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Protein

Kinesin-like protein KIFC1

Gene

KIFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).HMP:1 Publication

Miscellaneous

HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi410 – 417ATPIEP:8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC1
Alternative name(s):
Kinesin-like protein 2
Kinesin-related protein HSET
Gene namesi
Name:KIFC1
Synonyms:HSET, KNSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000237649.7.
HGNCiHGNC:6389. KIFC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3833.
OpenTargetsiENSG00000237649.
PharmGKBiPA30178.

Chemistry databases

ChEMBLiCHEMBL3351200.

Polymorphism and mutation databases

BioMutaiKIFC1.
DMDMi20138710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254281 – 673Kinesin-like protein KIFC1Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineND:1
Modified residuei26PhosphoserineND:1
Modified residuei31PhosphoserineND:1
Modified residuei33PhosphoserineND:1
Modified residuei359PhosphothreonineND:1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BW19.
MaxQBiQ9BW19.
PaxDbiQ9BW19.
PeptideAtlasiQ9BW19.
PRIDEiQ9BW19.

PTM databases

iPTMnetiQ9BW19.
PhosphoSitePlusiQ9BW19.

Expressioni

Gene expression databases

BgeeiENSG00000237649.
CleanExiHS_KIFC1.
ExpressionAtlasiQ9BW19. baseline and differential.
GenevisibleiQ9BW19. HS.

Organism-specific databases

HPAiHPA055997.
HPA062674.

Interactioni

Subunit structurei

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).HMP:

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110031. 19 interactors.
IntActiQ9BW19. 12 interactors.
MINTiMINT-3062538.
STRINGi9606.ENSP00000393963.

Chemistry databases

BindingDBiQ9BW19.

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi311 – 317ND:7
Beta strandi331 – 333ND:3
Beta strandi347 – 350ND:4
Beta strandi371 – 373ND:3
Beta strandi375 – 378ND:4
Helixi384 – 389ND:6
Helixi392 – 396ND:5
Helixi397 – 400ND:4
Beta strandi404 – 411ND:8
Helixi416 – 420ND:5
Helixi428 – 430ND:3
Helixi433 – 449ND:17
Turni450 – 452ND:3
Beta strandi453 – 465ND:13
Beta strandi468 – 471ND:4
Beta strandi487 – 489ND:3
Beta strandi497 – 499ND:3
Helixi510 – 526ND:17
Helixi535 – 537ND:3
Beta strandi538 – 554ND:17
Beta strandi556 – 565ND:10
Helixi596 – 607ND:12
Helixi615 – 617ND:3
Helixi619 – 624ND:6
Helixi625 – 627ND:3
Beta strandi633 – 640ND:8
Helixi644 – 646ND:3
Helixi647 – 662ND:16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WDHX-ray2.25A307-663[»]
ProteinModelPortaliQ9BW19.
SMRiQ9BW19.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BW19.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 663Kinesin motorIEP:Add BLAST354

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili142 – 306IEP:Add BLAST165

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOVERGENiHBG001080.
InParanoidiQ9BW19.
KOiK10405.
OMAiYNEVLYD.
OrthoDBiEOG091G0DJX.
PhylomeDBiQ9BW19.
TreeFamiTF105237.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR036961. Kinesin_motor_dom_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BW19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK
60 70 80 90 100
KRTRGLGATT KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA
110 120 130 140 150
TGLKNQKPVP AVPVQKSGTS GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL
160 170 180 190 200
KRCRERTQTL DQENQQLQDQ LRDAQQQVKA LGTERTTLEG HLAKVQAQAE
210 220 230 240 250
QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE RRGLMSQLEE
260 270 280 290 300
KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL
310 320 330 340 350
HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL
360 370 380 390 400
SRSDERRGTL SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD
410 420 430 440 450
GYPVCIFAYG QTGSGKTFTM EGGPGGDPQL EGLIPRALRH LFSVAQELSG
460 470 480 490 500
QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGGECEIRRA GPGSEELTVT
510 520 530 540 550
NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS VFQLQISGEH
560 570 580 590 600
SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG
610 620 630 640 650
LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES
660 670
LNSLRFASKV NQCVIGTAQA NRK
Length:673
Mass (Da):73,748
Last modified:January 23, 2002 - v2
Checksum:i9E99737665BF1E92
GO

Sequence cautioni

The sequence AAH00712 differs from that shown. Reason: Erroneous initiation.IKR:
The sequence AAH63567 differs from that shown. Reason: Erroneous initiation.IKR:
The sequence AAH73878 differs from that shown. Reason: Erroneous initiation.IKR:
The sequence AAH98438 differs from that shown. Reason: Erroneous initiation.IKR:
The sequence BAA03509 differs from that shown. Reason: Frameshift at positions 223 and 256.IKR:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368T → P in AAH00712 (PubMed:15489334).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012650219R → Q1 PublicationCorresponds to variant dbSNP:rs61736175Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010479 mRNA. Translation: CAA09217.1.
AL021366 Genomic DNA. Translation: CAA16157.1.
AL050332 Genomic DNA. Translation: CAB63782.1.
AL662799 Genomic DNA. No translation available.
BX088650 Genomic DNA. No translation available.
BX248088 Genomic DNA. No translation available.
BC000712 mRNA. Translation: AAH00712.2. Different initiation.
BC063567 mRNA. Translation: AAH63567.1. Different initiation.
BC073878 mRNA. Translation: AAH73878.1. Different initiation.
BC098438 mRNA. Translation: AAH98438.1. Different initiation.
BC121041 mRNA. Translation: AAI21042.1.
BC121042 mRNA. Translation: AAI21043.1.
D14678 mRNA. Translation: BAA03509.1. Frameshift.
CCDSiCCDS34430.1.
PIRiI54523.
RefSeqiNP_002254.2. NM_002263.3.
UniGeneiHs.436912.

Genome annotation databases

EnsembliENST00000374523; ENSP00000363647; ENSG00000204197.
ENST00000428849; ENSP00000393963; ENSG00000237649.
ENST00000448818; ENSP00000407885; ENSG00000233450.
GeneIDi3833.
KEGGihsa:3833.
UCSCiuc003oef.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKIFC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW19
Secondary accession number(s): O60887
, Q14834, Q4KMP0, Q5SU09, Q6GMS7, Q6P4A5, Q9UQP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 22, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families