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Q9BVX2 (T106C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 106C
Alternative name(s):
Endoplasmic reticulum membrane protein overexpressed in cancer
Gene names
Name:TMEM106C
Synonyms:EMOC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.

Sequence similarities

Belongs to the TMEM106 family.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BVX2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BVX2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     166-184: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Transmembrane protein 106C
PRO_0000243900

Regions

Transmembrane87 – 10721Helical; Potential
Transmembrane197 – 21721Helical; Potential

Natural variations

Alternative sequence166 – 18419Missing in isoform 2.
VSP_019483
Natural variant1031V → F. Ref.4
Corresponds to variant rs35000511 [ dbSNP | Ensembl ].
VAR_052338
Natural variant1751S → F.
Corresponds to variant rs2286025 [ dbSNP | Ensembl ].
VAR_026868

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: DD54511ADFA0F280

FASTA25027,875
        10         20         30         40         50         60 
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT CLTCQGTGYI 

        70         80         90        100        110        120 
PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG LVVFFLFPHS VLVDDDGIKV 

       130        140        150        160        170        180 
VKVTFNKQDS LVILTIMATL KIRNSNFYTV AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR 

       190        200        210        220        230        240 
SEQLVNFTGK AEMGGPFSYV YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY 

       250 
VDCGGNSTAI 

« Hide

Isoform 2 [UniParc].

Checksum: 861C68A4E638DFC9
Show »

FASTA23125,789

References

« Hide 'large scale' references
[1]"EMOC, a novel stress-regulated gene, encodes an endoplasmic reticulum transmembrane protein and is overexpressed in multiple human malignancies."
Jin W., Sun Q., Rong R., He Q., Sheikh M.S., Huang Y.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PHE-103.
Tissue: Cervix and Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ020163 mRNA. Translation: AAY84826.1.
AK299154 mRNA. Translation: BAH12960.1.
AK313698 mRNA. Translation: BAG36445.1.
CH471111 Genomic DNA. Translation: EAW57965.1.
BC000854 mRNA. Translation: AAH00854.1.
BC107792 mRNA. Translation: AAI07793.1.
CCDSCCDS44867.1. [Q9BVX2-2]
CCDS8758.1. [Q9BVX2-1]
RefSeqNP_001137313.1. NM_001143841.1. [Q9BVX2-2]
NP_001137314.1. NM_001143842.1. [Q9BVX2-1]
NP_001137315.1. NM_001143843.1. [Q9BVX2-2]
NP_076961.1. NM_024056.3. [Q9BVX2-1]
UniGeneHs.596726.

3D structure databases

ProteinModelPortalQ9BVX2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122490. 2 interactions.
IntActQ9BVX2. 1 interaction.

PTM databases

PhosphoSiteQ9BVX2.

Polymorphism databases

DMDM74733372.

Proteomic databases

MaxQBQ9BVX2.
PaxDbQ9BVX2.
PRIDEQ9BVX2.

Protocols and materials databases

DNASU79022.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256686; ENSP00000256686; ENSG00000134291. [Q9BVX2-2]
ENST00000429772; ENSP00000400471; ENSG00000134291. [Q9BVX2-1]
ENST00000449758; ENSP00000402705; ENSG00000134291. [Q9BVX2-2]
ENST00000550552; ENSP00000449737; ENSG00000134291. [Q9BVX2-2]
ENST00000552561; ENSP00000446657; ENSG00000134291. [Q9BVX2-1]
GeneID79022.
KEGGhsa:79022.
UCSCuc001rqo.3. human. [Q9BVX2-2]
uc001rqp.3. human. [Q9BVX2-1]

Organism-specific databases

CTD79022.
GeneCardsGC12P048357.
HGNCHGNC:28775. TMEM106C.
HPAHPA047204.
neXtProtNX_Q9BVX2.
PharmGKBPA142670757.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41095.
HOGENOMHOG000230966.
HOVERGENHBG055025.
InParanoidQ9BVX2.
OMADCGGNST.
PhylomeDBQ9BVX2.
TreeFamTF328907.

Gene expression databases

ArrayExpressQ9BVX2.
BgeeQ9BVX2.
CleanExHS_TMEM106C.
GenevestigatorQ9BVX2.

Family and domain databases

InterProIPR009790. DUF1356_TMEM106.
[Graphical view]
PfamPF07092. DUF1356. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM106C. human.
GenomeRNAi79022.
NextBio67698.
PROQ9BVX2.

Entry information

Entry nameT106C_HUMAN
AccessionPrimary (citable) accession number: Q9BVX2
Secondary accession number(s): B2R998, B7Z5M4, Q3B761
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM