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Protein

Tubulin polymerization-promoting protein family member 3

Gene

TPPP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.2 Publications

GO - Molecular functioni

  • tubulin binding Source: UniProtKB

GO - Biological processi

  • microtubule bundle formation Source: UniProtKB
  • microtubule polymerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polymerization-promoting protein family member 3
Alternative name(s):
TPPP/p20
Gene namesi
Name:TPPP3
ORF Names:CGI-38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24162. TPPP3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406823.

Polymorphism and mutation databases

DMDMi28380040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 176175Tubulin polymerization-promoting protein family member 3PRO_0000221138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BW30.
MaxQBiQ9BW30.
PaxDbiQ9BW30.
PeptideAtlasiQ9BW30.
PRIDEiQ9BW30.

PTM databases

iPTMnetiQ9BW30.
PhosphoSiteiQ9BW30.

Expressioni

Gene expression databases

BgeeiQ9BW30.
CleanExiHS_TPPP3.
ExpressionAtlasiQ9BW30. baseline and differential.
GenevisibleiQ9BW30. HS.

Organism-specific databases

HPAiHPA047629.

Interactioni

GO - Molecular functioni

  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119673. 1 interaction.
STRINGi9606.ENSP00000290942.

Structurei

Secondary structure

1
176
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Helixi9 – 1810Combined sources
Beta strandi19 – 213Combined sources
Beta strandi28 – 314Combined sources
Helixi32 – 4110Combined sources
Beta strandi47 – 504Combined sources
Helixi52 – 6211Combined sources
Beta strandi68 – 714Combined sources
Helixi72 – 8615Combined sources
Helixi92 – 10110Combined sources
Turni102 – 1054Combined sources
Beta strandi108 – 1125Combined sources
Beta strandi126 – 1294Combined sources
Beta strandi141 – 1433Combined sources
Turni146 – 1505Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JRFNMR-A1-176[»]
ProteinModelPortaliQ9BW30.
SMRiQ9BW30. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BW30.

Family & Domainsi

Sequence similaritiesi

Belongs to the TPPP family.Curated

Phylogenomic databases

eggNOGiKOG4070. Eukaryota.
ENOG4111H9J. LUCA.
GeneTreeiENSGT00390000014993.
HOGENOMiHOG000260314.
HOVERGENiHBG036683.
InParanoidiQ9BW30.
OMAiELNGKNW.
OrthoDBiEOG7NGQDH.
PhylomeDBiQ9BW30.
TreeFamiTF314440.

Family and domain databases

InterProiIPR011992. EF-hand-dom_pair.
IPR008907. P25-alpha.
IPR030795. TPPP3.
[Graphical view]
PANTHERiPTHR12932. PTHR12932. 1 hit.
PTHR12932:SF16. PTHR12932:SF16. 1 hit.
PfamiPF05517. p25-alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BW30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTDMAGL EESFRKFAIH GDPKASGQEM NGKNWAKLCK DCKVADGKSV
60 70 80 90 100
TGTDVDIVFS KVKGKSARVI NYEEFKKALE ELATKRFKGK SKEEAFDAIC
110 120 130 140 150
QLVAGKEPAN VGVTKAKTGG AVDRLTDTSR YTGSHKERFD ESGKGKGIAG
160 170
RQDILDDSGY VSAYKNAGTY DAKVKK
Length:176
Mass (Da):18,985
Last modified:June 1, 2001 - v1
Checksum:i20EA146E93FB1ADF
GO

Sequence cautioni

The sequence AAD44478.1 differs from that shown. Reason: Frameshift at positions 52, 77, 83 and 89. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71M → I in AAD44478 (PubMed:10931946).Curated
Sequence conflicti10 – 112LE → PK in AAD44478 (PubMed:10931946).Curated
Sequence conflicti52 – 543GTD → TP in AAD44478 (PubMed:10931946).Curated
Sequence conflicti88 – 881K → G in AAD44478 (PubMed:10931946).Curated
Sequence conflicti88 – 881K → Q in AAD27747 (PubMed:10810093).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132972 mRNA. Translation: AAD27747.1.
AF078846 mRNA. Translation: AAD44478.1. Frameshift.
BC000691 mRNA. Translation: AAH00691.1.
CCDSiCCDS10835.1.
RefSeqiNP_057048.2. NM_015964.3.
NP_057224.2. NM_016140.3.
UniGeneiHs.534458.

Genome annotation databases

EnsembliENST00000290942; ENSP00000290942; ENSG00000159713.
ENST00000393957; ENSP00000377529; ENSG00000159713.
ENST00000562206; ENSP00000457275; ENSG00000159713.
ENST00000564104; ENSP00000462435; ENSG00000159713.
GeneIDi51673.
KEGGihsa:51673.
UCSCiuc002esz.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132972 mRNA. Translation: AAD27747.1.
AF078846 mRNA. Translation: AAD44478.1. Frameshift.
BC000691 mRNA. Translation: AAH00691.1.
CCDSiCCDS10835.1.
RefSeqiNP_057048.2. NM_015964.3.
NP_057224.2. NM_016140.3.
UniGeneiHs.534458.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JRFNMR-A1-176[»]
ProteinModelPortaliQ9BW30.
SMRiQ9BW30. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119673. 1 interaction.
STRINGi9606.ENSP00000290942.

PTM databases

iPTMnetiQ9BW30.
PhosphoSiteiQ9BW30.

Polymorphism and mutation databases

DMDMi28380040.

Proteomic databases

EPDiQ9BW30.
MaxQBiQ9BW30.
PaxDbiQ9BW30.
PeptideAtlasiQ9BW30.
PRIDEiQ9BW30.

Protocols and materials databases

DNASUi51673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290942; ENSP00000290942; ENSG00000159713.
ENST00000393957; ENSP00000377529; ENSG00000159713.
ENST00000562206; ENSP00000457275; ENSG00000159713.
ENST00000564104; ENSP00000462435; ENSG00000159713.
GeneIDi51673.
KEGGihsa:51673.
UCSCiuc002esz.5. human.

Organism-specific databases

CTDi51673.
GeneCardsiTPPP3.
HGNCiHGNC:24162. TPPP3.
HPAiHPA047629.
neXtProtiNX_Q9BW30.
PharmGKBiPA162406823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4070. Eukaryota.
ENOG4111H9J. LUCA.
GeneTreeiENSGT00390000014993.
HOGENOMiHOG000260314.
HOVERGENiHBG036683.
InParanoidiQ9BW30.
OMAiELNGKNW.
OrthoDBiEOG7NGQDH.
PhylomeDBiQ9BW30.
TreeFamiTF314440.

Miscellaneous databases

ChiTaRSiTPPP3. human.
EvolutionaryTraceiQ9BW30.
GenomeRNAii51673.
PROiQ9BW30.

Gene expression databases

BgeeiQ9BW30.
CleanExiHS_TPPP3.
ExpressionAtlasiQ9BW30. baseline and differential.
GenevisibleiQ9BW30. HS.

Family and domain databases

InterProiIPR011992. EF-hand-dom_pair.
IPR008907. P25-alpha.
IPR030795. TPPP3.
[Graphical view]
PANTHERiPTHR12932. PTHR12932. 1 hit.
PTHR12932:SF16. PTHR12932:SF16. 1 hit.
PfamiPF05517. p25-alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions."
    Vincze O., Toekesi N., Olah J., Hlavanda E., Zotter A., Horvath I., Lehotzky A., Tirian L., Medzihradszky K.F., Kovacs J., Orosz F., Ovadi J.
    Biochemistry 45:13818-13826(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation."
    Zhou W., Wang X., Li L., Feng X., Yang Z., Zhang W., Hu R.
    Mol. Cell. Biochem. 333:91-98(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Solution NMR structure of tubulin polymerization-promoting protein family member 3 from Homo sapiens."
    Northeast structural genomics consortium (NESG)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiTPPP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BW30
Secondary accession number(s): Q49AH9, Q9Y326, Q9Y6H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.