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Q9BVX2

- T106C_HUMAN

UniProt

Q9BVX2 - T106C_HUMAN

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Protein

Transmembrane protein 106C

Gene

TMEM106C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 106C
Alternative name(s):
Endoplasmic reticulum membrane protein overexpressed in cancer
Gene namesi
Name:TMEM106C
Synonyms:EMOC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:28775. TMEM106C.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Transmembrane protein 106CPRO_0000243900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9BVX2.
PaxDbiQ9BVX2.
PRIDEiQ9BVX2.

PTM databases

PhosphoSiteiQ9BVX2.

Expressioni

Gene expression databases

BgeeiQ9BVX2.
CleanExiHS_TMEM106C.
ExpressionAtlasiQ9BVX2. baseline and differential.
GenevestigatoriQ9BVX2.

Organism-specific databases

HPAiHPA047204.

Interactioni

Protein-protein interaction databases

BioGridi122490. 2 interactions.
IntActiQ9BVX2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BVX2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM106 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41095.
GeneTreeiENSGT00390000013076.
HOGENOMiHOG000230966.
HOVERGENiHBG055025.
InParanoidiQ9BVX2.
OMAiDCGGNST.
PhylomeDBiQ9BVX2.
TreeFamiTF328907.

Family and domain databases

InterProiIPR009790. DUF1356_TMEM106.
[Graphical view]
PfamiPF07092. DUF1356. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BVX2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT
60 70 80 90 100
CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG
110 120 130 140 150
LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV
160 170 180 190 200
AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR SEQLVNFTGK AEMGGPFSYV
210 220 230 240 250
YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY VDCGGNSTAI
Length:250
Mass (Da):27,875
Last modified:June 1, 2001 - v1
Checksum:iDD54511ADFA0F280
GO
Isoform 2 (identifier: Q9BVX2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-184: Missing.

Show »
Length:231
Mass (Da):25,789
Checksum:i861C68A4E638DFC9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031V → F.1 Publication
Corresponds to variant rs35000511 [ dbSNP | Ensembl ].
VAR_052338
Natural varianti175 – 1751S → F.
Corresponds to variant rs2286025 [ dbSNP | Ensembl ].
VAR_026868

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei166 – 18419Missing in isoform 2. 2 PublicationsVSP_019483Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ020163 mRNA. Translation: AAY84826.1.
AK299154 mRNA. Translation: BAH12960.1.
AK313698 mRNA. Translation: BAG36445.1.
CH471111 Genomic DNA. Translation: EAW57965.1.
BC000854 mRNA. Translation: AAH00854.1.
BC107792 mRNA. Translation: AAI07793.1.
CCDSiCCDS44867.1. [Q9BVX2-2]
CCDS8758.1. [Q9BVX2-1]
RefSeqiNP_001137313.1. NM_001143841.1. [Q9BVX2-2]
NP_001137314.1. NM_001143842.1. [Q9BVX2-1]
NP_001137315.1. NM_001143843.1. [Q9BVX2-2]
NP_076961.1. NM_024056.3. [Q9BVX2-1]
UniGeneiHs.596726.

Genome annotation databases

EnsembliENST00000256686; ENSP00000256686; ENSG00000134291. [Q9BVX2-2]
ENST00000429772; ENSP00000400471; ENSG00000134291. [Q9BVX2-1]
ENST00000449758; ENSP00000402705; ENSG00000134291. [Q9BVX2-2]
ENST00000550552; ENSP00000449737; ENSG00000134291. [Q9BVX2-2]
ENST00000552561; ENSP00000446657; ENSG00000134291. [Q9BVX2-1]
GeneIDi79022.
KEGGihsa:79022.
UCSCiuc001rqo.3. human. [Q9BVX2-2]
uc001rqp.3. human. [Q9BVX2-1]

Polymorphism databases

DMDMi74733372.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ020163 mRNA. Translation: AAY84826.1 .
AK299154 mRNA. Translation: BAH12960.1 .
AK313698 mRNA. Translation: BAG36445.1 .
CH471111 Genomic DNA. Translation: EAW57965.1 .
BC000854 mRNA. Translation: AAH00854.1 .
BC107792 mRNA. Translation: AAI07793.1 .
CCDSi CCDS44867.1. [Q9BVX2-2 ]
CCDS8758.1. [Q9BVX2-1 ]
RefSeqi NP_001137313.1. NM_001143841.1. [Q9BVX2-2 ]
NP_001137314.1. NM_001143842.1. [Q9BVX2-1 ]
NP_001137315.1. NM_001143843.1. [Q9BVX2-2 ]
NP_076961.1. NM_024056.3. [Q9BVX2-1 ]
UniGenei Hs.596726.

3D structure databases

ProteinModelPortali Q9BVX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122490. 2 interactions.
IntActi Q9BVX2. 1 interaction.

PTM databases

PhosphoSitei Q9BVX2.

Polymorphism databases

DMDMi 74733372.

Proteomic databases

MaxQBi Q9BVX2.
PaxDbi Q9BVX2.
PRIDEi Q9BVX2.

Protocols and materials databases

DNASUi 79022.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256686 ; ENSP00000256686 ; ENSG00000134291 . [Q9BVX2-2 ]
ENST00000429772 ; ENSP00000400471 ; ENSG00000134291 . [Q9BVX2-1 ]
ENST00000449758 ; ENSP00000402705 ; ENSG00000134291 . [Q9BVX2-2 ]
ENST00000550552 ; ENSP00000449737 ; ENSG00000134291 . [Q9BVX2-2 ]
ENST00000552561 ; ENSP00000446657 ; ENSG00000134291 . [Q9BVX2-1 ]
GeneIDi 79022.
KEGGi hsa:79022.
UCSCi uc001rqo.3. human. [Q9BVX2-2 ]
uc001rqp.3. human. [Q9BVX2-1 ]

Organism-specific databases

CTDi 79022.
GeneCardsi GC12P048357.
HGNCi HGNC:28775. TMEM106C.
HPAi HPA047204.
neXtProti NX_Q9BVX2.
PharmGKBi PA142670757.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41095.
GeneTreei ENSGT00390000013076.
HOGENOMi HOG000230966.
HOVERGENi HBG055025.
InParanoidi Q9BVX2.
OMAi DCGGNST.
PhylomeDBi Q9BVX2.
TreeFami TF328907.

Miscellaneous databases

ChiTaRSi TMEM106C. human.
GenomeRNAii 79022.
NextBioi 67698.
PROi Q9BVX2.

Gene expression databases

Bgeei Q9BVX2.
CleanExi HS_TMEM106C.
ExpressionAtlasi Q9BVX2. baseline and differential.
Genevestigatori Q9BVX2.

Family and domain databases

InterProi IPR009790. DUF1356_TMEM106.
[Graphical view ]
Pfami PF07092. DUF1356. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "EMOC, a novel stress-regulated gene, encodes an endoplasmic reticulum transmembrane protein and is overexpressed in multiple human malignancies."
    Jin W., Sun Q., Rong R., He Q., Sheikh M.S., Huang Y.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PHE-103.
    Tissue: Cervix and Skin.

Entry informationi

Entry nameiT106C_HUMAN
AccessioniPrimary (citable) accession number: Q9BVX2
Secondary accession number(s): B2R998, B7Z5M4, Q3B761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3