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Q9BVX2

- T106C_HUMAN

UniProt

Q9BVX2 - T106C_HUMAN

Protein

Transmembrane protein 106C

Gene

TMEM106C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 106C
    Alternative name(s):
    Endoplasmic reticulum membrane protein overexpressed in cancer
    Gene namesi
    Name:TMEM106C
    Synonyms:EMOC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:28775. TMEM106C.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670757.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Transmembrane protein 106CPRO_0000243900Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9BVX2.
    PaxDbiQ9BVX2.
    PRIDEiQ9BVX2.

    PTM databases

    PhosphoSiteiQ9BVX2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BVX2.
    BgeeiQ9BVX2.
    CleanExiHS_TMEM106C.
    GenevestigatoriQ9BVX2.

    Organism-specific databases

    HPAiHPA047204.

    Interactioni

    Protein-protein interaction databases

    BioGridi122490. 2 interactions.
    IntActiQ9BVX2. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM106 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41095.
    HOGENOMiHOG000230966.
    HOVERGENiHBG055025.
    InParanoidiQ9BVX2.
    OMAiDCGGNST.
    PhylomeDBiQ9BVX2.
    TreeFamiTF328907.

    Family and domain databases

    InterProiIPR009790. DUF1356_TMEM106.
    [Graphical view]
    PfamiPF07092. DUF1356. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BVX2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT    50
    CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG 100
    LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV 150
    AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR SEQLVNFTGK AEMGGPFSYV 200
    YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY VDCGGNSTAI 250
    Length:250
    Mass (Da):27,875
    Last modified:June 1, 2001 - v1
    Checksum:iDD54511ADFA0F280
    GO
    Isoform 2 (identifier: Q9BVX2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         166-184: Missing.

    Show »
    Length:231
    Mass (Da):25,789
    Checksum:i861C68A4E638DFC9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031V → F.1 Publication
    Corresponds to variant rs35000511 [ dbSNP | Ensembl ].
    VAR_052338
    Natural varianti175 – 1751S → F.
    Corresponds to variant rs2286025 [ dbSNP | Ensembl ].
    VAR_026868

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei166 – 18419Missing in isoform 2. 2 PublicationsVSP_019483Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ020163 mRNA. Translation: AAY84826.1.
    AK299154 mRNA. Translation: BAH12960.1.
    AK313698 mRNA. Translation: BAG36445.1.
    CH471111 Genomic DNA. Translation: EAW57965.1.
    BC000854 mRNA. Translation: AAH00854.1.
    BC107792 mRNA. Translation: AAI07793.1.
    CCDSiCCDS44867.1. [Q9BVX2-2]
    CCDS8758.1. [Q9BVX2-1]
    RefSeqiNP_001137313.1. NM_001143841.1. [Q9BVX2-2]
    NP_001137314.1. NM_001143842.1. [Q9BVX2-1]
    NP_001137315.1. NM_001143843.1. [Q9BVX2-2]
    NP_076961.1. NM_024056.3. [Q9BVX2-1]
    UniGeneiHs.596726.

    Genome annotation databases

    EnsembliENST00000256686; ENSP00000256686; ENSG00000134291. [Q9BVX2-2]
    ENST00000429772; ENSP00000400471; ENSG00000134291. [Q9BVX2-1]
    ENST00000449758; ENSP00000402705; ENSG00000134291. [Q9BVX2-2]
    ENST00000550552; ENSP00000449737; ENSG00000134291. [Q9BVX2-2]
    ENST00000552561; ENSP00000446657; ENSG00000134291. [Q9BVX2-1]
    GeneIDi79022.
    KEGGihsa:79022.
    UCSCiuc001rqo.3. human. [Q9BVX2-2]
    uc001rqp.3. human. [Q9BVX2-1]

    Polymorphism databases

    DMDMi74733372.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ020163 mRNA. Translation: AAY84826.1 .
    AK299154 mRNA. Translation: BAH12960.1 .
    AK313698 mRNA. Translation: BAG36445.1 .
    CH471111 Genomic DNA. Translation: EAW57965.1 .
    BC000854 mRNA. Translation: AAH00854.1 .
    BC107792 mRNA. Translation: AAI07793.1 .
    CCDSi CCDS44867.1. [Q9BVX2-2 ]
    CCDS8758.1. [Q9BVX2-1 ]
    RefSeqi NP_001137313.1. NM_001143841.1. [Q9BVX2-2 ]
    NP_001137314.1. NM_001143842.1. [Q9BVX2-1 ]
    NP_001137315.1. NM_001143843.1. [Q9BVX2-2 ]
    NP_076961.1. NM_024056.3. [Q9BVX2-1 ]
    UniGenei Hs.596726.

    3D structure databases

    ProteinModelPortali Q9BVX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122490. 2 interactions.
    IntActi Q9BVX2. 1 interaction.

    PTM databases

    PhosphoSitei Q9BVX2.

    Polymorphism databases

    DMDMi 74733372.

    Proteomic databases

    MaxQBi Q9BVX2.
    PaxDbi Q9BVX2.
    PRIDEi Q9BVX2.

    Protocols and materials databases

    DNASUi 79022.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256686 ; ENSP00000256686 ; ENSG00000134291 . [Q9BVX2-2 ]
    ENST00000429772 ; ENSP00000400471 ; ENSG00000134291 . [Q9BVX2-1 ]
    ENST00000449758 ; ENSP00000402705 ; ENSG00000134291 . [Q9BVX2-2 ]
    ENST00000550552 ; ENSP00000449737 ; ENSG00000134291 . [Q9BVX2-2 ]
    ENST00000552561 ; ENSP00000446657 ; ENSG00000134291 . [Q9BVX2-1 ]
    GeneIDi 79022.
    KEGGi hsa:79022.
    UCSCi uc001rqo.3. human. [Q9BVX2-2 ]
    uc001rqp.3. human. [Q9BVX2-1 ]

    Organism-specific databases

    CTDi 79022.
    GeneCardsi GC12P048357.
    HGNCi HGNC:28775. TMEM106C.
    HPAi HPA047204.
    neXtProti NX_Q9BVX2.
    PharmGKBi PA142670757.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41095.
    HOGENOMi HOG000230966.
    HOVERGENi HBG055025.
    InParanoidi Q9BVX2.
    OMAi DCGGNST.
    PhylomeDBi Q9BVX2.
    TreeFami TF328907.

    Miscellaneous databases

    ChiTaRSi TMEM106C. human.
    GenomeRNAii 79022.
    NextBioi 67698.
    PROi Q9BVX2.

    Gene expression databases

    ArrayExpressi Q9BVX2.
    Bgeei Q9BVX2.
    CleanExi HS_TMEM106C.
    Genevestigatori Q9BVX2.

    Family and domain databases

    InterProi IPR009790. DUF1356_TMEM106.
    [Graphical view ]
    Pfami PF07092. DUF1356. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "EMOC, a novel stress-regulated gene, encodes an endoplasmic reticulum transmembrane protein and is overexpressed in multiple human malignancies."
      Jin W., Sun Q., Rong R., He Q., Sheikh M.S., Huang Y.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PHE-103.
      Tissue: Cervix and Skin.

    Entry informationi

    Entry nameiT106C_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVX2
    Secondary accession number(s): B2R998, B7Z5M4, Q3B761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3