90 100
TGTDVDIVFS KVKGKSARVI NYEEFKKALE ELATKRFKGK SKEEAFDAIC
110 120 130 140 150
QLVAGKEPAN VGVTKAKTGG AVDRLTDTSR YTGSHKERFD ESGKGKGIAG
160 170
RQDILDDSGY VSAYKNAGTY DAKVKK
Sequence cautioni
The sequence AAD44478 differs from that shown. Reason: Frameshift at positions 52, 77, 83 and 89.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | M → I in AAD44478 (PubMed:10931946).Curated | 1 | |
Sequence conflicti | 10 – 11 | LE → PK in AAD44478 (PubMed:10931946).Curated | 2 | |
Sequence conflicti | 52 – 54 | GTD → TP in AAD44478 (PubMed:10931946).Curated | 3 | |
Sequence conflicti | 88 | K → G in AAD44478 (PubMed:10931946).Curated | 1 | |
Sequence conflicti | 88 | K → Q in AAD27747 (PubMed:10810093).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132972 mRNA. Translation: AAD27747.1. AF078846 mRNA. Translation: AAD44478.1. Frameshift. BC000691 mRNA. Translation: AAH00691.1. |
CCDSi | CCDS10835.1. |
RefSeqi | NP_057048.2. NM_015964.3. NP_057224.2. NM_016140.3. |
UniGenei | Hs.534458. |
Genome annotation databases
Ensembli | ENST00000290942; ENSP00000290942; ENSG00000159713. ENST00000393957; ENSP00000377529; ENSG00000159713. ENST00000562206; ENSP00000457275; ENSG00000159713. ENST00000564104; ENSP00000462435; ENSG00000159713. |
GeneIDi | 51673. |
KEGGi | hsa:51673. |
UCSCi | uc002esz.5. human. |
Similar proteinsi
Entry informationi
Entry namei | TPPP3_HUMAN | |
Accessioni | Q9BW30Primary (citable) accession number: Q9BW30 Secondary accession number(s): Q49AH9, Q9Y326, Q9Y6H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |