TPPP3

Functionⁱ

Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.2 Publications

GO - Molecular functionⁱ

tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17105200

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

microtubule bundle formation
Source: UniProtKB
Inferred from direct assayⁱ
- 17105200
microtubule polymerization Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tubulin polymerization-promoting protein family member 3 Alternative name(s): TPPP/p20
Gene namesⁱ	Name:TPPP3 ORF Names:CGI-38
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159713.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24162 TPPP3
MIMⁱ	616957 gene
neXtProtⁱ	NX_Q9BW30

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51673
Open Targets More...OpenTargetsⁱ	ENSG00000159713
PharmGKBⁱ	PA162406823

Polymorphism and mutation databases

DMDMⁱ	28380040

DMDMⁱ

28380040

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000221138	2 – 176	Tubulin polymerization-promoting protein family member 3Add BLAST		175

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BW30
PaxDbⁱ	Q9BW30
PeptideAtlas More...PeptideAtlasⁱ	Q9BW30
PRIDEⁱ	Q9BW30
ProteomicsDBⁱ	79252

PTM databases

iPTMnetⁱ	Q9BW30
PhosphoSitePlusⁱ	Q9BW30

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000159713
CleanExⁱ	HS_TPPP3
ExpressionAtlasⁱ	Q9BW30 baseline and differential
Genevisibleⁱ	Q9BW30 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047629

HPAⁱ

HPA047629

Interactionⁱ

GO - Molecular functionⁱ

tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17105200

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119673, 1 interactor

BioGridⁱ

119673, 1 interactor

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 6	Combined sources	4
Helixⁱ	9 – 18	Combined sources	10
Beta strandⁱ	19 – 21	Combined sources	3
Beta strandⁱ	28 – 31	Combined sources	4
Helixⁱ	32 – 41	Combined sources	10
Beta strandⁱ	47 – 50	Combined sources	4
Helixⁱ	52 – 62	Combined sources	11
Beta strandⁱ	68 – 71	Combined sources	4
Helixⁱ	72 – 86	Combined sources	15
Helixⁱ	92 – 101	Combined sources	10
Turnⁱ	102 – 105	Combined sources	4
Beta strandⁱ	108 – 112	Combined sources	5
Beta strandⁱ	126 – 129	Combined sources	4
Beta strandⁱ	141 – 143	Combined sources	3
Turnⁱ	146 – 150	Combined sources	5

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JRF	NMR	-	A	1-176	[»]
ProteinModelPortalⁱ	Q9BW30
SMRⁱ	Q9BW30
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BW30

EvolutionaryTraceⁱ

Q9BW30

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TPPP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4070 Eukaryota ENOG4111H9J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014993
HOGENOMⁱ	HOG000260314
HOVERGENⁱ	HBG036683
InParanoidⁱ	Q9BW30
OMAⁱ	EPTNVGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PC4
PhylomeDBⁱ	Q9BW30
TreeFamⁱ	TF314440

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR008907 P25-alpha IPR030795 TPPP3
PANTHERⁱ	PTHR12932 PTHR12932, 1 hit PTHR12932:SF16 PTHR12932:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05517 p25-alpha, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9BW30-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAASTDMAGL EESFRKFAIH GDPKASGQEM NGKNWAKLCK DCKVADGKSV 
        60         70         80         90        100
TGTDVDIVFS KVKGKSARVI NYEEFKKALE ELATKRFKGK SKEEAFDAIC 
       110        120        130        140        150
QLVAGKEPAN VGVTKAKTGG AVDRLTDTSR YTGSHKERFD ESGKGKGIAG 
       160        170 
RQDILDDSGY VSAYKNAGTY DAKVKK

Length:176

Mass (Da):18,985

Last modified:June 1, 2001 - v1

Checksum:ⁱ20EA146E93FB1ADF

GO

Sequence cautionⁱ

The sequence AAD44478 differs from that shown. Reason: Frameshift at positions 52, 77, 83 and 89.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	7	M → I in AAD44478 (PubMed:10931946).Curated	1
Sequence conflictⁱ	10 – 11	LE → PK in AAD44478 (PubMed:10931946).Curated	2
Sequence conflictⁱ	52 – 54	GTD → TP in AAD44478 (PubMed:10931946).Curated	3
Sequence conflictⁱ	88	K → G in AAD44478 (PubMed:10931946).Curated	1
Sequence conflictⁱ	88	K → Q in AAD27747 (PubMed:10810093).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132972 mRNA Translation: AAD27747.1 AF078846 mRNA Translation: AAD44478.1 Frameshift. BC000691 mRNA Translation: AAH00691.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10835.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057048.2, NM_015964.3 NP_057224.2, NM_016140.3
UniGeneⁱ	Hs.534458

Genome annotation databases

Ensemblⁱ	ENST00000290942; ENSP00000290942; ENSG00000159713 ENST00000393957; ENSP00000377529; ENSG00000159713 ENST00000562206; ENSP00000457275; ENSG00000159713 ENST00000564104; ENSP00000462435; ENSG00000159713
GeneIDⁱ	51673
KEGGⁱ	hsa:51673
UCSC genome browser More...UCSCⁱ	uc002esz.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9BW30	Brain specific protein, isoform CRA_a		HUMAN		176
Uncharacterized protein		MACFA		211
Tubulin polymerization promoting protein family member 3		PAPAN		200
Tubulin polymerization promoting protein family member 3		OTOGA		182
UPI00027422A9		MICMU		176
+74

Protein	Similar proteins		Species	Score	Length
Q9BW30	Brain specific protein, isoform CRA_a		HUMAN		176
Uncharacterized protein		MACFA		211
Tubulin polymerization promoting protein family member 3		PAPAN		200
Tubulin polymerization promoting protein family member 3		OTOGA		182
UPI00027422A9		MICMU		176
+99

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132972 mRNA Translation: AAD27747.1 AF078846 mRNA Translation: AAD44478.1 Frameshift. BC000691 mRNA Translation: AAH00691.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10835.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057048.2, NM_015964.3 NP_057224.2, NM_016140.3
UniGeneⁱ	Hs.534458

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JRF	NMR	-	A	1-176	[»]
ProteinModelPortalⁱ	Q9BW30
SMRⁱ	Q9BW30
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119673, 1 interactor

BioGridⁱ

119673, 1 interactor

PTM databases

iPTMnetⁱ	Q9BW30
PhosphoSitePlusⁱ	Q9BW30

Polymorphism and mutation databases

DMDMⁱ	28380040

DMDMⁱ

28380040

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BW30
PaxDbⁱ	Q9BW30
PeptideAtlas More...PeptideAtlasⁱ	Q9BW30
PRIDEⁱ	Q9BW30
ProteomicsDBⁱ	79252

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51673
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000290942; ENSP00000290942; ENSG00000159713 ENST00000393957; ENSP00000377529; ENSG00000159713 ENST00000562206; ENSP00000457275; ENSG00000159713 ENST00000564104; ENSP00000462435; ENSG00000159713
GeneIDⁱ	51673
KEGGⁱ	hsa:51673
UCSC genome browser More...UCSCⁱ	uc002esz.5 human

Organism-specific databases

CTDⁱ	51673
DisGeNET More...DisGeNETⁱ	51673
EuPathDBⁱ	HostDB:ENSG00000159713.10
GeneCardsⁱ	TPPP3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24162 TPPP3
Human Protein Atlas More...HPAⁱ	HPA047629
MIMⁱ	616957 gene
neXtProtⁱ	NX_Q9BW30
Open Targets More...OpenTargetsⁱ	ENSG00000159713
PharmGKBⁱ	PA162406823
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4070 Eukaryota ENOG4111H9J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014993
HOGENOMⁱ	HOG000260314
HOVERGENⁱ	HBG036683
InParanoidⁱ	Q9BW30
OMAⁱ	EPTNVGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PC4
PhylomeDBⁱ	Q9BW30
TreeFamⁱ	TF314440

Miscellaneous databases

ChiTaRSⁱ	TPPP3 human
EvolutionaryTraceⁱ	Q9BW30
GenomeRNAiⁱ	51673
Protein Ontology More...PROⁱ	PR:Q9BW30
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159713
CleanExⁱ	HS_TPPP3
ExpressionAtlasⁱ	Q9BW30 baseline and differential
Genevisibleⁱ	Q9BW30 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR008907 P25-alpha IPR030795 TPPP3
PANTHERⁱ	PTHR12932 PTHR12932, 1 hit PTHR12932:SF16 PTHR12932:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05517 p25-alpha, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPPP3_HUMAN
Accessionⁱ	Q9BW30Primary (citable) accession number: Q9BW30 Secondary accession number(s): Q49AH9, Q9Y326, Q9Y6H0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
	Last sequence update:	June 1, 2001
	Last modified:	June 20, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BW30 (TPPP3_HUMAN)

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Tubulin polymerization-promoting protein family member 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ