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Q9BW19

- KIFC1_HUMAN

UniProt

Q9BW19 - KIFC1_HUMAN

Protein

Kinesin-like protein KIFC1

Gene

KIFC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi410 – 4178ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. microtubule motor activity Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. metabolic process Source: GOC
    3. microtubule-based movement Source: Reactome
    4. mitotic sister chromatid segregation Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_25201. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIFC1
    Alternative name(s):
    Kinesin-like protein 2
    Kinesin-related protein HSET
    Gene namesi
    Name:KIFC1
    Synonyms:HSET, KNSL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6389. KIFC1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Early endosome By similarity
    Note: Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. kinesin complex Source: InterPro
    3. membrane Source: UniProtKB
    4. microtubule Source: UniProtKB-KW
    5. microtubule organizing center Source: UniProtKB-SubCell
    6. nucleus Source: UniProtKB-SubCell
    7. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30178.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 673673Kinesin-like protein KIFC1PRO_0000125428Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BW19.
    PaxDbiQ9BW19.
    PeptideAtlasiQ9BW19.
    PRIDEiQ9BW19.

    PTM databases

    PhosphoSiteiQ9BW19.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BW19.
    BgeeiQ9BW19.
    CleanExiHS_KIFC1.
    GenevestigatoriQ9BW19.

    Organism-specific databases

    HPAiHPA055997.

    Interactioni

    Subunit structurei

    Binds NUBP1 and NUBP2. Interacts with PPP1R42 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi110031. 5 interactions.
    IntActiQ9BW19. 5 interactions.
    MINTiMINT-3062538.

    Structurei

    Secondary structure

    1
    673
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi311 – 3177
    Helixi329 – 3313
    Beta strandi347 – 3493
    Beta strandi371 – 3733
    Beta strandi375 – 3784
    Helixi384 – 39613
    Helixi397 – 4004
    Beta strandi404 – 4096
    Helixi416 – 4205
    Helixi428 – 4303
    Helixi433 – 44715
    Helixi448 – 4514
    Beta strandi453 – 46513
    Beta strandi468 – 4714
    Beta strandi487 – 4893
    Beta strandi497 – 4993
    Beta strandi505 – 5073
    Helixi510 – 52617
    Helixi535 – 5373
    Beta strandi538 – 55316
    Beta strandi556 – 56510
    Helixi596 – 60712
    Helixi615 – 6173
    Helixi619 – 6235
    Helixi625 – 6273
    Beta strandi633 – 6408
    Helixi644 – 6463
    Helixi647 – 66014

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2REPX-ray2.60A307-663[»]
    ProteinModelPortaliQ9BW19.
    SMRiQ9BW19. Positions 138-167, 193-661.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BW19.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini310 – 663354Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili142 – 306165Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOVERGENiHBG001080.
    InParanoidiQ9BW19.
    KOiK10405.
    OMAiQISGEHS.
    PhylomeDBiQ9BW19.
    TreeFamiTF105237.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BW19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK    50
    KRTRGLGATT KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA 100
    TGLKNQKPVP AVPVQKSGTS GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL 150
    KRCRERTQTL DQENQQLQDQ LRDAQQQVKA LGTERTTLEG HLAKVQAQAE 200
    QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE RRGLMSQLEE 250
    KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL 300
    HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL 350
    SRSDERRGTL SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD 400
    GYPVCIFAYG QTGSGKTFTM EGGPGGDPQL EGLIPRALRH LFSVAQELSG 450
    QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGGECEIRRA GPGSEELTVT 500
    NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS VFQLQISGEH 550
    SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG 600
    LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES 650
    LNSLRFASKV NQCVIGTAQA NRK 673
    Length:673
    Mass (Da):73,748
    Last modified:January 23, 2002 - v2
    Checksum:i9E99737665BF1E92
    GO

    Sequence cautioni

    The sequence BAA03509.1 differs from that shown. Reason: Frameshift at positions 223 and 256.
    The sequence AAH00712.2 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH63567.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH73878.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH98438.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti368 – 3681T → P in AAH00712. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti219 – 2191R → Q.1 Publication
    VAR_012650

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010479 mRNA. Translation: CAA09217.1.
    AL021366 Genomic DNA. Translation: CAA16157.1.
    AL050332 Genomic DNA. Translation: CAB63782.1.
    AL662799 Genomic DNA. Translation: CAI18269.1.
    BX088650 Genomic DNA. Translation: CAM26294.1.
    BX248088 Genomic DNA. Translation: CAI41792.1.
    BC000712 mRNA. Translation: AAH00712.2. Different initiation.
    BC063567 mRNA. Translation: AAH63567.1. Different initiation.
    BC073878 mRNA. Translation: AAH73878.1. Different initiation.
    BC098438 mRNA. Translation: AAH98438.1. Different initiation.
    BC121041 mRNA. Translation: AAI21042.1.
    BC121042 mRNA. Translation: AAI21043.1.
    D14678 mRNA. Translation: BAA03509.1. Frameshift.
    CCDSiCCDS34430.1.
    PIRiI54523.
    RefSeqiNP_002254.2. NM_002263.3.
    UniGeneiHs.436912.

    Genome annotation databases

    EnsembliENST00000374523; ENSP00000363647; ENSG00000204197.
    ENST00000428849; ENSP00000393963; ENSG00000237649.
    ENST00000448818; ENSP00000407885; ENSG00000233450.
    GeneIDi3833.
    KEGGihsa:3833.
    UCSCiuc003oef.4. human.

    Polymorphism databases

    DMDMi20138710.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010479 mRNA. Translation: CAA09217.1 .
    AL021366 Genomic DNA. Translation: CAA16157.1 .
    AL050332 Genomic DNA. Translation: CAB63782.1 .
    AL662799 Genomic DNA. Translation: CAI18269.1 .
    BX088650 Genomic DNA. Translation: CAM26294.1 .
    BX248088 Genomic DNA. Translation: CAI41792.1 .
    BC000712 mRNA. Translation: AAH00712.2 . Different initiation.
    BC063567 mRNA. Translation: AAH63567.1 . Different initiation.
    BC073878 mRNA. Translation: AAH73878.1 . Different initiation.
    BC098438 mRNA. Translation: AAH98438.1 . Different initiation.
    BC121041 mRNA. Translation: AAI21042.1 .
    BC121042 mRNA. Translation: AAI21043.1 .
    D14678 mRNA. Translation: BAA03509.1 . Frameshift.
    CCDSi CCDS34430.1.
    PIRi I54523.
    RefSeqi NP_002254.2. NM_002263.3.
    UniGenei Hs.436912.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2REP X-ray 2.60 A 307-663 [» ]
    ProteinModelPortali Q9BW19.
    SMRi Q9BW19. Positions 138-167, 193-661.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110031. 5 interactions.
    IntActi Q9BW19. 5 interactions.
    MINTi MINT-3062538.

    PTM databases

    PhosphoSitei Q9BW19.

    Polymorphism databases

    DMDMi 20138710.

    Proteomic databases

    MaxQBi Q9BW19.
    PaxDbi Q9BW19.
    PeptideAtlasi Q9BW19.
    PRIDEi Q9BW19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374523 ; ENSP00000363647 ; ENSG00000204197 .
    ENST00000428849 ; ENSP00000393963 ; ENSG00000237649 .
    ENST00000448818 ; ENSP00000407885 ; ENSG00000233450 .
    GeneIDi 3833.
    KEGGi hsa:3833.
    UCSCi uc003oef.4. human.

    Organism-specific databases

    CTDi 3833.
    GeneCardsi GC06P033359.
    GC06Pn33288.
    GC06Po33498.
    HGNCi HGNC:6389. KIFC1.
    HPAi HPA055997.
    MIMi 603763. gene.
    neXtProti NX_Q9BW19.
    PharmGKBi PA30178.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOVERGENi HBG001080.
    InParanoidi Q9BW19.
    KOi K10405.
    OMAi QISGEHS.
    PhylomeDBi Q9BW19.
    TreeFami TF105237.

    Enzyme and pathway databases

    Reactomei REACT_25201. Kinesins.

    Miscellaneous databases

    EvolutionaryTracei Q9BW19.
    GeneWikii KIFC1.
    GenomeRNAii 3833.
    NextBioi 15065.
    PROi Q9BW19.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BW19.
    Bgeei Q9BW19.
    CleanExi HS_KIFC1.
    Genevestigatori Q9BW19.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)."
      Janitz K., Wild A., Beck S., Savasta S., Beluffi G., Ziegler A., Volz A.
      Immunogenetics 49:644-652(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-219.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Kidney, Muscle and Uterus.
    4. "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region."
      Ando A., Yara-Kikuti Y., Kawata H., Okamoto N., Imai T., Eki T., Yokoyama K., Soeda E., Ikemura T., Abe K., Inoko H.
      Immunogenetics 39:194-200(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-673.
      Tissue: Testis.
    5. "Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference."
      Zhu C., Zhao J., Bibikova M., Leverson J.D., Bossy-Wetzel E., Fan J.-B., Abraham R.T., Jiang W.
      Mol. Biol. Cell 16:3187-3199(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKIFC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BW19
    Secondary accession number(s): O60887
    , Q14834, Q4KMP0, Q5SU09, Q6GMS7, Q6P4A5, Q9UQP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3