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Q9BVV8

- CS024_HUMAN

UniProt

Q9BVV8 - CS024_HUMAN

Protein

Uncharacterized membrane protein C19orf24

Gene

C19orf24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized membrane protein C19orf24
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26073. C19orf24.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. extracellular region Source: BHF-UCL
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134930220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 132106Uncharacterized membrane protein C19orf24PRO_0000079385Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Modified residuei113 – 1131Phosphothreonine1 Publication
    Modified residuei117 – 1171Phosphoserine3 Publications
    Modified residuei120 – 1201Phosphoserine3 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9BVV8.

    PTM databases

    PhosphoSiteiQ9BVV8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BVV8.
    BgeeiQ9BVV8.
    CleanExiHS_C19orf24.
    GenevestigatoriQ9BVV8.

    Organism-specific databases

    HPAiHPA043279.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9BVV8. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000111985.
    InParanoidiQ9BVV8.
    OMAiQPGAPHN.
    OrthoDBiEOG77HDHP.
    PhylomeDBiQ9BVV8.
    TreeFamiTF339572.

    Family and domain databases

    InterProiIPR009565. DUF1180.
    [Graphical view]
    PfamiPF06679. DUF1180. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BVV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPRVLQPPL LLLLLALLLA ALPCGAEEAS PLRPAQVTLS PPPAVTNGSQ    50
    PGAPHNSTHT RPPGASGSAL TRSFYVILGF CGLTALYFLI RAFRLKKPQR 100
    RRYGLLANTE DPTEMASLDS DEETVFESRN LR 132
    Length:132
    Mass (Da):14,249
    Last modified:April 20, 2010 - v2
    Checksum:i58C95478850F1818
    GO

    Sequence cautioni

    The sequence BAA91305.1 differs from that shown. Reason:

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004258 Genomic DNA. No translation available.
    BC000890 mRNA. Translation: AAH00890.2.
    AK000647 mRNA. Translation: BAA91305.1. Sequence problems.
    CCDSiCCDS12060.2.
    RefSeqiNP_060384.3. NM_017914.3.
    UniGeneiHs.591383.

    Genome annotation databases

    EnsembliENST00000409293; ENSP00000386557; ENSG00000228300.
    GeneIDi55009.
    KEGGihsa:55009.
    UCSCiuc002lrw.4. human.

    Polymorphism databases

    DMDMi294862428.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004258 Genomic DNA. No translation available.
    BC000890 mRNA. Translation: AAH00890.2 .
    AK000647 mRNA. Translation: BAA91305.1 . Sequence problems.
    CCDSi CCDS12060.2.
    RefSeqi NP_060384.3. NM_017914.3.
    UniGenei Hs.591383.

    3D structure databases

    ProteinModelPortali Q9BVV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BVV8. 1 interaction.

    PTM databases

    PhosphoSitei Q9BVV8.

    Polymorphism databases

    DMDMi 294862428.

    Proteomic databases

    PRIDEi Q9BVV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409293 ; ENSP00000386557 ; ENSG00000228300 .
    GeneIDi 55009.
    KEGGi hsa:55009.
    UCSCi uc002lrw.4. human.

    Organism-specific databases

    CTDi 55009.
    GeneCardsi GC19P001289.
    HGNCi HGNC:26073. C19orf24.
    HPAi HPA043279.
    neXtProti NX_Q9BVV8.
    PharmGKBi PA134930220.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000111985.
    InParanoidi Q9BVV8.
    OMAi QPGAPHN.
    OrthoDBi EOG77HDHP.
    PhylomeDBi Q9BVV8.
    TreeFami TF339572.

    Miscellaneous databases

    GenomeRNAii 55009.
    NextBioi 58357.

    Gene expression databases

    ArrayExpressi Q9BVV8.
    Bgeei Q9BVV8.
    CleanExi HS_C19orf24.
    Genevestigatori Q9BVV8.

    Family and domain databases

    InterProi IPR009565. DUF1180.
    [Graphical view ]
    Pfami PF06679. DUF1180. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-132.
      Tissue: Cervix.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-132.
      Tissue: Carcinoma.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-113; SER-117 AND SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCS024_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVV8
    Secondary accession number(s): Q9NWS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM

    External Data

    Dasty 3