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Protein

TIMELESS-interacting protein

Gene

TIPIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.3 Publications

GO - Molecular functioni

GO - Biological processi

  • cell cycle phase transition Source: BHF-UCL
  • cell division Source: UniProtKB-KW
  • DNA replication Source: Reactome
  • DNA replication checkpoint Source: HGNC
  • intra-S DNA damage checkpoint Source: HGNC
  • positive regulation of cell proliferation Source: HGNC
  • regulation of nuclear cell cycle DNA replication Source: HGNC
  • replication fork arrest Source: GO_Central
  • replication fork protection Source: GO_Central
  • response to UV Source: Ensembl

Keywordsi

Biological processCell cycle, Cell division, DNA damage, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-5693607. Processing of DNA double-strand break ends.

Names & Taxonomyi

Protein namesi
Recommended name:
TIMELESS-interacting protein
Gene namesi
Name:TIPIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000075131.9.
HGNCiHGNC:30750. TIPIN.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54962.
OpenTargetsiENSG00000075131.
PharmGKBiPA147357269.

Polymorphism and mutation databases

BioMutaiTIPIN.
DMDMi296452932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052531 – 301TIMELESS-interacting proteinAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei233PhosphothreonineCombined sources1
Modified residuei244PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BVW5.
MaxQBiQ9BVW5.
PaxDbiQ9BVW5.
PeptideAtlasiQ9BVW5.
PRIDEiQ9BVW5.

PTM databases

iPTMnetiQ9BVW5.
PhosphoSitePlusiQ9BVW5.

Expressioni

Gene expression databases

BgeeiENSG00000075131.
CleanExiHS_TIPIN.
ExpressionAtlasiQ9BVW5. baseline and differential.
GenevisibleiQ9BVW5. HS.

Organism-specific databases

HPAiHPA039704.
HPA058799.

Interactioni

Subunit structurei

Interacts with TIMELESS, which impairs TIMELESS self-association. Interacts with RPA2, PRDX2, MCM6 and MCM7.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120300. 18 interactors.
DIPiDIP-53658N.
ELMiQ9BVW5.
IntActiQ9BVW5. 21 interactors.
MINTiMINT-4650579.
STRINGi9606.ENSP00000261881.

Structurei

3D structure databases

ProteinModelPortaliQ9BVW5.
SMRiQ9BVW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 143Interaction with TIMELESSAdd BLAST77

Sequence similaritiesi

Belongs to the CSM3 family.Curated

Phylogenomic databases

eggNOGiKOG3004. Eukaryota.
ENOG4111VXN. LUCA.
GeneTreeiENSGT00390000005764.
HOGENOMiHOG000154594.
HOVERGENiHBG061130.
InParanoidiQ9BVW5.
KOiK10904.
OMAiMLEPQEN.
OrthoDBiEOG091G0H5F.
PhylomeDBiQ9BVW5.
TreeFamiTF313290.

Family and domain databases

InterProiView protein in InterPro
IPR012923. Csm3.
PfamiView protein in Pfam
PF07962. Swi3. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD089639. Swi3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BVW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEPQENGVI DLPDYEHVED ETFPPFPPPA SPERQDGEGT EPDEESGNGA
60 70 80 90 100
PVRVPPKRTV KRNIPKLDAQ RLISERGLPA LRHVFDKAKF KGKGHEAEDL
110 120 130 140 150
KMLIRHMEHW AHRLFPKLQF EDFIDRVEYL GSKKEVQTCL KRIRLDLPIL
160 170 180 190 200
HEDFVSNNDE VAENNEHDVT STELDPFLTN LSESEMFASE LSRSLTEEQQ
210 220 230 240 250
QRIERNKQLA LERRQAKLLS NSQTLGNDML MNTPRAHTVE EVNTDEDQKE
260 270 280 290 300
ESNGLNEDIL DNPCNDAIAN TLNEEETLLD QSFKNVQQQL DATSRNITEA

R
Length:301
Mass (Da):34,555
Last modified:May 18, 2010 - v2
Checksum:iB0C69117A636CE3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201Q → R in BAA91229 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03519453R → P4 PublicationsCorresponds to variant dbSNP:rs9806123Ensembl.1
Natural variantiVAR_035195111A → G1 PublicationCorresponds to variant dbSNP:rs2063690Ensembl.1
Natural variantiVAR_053952260L → P. Corresponds to variant dbSNP:rs3759787Ensembl.1
Natural variantiVAR_035196267A → S1 PublicationCorresponds to variant dbSNP:rs3759786Ensembl.1
Natural variantiVAR_062207270N → D. Corresponds to variant dbSNP:rs34848112Ensembl.1
Natural variantiVAR_054483270N → S1 PublicationCorresponds to variant dbSNP:rs780014564Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000523 mRNA. Translation: BAA91229.1.
EU551725 Genomic DNA. Translation: ACB21044.1.
AC055855 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77762.1.
BC000870 mRNA. Translation: AAH00870.1.
BK001386 mRNA. Translation: DAA01365.1.
CCDSiCCDS10215.1.
RefSeqiNP_001276915.1. NM_001289986.1.
NP_060328.2. NM_017858.2.
XP_005254578.1. XM_005254521.2.
XP_005254579.1. XM_005254522.4.
XP_006720657.1. XM_006720594.3.
XP_011520045.1. XM_011521743.1.
XP_016877879.1. XM_017022390.1.
UniGeneiHs.744308.

Genome annotation databases

EnsembliENST00000261881; ENSP00000261881; ENSG00000075131.
GeneIDi54962.
KEGGihsa:54962.
UCSCiuc002apr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTIPIN_HUMAN
AccessioniPrimary (citable) accession number: Q9BVW5
Secondary accession number(s): B2CW64, Q9NWZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 18, 2010
Last modified: October 25, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families