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Protein

Kinesin-like protein KIFC1

Gene

KIFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi410 – 417ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB
  • microtubule motor activity Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule-based movement Source: GO_Central
  • mitotic metaphase plate congression Source: UniProtKB
  • mitotic sister chromatid segregation Source: UniProtKB
  • mitotic spindle assembly Source: UniProtKB
  • spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000056678-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC1
Alternative name(s):
Kinesin-like protein 2
Kinesin-related protein HSET
Gene namesi
Name:KIFC1
Synonyms:HSET, KNSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6389. KIFC1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
  • Cytoplasmcytoskeletonspindle By similarity
  • Early endosome By similarity

  • Note: Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.By similarity

GO - Cellular componenti

  • early endosome Source: UniProtKB-SubCell
  • kinesin complex Source: GO_Central
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • microtubule organizing center Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3833.
OpenTargetsiENSG00000204197.
ENSG00000233450.
ENSG00000237649.
PharmGKBiPA30178.

Chemistry databases

ChEMBLiCHEMBL3351200.

Polymorphism and mutation databases

BioMutaiKIFC1.
DMDMi20138710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254281 – 673Kinesin-like protein KIFC1Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei359PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BW19.
MaxQBiQ9BW19.
PaxDbiQ9BW19.
PeptideAtlasiQ9BW19.
PRIDEiQ9BW19.

PTM databases

iPTMnetiQ9BW19.
PhosphoSitePlusiQ9BW19.

Expressioni

Gene expression databases

BgeeiENSG00000204197.
CleanExiHS_KIFC1.
ExpressionAtlasiQ9BW19. baseline and differential.
GenevisibleiQ9BW19. HS.

Organism-specific databases

HPAiHPA055997.
HPA062674.

Interactioni

Subunit structurei

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).By similarity

Protein-protein interaction databases

BioGridi110031. 17 interactors.
IntActiQ9BW19. 11 interactors.
MINTiMINT-3062538.
STRINGi9606.ENSP00000393963.

Chemistry databases

BindingDBiQ9BW19.

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi311 – 317Combined sources7
Helixi329 – 331Combined sources3
Beta strandi347 – 349Combined sources3
Beta strandi371 – 373Combined sources3
Beta strandi375 – 378Combined sources4
Helixi384 – 396Combined sources13
Helixi397 – 400Combined sources4
Beta strandi404 – 409Combined sources6
Helixi416 – 420Combined sources5
Helixi428 – 430Combined sources3
Helixi433 – 447Combined sources15
Helixi448 – 451Combined sources4
Beta strandi453 – 465Combined sources13
Beta strandi468 – 471Combined sources4
Beta strandi487 – 489Combined sources3
Beta strandi497 – 499Combined sources3
Beta strandi505 – 507Combined sources3
Helixi510 – 526Combined sources17
Helixi535 – 537Combined sources3
Beta strandi538 – 553Combined sources16
Beta strandi556 – 565Combined sources10
Helixi596 – 607Combined sources12
Helixi615 – 617Combined sources3
Helixi619 – 623Combined sources5
Helixi625 – 627Combined sources3
Beta strandi633 – 640Combined sources8
Helixi644 – 646Combined sources3
Helixi647 – 660Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2REPX-ray2.60A307-663[»]
ProteinModelPortaliQ9BW19.
SMRiQ9BW19.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BW19.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 663Kinesin motorPROSITE-ProRule annotationAdd BLAST354

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili142 – 306Sequence analysisAdd BLAST165

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOVERGENiHBG001080.
InParanoidiQ9BW19.
KOiK10405.
OMAiWQETAAQ.
OrthoDBiEOG091G0DJX.
PhylomeDBiQ9BW19.
TreeFamiTF105237.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BW19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK
60 70 80 90 100
KRTRGLGATT KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA
110 120 130 140 150
TGLKNQKPVP AVPVQKSGTS GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL
160 170 180 190 200
KRCRERTQTL DQENQQLQDQ LRDAQQQVKA LGTERTTLEG HLAKVQAQAE
210 220 230 240 250
QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE RRGLMSQLEE
260 270 280 290 300
KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL
310 320 330 340 350
HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL
360 370 380 390 400
SRSDERRGTL SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD
410 420 430 440 450
GYPVCIFAYG QTGSGKTFTM EGGPGGDPQL EGLIPRALRH LFSVAQELSG
460 470 480 490 500
QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGGECEIRRA GPGSEELTVT
510 520 530 540 550
NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS VFQLQISGEH
560 570 580 590 600
SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG
610 620 630 640 650
LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES
660 670
LNSLRFASKV NQCVIGTAQA NRK
Length:673
Mass (Da):73,748
Last modified:January 23, 2002 - v2
Checksum:i9E99737665BF1E92
GO

Sequence cautioni

The sequence AAH00712 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH63567 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH73878 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH98438 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA03509 differs from that shown. Reason: Frameshift at positions 223 and 256.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368T → P in AAH00712 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012650219R → Q.1 PublicationCorresponds to variant rs61736175dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010479 mRNA. Translation: CAA09217.1.
AL021366 Genomic DNA. Translation: CAA16157.1.
AL050332 Genomic DNA. Translation: CAB63782.1.
AL662799 Genomic DNA. Translation: CAI18269.1.
BX088650 Genomic DNA. Translation: CAM26294.1.
BX248088 Genomic DNA. Translation: CAI41792.1.
BC000712 mRNA. Translation: AAH00712.2. Different initiation.
BC063567 mRNA. Translation: AAH63567.1. Different initiation.
BC073878 mRNA. Translation: AAH73878.1. Different initiation.
BC098438 mRNA. Translation: AAH98438.1. Different initiation.
BC121041 mRNA. Translation: AAI21042.1.
BC121042 mRNA. Translation: AAI21043.1.
D14678 mRNA. Translation: BAA03509.1. Frameshift.
CCDSiCCDS34430.1.
PIRiI54523.
RefSeqiNP_002254.2. NM_002263.3.
UniGeneiHs.436912.

Genome annotation databases

EnsembliENST00000374523; ENSP00000363647; ENSG00000204197.
ENST00000428849; ENSP00000393963; ENSG00000237649.
ENST00000448818; ENSP00000407885; ENSG00000233450.
GeneIDi3833.
KEGGihsa:3833.
UCSCiuc003oef.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010479 mRNA. Translation: CAA09217.1.
AL021366 Genomic DNA. Translation: CAA16157.1.
AL050332 Genomic DNA. Translation: CAB63782.1.
AL662799 Genomic DNA. Translation: CAI18269.1.
BX088650 Genomic DNA. Translation: CAM26294.1.
BX248088 Genomic DNA. Translation: CAI41792.1.
BC000712 mRNA. Translation: AAH00712.2. Different initiation.
BC063567 mRNA. Translation: AAH63567.1. Different initiation.
BC073878 mRNA. Translation: AAH73878.1. Different initiation.
BC098438 mRNA. Translation: AAH98438.1. Different initiation.
BC121041 mRNA. Translation: AAI21042.1.
BC121042 mRNA. Translation: AAI21043.1.
D14678 mRNA. Translation: BAA03509.1. Frameshift.
CCDSiCCDS34430.1.
PIRiI54523.
RefSeqiNP_002254.2. NM_002263.3.
UniGeneiHs.436912.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2REPX-ray2.60A307-663[»]
ProteinModelPortaliQ9BW19.
SMRiQ9BW19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110031. 17 interactors.
IntActiQ9BW19. 11 interactors.
MINTiMINT-3062538.
STRINGi9606.ENSP00000393963.

Chemistry databases

BindingDBiQ9BW19.
ChEMBLiCHEMBL3351200.

PTM databases

iPTMnetiQ9BW19.
PhosphoSitePlusiQ9BW19.

Polymorphism and mutation databases

BioMutaiKIFC1.
DMDMi20138710.

Proteomic databases

EPDiQ9BW19.
MaxQBiQ9BW19.
PaxDbiQ9BW19.
PeptideAtlasiQ9BW19.
PRIDEiQ9BW19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374523; ENSP00000363647; ENSG00000204197.
ENST00000428849; ENSP00000393963; ENSG00000237649.
ENST00000448818; ENSP00000407885; ENSG00000233450.
GeneIDi3833.
KEGGihsa:3833.
UCSCiuc003oef.5. human.

Organism-specific databases

CTDi3833.
DisGeNETi3833.
GeneCardsiKIFC1.
HGNCiHGNC:6389. KIFC1.
HPAiHPA055997.
HPA062674.
MIMi603763. gene.
neXtProtiNX_Q9BW19.
OpenTargetsiENSG00000204197.
ENSG00000233450.
ENSG00000237649.
PharmGKBiPA30178.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOVERGENiHBG001080.
InParanoidiQ9BW19.
KOiK10405.
OMAiWQETAAQ.
OrthoDBiEOG091G0DJX.
PhylomeDBiQ9BW19.
TreeFamiTF105237.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000056678-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIFC1. human.
EvolutionaryTraceiQ9BW19.
GeneWikiiKIFC1.
GenomeRNAii3833.
PROiQ9BW19.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204197.
CleanExiHS_KIFC1.
ExpressionAtlasiQ9BW19. baseline and differential.
GenevisibleiQ9BW19. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIFC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW19
Secondary accession number(s): O60887
, Q14834, Q4KMP0, Q5SU09, Q6GMS7, Q6P4A5, Q9UQP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 30, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.