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Protein

Tubulin polymerization-promoting protein family member 3

Gene

TPPP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.2 Publications

GO - Molecular functioni

  • tubulin binding Source: UniProtKB

GO - Biological processi

  • microtubule bundle formation Source: UniProtKB
  • microtubule polymerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polymerization-promoting protein family member 3
Alternative name(s):
TPPP/p20
Gene namesi
Name:TPPP3
ORF Names:CGI-38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24162. TPPP3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi51673.
OpenTargetsiENSG00000159713.
PharmGKBiPA162406823.

Polymorphism and mutation databases

DMDMi28380040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002211382 – 176Tubulin polymerization-promoting protein family member 3Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BW30.
PaxDbiQ9BW30.
PeptideAtlasiQ9BW30.
PRIDEiQ9BW30.

PTM databases

iPTMnetiQ9BW30.
PhosphoSitePlusiQ9BW30.

Expressioni

Gene expression databases

BgeeiENSG00000159713.
CleanExiHS_TPPP3.
ExpressionAtlasiQ9BW30. baseline and differential.
GenevisibleiQ9BW30. HS.

Organism-specific databases

HPAiHPA047629.

Interactioni

GO - Molecular functioni

  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119673. 1 interactor.
STRINGi9606.ENSP00000290942.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Helixi9 – 18Combined sources10
Beta strandi19 – 21Combined sources3
Beta strandi28 – 31Combined sources4
Helixi32 – 41Combined sources10
Beta strandi47 – 50Combined sources4
Helixi52 – 62Combined sources11
Beta strandi68 – 71Combined sources4
Helixi72 – 86Combined sources15
Helixi92 – 101Combined sources10
Turni102 – 105Combined sources4
Beta strandi108 – 112Combined sources5
Beta strandi126 – 129Combined sources4
Beta strandi141 – 143Combined sources3
Turni146 – 150Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRFNMR-A1-176[»]
ProteinModelPortaliQ9BW30.
SMRiQ9BW30.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BW30.

Family & Domainsi

Sequence similaritiesi

Belongs to the TPPP family.Curated

Phylogenomic databases

eggNOGiKOG4070. Eukaryota.
ENOG4111H9J. LUCA.
GeneTreeiENSGT00390000014993.
HOGENOMiHOG000260314.
HOVERGENiHBG036683.
InParanoidiQ9BW30.
OMAiKSGRENI.
OrthoDBiEOG091G0PC4.
PhylomeDBiQ9BW30.
TreeFamiTF314440.

Family and domain databases

InterProiIPR011992. EF-hand-dom_pair.
IPR008907. P25-alpha.
IPR030795. TPPP3.
[Graphical view]
PANTHERiPTHR12932. PTHR12932. 1 hit.
PTHR12932:SF16. PTHR12932:SF16. 1 hit.
PfamiPF05517. p25-alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BW30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTDMAGL EESFRKFAIH GDPKASGQEM NGKNWAKLCK DCKVADGKSV
60 70 80 90 100
TGTDVDIVFS KVKGKSARVI NYEEFKKALE ELATKRFKGK SKEEAFDAIC
110 120 130 140 150
QLVAGKEPAN VGVTKAKTGG AVDRLTDTSR YTGSHKERFD ESGKGKGIAG
160 170
RQDILDDSGY VSAYKNAGTY DAKVKK
Length:176
Mass (Da):18,985
Last modified:June 1, 2001 - v1
Checksum:i20EA146E93FB1ADF
GO

Sequence cautioni

The sequence AAD44478 differs from that shown. Reason: Frameshift at positions 52, 77, 83 and 89.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7M → I in AAD44478 (PubMed:10931946).Curated1
Sequence conflicti10 – 11LE → PK in AAD44478 (PubMed:10931946).Curated2
Sequence conflicti52 – 54GTD → TP in AAD44478 (PubMed:10931946).Curated3
Sequence conflicti88K → G in AAD44478 (PubMed:10931946).Curated1
Sequence conflicti88K → Q in AAD27747 (PubMed:10810093).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132972 mRNA. Translation: AAD27747.1.
AF078846 mRNA. Translation: AAD44478.1. Frameshift.
BC000691 mRNA. Translation: AAH00691.1.
CCDSiCCDS10835.1.
RefSeqiNP_057048.2. NM_015964.3.
NP_057224.2. NM_016140.3.
UniGeneiHs.534458.

Genome annotation databases

EnsembliENST00000290942; ENSP00000290942; ENSG00000159713.
ENST00000393957; ENSP00000377529; ENSG00000159713.
ENST00000562206; ENSP00000457275; ENSG00000159713.
ENST00000564104; ENSP00000462435; ENSG00000159713.
GeneIDi51673.
KEGGihsa:51673.
UCSCiuc002esz.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132972 mRNA. Translation: AAD27747.1.
AF078846 mRNA. Translation: AAD44478.1. Frameshift.
BC000691 mRNA. Translation: AAH00691.1.
CCDSiCCDS10835.1.
RefSeqiNP_057048.2. NM_015964.3.
NP_057224.2. NM_016140.3.
UniGeneiHs.534458.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRFNMR-A1-176[»]
ProteinModelPortaliQ9BW30.
SMRiQ9BW30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119673. 1 interactor.
STRINGi9606.ENSP00000290942.

PTM databases

iPTMnetiQ9BW30.
PhosphoSitePlusiQ9BW30.

Polymorphism and mutation databases

DMDMi28380040.

Proteomic databases

MaxQBiQ9BW30.
PaxDbiQ9BW30.
PeptideAtlasiQ9BW30.
PRIDEiQ9BW30.

Protocols and materials databases

DNASUi51673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290942; ENSP00000290942; ENSG00000159713.
ENST00000393957; ENSP00000377529; ENSG00000159713.
ENST00000562206; ENSP00000457275; ENSG00000159713.
ENST00000564104; ENSP00000462435; ENSG00000159713.
GeneIDi51673.
KEGGihsa:51673.
UCSCiuc002esz.5. human.

Organism-specific databases

CTDi51673.
DisGeNETi51673.
GeneCardsiTPPP3.
HGNCiHGNC:24162. TPPP3.
HPAiHPA047629.
MIMi616957. gene.
neXtProtiNX_Q9BW30.
OpenTargetsiENSG00000159713.
PharmGKBiPA162406823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4070. Eukaryota.
ENOG4111H9J. LUCA.
GeneTreeiENSGT00390000014993.
HOGENOMiHOG000260314.
HOVERGENiHBG036683.
InParanoidiQ9BW30.
OMAiKSGRENI.
OrthoDBiEOG091G0PC4.
PhylomeDBiQ9BW30.
TreeFamiTF314440.

Miscellaneous databases

ChiTaRSiTPPP3. human.
EvolutionaryTraceiQ9BW30.
GenomeRNAii51673.
PROiQ9BW30.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159713.
CleanExiHS_TPPP3.
ExpressionAtlasiQ9BW30. baseline and differential.
GenevisibleiQ9BW30. HS.

Family and domain databases

InterProiIPR011992. EF-hand-dom_pair.
IPR008907. P25-alpha.
IPR030795. TPPP3.
[Graphical view]
PANTHERiPTHR12932. PTHR12932. 1 hit.
PTHR12932:SF16. PTHR12932:SF16. 1 hit.
PfamiPF05517. p25-alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPPP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BW30
Secondary accession number(s): Q49AH9, Q9Y326, Q9Y6H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.