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Q9BVV8

- CS024_HUMAN

UniProt

Q9BVV8 - CS024_HUMAN

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Protein

Uncharacterized membrane protein C19orf24

Gene

C19orf24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized membrane protein C19orf24
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26073. C19orf24.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: HGNC
  2. extracellular region Source: BHF-UCL
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 132106Uncharacterized membrane protein C19orf24PRO_0000079385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Modified residuei113 – 1131Phosphothreonine1 Publication
Modified residuei117 – 1171Phosphoserine3 Publications
Modified residuei120 – 1201Phosphoserine3 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9BVV8.
PRIDEiQ9BVV8.

PTM databases

PhosphoSiteiQ9BVV8.

Expressioni

Gene expression databases

BgeeiQ9BVV8.
CleanExiHS_C19orf24.
ExpressionAtlasiQ9BVV8. baseline and differential.
GenevestigatoriQ9BVV8.

Organism-specific databases

HPAiHPA043279.

Interactioni

Protein-protein interaction databases

IntActiQ9BVV8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BVV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000064649.
HOGENOMiHOG000111985.
InParanoidiQ9BVV8.
OMAiQPGAPHN.
OrthoDBiEOG77HDHP.
PhylomeDBiQ9BVV8.
TreeFamiTF339572.

Family and domain databases

InterProiIPR009565. DUF1180.
[Graphical view]
PfamiPF06679. DUF1180. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BVV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPRVLQPPL LLLLLALLLA ALPCGAEEAS PLRPAQVTLS PPPAVTNGSQ
60 70 80 90 100
PGAPHNSTHT RPPGASGSAL TRSFYVILGF CGLTALYFLI RAFRLKKPQR
110 120 130
RRYGLLANTE DPTEMASLDS DEETVFESRN LR
Length:132
Mass (Da):14,249
Last modified:April 20, 2010 - v2
Checksum:i58C95478850F1818
GO

Sequence cautioni

The sequence BAA91305.1 differs from that shown. Reason: Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004258 Genomic DNA. No translation available.
BC000890 mRNA. Translation: AAH00890.2.
AK000647 mRNA. Translation: BAA91305.1. Sequence problems.
CCDSiCCDS12060.2.
RefSeqiNP_060384.3. NM_017914.3.
UniGeneiHs.591383.

Genome annotation databases

EnsembliENST00000409293; ENSP00000386557; ENSG00000228300.
GeneIDi55009.
KEGGihsa:55009.
UCSCiuc002lrw.4. human.

Polymorphism databases

DMDMi294862428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004258 Genomic DNA. No translation available.
BC000890 mRNA. Translation: AAH00890.2 .
AK000647 mRNA. Translation: BAA91305.1 . Sequence problems.
CCDSi CCDS12060.2.
RefSeqi NP_060384.3. NM_017914.3.
UniGenei Hs.591383.

3D structure databases

ProteinModelPortali Q9BVV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BVV8. 1 interaction.

PTM databases

PhosphoSitei Q9BVV8.

Polymorphism databases

DMDMi 294862428.

Proteomic databases

MaxQBi Q9BVV8.
PRIDEi Q9BVV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409293 ; ENSP00000386557 ; ENSG00000228300 .
GeneIDi 55009.
KEGGi hsa:55009.
UCSCi uc002lrw.4. human.

Organism-specific databases

CTDi 55009.
GeneCardsi GC19P001289.
HGNCi HGNC:26073. C19orf24.
HPAi HPA043279.
neXtProti NX_Q9BVV8.
PharmGKBi PA134930220.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000064649.
HOGENOMi HOG000111985.
InParanoidi Q9BVV8.
OMAi QPGAPHN.
OrthoDBi EOG77HDHP.
PhylomeDBi Q9BVV8.
TreeFami TF339572.

Miscellaneous databases

GenomeRNAii 55009.
NextBioi 58357.

Gene expression databases

Bgeei Q9BVV8.
CleanExi HS_C19orf24.
ExpressionAtlasi Q9BVV8. baseline and differential.
Genevestigatori Q9BVV8.

Family and domain databases

InterProi IPR009565. DUF1180.
[Graphical view ]
Pfami PF06679. DUF1180. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-132.
    Tissue: Cervix.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-132.
    Tissue: Carcinoma.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-113; SER-117 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCS024_HUMAN
AccessioniPrimary (citable) accession number: Q9BVV8
Secondary accession number(s): Q9NWS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

External Data

Dasty 3