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Protein

Specifically androgen-regulated gene protein

Gene

SARG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative androgen-specific receptor.1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Specifically androgen-regulated gene protein
Gene namesi
Name:SARG
Synonyms:C1orf116
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28667. C1orf116.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672500.

Polymorphism and mutation databases

BioMutaiSARG.
DMDMi296452897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Specifically androgen-regulated gene proteinPRO_0000318575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei519 – 5191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BW04.
MaxQBiQ9BW04.
PaxDbiQ9BW04.
PeptideAtlasiQ9BW04.
PRIDEiQ9BW04.

PTM databases

iPTMnetiQ9BW04.
PhosphoSiteiQ9BW04.

Expressioni

Tissue specificityi

Highly expressed in prostate.1 Publication

Inductioni

Expression is up-regulated by androgen, but not by glucocorticoids.

Gene expression databases

BgeeiQ9BW04.
CleanExiHS_C1orf116.
GenevisibleiQ9BW04. HS.

Organism-specific databases

HPAiHPA011888.
HPA011889.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HOMER1Q86YM74EBI-2320464,EBI-746815

Protein-protein interaction databases

BioGridi122545. 4 interactions.
IntActiQ9BW04. 3 interactions.
MINTiMINT-5003522.
STRINGi9606.ENSP00000352447.

Structurei

3D structure databases

ProteinModelPortaliQ9BW04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi387 – 42135Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the SARG family.Curated

Phylogenomic databases

eggNOGiENOG410IJHF. Eukaryota.
ENOG410YNWD. LUCA.
GeneTreeiENSGT00390000017874.
HOGENOMiHOG000154256.
HOVERGENiHBG108458.
InParanoidiQ9BW04.
OMAiSCDSMMS.
OrthoDBiEOG7WDN3B.
PhylomeDBiQ9BW04.
TreeFamiTF336615.

Family and domain databases

InterProiIPR026152. SARG.
[Graphical view]
PANTHERiPTHR21555. PTHR21555. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9BW04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPERELWPAG TGSEPVTRVG SCDSMMSSTS TRSGSSDSSY DFLSTEEKEC
60 70 80 90 100
LLFLEETIGS LDTEADSGLS TDESEPATTP RGFRALPITQ PTPRGGPEET
110 120 130 140 150
ITQQGRTPRT VTESSSSHPP EPQGLGLRSG SYSLPRNIHI ARSQNFRKST
160 170 180 190 200
TQASSHNPGE PGRLAPEPEK EQVSQSSQPR QAPASPQEAA LDLDVVLIPP
210 220 230 240 250
PEAFRDTQPE QCREASLPEG PGQQGHTPQL HTPSSSQERE QTPSEAMSQK
260 270 280 290 300
AKETVSTRYT QPQPPPAGLP QNARAEDAPL SSGEDPNSRL APLTTPKPRK
310 320 330 340 350
LPPNIVLKSS RSSFHSDPQH WLSRHTEAAP GDSGLISCSL QEQRKARKEA
360 370 380 390 400
LEKLGLPQDQ DEPGLHLSKP TSSIRPKETR AQHLSPAPGL AQPAAPAQAS
410 420 430 440 450
AAIPAAGKAL AQAPAPAPGP AQGPLPMKSP APGNVAASKS MPISIPKAPR
460 470 480 490 500
ANSALTPPKP ESGLTLQESN TPGLRQMNFK SNTLERSGVG LSSYLSTEKD
510 520 530 540 550
ASPKTSTSLG KGSFLDKISP SVLRNSRPRP ASLGTGKDFA GIQVGKLADL
560 570 580 590 600
EQEQSSKRLS YQGQSRDKLP RPPCVSVKIS PKGVPNEHRR EALKKLGLLK

E
Length:601
Mass (Da):63,964
Last modified:May 18, 2010 - v2
Checksum:i01CEBFF2712332AC
GO
Isoform 2 (identifier: Q9BW04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.

Show »
Length:355
Mass (Da):37,524
Checksum:i15F820E4F4EF2AE1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871P → S.
Corresponds to variant rs706846 [ dbSNP | Ensembl ].
VAR_038775
Natural varianti107 – 1071T → A.
Corresponds to variant rs35299018 [ dbSNP | Ensembl ].
VAR_038776
Natural varianti157 – 1571N → T.
Corresponds to variant rs34660159 [ dbSNP | Ensembl ].
VAR_038777
Natural varianti258 – 2581R → G.
Corresponds to variant rs12062114 [ dbSNP | Ensembl ].
VAR_038778
Natural varianti434 – 4341N → S.
Corresponds to variant rs35267170 [ dbSNP | Ensembl ].
VAR_038779
Natural varianti444 – 4441S → P.5 Publications
Corresponds to variant rs2842726 [ dbSNP | Ensembl ].
VAR_038780
Natural varianti514 – 5141F → S.
Corresponds to variant rs11799966 [ dbSNP | Ensembl ].
VAR_038781

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 246246Missing in isoform 2. 1 PublicationVSP_031228Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352640 mRNA. Translation: AAR11484.1.
AK093826 mRNA. Translation: BAC04233.1.
AC098935 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93511.1.
BC000765 mRNA. Translation: AAH00765.1.
AL832940 mRNA. Translation: CAH56284.1.
CCDSiCCDS1475.1. [Q9BW04-1]
CCDS44306.1. [Q9BW04-2]
RefSeqiNP_001077393.1. NM_001083924.1. [Q9BW04-2]
NP_076427.2. NM_023938.5. [Q9BW04-1]
XP_005273316.1. XM_005273259.1. [Q9BW04-2]
XP_006711593.1. XM_006711530.1. [Q9BW04-1]
XP_011508275.1. XM_011509973.1. [Q9BW04-2]
UniGeneiHs.32417.

Genome annotation databases

EnsembliENST00000359470; ENSP00000352447; ENSG00000182795. [Q9BW04-1]
ENST00000461135; ENSP00000436862; ENSG00000182795. [Q9BW04-2]
GeneIDi79098.
KEGGihsa:79098.
UCSCiuc001hfd.3. human. [Q9BW04-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352640 mRNA. Translation: AAR11484.1.
AK093826 mRNA. Translation: BAC04233.1.
AC098935 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93511.1.
BC000765 mRNA. Translation: AAH00765.1.
AL832940 mRNA. Translation: CAH56284.1.
CCDSiCCDS1475.1. [Q9BW04-1]
CCDS44306.1. [Q9BW04-2]
RefSeqiNP_001077393.1. NM_001083924.1. [Q9BW04-2]
NP_076427.2. NM_023938.5. [Q9BW04-1]
XP_005273316.1. XM_005273259.1. [Q9BW04-2]
XP_006711593.1. XM_006711530.1. [Q9BW04-1]
XP_011508275.1. XM_011509973.1. [Q9BW04-2]
UniGeneiHs.32417.

3D structure databases

ProteinModelPortaliQ9BW04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122545. 4 interactions.
IntActiQ9BW04. 3 interactions.
MINTiMINT-5003522.
STRINGi9606.ENSP00000352447.

PTM databases

iPTMnetiQ9BW04.
PhosphoSiteiQ9BW04.

Polymorphism and mutation databases

BioMutaiSARG.
DMDMi296452897.

Proteomic databases

EPDiQ9BW04.
MaxQBiQ9BW04.
PaxDbiQ9BW04.
PeptideAtlasiQ9BW04.
PRIDEiQ9BW04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359470; ENSP00000352447; ENSG00000182795. [Q9BW04-1]
ENST00000461135; ENSP00000436862; ENSG00000182795. [Q9BW04-2]
GeneIDi79098.
KEGGihsa:79098.
UCSCiuc001hfd.3. human. [Q9BW04-1]

Organism-specific databases

CTDi79098.
GeneCardsiC1orf116.
H-InvDBHIX0001534.
HGNCiHGNC:28667. C1orf116.
HPAiHPA011888.
HPA011889.
MIMi611680. gene.
neXtProtiNX_Q9BW04.
PharmGKBiPA142672500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJHF. Eukaryota.
ENOG410YNWD. LUCA.
GeneTreeiENSGT00390000017874.
HOGENOMiHOG000154256.
HOVERGENiHBG108458.
InParanoidiQ9BW04.
OMAiSCDSMMS.
OrthoDBiEOG7WDN3B.
PhylomeDBiQ9BW04.
TreeFamiTF336615.

Miscellaneous databases

ChiTaRSiC1orf116. human.
GenomeRNAii79098.
NextBioi67961.
PROiQ9BW04.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BW04.
CleanExiHS_C1orf116.
GenevisibleiQ9BW04. HS.

Family and domain databases

InterProiIPR026152. SARG.
[Graphical view]
PANTHERiPTHR21555. PTHR21555. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron."
    Steketee K., Ziel-van der Made A.C., van der Korput H.A., Houtsmuller A.B., Trapman J.
    J. Mol. Endocrinol. 33:477-491(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANT PRO-444.
    Tissue: Prostatic adenocarcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-444.
    Tissue: Trachea.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-444.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-444.
    Tissue: Lung.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 224-601 (ISOFORM 1), VARIANT PRO-444.
    Tissue: Stomach.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSARG_HUMAN
AccessioniPrimary (citable) accession number: Q9BW04
Secondary accession number(s): C9JV41, Q658X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.